Results 11 to 20 of about 7,262 (218)

Harmine activates intrinsic and extrinsic pathways of apoptosis in B16F-10 melanoma [PDF]

Chinese Medicine, 2011
Background Harmine is a beta-carboline alkaloid from the plant Peganum harmala. Previous studies found that harmine inhibited metastasis of B16F-10 melanoma cells. This study aims to elucidate the role of harmine in apoptosis of B16F-10 cells.
Kuttan Girija, Hamsa Thayele
doaj   +3 more sources

Exploration of the potential neurotransmitter or neuromodulator-like properties of harmine: evidence from synthesis to synaptic modulation [PDF]

Frontiers in Pharmacology
Background:The discovery of new neurotransmitters is crucial for the in-depth understanding of neural signal transmission, neurological disorders, and relevant treatment strategies.
Zhejun Xie, Ning Cao, Manlin Li, Hanxue Wang, Huida Guan, Xuemei Cheng, Changhong Wang   +6 more
doaj   +2 more sources

Harmine stimulates proliferation of human neural progenitors [PDF]

PeerJ, 2016
Harmine is the β-carboline alkaloid with the highest concentration in the psychotropic plant decoction Ayahuasca. In rodents, classical antidepressants reverse the symptoms of depression by stimulating neuronal proliferation.
Vanja Dakic, Renata de Moraes Maciel, Hannah Drummond, Juliana M. Nascimento, Pablo Trindade, Stevens K. Rehen   +5 more
doaj   +4 more sources

The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype [PDF]

PeerJ, 2013
The end replication problem, which occurs in normal somatic cells inducing replicative senescence, is solved in most cancer cells by activating telomerase.
Lei Zhao, Michael Wink
doaj   +4 more sources

Anti-inflammatory effects of Banisteriopsis caapi and beta-carbolines in neuronal cells: potential implications for neuro-COVID [PDF]

Frontiers in Pharmacology
BackgroundNeuroinflammation plays a central role in neurodegenerative diseases such as Alzheimer’s and Parkinson’s, along with depression, anxiety, and infectious diseases including COVID-19.
Laura Seixas Bianco, Tiago Nicoliche, Nelson Francisco Corrêa-Neto, Rafael Lanaro, Ariadiny L. Caetano, Carla Maximo Prado, Rodrigo Portes Ureshino, Rodrigo Portes Ureshino, Iolanda de Fátima Lopes Calvo Tibério, Renato Fraga Righetti, Renato Fraga Righetti, Roberta Sessa Stilhano, Alessandra Linardi   +12 more
doaj   +2 more sources

Potential anticancer effects of Peganum harmala in human papillomavirus-related cervical and head and neck cancer cells [PDF]

Frontiers in Pharmacology
BackgroundP. harmala L (P. harmala) has a longstanding role in ethnomedical treatments. Its reported anticancer effects have led to increased research interest; however, its antineoplastic properties on cervical and head and neck (HN) cancer cells need ...
Hiba F. Muddather, Tohfa Nasibova, Tohfa Nasibova, Gábor J. Szebeni, Gábor J. Szebeni, Nikolett Gémes, Noémi Bózsity, Renáta Minorics, Eldar Garayev, Ilkay Erdogan Orhan, Gaëtan Herbette, Gaëtan Herbette, Zsuzsanna Schelz, Judit Hohmann, Judit Hohmann, István Zupkó, István Zupkó   +16 more
doaj   +2 more sources

Harmine alleviates LPS-induced acute lung injury by inhibiting CSF3-mediated MAPK/NF-κB signaling pathway [PDF]

Respiratory Research
Background Acute lung injury (ALI) is a life-threatening inflammatory lung disease that lacks safe and effective treatment strategies. Harmine, an alkaloid derived from Peganum harmala L plants, exhibits anti-inflammatory activity.
Yihui Zhai, Kejie Chen, Zichuang Xu, Xiaojian Chen, Jiaying Tong, Yeying He, Chaoyue Chen, Meiqing Ding, Guang Liang, Xiaohui Zheng   +9 more
doaj   +2 more sources

Research progress on the antitumor effects of harmine

Frontiers in Oncology
Harmine is a naturally occurring β-carboline alkaloid originally isolated from Peganum harmala. As a major active component, harmine exhibits a broad spectrum of pharmacological properties, particularly remarkable antitumor effects.
Yonghua Hu, Yonghua Hu, Yonghua Hu, Xiaoli Yu, Lei Yang, Gaimei Xue, Qinglin Wei, Zhijian Han, Hao Chen   +8 more
doaj   +3 more sources

Anti-tumor potential of Harmine and its derivatives: recent trends and advancements [PDF]

Discover Oncology
Harmine is a β-carboline alkaloid derived from Peganum harmala, showing a solid antitumor potential in different types of human cancer cells. Unfortunately, the clinical application of this natural alkaloid has been impeded till now by severe toxic side ...
Hemant Joshi, Sakshi Bhushan, Tanisha Dimri, Deepak Sharma, Katrin Sak, Abhishek Chauhan, Ritu Chauhan, Shafiul Haque, Faraz Ahmad, Manoj Kumar, Hardeep Singh Tuli, Damandeep Kaur   +11 more
doaj   +2 more sources

Measurement of Tau Protein and Aβ Amyloid Plaques in Postmortem Human Brains of Down Syndrome and Alzheimer's Disease by Using [¹²⁵I]IPPI and [¹²⁵I]IBETA Autoradiography. [PDF]

Synapse
ABSTRACT The accumulation of tau tangles and Aβ plaques are prominent neuropathologies that characterize Alzheimer's disease (AD) and Down syndrome (DS). Continuous developments of PET tracers as biomarkers can be supported by autoradiography to validate effectiveness and accuracy of binding properties that elucidate the pathophysiology of DSAD and AD.
Biju AP, Karim F, Schafer DM, Sison SA, Liang C, Head E, Mukherjee J.   +6 more
europepmc   +2 more sources