Results 11 to 20 of about 4,239 (221)

Monoamine Oxidase Inhibition by Plant-Derived β-Carbolines; Implications for the Psychopharmacology of Tobacco and Ayahuasca [PDF]

Frontiers in Pharmacology, 2022
The monoamine oxidases (MAOs) are flavin-containing amine oxidoreductases responsible for metabolism of many biogenic amine molecules in the brain and peripheral tissues.
Ilana Berlowitz, Klemens Egger, Paul Cumming, Paul Cumming   +3 more
doaj   +2 more sources

Anti-inflammatory effects of Banisteriopsis caapi and beta-carbolines in neuronal cells: potential implications for neuro-COVID [PDF]

Frontiers in Pharmacology
BackgroundNeuroinflammation plays a central role in neurodegenerative diseases such as Alzheimer’s and Parkinson’s, along with depression, anxiety, and infectious diseases including COVID-19.
Laura Seixas Bianco, Tiago Nicoliche, Nelson Francisco Corrêa-Neto, Rafael Lanaro, Ariadiny L. Caetano, Carla Maximo Prado, Rodrigo Portes Ureshino, Rodrigo Portes Ureshino, Iolanda de Fátima Lopes Calvo Tibério, Renato Fraga Righetti, Renato Fraga Righetti, Roberta Sessa Stilhano, Alessandra Linardi   +12 more
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Bioactive β-Carbolines Harman and Norharman in Sesame Seed Oils in China

Molecules, 2022
The β-carbolines in our diet, mainly including harman and norharman, are a group of biologically active, naturally occurring plant-derived alkaloids. Fragrant sesame seed oil is one of the most popular flavor edible oils in China. Considering that sesame
Wei Liu, Zhaoyu Yang, Lili Shi, Yun Li
doaj   +2 more sources

Comprehensive review of β-carbolines from microbes and their biosynthesis

European Journal of Medicinal Chemistry Reports
β-carbolines were historically known as plant-derived metabolites. They are known to exhibit a broad spectrum of biological activities with clinical and economic significance.
Mary Ayeko Twumasi, Matthew Peter Kusche, Amna Farzeen Baig, S. Eric Nybo, Madan Kumar Kharel   +4 more
doaj   +2 more sources

Photocatalytic Enantioselective Radical Cascade Multicomponent Minisci Reaction of β‐Carbolines Using Diazo Compounds as Radical Precursors [PDF]

Advanced Science
Here, a photocatalytic asymmetric multicomponent cascade Minisci reaction of β‐carbolines with enamides and diazo compounds is reported, enabling an effective enantioselective radical C─H functionalization of β‐carbolines with high yields and ...
Yi‐Jie Gu, Mu‐Peng Luo, Hua Yuan, Guo‐Kai Liu, Shou‐Guo Wang   +4 more
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3-(1,2,3-Triazol-4-yl)-β-Carbolines and 3-(1H-Tetrazol-5-yl)-β-Carbolines: Synthesis and Evaluation as Anticancer Agents

Pharmaceuticals, 2022
Herein, the synthesis and anticancer activity evaluation of a series of novel β-carbolines is reported. The reactivity of nitrosoalkenes towards indole was explored for the synthesis of novel tryptophan analogs where the carboxylic acid was replaced by a
João L. P. Ribeiro, Joana B. Loureiro, Susana M. M. Lopes, Lucília Saraiva, Teresa M. V. D. Pinho e Melo   +4 more
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An intramolecular inverse electron demand Diels–Alder approach to annulated α-carbolines

Beilstein Journal of Organic Chemistry, 2012
Intramolecular inverse electron demand cycloadditions of isatin-derived 1,2,4-triazines with acetylenic dienophiles tethered by amidations or transesterifications proceed in excellent yields to produce lactam- or lactone-fused α-carbolines.
Zhiyuan Ma, Feng Ni, Grace H. C. Woo, Sie-Mun Lo, Philip M. Roveto, Scott E. Schaus, John K. Snyder   +6 more
doaj   +2 more sources

Effect of Chemical Refining on the Reduction of β-Carboline Content in Sesame Seed Oil

Molecules, 2023
β-carbolines (harman and norharman) are potentially mutagenic and have been reported in some vegetable oils. Sesame seed oil is obtained from roasted sesame seeds. During sesame oil processing, roasting is the key procedure to aroma enhancement, in which
Lili Shi, Ziyu Cui, Wei Liu
doaj   +1 more source

Application of High-Performance Liquid Chromatography with Fluorescence Detection for Non-Polar Heterocyclic Aromatic Amines and Acridine Derivatives Determination in Pork Loin Roasted in a Roasting Bag

Foods, 2022
Heat treatment of meat can lead to the formation of carcinogenic organic compounds. The influence of dried fruits on the formation of non-polar heterocyclic aromatic amines (carbolines) and nitrogen derivatives of polycyclic aromatic hydrocarbons ...
Ewa Śnieżek, Magdalena Szumska, Agnieszka Nowak, Roksana Muzyka, Beata Janoszka   +4 more
doaj   +1 more source

Degradation of β-Carbolines Harman and Norharman in Edible Oils during Heating

Molecules, 2021
The β-carbolines, mainly including harman and norharman, are a group of naturally occurring, plant-derived alkaloids, and are also considered as nonpolar heterocyclic aromatic amines.
Wei Liu, Zhaoyu Yang, Lili Shi, Ziyu Cui, Yun Li   +4 more
doaj   +1 more source