Results 11 to 20 of about 4,342 (172)

Registered Clinical Trials of Ayahuasca and DMT: A Scoping Review. [PDF]

Clin Pharmacol Ther
Interest in ayahuasca and its main component, N,N‐Dimethyltryptamine (DMT), has currently moved from historical and experimental use into modern clinical development. Yet, current evidence is fragmented, and systematic mapping of trial methods and design choices remains limited.
Stojanović T, Nilsson KW, Fredriksson R, Schiöth HB, Moulin TC.   +4 more
europepmc   +2 more sources

Exploration of the potential neurotransmitter or neuromodulator-like properties of harmine: evidence from synthesis to synaptic modulation [PDF]

Frontiers in Pharmacology
Background:The discovery of new neurotransmitters is crucial for the in-depth understanding of neural signal transmission, neurological disorders, and relevant treatment strategies.
Zhejun Xie, Ning Cao, Manlin Li, Hanxue Wang, Huida Guan, Xuemei Cheng, Changhong Wang   +6 more
doaj   +2 more sources

Harmine Targets Peroxiredoxin 6 to Enhance Macrophage Immunity Against Pseudomonas plecoglossicida in Ayu (Plecoglossus altivelis) [PDF]

Antioxidants
Pseudomonas plecoglossicida causes bacterial hemorrhagic ascites in ayu (Plecoglossus altivelis), a lethal disease characterized by abdominal distension with hemorrhagic ascites, multifocal organ hemorrhages, and histopathologically evident ...
Yan-Jun Liu, Xiang Li, Yi-Fang Jiang, Ran Wang, Jing Yu, Zhi-Guo Liu, Jia-Feng Cao, Guan-Jun Yang, Jiong Chen   +8 more
doaj   +2 more sources

Anti-inflammatory effects of Banisteriopsis caapi and beta-carbolines in neuronal cells: potential implications for neuro-COVID [PDF]

Frontiers in Pharmacology
BackgroundNeuroinflammation plays a central role in neurodegenerative diseases such as Alzheimer’s and Parkinson’s, along with depression, anxiety, and infectious diseases including COVID-19.
Laura Seixas Bianco, Tiago Nicoliche, Nelson Francisco Corrêa-Neto, Rafael Lanaro, Ariadiny L. Caetano, Carla Maximo Prado, Rodrigo Portes Ureshino, Rodrigo Portes Ureshino, Iolanda de Fátima Lopes Calvo Tibério, Renato Fraga Righetti, Renato Fraga Righetti, Roberta Sessa Stilhano, Alessandra Linardi   +12 more
doaj   +2 more sources

Potential anticancer effects of Peganum harmala in human papillomavirus-related cervical and head and neck cancer cells [PDF]

Frontiers in Pharmacology
BackgroundP. harmala L (P. harmala) has a longstanding role in ethnomedical treatments. Its reported anticancer effects have led to increased research interest; however, its antineoplastic properties on cervical and head and neck (HN) cancer cells need ...
Hiba F. Muddather, Tohfa Nasibova, Tohfa Nasibova, Gábor J. Szebeni, Gábor J. Szebeni, Nikolett Gémes, Noémi Bózsity, Renáta Minorics, Eldar Garayev, Ilkay Erdogan Orhan, Gaëtan Herbette, Gaëtan Herbette, Zsuzsanna Schelz, Judit Hohmann, Judit Hohmann, István Zupkó, István Zupkó   +16 more
doaj   +2 more sources

Harmine alleviates LPS-induced acute lung injury by inhibiting CSF3-mediated MAPK/NF-κB signaling pathway [PDF]

Respiratory Research
Background Acute lung injury (ALI) is a life-threatening inflammatory lung disease that lacks safe and effective treatment strategies. Harmine, an alkaloid derived from Peganum harmala L plants, exhibits anti-inflammatory activity.
Yihui Zhai, Kejie Chen, Zichuang Xu, Xiaojian Chen, Jiaying Tong, Yeying He, Chaoyue Chen, Meiqing Ding, Guang Liang, Xiaohui Zheng   +9 more
doaj   +2 more sources

Anti-tumor potential of Harmine and its derivatives: recent trends and advancements [PDF]

Discover Oncology
Harmine is a β-carboline alkaloid derived from Peganum harmala, showing a solid antitumor potential in different types of human cancer cells. Unfortunately, the clinical application of this natural alkaloid has been impeded till now by severe toxic side ...
Hemant Joshi, Sakshi Bhushan, Tanisha Dimri, Deepak Sharma, Katrin Sak, Abhishek Chauhan, Ritu Chauhan, Shafiul Haque, Faraz Ahmad, Manoj Kumar, Hardeep Singh Tuli, Damandeep Kaur   +11 more
doaj   +2 more sources

A screening identifies harmine as a novel antibacterial compound against Ralstonia solanacearum

Frontiers in Microbiology, 2023
Ralstonia solanacearum, the causal agent of bacterial wilt, is a devastating plant pathogenic bacterium that infects more than 450 plant species. Until now, there has been no efficient control strategy against bacterial wilt. In this study, we screened a
Hongkai Xia, Hongkai Xia, Yanxia Huang, Ruoyu Wu, Xin Tang, Jun Cai, Shun-xiang Li, Lin Jiang, Dousheng Wu, Dousheng Wu   +9 more
doaj   +1 more source

Harmine Alleviated Sepsis-Induced Cardiac Dysfunction by Modulating Macrophage Polarization via the STAT/MAPK/NF-κB Pathway

Frontiers in Cell and Developmental Biology, 2022
Sepsis is a dysregulated systemic inflammatory response that often leads to cardiac dysfunction, which is termed sepsis-induced cardiomyopathy (SIC). Harmine, a natural β-carboline alkaloid compound, has been shown to exert pharmacological effects on ...
Weibin Ruan, Xinyun Ji, Yating Qin, Xinxin Zhang, Xiaoning Wan, Chuanmeng Zhu, Chao Lv, Chongqing Hu, Juan Zhou, Li Lu, Li Lu, Xiaomei Guo   +11 more
doaj   +1 more source

Exposure Characteristics of the Analogous β-Carboline Alkaloids Harmaline and Harmine Based on the Efflux Transporter of Multidrug Resistance Protein 2

Frontiers in Pharmacology, 2017
Harmaline and harmine occur naturally in plants and are distributed endogenously in human and animal tissues. The two β-carboline alkaloids possess potential for treating Alzheimer's disease, Parkinson's disease, depression and other central nervous ...
Shuping Li, Yunpeng Zhang, Gang Deng, Yuwen Wang, Shenglan Qi, Xuemei Cheng, Xuemei Cheng, Yueming Ma, Yan Xie, Changhong Wang, Changhong Wang   +10 more
doaj   +1 more source