Synthetic Derivatives of Natural Alkaloid Harmine
Eurasian Chemico-Technological Journal, 2009 The indole alkaloid harmine was extracted from underground part of Peganum harmala L. With the purpose of obtaining the new biological active derivatives on base of alkaloid harmine the chemical modification was carried out.
M. M. Ismagulova +4 more
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Harmaline Tremor: Underlying Mechanisms in a Potential Animal Model of Essential Tremor [PDF]
, 2012 Background: Harmaline and harmine are tremorigenic β-carbolines that, on administration to experimental animals, induce an acute postural and kinetic tremor of axial and truncal musculature. This drug-induced action tremor has been proposed as a model of
Handforth, Adrian
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Dyrk1A Influences Neuronal Morphogenesis Through Regulation of Cytoskeletal Dynamics in Mammalian Cortical Neurons [PDF]
, 2012 Down syndrome (DS) is the most frequent genetic cause of mental retardation. Cognitive dysfunction in these patients is correlated with reduced dendritic branching and complexity, along with fewer spines of abnormal shape that characterize the cortical ...
Ahn +39 more
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Elevated blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor [PDF]
, 2008 Essential tremor (ET) is a widespread late-life neurological disease. Genetic and environmental factors likely play an etiological role. Harmane (1-methyl-9H-pyrido[3,4-b]indole) is a potent tremor-producing neurotoxin.
Factor-Litvak, Pam +6 more
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BMC Infectious DiseasesBackground As antimicrobial resistance (AMR) has become a global health crisis, new strategies against AMR infection are urgently needed. Quorum sensing (QS), responsible for bacterial communication and pathogenicity, is among the targets for anti ...
Pei Chen +4 more
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Cytotoxic activity of methanolic extract and two alkaloids extracted from seeds of Peganum harmala L. [PDF]
, 2005 To study the cytotoxic activity of P. harmala. Materials and method: The alkaloids harmine and harmaline have been isolated from a methanolic extract from the seeds of P. harmala L.
Berrougui, Hicham +5 more
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In vitro monoamine oxidase inhibition potential of alpha- methyltryptamine analog new psychoactive substances for assessing possible toxic risks [PDF]
Tryptamines have emerged as new psychoactive substances (NPS), which are distributed and consumed recreationally without preclinical studies or safety tests.
Brandt, SD +4 more
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A review study of therapeutic effects of Peganum harmala [PDF]
, 2016 Peganum harmala. belongs to Asian Origin and grows in the Middle East and in part of South mainly in India and Pakistan, is a plant of the family Nitrariaceae. It is a perennial plant which can grow to about 0.8 m tall.
Miraj, S.
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Isoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1 [PDF]
, 2016 Camptothecin (CPT), a topoisomerase I (TOP1) inhibitor, exhibits anti-tumor activity against a wide range of tumors. Redundancy of TOP1-mediated repair mechanisms is a major challenge facing the efficiency of TOP1-targetting therapies. This study aims to
El-Khamisy, S.F. +4 more
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بررسی سميت سلولی عصاره دانه گياه اسفند و ارتباط آن با ميزان آلکالوئيدهای بتا ـ کاربولينی موجود در عصاره [PDF]
, 2002 عصاره دانه گياه اسفند ( Peganum harmala L. ) از جمله اجزای تشکيل دهنده يکی از فرآوردههای گياهی بومی بکار رفته جهت درمان سرطان در ايران است. آلکالوئيدهای بتا ـ کاربولينی نظير هارمين و هارمالين قسمت اعظم ترکيبات فعال موجود در اسفند را تشکيل میدهند.
احمد ابراهيمی, سلطان +4 more
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