Monoamine Oxidase Inhibition by Plant-Derived β-Carbolines; Implications for the Psychopharmacology of Tobacco and Ayahuasca [PDF]
Frontiers in Pharmacology, 2022 The monoamine oxidases (MAOs) are flavin-containing amine oxidoreductases responsible for metabolism of many biogenic amine molecules in the brain and peripheral tissues.
Ilana Berlowitz +3 more
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Bioactive β-Carbolines Harman and Norharman in Sesame Seed Oils in China
Molecules, 2022 The β-carbolines in our diet, mainly including harman and norharman, are a group of biologically active, naturally occurring plant-derived alkaloids. Fragrant sesame seed oil is one of the most popular flavor edible oils in China. Considering that sesame
Wei Liu, Zhaoyu Yang, Lili Shi, Yun Li
doaj +3 more sources
Degradation of β-Carbolines Harman and Norharman in Edible Oils during Heating
Molecules, 2021 The β-carbolines, mainly including harman and norharman, are a group of naturally occurring, plant-derived alkaloids, and are also considered as nonpolar heterocyclic aromatic amines.
Wei Liu +4 more
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Metal-Catalyzed Cyclotrimerization Reactions of Cyanamides: Synthesis of 2-Aryl-α-carbolines
Organic Letters, 2020 The synthesis of annulated 2-aryl-α-carboline heterocycles is described using transition metal catalysis. A linear strategy is described that uses Rh(I) catalysis to form the α-carboline scaffold by [2+2+2] cyclotrimerization.
Kyle Medas +5 more
semanticscholar +2 more sources
A β-carboline natural product induces oxidative stress in Fusarium graminearum and limits the virulence of multiple fungal phytopathogens [PDF]
mBioThe emergence of fungicide-resistant pathogens of many agronomically important crop species necessitates the development of novel strategies for controlling diseases caused by fungi.
Bradley Laflamme +13 more
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Anti-inflammatory effects of Banisteriopsis caapi and beta-carbolines in neuronal cells: potential implications for neuro-COVID [PDF]
Frontiers in PharmacologyBackgroundNeuroinflammation plays a central role in neurodegenerative diseases such as Alzheimer’s and Parkinson’s, along with depression, anxiety, and infectious diseases including COVID-19.
Laura Seixas Bianco +12 more
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Nature Communications, 2019 Tetrahydro-γ-carbolines are the basic structural unit in many natural products and pharmaceuticals. Here, the authors report a synergistic Cu/Ir system to assemble chiral tetrahydro-γ-carbolines via a stereodivergent allylation followed by a ...
Shi-Ming Xu +5 more
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Comprehensive review of β-carbolines from microbes and their biosynthesis
European Journal of Medicinal Chemistry Reportsβ-carbolines were historically known as plant-derived metabolites. They are known to exhibit a broad spectrum of biological activities with clinical and economic significance.
Mary Ayeko Twumasi +4 more
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Photocatalytic Enantioselective Radical Cascade Multicomponent Minisci Reaction of β‐Carbolines Using Diazo Compounds as Radical Precursors [PDF]
Advanced ScienceHere, a photocatalytic asymmetric multicomponent cascade Minisci reaction of β‐carbolines with enamides and diazo compounds is reported, enabling an effective enantioselective radical C─H functionalization of β‐carbolines with high yields and ...
Yi‐Jie Gu +4 more
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A Structure–Activity Relationship Study of Trypargine and Opacaline β-Carbolines [PDF]
Marine DrugsThe marine environment represents a rich source of novel antimicrobial compounds. This study investigated the isolation and synthesis of antimicrobial agents from the New Zealand ascidian Pseudodistoma opacum to identify natural products and derivatives ...
Dan Chen +4 more
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