Results 21 to 30 of about 5,752 (199)
HeliyonSmall molecules as ligands target multifunctional ribonucleic acids (RNA) for therapeutic engagement. This study explores how the anticancer DNA intercalator harmine interacts various motifs of RNAs, including the single-stranded A-form poly (rA), the ...
Paromita Sarkar +7 more
doaj +2 more sources
Registered Clinical Trials of Ayahuasca and DMT: A Scoping Review. [PDF]
Clin Pharmacol TherInterest in ayahuasca and its main component, N,N‐Dimethyltryptamine (DMT), has currently moved from historical and experimental use into modern clinical development. Yet, current evidence is fragmented, and systematic mapping of trial methods and design choices remains limited.
Stojanović T +4 more
europepmc +2 more sources
IRF-1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α. [PDF]
Animal Model Exp MedIRF‐1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α. Abstract Background The purpose is to define the contribution of the interferon regulatory factor‐1–dual‐specificity tyrosine phosphorylation‐regulated kinase 1α (IRF‐1–DYRK1α) axis to hepatocellular ferroptosis during liver ischemia/reperfusion injury ...
Zhang J +6 more
europepmc +2 more sources
Scripta Score Scientific Medical Journal, 2021 Background: Type 1 and 2 diabetes mellitus (DM) is a chronic metabolic disease most commonly affects millions of people worldwide. Despite the differences in pathogenesis, both share one thing in common - that is the drastic depletion in the number of ...
Ghea Mangkuliguna +2 more
doaj +1 more source
Loading Harmine On Nanographene Changes The Inhibitory Effects of Free Harmine Against MCF7 and Fibroblast Cells [PDF]
Medicinal Chemistry Research, 2021 Abstract Today cancer is one of the main causes of death all over the world. Chemotherapy, which is one of the main therapies in the treatment of cancer, causes several side effects by damaging healthy cells. Therefore, carbon nanomaterial systems have been developed to optimize therapeutics procedures with the least negative consequences ...
Newsha Mortazavi +4 more
openaire +3 more sources
Life, 2022 Harmine is a beta-carboline alkaloid present in various plants, including in the seeds of Peganum harmala L. This study aimed to investigate the anti-inflammatory activity and mechanism of harmine using macrophages stimulated with various toll-like ...
So-Jung Jin +5 more
doaj +1 more source
Frontiers in Immunology, 2021 Peri-prosthetic osteolysis (PPO) and following aseptic loosening are regarded as the prime reasons for implant failure after joint replacement. Increasing evidence indicated that wear-debris-irritated inflammatory response and macrophage polarization ...
Liangliang Wang +13 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Sepsis is a dysregulated systemic inflammatory response that often leads to cardiac dysfunction, which is termed sepsis-induced cardiomyopathy (SIC). Harmine, a natural β-carboline alkaloid compound, has been shown to exert pharmacological effects on ...
Weibin Ruan +11 more
doaj +1 more source
Frontiers in Pharmacology, 2017 Harmaline and harmine occur naturally in plants and are distributed endogenously in human and animal tissues. The two β-carboline alkaloids possess potential for treating Alzheimer's disease, Parkinson's disease, depression and other central nervous ...
Shuping Li +10 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Diabetes mellitus (DM) is considered a risk factor for cognitive dysfunction. Harmine not only effectively improves the symptoms of DM but also provides neuroprotective effects in central nervous system diseases. However, whether harmine has an effect on
Peifang Liu +7 more
doaj +1 more source