Results 1 to 10 of about 4,239 (221)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Cigarette Smoke Extract, but Not Electronic Cigarette Aerosol Extract, Inhibits Monoamine Oxidase in vitro and Produces Greater Acute Aversive/Anhedonic Effects Than Nicotine Alone on Intracranial Self-Stimulation in Rats

Frontiers in Neuroscience, 2022
Conventional tobacco cigarettes appear to have greater abuse liability than non-combusted products such as electronic cigarettes (ECs) and nicotine replacement therapy (NRT).
Andrew C. Harris, Andrew C. Harris, Andrew C. Harris, Peter Muelken, Aleksandra Alcheva, Irina Stepanov, Mark G. LeSage, Mark G. LeSage, Mark G. LeSage   +8 more
doaj   +1 more source

Racemisation of Amino Acids: From Synthetic Challenge to Biological Significance

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Racemisation, once considered an undesirable synthetic side reaction, also occurs naturally in amino acids and influences biological processes. Evidence links stereochemical conversion to ageing, protein turnover, and cellular development. This review examines mechanisms, control strategies in synthesis, applications and implications in physiology ...
Othman Al Musaimi
wiley   +1 more source

Innovating Electrosynthesis From Metal Electrodeposition to Organic Chemistry: Deep Eutectic Solvents as Efficient and Sustainable Media

ChemSusChem, Volume 19, Issue 11, 15 June 2026.
This review analyzes deep eutectic solvents (DESs) as efficient media for both organic and inorganic electrosynthesis. The improvements in terms of synthetic opportunities and sustainability are discussed, by exploring the multiple roles of DESs as solvents, electrolytes, and promoters, enabling effective and selective electrosynthesis under mild and ...
Cristiana Margarita, Stefano Nejrotti, Alejandro Leal‐Duaso, Marta Feroci, Alessandra Sanson, Claudia Barolo, Matteo Bonomo   +6 more
wiley   +1 more source

From Quinoxaline, Pyrido[2,3-b]pyrazine and Pyrido[3,4-b]pyrazine to Pyrazino-Fused Carbazoles and Carbolines

Molecules, 2018
2,3-Diphenylated quinoxaline, pyrido[2,3-b]pyrazine and 8-bromopyrido[3,4-b]pyrazine were halogenated in deprotometalation-trapping reactions using mixed 2,2,6,6-tetramethyl piperidino-based lithium-zinc combinations in tetrahydrofuran.
Frédéric Lassagne, Timothy Langlais, Elsa Caytan, Emmanuelle Limanton, Ludovic Paquin, Manon Boullard, Coline Courtel, Idriss Curbet, Clément Gédéon, Julien Lebreton, Laurent Picot, Valérie Thiéry, Mohamed Souab, Blandine Baratte, Sandrine Ruchaud, Stéphane Bach, Thierry Roisnel, Florence Mongin   +17 more
doaj   +1 more source

Foodborne Carcinogens: Formation Pathways, Health Risks, and Cutting‐Edge Physical and Chemical Prevention Strategies

eFood, Volume 7, Issue 3, June 2026.
This review highlights the formation of foodborne carcinogens during processing and evaluates different mitigation strategies, including natural antioxidants and modern cooking techniques, to reduce associated cancer risks and enhance food safety. ABSTRACT Food processing methods, though vital for improving food safety, taste, and shelf life, can ...
Naglaa S. Ashmawy, Ahmed A. Zaky, Noha H. Badr, Ali Korin, Mohamed A. Farag   +4 more
wiley   +1 more source

Nutritional Composition, Odor‐Contributing Volatile Compounds, and Antioxidant Capacity of the Wild Edible Mushroom Entoloma clypeatum

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Nutritional composition, free amino acids, fatty acids, minerals, 5′ ‐nucleotides, volatile compounds, and antioxidant activities of Entoloma clypeatum. ABSTRACT Wild mushrooms are increasingly valued in diets for their nutrients and health benefits. The nutritional composition of Entoloma clypeatum, a wild mycorrhizal edible species that grows under ...
Cuiduan Wang, Zhuang Li, Xiaomin Yang, Jianhua Lv, Jinxiu Zhang   +4 more
wiley   +1 more source

Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview

MedComm, Volume 7, Issue 6, June 2026.
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele, Ajit Manchare, Swapnali Parit, Amol D. Gholap, Krishna Jadhav, Navnath Hatvate, Keshav Raj Paudel, Satish Rojekar   +7 more
wiley   +1 more source

Oxidative Asymmetric Formal Aza-Diels–Alder Reactions of Tetrahydro-β-carboline with Enones in the Synthesis of Indoloquinolizidine-2-ones

Molecules, 2018
Ru-catalyzed tandem amine oxidative dehydrogenation/formal aza-Diels–Alder reaction for enantio- and diastereoselective synthesis of indoloquinolizidine-2-ones from tetrahydro-β-carbolines and α,β-unsaturated ketones is described ...
Xiang Wu, Shi-Bao Zhao, Lang-Lang Zheng, You-Gui Li   +3 more
doaj   +1 more source

Et3N/DMSO-supported one-pot synthesis of highly fluorescent β-carboline-linked benzothiophenones via sulfur insertion and estimation of the photophysical properties

Beilstein Journal of Organic Chemistry, 2020
A robust transition-metal-free strategy is presented to access novel β-carboline-tethered benzothiophenone derivatives from 1(3)-formyl-β-carbolines using elemental sulfur activated by Et3N/DMSO.
Dharmender Singh, Vipin Kumar, Virender Singh   +2 more
doaj   +1 more source