Results 11 to 20 of about 2,640 (185)
Frontiers in Pharmacology, 2022 The monoamine oxidases (MAOs) are flavin-containing amine oxidoreductases responsible for metabolism of many biogenic amine molecules in the brain and peripheral tissues.
Ilana Berlowitz +3 more
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2-(2,5-Dimethoxyphenyl)pyrrole-3-carbonitrile
Molbank, 2023 The Cadogan reaction of 2-aryl-3-nitropyridines leads to δ-carbolines. The title compound is a side product in this reaction, generated via a ring opening of a nitrene and cyclization. A crystal structure analysis gives an enormous unit cell.
Yannic Grimm +2 more
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Acta Crystallographica Section C Crystal Structure Communications, 2011 The structure of β-carboline, also called norharman (systematic name: 9H-pyrido[3,4-b]indole), C(11)H(8)N(2), has been determined at 110 K. Norharman is prevalent in the environment and the human body and is of wide biological interest. The structure exhibits intermolecular N-H···N hydrogen bonding, which results in a one-dimensional herringbone motif.
Robert J, Thatcher +1 more
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Mild and efficient ammonium chloride catalyzed Greener synthesis of tetrahydro-β-carboline
Current Research in Green and Sustainable Chemistry, 2022 This protocol involves the NH4Cl catalyzed Pictet−Spengler reactions of tryptamine and arylaldehydes in anhydrous MeOH solvent to gives corresponding tetrahydro-β-carbolines (THβC) with 90% yield. This methodology offers mild, efficient and green reagent
Milind V. Gaikwad +2 more
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Frontiers in Nutrition, 2022 This study investigated the effect of multiple precursor amino acids on the simultaneous formation of acrylamide, β-carbolines (i. e., harmane and norharmane), and advanced glycation end products (AGEs) [i.e., Nε-(carboxymethyl)lysine and Nε ...
Cuyu Chen +8 more
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Journal of Spectroscopy, 1997 The reactions of carboline under various oxidative conditions are reported. The soft aerobic radiolysis, hydroxylation and rearrangement transformations are studied using isotopic labelling and GC–MS techniques.
Christophe Dardonville +3 more
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An intramolecular inverse electron demand Diels–Alder approach to annulated α-carbolines
Beilstein Journal of Organic Chemistry, 2012 Intramolecular inverse electron demand cycloadditions of isatin-derived 1,2,4-triazines with acetylenic dienophiles tethered by amidations or transesterifications proceed in excellent yields to produce lactam- or lactone-fused α-carbolines.
Zhiyuan Ma +6 more
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Marine Drugs, 2015 Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development.
Natalie Netz, Till Opatz
doaj +1 more source
Nature Communications, 2019 Tetrahydro-γ-carbolines are the basic structural unit in many natural products and pharmaceuticals. Here, the authors report a synergistic Cu/Ir system to assemble chiral tetrahydro-γ-carbolines via a stereodivergent allylation followed by a ...
Shi-Ming Xu +5 more
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Cytotoxic Bis-3,4-dihydro-β-carbolines and Bis-β-carbolines [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2002 Ten bis-beta-carboline 1, 2 and bis-3,4-dihydro-beta-carboline 3, 4 derivatives, linked between carbons 1 and 1' by a polymethylene spacer, were synthesized from bistryptamine amides 9, 10. Some of them display a micromolar IC50 towards L-1210 cells.
Wei-Qun, Jiang +6 more
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