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Research progress on the antitumor effects of harmine
Frontiers in OncologyHarmine is a naturally occurring β-carboline alkaloid originally isolated from Peganum harmala. As a major active component, harmine exhibits a broad spectrum of pharmacological properties, particularly remarkable antitumor effects.
Xiaoli Yu, Yu Xiaoli
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Harmine stimulates proliferation of human neural progenitors [PDF]
PeerJ, 2016 Harmine is the β-carboline alkaloid with the highest concentration in the psychotropic plant decoction Ayahuasca. In rodents, classical antidepressants reverse the symptoms of depression by stimulating neuronal proliferation.
Vanja Dakic +5 more
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Binding of Harmine Derivatives to DNA: A Spectroscopic Investigation [PDF]
Molecules, 2017 Harmine belongs to a group of β-carboline alkaloids endowed with antitumor properties. Harmine and its derivatives are thought to bind to DNA and interfere with topoisomerase activities. We investigated the base-dependent binding of harmine, and three of
Bruno Pagano +3 more
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Harmine Mitigates Liver Injury Induced by Mercuric Chloride via the Inhibition of Oxidative Stress [PDF]
Research Journal of Pharmacognosy, 2021 Background and objective: The mercury-induced liver pathogenesis is mainly mediated by oxidative stress. The aim of the current study was to evaluate the possible ameliorative effect of harmine, a natural compound, on liver toxicity induced by mercury ...
Cyrus Jalili +3 more
doaj +1 more source
Harmine Has Nephroprotective Effect Against Methotrexate-Induced Injury in Mice via Inhibition of Oxidative Stress [PDF]
Research Journal of Pharmacognosy, 2021 Background and objectives: Despite clinical use, the efficacy of methotrexate is often limited by some adverse effects, mainly nephrotoxicity. The most common mechanism of methotrexate-induced kidney damages is oxidative stress.
Cyrus Jalili +5 more
doaj +1 more source
Scripta Score Scientific Medical Journal, 2021 Background: Type 1 and 2 diabetes mellitus (DM) is a chronic metabolic disease most commonly affects millions of people worldwide. Despite the differences in pathogenesis, both share one thing in common - that is the drastic depletion in the number of ...
Ghea Mangkuliguna +2 more
doaj +1 more source
Effect and Mechanism of Harmine on Echinococcosis Based on Network Pharmacology
Natural Product Communications, 2023 Objective The aim of this research was to explore the effects on echinococcosis of harmine, an active ingredient of Peganum harmala . Methods The gene targets were screened out by use of an online database.
Bei Chen +6 more
doaj +1 more source
Life, 2022 Harmine is a beta-carboline alkaloid present in various plants, including in the seeds of Peganum harmala L. This study aimed to investigate the anti-inflammatory activity and mechanism of harmine using macrophages stimulated with various toll-like ...
So-Jung Jin +5 more
doaj +1 more source
Loading Harmine On Nanographene Changes The Inhibitory Effects of Free Harmine Against MCF7 and Fibroblast Cells [PDF]
Medicinal Chemistry Research, 2021 Abstract Today cancer is one of the main causes of death all over the world. Chemotherapy, which is one of the main therapies in the treatment of cancer, causes several side effects by damaging healthy cells. Therefore, carbon nanomaterial systems have been developed to optimize therapeutics procedures with the least negative consequences ...
Newsha Mortazavi +4 more
openaire +3 more sources
Frontiers in Immunology, 2021 Peri-prosthetic osteolysis (PPO) and following aseptic loosening are regarded as the prime reasons for implant failure after joint replacement. Increasing evidence indicated that wear-debris-irritated inflammatory response and macrophage polarization ...
Liangliang Wang +13 more
doaj +1 more source