Research progress on the antitumor effects of harmine
Frontiers in OncologyHarmine is a naturally occurring β-carboline alkaloid originally isolated from Peganum harmala. As a major active component, harmine exhibits a broad spectrum of pharmacological properties, particularly remarkable antitumor effects.
Xiaoli Yu, Yu Xiaoli
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Exploration of the potential neurotransmitter or neuromodulator-like properties of harmine: evidence from synthesis to synaptic modulation [PDF]
Frontiers in PharmacologyBackground:The discovery of new neurotransmitters is crucial for the in-depth understanding of neural signal transmission, neurological disorders, and relevant treatment strategies.
Zhejun Xie +6 more
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Harmine Targets Peroxiredoxin 6 to Enhance Macrophage Immunity Against Pseudomonas plecoglossicida in Ayu (Plecoglossus altivelis) [PDF]
AntioxidantsPseudomonas plecoglossicida causes bacterial hemorrhagic ascites in ayu (Plecoglossus altivelis), a lethal disease characterized by abdominal distension with hemorrhagic ascites, multifocal organ hemorrhages, and histopathologically evident ...
Yan-Jun Liu +8 more
doaj +2 more sources
Harmine stimulates proliferation of human neural progenitors [PDF]
PeerJ, 2016 Harmine is the β-carboline alkaloid with the highest concentration in the psychotropic plant decoction Ayahuasca. In rodents, classical antidepressants reverse the symptoms of depression by stimulating neuronal proliferation.
Vanja Dakic +5 more
doaj +4 more sources
Anti-inflammatory effects of Banisteriopsis caapi and beta-carbolines in neuronal cells: potential implications for neuro-COVID [PDF]
Frontiers in PharmacologyBackgroundNeuroinflammation plays a central role in neurodegenerative diseases such as Alzheimer’s and Parkinson’s, along with depression, anxiety, and infectious diseases including COVID-19.
Laura Seixas Bianco +12 more
doaj +2 more sources
Potential anticancer effects of Peganum harmala in human papillomavirus-related cervical and head and neck cancer cells [PDF]
Frontiers in PharmacologyBackgroundP. harmala L (P. harmala) has a longstanding role in ethnomedical treatments. Its reported anticancer effects have led to increased research interest; however, its antineoplastic properties on cervical and head and neck (HN) cancer cells need ...
Hiba F. Muddather +16 more
doaj +2 more sources
Harmine alleviates LPS-induced acute lung injury by inhibiting CSF3-mediated MAPK/NF-κB signaling pathway [PDF]
Respiratory ResearchBackground Acute lung injury (ALI) is a life-threatening inflammatory lung disease that lacks safe and effective treatment strategies. Harmine, an alkaloid derived from Peganum harmala L plants, exhibits anti-inflammatory activity.
Yihui Zhai +9 more
doaj +2 more sources
Binding of Harmine Derivatives to DNA: A Spectroscopic Investigation [PDF]
Molecules, 2017 Harmine belongs to a group of β-carboline alkaloids endowed with antitumor properties. Harmine and its derivatives are thought to bind to DNA and interfere with topoisomerase activities. We investigated the base-dependent binding of harmine, and three of
Bruno Pagano +3 more
doaj +3 more sources
Anti-tumor potential of Harmine and its derivatives: recent trends and advancements [PDF]
Discover OncologyHarmine is a β-carboline alkaloid derived from Peganum harmala, showing a solid antitumor potential in different types of human cancer cells. Unfortunately, the clinical application of this natural alkaloid has been impeded till now by severe toxic side ...
Hemant Joshi +11 more
doaj +2 more sources
Harmine Mitigates Liver Injury Induced by Mercuric Chloride via the Inhibition of Oxidative Stress [PDF]
Research Journal of Pharmacognosy, 2021 Background and objective: The mercury-induced liver pathogenesis is mainly mediated by oxidative stress. The aim of the current study was to evaluate the possible ameliorative effect of harmine, a natural compound, on liver toxicity induced by mercury ...
Cyrus Jalili +3 more
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