Results 21 to 30 of about 4,328 (171)

Harmine Alleviated Sepsis-Induced Cardiac Dysfunction by Modulating Macrophage Polarization via the STAT/MAPK/NF-κB Pathway

Frontiers in Cell and Developmental Biology, 2022
Sepsis is a dysregulated systemic inflammatory response that often leads to cardiac dysfunction, which is termed sepsis-induced cardiomyopathy (SIC). Harmine, a natural β-carboline alkaloid compound, has been shown to exert pharmacological effects on ...
Weibin Ruan, Xinyun Ji, Yating Qin, Xinxin Zhang, Xiaoning Wan, Chuanmeng Zhu, Chao Lv, Chongqing Hu, Juan Zhou, Li Lu, Li Lu, Xiaomei Guo   +11 more
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Exposure Characteristics of the Analogous β-Carboline Alkaloids Harmaline and Harmine Based on the Efflux Transporter of Multidrug Resistance Protein 2

Frontiers in Pharmacology, 2017
Harmaline and harmine occur naturally in plants and are distributed endogenously in human and animal tissues. The two β-carboline alkaloids possess potential for treating Alzheimer's disease, Parkinson's disease, depression and other central nervous ...
Shuping Li, Yunpeng Zhang, Gang Deng, Yuwen Wang, Shenglan Qi, Xuemei Cheng, Xuemei Cheng, Yueming Ma, Yan Xie, Changhong Wang, Changhong Wang   +10 more
doaj   +1 more source

Harmine Ameliorates Cognitive Impairment by Inhibiting NLRP3 Inflammasome Activation and Enhancing the BDNF/TrkB Signaling Pathway in STZ-Induced Diabetic Rats

Frontiers in Pharmacology, 2020
Diabetes mellitus (DM) is considered a risk factor for cognitive dysfunction. Harmine not only effectively improves the symptoms of DM but also provides neuroprotective effects in central nervous system diseases. However, whether harmine has an effect on
Peifang Liu, Hui Li, Yueqiu Wang, Xiaolin Su, Yang Li, Meiling Yan, Lan Ma, Hui Che   +7 more
doaj   +1 more source

A pilot study of cerebral metabolism and serotonin 5-HT2A receptor occupancy in rats treated with the psychedelic tryptamine DMT in conjunction with the MAO inhibitor harmine

Frontiers in Pharmacology, 2023
Rationale: The psychedelic effects of the traditional Amazonian botanical decoction known as ayahuasca are often attributed to agonism at brain serotonin 5-HT2A receptors by N,N-dimethyltryptamine (DMT).
Klemens Egger, Klemens Egger, Klemens Egger, Frederik Gudmundsen, Frederik Gudmundsen, Naja Støckel Jessen, Naja Støckel Jessen, Naja Støckel Jessen, Christina Baun, Christina Baun, Sandra N. Poetzsch, Vladimir Shalgunov, Vladimir Shalgunov, Matthias M. Herth, Matthias M. Herth, Boris B. Quednow, Boris B. Quednow, Chantal Martin-Soelch, Dario Dornbierer, Milan Scheidegger, Milan Scheidegger, Paul Cumming, Paul Cumming, Mikael Palner, Mikael Palner, Mikael Palner   +25 more
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Harmine and 7,8-dihydroxyflavone synergistically suitable for amyotrophic lateral sclerosis management: An in silico study [PDF]

Research Results in Pharmacology, 2022
Introduction: Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease characterized by progressive degeneration of both upper and lower motor neurons, resulting in paralysis and eventually leads to death from respiratory failure typically ...
Toluwase Fatoki, Stanley Chukwuejim, Omodele Ibraheem, Christiana Oke, Blessing Ejimadu, Isaiah Olaoye, Oluwabukola Oyegbenro, Taiwo Salami, Romilola Basorun, Oluwafisayomi Oluwadare, Yetunde Salawudeen   +10 more
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Harmine activates intrinsic and extrinsic pathways of apoptosis in B16F-10 melanoma

Chinese Medicine, 2011
Background Harmine is a beta-carboline alkaloid from the plant Peganum harmala. Previous studies found that harmine inhibited metastasis of B16F-10 melanoma cells. This study aims to elucidate the role of harmine in apoptosis of B16F-10 cells.
Kuttan Girija, Hamsa Thayele
doaj   +1 more source

The inhibitory effects of compound Muniziqi granule against B16 cells and harmine induced autophagy and apoptosis by inhibiting Akt/mTOR pathway

BMC Complementary and Alternative Medicine, 2017
Background Compound Muniziqi granule (MNZQ) is a multi-component herbal preparation and a popular traditional Uighur medicine used in China for treating endocrine disorder-induced acne, chloasma, dysmenorrhea, menopausal syndrome, and melanoma.
Nan Zou, Yue Wei, Fenghua Li, Yang Yang, Xuemei Cheng, Changhong Wang   +5 more
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A natural small molecule harmine inhibits angiogenesis and suppresses tumour growth through activation of p53 in endothelial cells. [PDF]

PLoS ONE, 2012
Activation of p53 effectively inhibits tumor angiogenesis that is necessary for tumor growth and metastasis. Reactivation of the p53 by small molecules has emerged as a promising new strategy for cancer therapy.
Fujun Dai, Yihua Chen, Yajuan Song, Li Huang, Dong Zhai, Yanmin Dong, Li Lai, Tao Zhang, Dali Li, Xiufeng Pang, Mingyao Liu, Zhengfang Yi   +11 more
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Harmine mitigates cisplatin-induced renal injury in male mice through antioxidant, anti-inflammatory, and anti-apoptosis effects

Research in Pharmaceutical Sciences, 2022
Background and purpose: Cisplatin is a chemotherapeutic drug used to treat cancer, however, causes kidney toxicity. Harmine is a plant-derived alkaloid with a wide range of therapeutic applications.
Ali Ghanbari, Cyrus Jalili, Mohammad Reza Salahshoor, Setareh Javanmardy, Saeed Ravankhah, Nasim Akhshi   +5 more
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Structure–Activity Relationships and Biological Evaluation of 7-Substituted Harmine Analogs for Human β-Cell Proliferation

Molecules, 2020
Recently, we have shown that harmine induces β-cell proliferation both in vitro and in vivo, mediated via the DYRK1A-NFAT pathway. We explore structure–activity relationships of the 7-position of harmine for both DYRK1A kinase inhibition and β-cell ...
Kunal Kumar, Peng Wang, Ethan A. Swartz, Susmita Khamrui, Cody Secor, Michael B. Lazarus, Roberto Sanchez, Andrew F. Stewart, Robert J. DeVita   +8 more
doaj   +1 more source