Results 21 to 30 of about 5,636 (198)

ANTIDEPRESSANT ACTION OF HARMINE HYDROCHLORIDE [PDF]

Pharmacy & Pharmacology, 2015
The articles presents the results of antridepressant action of water-soluble form of harmine hydrochloride.
Zh. S. Nurmaganbetov, L. I. Arystan, A. Zh. Turmukhambetov, A. A. Anaev, T. A. Voronina, A. K. Sariev, S. M. Adekenov   +6 more
openaire   +4 more sources

Structure–Activity Relationships and Biological Evaluation of 7-Substituted Harmine Analogs for Human β-Cell Proliferation

Molecules, 2020
Recently, we have shown that harmine induces β-cell proliferation both in vitro and in vivo, mediated via the DYRK1A-NFAT pathway. We explore structure–activity relationships of the 7-position of harmine for both DYRK1A kinase inhibition and β-cell ...
Kunal Kumar, Peng Wang, Ethan A. Swartz, Susmita Khamrui, Cody Secor, Michael B. Lazarus, Roberto Sanchez, Andrew F. Stewart, Robert J. DeVita   +8 more
doaj   +2 more sources

Synthetic Derivatives of Natural Alkaloid Harmine [PDF]

Eurasian Chemico-Technological Journal, 2009
The indole alkaloid harmine was extracted from underground part of Peganum harmala L. With the purpose of obtaining the new biological active derivatives on base of alkaloid harmine the chemical modification was carried out.
M. M. Ismagulova, Zh. S. Nurmaganbetov, A. Zh. Turmukhambetov, T. S. Seitembetov, S. M. Adekenov   +4 more
doaj   +2 more sources

Anti-inflammatory effects of Banisteriopsis caapi and beta-carbolines in neuronal cells: potential implications for neuro-COVID [PDF]

Frontiers in Pharmacology
BackgroundNeuroinflammation plays a central role in neurodegenerative diseases such as Alzheimer’s and Parkinson’s, along with depression, anxiety, and infectious diseases including COVID-19.
Laura Seixas Bianco, Tiago Nicoliche, Nelson Francisco Corrêa-Neto, Rafael Lanaro, Ariadiny L. Caetano, Carla Maximo Prado, Rodrigo Portes Ureshino, Rodrigo Portes Ureshino, Iolanda de Fátima Lopes Calvo Tibério, Renato Fraga Righetti, Renato Fraga Righetti, Roberta Sessa Stilhano, Alessandra Linardi   +12 more
doaj   +2 more sources

Harmine acts as a quorum sensing inhibitor decreasing the virulence and antibiotic resistance of Pseudomonas aeruginosa

BMC Infectious Diseases
Background As antimicrobial resistance (AMR) has become a global health crisis, new strategies against AMR infection are urgently needed. Quorum sensing (QS), responsible for bacterial communication and pathogenicity, is among the targets for anti ...
Pei Chen, Jiangyue Qin, Helene K. Su, Lianming Du, Qianglin Zeng   +4 more
doaj   +2 more sources

Potential anticancer effects of Peganum harmala in human papillomavirus-related cervical and head and neck cancer cells [PDF]

Frontiers in Pharmacology
BackgroundP. harmala L (P. harmala) has a longstanding role in ethnomedical treatments. Its reported anticancer effects have led to increased research interest; however, its antineoplastic properties on cervical and head and neck (HN) cancer cells need ...
Hiba F. Muddather, Tohfa Nasibova, Tohfa Nasibova, Gábor J. Szebeni, Gábor J. Szebeni, Nikolett Gémes, Noémi Bózsity, Renáta Minorics, Eldar Garayev, Ilkay Erdogan Orhan, Gaëtan Herbette, Gaëtan Herbette, Zsuzsanna Schelz, Judit Hohmann, Judit Hohmann, István Zupkó, István Zupkó   +16 more
doaj   +2 more sources

Registered Clinical Trials of Ayahuasca and DMT: A Scoping Review. [PDF]

Clin Pharmacol Ther
Interest in ayahuasca and its main component, N,N‐Dimethyltryptamine (DMT), has currently moved from historical and experimental use into modern clinical development. Yet, current evidence is fragmented, and systematic mapping of trial methods and design choices remains limited.
Stojanović T, Nilsson KW, Fredriksson R, Schiöth HB, Moulin TC.   +4 more
europepmc   +2 more sources

IRF-1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α. [PDF]

Animal Model Exp Med
IRF‐1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α. Abstract Background The purpose is to define the contribution of the interferon regulatory factor‐1–dual‐specificity tyrosine phosphorylation‐regulated kinase 1α (IRF‐1–DYRK1α) axis to hepatocellular ferroptosis during liver ischemia/reperfusion injury ...
Zhang J, Zhang J, Song S, Li M, Sun L, Zhu Z, Lin D.   +6 more
europepmc   +2 more sources

Harmine Mitigates Liver Injury Induced by Mercuric Chloride via the Inhibition of Oxidative Stress [PDF]

Research Journal of Pharmacognosy, 2021
Background and objective: The mercury-induced liver pathogenesis is mainly mediated by oxidative stress. The aim of the current study was to evaluate the possible ameliorative effect of harmine, a natural compound, on liver toxicity induced by mercury ...
Cyrus Jalili, Sara Darakhshan, Mohammadreza Azimi, Ali Ghanbari*   +3 more
doaj   +1 more source

Harmine Has Nephroprotective Effect Against Methotrexate-Induced Injury in Mice via Inhibition of Oxidative Stress [PDF]

Research Journal of Pharmacognosy, 2021
Background and objectives: Despite clinical use, the efficacy of methotrexate is often limited by some adverse effects, mainly nephrotoxicity. The most common mechanism of methotrexate-induced kidney damages is oxidative stress.
Cyrus Jalili, Sara Darakhshan, Nasim Akhshi, Amir Abdolmaleki, Abdolnasir Abdi, Ali Ghanbari*   +5 more
doaj   +1 more source