Results 11 to 20 of about 4,328 (171)

Harmine Has Nephroprotective Effect Against Methotrexate-Induced Injury in Mice via Inhibition of Oxidative Stress [PDF]

Research Journal of Pharmacognosy, 2021
Background and objectives: Despite clinical use, the efficacy of methotrexate is often limited by some adverse effects, mainly nephrotoxicity. The most common mechanism of methotrexate-induced kidney damages is oxidative stress.
Cyrus Jalili, Sara Darakhshan, Nasim Akhshi, Amir Abdolmaleki, Abdolnasir Abdi, Ali Ghanbari*   +5 more
doaj   +1 more source

Measurement of Tau Protein and Aβ Amyloid Plaques in Postmortem Human Brains of Down Syndrome and Alzheimer's Disease by Using [¹²⁵I]IPPI and [¹²⁵I]IBETA Autoradiography. [PDF]

Synapse
ABSTRACT The accumulation of tau tangles and Aβ plaques are prominent neuropathologies that characterize Alzheimer's disease (AD) and Down syndrome (DS). Continuous developments of PET tracers as biomarkers can be supported by autoradiography to validate effectiveness and accuracy of binding properties that elucidate the pathophysiology of DSAD and AD.
Biju AP, Karim F, Schafer DM, Sison SA, Liang C, Head E, Mukherjee J.   +6 more
europepmc   +2 more sources

1-hydroxymethyl Harmine-TGFβSF Inhibitor: Inovasi Terapi Diabetes Melitus Terbaru Melalui Inisiasi Proses Regenerasi Sel β Pankreas pada Penderita DM Tipe 1 dan 2

Scripta Score Scientific Medical Journal, 2021
Background: Type 1 and 2 diabetes mellitus (DM) is a chronic metabolic disease most commonly affects millions of people worldwide. Despite the differences in pathogenesis, both share one thing in common - that is the drastic depletion in the number of ...
Ghea Mangkuliguna, Glenardi, Rexel Kuatama   +2 more
doaj   +1 more source

Effect and Mechanism of Harmine on Echinococcosis Based on Network Pharmacology

Natural Product Communications, 2023
Objective The aim of this research was to explore the effects on echinococcosis of harmine, an active ingredient of Peganum harmala . Methods The gene targets were screened out by use of an online database.
Bei Chen, Jun Zhao, Liang Teng, Yimaierjiang Buhuliqianmu, Zhaohui Xu, Yuehong Gong, Huijing Gao   +6 more
doaj   +1 more source

Loading Harmine On Nanographene Changes The Inhibitory Effects of Free Harmine Against MCF7 and Fibroblast Cells [PDF]

Medicinal Chemistry Research, 2021
Abstract Today cancer is one of the main causes of death all over the world. Chemotherapy, which is one of the main therapies in the treatment of cancer, causes several side effects by damaging healthy cells. Therefore, carbon nanomaterial systems have been developed to optimize therapeutics procedures with the least negative consequences ...
Newsha Mortazavi, Mahboobeh Heidari, Zohreh Rabiei, Sattar Tahmasebi Enferadi, Maryam Monazzah   +4 more
openaire   +3 more sources

Harmine Inhibits Multiple TLR-Induced Inflammatory Expression through Modulation of NF-κB p65, JNK, and STAT1

Life, 2022
Harmine is a beta-carboline alkaloid present in various plants, including in the seeds of Peganum harmala L. This study aimed to investigate the anti-inflammatory activity and mechanism of harmine using macrophages stimulated with various toll-like ...
So-Jung Jin, Youngju Song, Hong Shik Park, Kye Won Park, SeungGwan Lee, Hee Kang   +5 more
doaj   +1 more source

Harmine Derivatives as Anticancer Agents Endowed With Potent and Selective Antileukemia Activity: Synthesis, Biological Evaluation, Proapoptotic and Genotoxic Activity. [PDF]

Arch Pharm (Weinheim)
We identified a novel N9‐substituted harmine analog, compound 6, that selectively suppresses leukemic cell growth, triggers DNA damage, and activates apoptosis while sparing healthy fibroblasts. This discovery highlights N9‐modified β‐carbolines as a powerful new class of selective antileukemic agents, bridging natural product chemistry with next ...
Timbilla AA, Pidany F, Kohelova E, Kroustkova J, Kralovec K, Rataj J, Ceckova M, Maafi N, Lopez V, Langa CM, Kosturko S, Jenco J, Muthna D, Koutova D, Rezacova M, Cahlikova L, Chlebek J, Havelek R.   +17 more
europepmc   +2 more sources

Harmine Alleviates Titanium Particle-Induced Inflammatory Bone Destruction by Immunomodulatory Effect on the Macrophage Polarization and Subsequent Osteogenic Differentiation

Frontiers in Immunology, 2021
Peri-prosthetic osteolysis (PPO) and following aseptic loosening are regarded as the prime reasons for implant failure after joint replacement. Increasing evidence indicated that wear-debris-irritated inflammatory response and macrophage polarization ...
Liangliang Wang, Qing Wang, Wei Wang, Gaoran Ge, Nanwei Xu, Dong Zheng, Shijie Jiang, Gongyin Zhao, Yaozeng Xu, Yuji Wang, Yuji Wang, Yuji Wang, Ruixia Zhu, Dechun Geng   +13 more
doaj   +1 more source

A screening identifies harmine as a novel antibacterial compound against Ralstonia solanacearum

Frontiers in Microbiology, 2023
Ralstonia solanacearum, the causal agent of bacterial wilt, is a devastating plant pathogenic bacterium that infects more than 450 plant species. Until now, there has been no efficient control strategy against bacterial wilt. In this study, we screened a
Hongkai Xia, Hongkai Xia, Yanxia Huang, Ruoyu Wu, Xin Tang, Jun Cai, Shun-xiang Li, Lin Jiang, Dousheng Wu, Dousheng Wu   +9 more
doaj   +1 more source

Intra- and extra-cellular DNA damage by harmine and 9-methyl-harmine

Journal of Photochemistry and Photobiology B: Biology, 2014
It is known that β-carbolines are able to produce photosensitized damage in cell-free DNA, but there is little information on their effects on cellular DNA. Therefore, we have analyzed the DNA damage produced by harmine and 9-methyl-harmine under UVA irradiation in V79 cells, together with the associated generation of micronuclei and photocytotoxicity.
Vignoni, Mariana, Erra Balsells, Rosa, Epe, Bernd, Cabrerizo, Franco Martín   +3 more
openaire   +5 more sources