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β-Carboline (norharman) [PDF]

open access: yesActa Crystallographica Section C Crystal Structure Communications, 2011
The structure of β-carboline, also called norharman (systematic name: 9H-pyrido[3,4-b]indole), C(11)H(8)N(2), has been determined at 110 K. Norharman is prevalent in the environment and the human body and is of wide biological interest. The structure exhibits intermolecular N-H···N hydrogen bonding, which results in a one-dimensional herringbone motif.
Robert J, Thatcher   +1 more
openaire   +2 more sources

Trait Anxiety, Coping with Stress, and Norharman

open access: yesPsychological Reports, 1997
Plasma levels of the β-carboline norharman, concentration of platelet 5-HT, trait measures of anxiety, and measures of coping and defense mechanisms were compared for 15 patients with panic disorder and 24 healthy volunteers. Patients indicated that they made less use of the defense mechanism of principalization than control subjects.
Verheij, René   +4 more
openaire   +4 more sources

Interactions of norharman and harman with DNA

open access: yesNucleic Acids Research, 1977
The interactions of norharman (9H-pyrido [3,4-b] indole) and harman (1-methyl-9H-pyrido [3,4-b] indole) with DNA were studied. DNA caused remarkable fluorescence quenching and change in the absorption spectra of the dyes. Scatchard plots obtained by optical titration gave Kd values of 2.2 X 10(-5)M and 7.7 X 10(-6)M, and apparent numbers of binding ...
K, Hayashi, M, Nagao, T, Sugimura
openaire   +3 more sources

Norharman and Harman in Human Urine.

open access: yesProceedings of the Japan Academy, Series B, 1995
It has been shown that norharman and harman, present in our environment, may act as genotoxic compounds in human body. In order to have an insight of the extents of exposure to these β-carbolines, we measured their levels in human urine. Samples of 24-hr urine were collected from ten healthy volunteers eating a normal diet and three patients receiving ...
USHIYAMA, Hirofumi   +5 more
openaire   +2 more sources

Occurence and partition of the β-carboline norharman in rat organs [PDF]

open access: yesLife Sciences, 1993
The beta-carboline norharman was determined in plasma, brain, liver, kidney, spleen, heart and lung of the rat using HPLC with fluorescence detection. In order to improve the speed and sensitivity of this assay an earlier published sample clean-up extraction procedure and HPLC method were adjusted. Norharman was found to be present in plasma as well as
D, Fekkes, W T, Bode
openaire   +2 more sources

Antimicrobial and autophototoxic effects of norharmane in termites

open access: yes, 2004
The fluorescent alkaloid norharmane has been isolated from Reticulitermes termites and characterized by microcoil 1H NMR, UV/Vis, mass spectrometry and GC/MS. This is the first report of norharmane in insects, which is the major component in termite fluorescence under ultraviolet light.
Siderhurst, Matthew Samuel, author   +4 more
openaire   +2 more sources

The role of beta-carbolines (harman/norharman) in heroin addicts

open access: yesEuropean Psychiatry, 1995
SummaryEndogenous substances resulting from interactions between alcohol and possibly opioid metabolites and neurotransmitters (dopamine, indolamines) could be mediators of the pathochemical process towards dependence. Beta-carbolines (harman/norharman) are increased in alcoholics and — according to the presented results — in heroin addicts ...
Stohler R, Rommelspacher H, Ladewig D
openaire   +3 more sources

Norharman, a normal body constituent [PDF]

open access: yesThe Lancet, 1992
D, Fekkes   +5 more
openaire   +2 more sources

CLXXXV.—Harmine and harmaline. Part V. The synthesis of norharman

open access: yesJ. Chem. Soc., Trans., 1921
n ...
Kermack, William Ogilvy   +2 more
openaire   +2 more sources

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