Research progress on the antitumor effects of harmine [PDF]
Frontiers in OncologyHarmine is a naturally occurring β-carboline alkaloid originally isolated from Peganum harmala. As a major active component, harmine exhibits a broad spectrum of pharmacological properties, particularly remarkable antitumor effects.
Yonghua Hu +8 more
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A screening identifies harmine as a novel antibacterial compound against Ralstonia solanacearum [PDF]
Frontiers in Microbiology, 2023 Ralstonia solanacearum, the causal agent of bacterial wilt, is a devastating plant pathogenic bacterium that infects more than 450 plant species. Until now, there has been no efficient control strategy against bacterial wilt. In this study, we screened a
Hongkai Xia +9 more
doaj +4 more sources
Harmine reduces ROS-mediated hepatotoxicity in a cisplatin mouse model [PDF]
Research in Pharmaceutical SciencesBackground and purpose: Cisplatin, a widely used anticancer agent, has adverse effects on normal tissues during cancer treatment. This study aimed to investigate the use of harmine, a plant β-carboline alkaloid, against pathways associated with ROS ...
Cyrus Jalili +7 more
doaj +3 more sources
Harmine Targets Peroxiredoxin 6 to Enhance Macrophage Immunity Against Pseudomonas plecoglossicida in Ayu (Plecoglossus altivelis) [PDF]
AntioxidantsPseudomonas plecoglossicida causes bacterial hemorrhagic ascites in ayu (Plecoglossus altivelis), a lethal disease characterized by abdominal distension with hemorrhagic ascites, multifocal organ hemorrhages, and histopathologically evident ...
Yan-Jun Liu +8 more
doaj +2 more sources
Exploration of the potential neurotransmitter or neuromodulator-like properties of harmine: evidence from synthesis to synaptic modulation [PDF]
Frontiers in PharmacologyBackground:The discovery of new neurotransmitters is crucial for the in-depth understanding of neural signal transmission, neurological disorders, and relevant treatment strategies.
Zhejun Xie +6 more
doaj +2 more sources
Anti-inflammatory effects of Banisteriopsis caapi and beta-carbolines in neuronal cells: potential implications for neuro-COVID [PDF]
Frontiers in PharmacologyBackgroundNeuroinflammation plays a central role in neurodegenerative diseases such as Alzheimer’s and Parkinson’s, along with depression, anxiety, and infectious diseases including COVID-19.
Laura Seixas Bianco +12 more
doaj +2 more sources
Potential anticancer effects of Peganum harmala in human papillomavirus-related cervical and head and neck cancer cells [PDF]
Frontiers in PharmacologyBackgroundP. harmala L (P. harmala) has a longstanding role in ethnomedical treatments. Its reported anticancer effects have led to increased research interest; however, its antineoplastic properties on cervical and head and neck (HN) cancer cells need ...
Hiba F. Muddather +16 more
doaj +2 more sources
Harmine Mitigates Liver Injury Induced by Mercuric Chloride via the Inhibition of Oxidative Stress [PDF]
Research Journal of Pharmacognosy, 2021 Background and objective: The mercury-induced liver pathogenesis is mainly mediated by oxidative stress. The aim of the current study was to evaluate the possible ameliorative effect of harmine, a natural compound, on liver toxicity induced by mercury ...
Cyrus Jalili +3 more
doaj +1 more source
Harmine Has Nephroprotective Effect Against Methotrexate-Induced Injury in Mice via Inhibition of Oxidative Stress [PDF]
Research Journal of Pharmacognosy, 2021 Background and objectives: Despite clinical use, the efficacy of methotrexate is often limited by some adverse effects, mainly nephrotoxicity. The most common mechanism of methotrexate-induced kidney damages is oxidative stress.
Cyrus Jalili +5 more
doaj +1 more source
Effect and Mechanism of Harmine on Echinococcosis Based on Network Pharmacology
Natural Product Communications, 2023 Objective The aim of this research was to explore the effects on echinococcosis of harmine, an active ingredient of Peganum harmala . Methods The gene targets were screened out by use of an online database.
Bei Chen +6 more
doaj +1 more source