Results 1 to 10 of about 5,636 (198)

Quantification of glycosaminoglycans using harmine extract from Peganum harmala L. in mucopolysaccharidoses researches

Biomedical and Biotechnology Research Journal
Background: Harmine is used in the quantification of glycosaminoglycans (GAGs) for the research on mucopolysaccharidoses (MPSs). Although this product is commercially available, researchers may consider preparing it under laboratory conditions when it is
Houda El Fissi, Fadoua Bouzid, Ikram Achqra, Mohammed Said Sebbar, Fouad Msanda, Mohamed Amine Serghini, Najat Alif   +6 more
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Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma

Cancer Cell International, 2018
Background Neuroblastoma (NB) is an early childhood malignancy that arises from the developing sympathetic nervous system. Harmine is a tricyclic β-carboline alkaloid isolated from the harmal plant that exhibits both cytostatic and cytotoxic effects ...
Katie L. Uhl, Chad R. Schultz, Dirk Geerts, André S. Bachmann   +3 more
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Dynamic Changes of Endogenic or Exogenic β-Carboline Alkaloid Harmine in Different Mammals and Human in vivo at Developmental and Physiological States

Frontiers in Aging Neuroscience, 2022
ObjectiveSeveral β-carboline alkaloids (βCBs), such as harmine, harmaline, harmane, and nor-harmane, are effective for Alzheimer’s disease mouse models. They can be found in some plants, common foodstuffs, and blank plasma of various mammals.
Ning Cao, Shuping Li, Aimin Xu, Manlin Li, Xiaoguang Zou, Zunji Ke, Gang Deng, Xuemei Cheng, Changhong Wang   +8 more
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Innovative spectrofluorometric method for determination of harmaline and harmine in different matrices

Scientific Reports, 2023
Harmaline and harmine are naturally occurring closely related β-carboline alkaloids found in Peganum and Banisteriopsis plants. They have historical significance in traditional practices due to their potential psychoactive and therapeutic properties ...
Ahmed H. Abdelazim, Majed A. Algarni, Atiah H. Almalki   +2 more
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An experimental study of the systemic bioavailability of the drug "Harmin hydrochloride, capsules" in comparison with native garmin on chinchilla rabbits

Фармакокинетика и Фармакодинамика, 2020
An experimental comparative study of the relative bioavailability of plant alkaloid harmine (native, in the form of a base) in comparison with its derivative harmine hydrochloride was carried out on chinchilla rabbit.
S. M. Adekenov, V. S. Schnaukshta, E. V. Epifantseva, D. A. Abaimov, M. G. Abdrakhmanova, A. K. Sariev   +5 more
doaj   +1 more source

Harmine, an inhibitor of the type III secretion system of Salmonella enterica serovar Typhimurium

Frontiers in Cellular and Infection Microbiology, 2022
New therapeutic strategies for clinical Salmonella enterica serovar Typhimurium (S. Typhimurium) infection are urgently needed due to the generation of antibiotic-resistant bacteria.
Yunjia Shi, Xindi Chen, Jingyan Shu, Yang Liu, Yong Zhang, Qianghua Lv, Jianfeng Wang, Xuming Deng, Hongtao Liu, Jiazhang Qiu   +9 more
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Effect of harmine on nicotine-induced kidney dysfunction in male mice

International Journal of Preventive Medicine, 2019
Background: The nicotine content of cigarettes plays a key role in the pathogenesis of kidney disease. Harmine is a harmal-derived alkaloid with antioxidant properties.
Mohammad Reza Salahshoor, Shiva Roshankhah, Vahid Motavalian, Cyrus Jalili   +3 more
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Suppression of Non-Small Cell Lung Cancer Growth and Metastasis by a Novel Small Molecular Activator of RECK

Cellular Physiology and Biochemistry, 2018
Background/Aims: Reversion-inducing cysteine-rich protein with kazal motifs (RECK) is a novel tumor suppressor gene that is critical for regulating tumor cell invasion and metastasis. The expression of RECK is dramatically down-regulated in human cancers.
Jia Shen, Banghua Wang, Tao Zhang, Ni Zhu, Zexia Wang, Jing Jin, Yi He, Meichun Hu   +7 more
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Solid-Contact Potentiometric Sensors Based on Main-Tailored Bio-Mimics for Trace Detection of Harmine Hallucinogen in Urine Specimens

Molecules, 2021
All-solid-state potentiometric sensors have attracted great attention over other types of potentiometric sensors due to their outstanding properties such as enhanced portability, simplicity of handling, affordability and flexibility.
Abde El-Galil E. Amr, Ayman H. Kamel, Abdulrahman A. Almehizia, Ahmed Y. A. Sayed, Hisham S. M. Abd-Rabboh   +4 more
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Targeted delivery of harmine to xenografted human pancreatic islets promotes robust cell proliferation

Scientific Reports, 2022
Type 1 diabetes (T1D) occurs as a consequence of the autoimmune destruction of insulin-producing pancreatic beta (β) cells and commonly presents with insulin deficiency and unregulated glycemic control.
Swati Mishra, Philip R. Streeter
doaj   +1 more source