Research progress on the antitumor effects of harmine [PDF]
Frontiers in OncologyHarmine is a naturally occurring β-carboline alkaloid originally isolated from Peganum harmala. As a major active component, harmine exhibits a broad spectrum of pharmacological properties, particularly remarkable antitumor effects.
Yonghua Hu +8 more
exaly +6 more sources
Harmine stimulates proliferation of human neural progenitors [PDF]
PeerJ, 2016 Harmine is the β-carboline alkaloid with the highest concentration in the psychotropic plant decoction Ayahuasca. In rodents, classical antidepressants reverse the symptoms of depression by stimulating neuronal proliferation.
Vanja Dakic +5 more
doaj +8 more sources
Harmine reduces ROS-mediated hepatotoxicity in a cisplatin mouse model [PDF]
Research in Pharmaceutical SciencesBackground and purpose: Cisplatin, a widely used anticancer agent, has adverse effects on normal tissues during cancer treatment. This study aimed to investigate the use of harmine, a plant β-carboline alkaloid, against pathways associated with ROS ...
Cyrus Jalili +7 more
doaj +3 more sources
Binding of Harmine Derivatives to DNA: A Spectroscopic Investigation [PDF]
Molecules, 2017 Harmine belongs to a group of β-carboline alkaloids endowed with antitumor properties. Harmine and its derivatives are thought to bind to DNA and interfere with topoisomerase activities. We investigated the base-dependent binding of harmine, and three of
Bruno Pagano +3 more
doaj +4 more sources
Harmine alleviates LPS-induced acute lung injury by inhibiting CSF3-mediated MAPK/NF-κB signaling pathway [PDF]
Respiratory ResearchBackground Acute lung injury (ALI) is a life-threatening inflammatory lung disease that lacks safe and effective treatment strategies. Harmine, an alkaloid derived from Peganum harmala L plants, exhibits anti-inflammatory activity.
Yihui Zhai +9 more
doaj +3 more sources
, 2022 Basic research project with rodents. Rodents were administerred DMT and/or harmine and to investigate effects on 5HT2A receptor occupancy of DMT, changes in FDG uptake and brain concentrations of DMT, harmine and their metabolites. This work is published at Frontiers in Pharmacology (DOI: 10.3389/fphar.2023.1140656).
Scheidegger, Milan +2 more
openaire +2 more sources
Harmine activates intrinsic and extrinsic pathways of apoptosis in B16F-10 melanoma [PDF]
Chinese Medicine, 2011 Background Harmine is a beta-carboline alkaloid from the plant Peganum harmala. Previous studies found that harmine inhibited metastasis of B16F-10 melanoma cells. This study aims to elucidate the role of harmine in apoptosis of B16F-10 cells.
Kuttan Girija, Hamsa Thayele
doaj +2 more sources
Harmine Targets Peroxiredoxin 6 to Enhance Macrophage Immunity Against Pseudomonas plecoglossicida in Ayu (Plecoglossus altivelis) [PDF]
AntioxidantsPseudomonas plecoglossicida causes bacterial hemorrhagic ascites in ayu (Plecoglossus altivelis), a lethal disease characterized by abdominal distension with hemorrhagic ascites, multifocal organ hemorrhages, and histopathologically evident ...
Yan-Jun Liu +8 more
doaj +2 more sources
Exploration of the potential neurotransmitter or neuromodulator-like properties of harmine: evidence from synthesis to synaptic modulation [PDF]
Frontiers in PharmacologyBackground:The discovery of new neurotransmitters is crucial for the in-depth understanding of neural signal transmission, neurological disorders, and relevant treatment strategies.
Zhejun Xie +6 more
doaj +2 more sources
A screening identifies harmine as a novel antibacterial compound against Ralstonia solanacearum [PDF]
Frontiers in Microbiology, 2023 Ralstonia solanacearum, the causal agent of bacterial wilt, is a devastating plant pathogenic bacterium that infects more than 450 plant species. Until now, there has been no efficient control strategy against bacterial wilt. In this study, we screened a
Hongkai Xia +9 more
doaj +2 more sources