Results 11 to 20 of about 5,752 (199)
Harmine stimulates proliferation of human neural progenitors [PDF]
PeerJ, 2016 Harmine is the β-carboline alkaloid with the highest concentration in the psychotropic plant decoction Ayahuasca. In rodents, classical antidepressants reverse the symptoms of depression by stimulating neuronal proliferation.
Vanja Dakic +5 more
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Binding of Harmine Derivatives to DNA: A Spectroscopic Investigation [PDF]
Molecules, 2017 Harmine belongs to a group of β-carboline alkaloids endowed with antitumor properties. Harmine and its derivatives are thought to bind to DNA and interfere with topoisomerase activities. We investigated the base-dependent binding of harmine, and three of
Bruno Pagano +3 more
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, 2022 Basic research project with rodents. Rodents were administerred DMT and/or harmine and to investigate effects on 5HT2A receptor occupancy of DMT, changes in FDG uptake and brain concentrations of DMT, harmine and their metabolites. This work is published at Frontiers in Pharmacology (DOI: 10.3389/fphar.2023.1140656).
Scheidegger, Milan +2 more
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Biomedical and Biotechnology Research JournalBackground: Harmine is used in the quantification of glycosaminoglycans (GAGs) for the research on mucopolysaccharidoses (MPSs). Although this product is commercially available, researchers may consider preparing it under laboratory conditions when it is
Houda El Fissi +6 more
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A pilot study of cerebral metabolism and serotonin 5-HT2A receptor occupancy in rats treated with the psychedelic tryptamine DMT in conjunction with the MAO inhibitor harmine [PDF]
Frontiers in Pharmacology, 2023 Rationale: The psychedelic effects of the traditional Amazonian botanical decoction known as ayahuasca are often attributed to agonism at brain serotonin 5-HT2A receptors by N,N-dimethyltryptamine (DMT).
Klemens Egger +25 more
doaj +3 more sources
Harmine activates intrinsic and extrinsic pathways of apoptosis in B16F-10 melanoma [PDF]
Chinese Medicine, 2011 Background Harmine is a beta-carboline alkaloid from the plant Peganum harmala. Previous studies found that harmine inhibited metastasis of B16F-10 melanoma cells. This study aims to elucidate the role of harmine in apoptosis of B16F-10 cells.
Kuttan Girija, Hamsa Thayele
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ANTIDEPRESSANT ACTION OF HARMINE HYDROCHLORIDE [PDF]
Pharmacy & Pharmacology, 2015 The articles presents the results of antridepressant action of water-soluble form of harmine hydrochloride.
Zh. S. Nurmaganbetov +6 more
openaire +4 more sources
A natural small molecule harmine inhibits angiogenesis and suppresses tumour growth through activation of p53 in endothelial cells. [PDF]
PLoS ONE, 2012 Activation of p53 effectively inhibits tumor angiogenesis that is necessary for tumor growth and metastasis. Reactivation of the p53 by small molecules has emerged as a promising new strategy for cancer therapy.
Fujun Dai +11 more
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Synthetic Derivatives of Natural Alkaloid Harmine [PDF]
Eurasian Chemico-Technological Journal, 2009 The indole alkaloid harmine was extracted from underground part of Peganum harmala L. With the purpose of obtaining the new biological active derivatives on base of alkaloid harmine the chemical modification was carried out.
M. M. Ismagulova +4 more
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BMC Infectious DiseasesBackground As antimicrobial resistance (AMR) has become a global health crisis, new strategies against AMR infection are urgently needed. Quorum sensing (QS), responsible for bacterial communication and pathogenicity, is among the targets for anti ...
Pei Chen +4 more
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