Results 21 to 30 of about 4,342 (172)

Harmine Ameliorates Cognitive Impairment by Inhibiting NLRP3 Inflammasome Activation and Enhancing the BDNF/TrkB Signaling Pathway in STZ-Induced Diabetic Rats

Frontiers in Pharmacology, 2020
Diabetes mellitus (DM) is considered a risk factor for cognitive dysfunction. Harmine not only effectively improves the symptoms of DM but also provides neuroprotective effects in central nervous system diseases. However, whether harmine has an effect on
Peifang Liu, Hui Li, Yueqiu Wang, Xiaolin Su, Yang Li, Meiling Yan, Lan Ma, Hui Che   +7 more
doaj   +1 more source

A pilot study of cerebral metabolism and serotonin 5-HT2A receptor occupancy in rats treated with the psychedelic tryptamine DMT in conjunction with the MAO inhibitor harmine

Frontiers in Pharmacology, 2023
Rationale: The psychedelic effects of the traditional Amazonian botanical decoction known as ayahuasca are often attributed to agonism at brain serotonin 5-HT2A receptors by N,N-dimethyltryptamine (DMT).
Klemens Egger, Klemens Egger, Klemens Egger, Frederik Gudmundsen, Frederik Gudmundsen, Naja Støckel Jessen, Naja Støckel Jessen, Naja Støckel Jessen, Christina Baun, Christina Baun, Sandra N. Poetzsch, Vladimir Shalgunov, Vladimir Shalgunov, Matthias M. Herth, Matthias M. Herth, Boris B. Quednow, Boris B. Quednow, Chantal Martin-Soelch, Dario Dornbierer, Milan Scheidegger, Milan Scheidegger, Paul Cumming, Paul Cumming, Mikael Palner, Mikael Palner, Mikael Palner   +25 more
doaj   +1 more source

Harmine activates intrinsic and extrinsic pathways of apoptosis in B16F-10 melanoma

Chinese Medicine, 2011
Background Harmine is a beta-carboline alkaloid from the plant Peganum harmala. Previous studies found that harmine inhibited metastasis of B16F-10 melanoma cells. This study aims to elucidate the role of harmine in apoptosis of B16F-10 cells.
Kuttan Girija, Hamsa Thayele
doaj   +1 more source

Harmine and 7,8-dihydroxyflavone synergistically suitable for amyotrophic lateral sclerosis management: An in silico study [PDF]

Research Results in Pharmacology, 2022
Introduction: Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease characterized by progressive degeneration of both upper and lower motor neurons, resulting in paralysis and eventually leads to death from respiratory failure typically ...
Toluwase Fatoki, Stanley Chukwuejim, Omodele Ibraheem, Christiana Oke, Blessing Ejimadu, Isaiah Olaoye, Oluwabukola Oyegbenro, Taiwo Salami, Romilola Basorun, Oluwafisayomi Oluwadare, Yetunde Salawudeen   +10 more
doaj   +3 more sources

Intra- and extra-cellular DNA damage by harmine and 9-methyl-harmine

Journal of Photochemistry and Photobiology B: Biology, 2014
It is known that β-carbolines are able to produce photosensitized damage in cell-free DNA, but there is little information on their effects on cellular DNA. Therefore, we have analyzed the DNA damage produced by harmine and 9-methyl-harmine under UVA irradiation in V79 cells, together with the associated generation of micronuclei and photocytotoxicity.
Vignoni, Mariana, Erra Balsells, Rosa, Epe, Bernd, Cabrerizo, Franco Martín   +3 more
openaire   +4 more sources

The inhibitory effects of compound Muniziqi granule against B16 cells and harmine induced autophagy and apoptosis by inhibiting Akt/mTOR pathway

BMC Complementary and Alternative Medicine, 2017
Background Compound Muniziqi granule (MNZQ) is a multi-component herbal preparation and a popular traditional Uighur medicine used in China for treating endocrine disorder-induced acne, chloasma, dysmenorrhea, menopausal syndrome, and melanoma.
Nan Zou, Yue Wei, Fenghua Li, Yang Yang, Xuemei Cheng, Changhong Wang   +5 more
doaj   +1 more source

Harmine enhances the activity of the HIV-1 latency-reversing agents ingenol A and SAHA

Biology Open, 2020
Infection with human immunodeficiency virus 1 (HIV-1) remains incurable because long-lived, latently-infected cells persist during prolonged antiretroviral therapy.
Jared P. Taylor, Lucas H. Armitage, Daniel L. Aldridge, Melanie N. Cash, Mark A. Wallet   +4 more
doaj   +1 more source

A natural small molecule harmine inhibits angiogenesis and suppresses tumour growth through activation of p53 in endothelial cells. [PDF]

PLoS ONE, 2012
Activation of p53 effectively inhibits tumor angiogenesis that is necessary for tumor growth and metastasis. Reactivation of the p53 by small molecules has emerged as a promising new strategy for cancer therapy.
Fujun Dai, Yihua Chen, Yajuan Song, Li Huang, Dong Zhai, Yanmin Dong, Li Lai, Tao Zhang, Dali Li, Xiufeng Pang, Mingyao Liu, Zhengfang Yi   +11 more
doaj   +1 more source

Harmine mitigates cisplatin-induced renal injury in male mice through antioxidant, anti-inflammatory, and anti-apoptosis effects

Research in Pharmaceutical Sciences, 2022
Background and purpose: Cisplatin is a chemotherapeutic drug used to treat cancer, however, causes kidney toxicity. Harmine is a plant-derived alkaloid with a wide range of therapeutic applications.
Ali Ghanbari, Cyrus Jalili, Mohammad Reza Salahshoor, Setareh Javanmardy, Saeed Ravankhah, Nasim Akhshi   +5 more
doaj   +1 more source

The Role of Harmine in Up-regulating p53 Gene Expression and Inducing Apoptosis in MCF-7 Cell Line

Middle East Journal of Cancer, 2020
Background: As a major tumor suppressor gene, P53 plays a principal role in the apoptosis of cancer cells. Harmine is a harmal-derived alkaloid with antioxidant and anticancer properties.
Shiva Roshankhah, Babak Arji Rodsari, Cyrus Jalili, Mohammad Reza Salahshoor   +3 more
doaj   +1 more source