Harmine Mitigates Liver Injury Induced by Mercuric Chloride via the Inhibition of Oxidative Stress [PDF]
Research Journal of Pharmacognosy, 2021 Background and objective: The mercury-induced liver pathogenesis is mainly mediated by oxidative stress. The aim of the current study was to evaluate the possible ameliorative effect of harmine, a natural compound, on liver toxicity induced by mercury ...
Cyrus Jalili +3 more
doaj +1 more source
Synthesis and Evaluation of Radioiodinated [<sup>125</sup>I]7-Iodo-5H-Pyrido[4,3-B]Indole ([<sup>125</sup>I]CTAU) in Postmortem Human Alzheimer's Disease Brain. [PDF]
J Labelled Comp Radiopharm[125I]CTAU, a new analog of [18F]T807, was found to be suitable for imaging tau protein in postmortem human Alzheimer's disease brain slices. [125I]CTAU may be among the smaller ring structures that bind to tau protein. ABSTRACT The aim of this study was to further understand the tau imaging agent, flortaucipir (T807), by making small modifications and
McNamara CC +5 more
europepmc +2 more sources
Harmine Has Nephroprotective Effect Against Methotrexate-Induced Injury in Mice via Inhibition of Oxidative Stress [PDF]
Research Journal of Pharmacognosy, 2021 Background and objectives: Despite clinical use, the efficacy of methotrexate is often limited by some adverse effects, mainly nephrotoxicity. The most common mechanism of methotrexate-induced kidney damages is oxidative stress.
Cyrus Jalili +5 more
doaj +1 more source
Harmine Derivatives as Anticancer Agents Endowed With Potent and Selective Antileukemia Activity: Synthesis, Biological Evaluation, Proapoptotic and Genotoxic Activity. [PDF]
Arch Pharm (Weinheim)We identified a novel N9‐substituted harmine analog, compound 6, that selectively suppresses leukemic cell growth, triggers DNA damage, and activates apoptosis while sparing healthy fibroblasts. This discovery highlights N9‐modified β‐carbolines as a powerful new class of selective antileukemic agents, bridging natural product chemistry with next ...
Timbilla AA +17 more
europepmc +2 more sources
Scripta Score Scientific Medical Journal, 2021 Background: Type 1 and 2 diabetes mellitus (DM) is a chronic metabolic disease most commonly affects millions of people worldwide. Despite the differences in pathogenesis, both share one thing in common - that is the drastic depletion in the number of ...
Ghea Mangkuliguna +2 more
doaj +1 more source
Loading Harmine On Nanographene Changes The Inhibitory Effects of Free Harmine Against MCF7 and Fibroblast Cells [PDF]
Medicinal Chemistry Research, 2021 Abstract Today cancer is one of the main causes of death all over the world. Chemotherapy, which is one of the main therapies in the treatment of cancer, causes several side effects by damaging healthy cells. Therefore, carbon nanomaterial systems have been developed to optimize therapeutics procedures with the least negative consequences ...
Newsha Mortazavi +4 more
openaire +3 more sources
Effect and Mechanism of Harmine on Echinococcosis Based on Network Pharmacology
Natural Product Communications, 2023 Objective The aim of this research was to explore the effects on echinococcosis of harmine, an active ingredient of Peganum harmala . Methods The gene targets were screened out by use of an online database.
Bei Chen +6 more
doaj +1 more source
Life, 2022 Harmine is a beta-carboline alkaloid present in various plants, including in the seeds of Peganum harmala L. This study aimed to investigate the anti-inflammatory activity and mechanism of harmine using macrophages stimulated with various toll-like ...
So-Jung Jin +5 more
doaj +1 more source
A screening identifies harmine as a novel antibacterial compound against Ralstonia solanacearum
Frontiers in Microbiology, 2023 Ralstonia solanacearum, the causal agent of bacterial wilt, is a devastating plant pathogenic bacterium that infects more than 450 plant species. Until now, there has been no efficient control strategy against bacterial wilt. In this study, we screened a
Hongkai Xia +9 more
doaj +1 more source
Probing solute distribution and acid-base behaviour in water-in-oil microemulsions by fluorescence techniques [PDF]
, 1993 The distribution and acid-base behaviour of the four solutes harmine, chromotropic acid (4,5-dihydroxynaphthalene-2,7-disulfonate, disodium salt), 2-naphthol and 5,10,15,20-tetrakis [4-trimethylammonium)phenyl]-21H,23H-porphine tetra-p-tosylate (TTMP ...
Miguel, Maria da Graça +3 more
core +5 more sources