Results 41 to 50 of about 5,752 (199)

Acute ayahuasca administration attenuates binge‐like eating and anxiety‐related behaviors in mice subjected to intermittent fasting [PDF]

J Neuroendocrinol
Abstract Human binge eating disorder is characterized by recurrent episodes of excessive food consumption accompanied by loss of control and is strongly associated with alterations in reward processing and emotional regulation. Ayahuasca, a psychoactive botanical preparation traditionally used in Amazonian medicine, has been shown to modulate ...
Corona C, Lima F, da Silva Sumensse J, Carvalho K, Grignet P, Confortim H, Gross M, Firmino F, Evangelista F, Nascimento F, Vettorazzi J.   +10 more
europepmc   +2 more sources

Cardiovascular and Respiratory Effects of Harmine

Experimental Biology and Medicine, 1970
SummaryIntravenously administered harmine in cats, rats, and humans induced bradycardia and hypotension; cats exhibited apnea and ventricular arrhythmias. In the cat, bradycardia was eliminated by vagotomy and apnea by atropinization. The effects of acetylcholine and epinephrine were potentiated by harmine; possibly this was due to the inhibition of ...
T A, Slotkin, V, DiStefano
openaire   +2 more sources

CCXXVI.—Harmine and harmaline. Part VI. The synthesis of N-methyltetrahydronorharmine and the constitution of harmaline and of the alkylated harmines [PDF]

J. Chem. Soc., Trans., 1922
n ...
Kermack, William Ogilvy, Perkin, William Henry, Robinson, Robert   +2 more
openaire   +1 more source

Integrative Insights Into DYRK1A From Molecular Function to Therapeutic Advancement. [PDF]

Chem Biol Drug Des
At the center the 3D structure of DYRK1A has been displayed. The dual‐function of DYRK1A involved in cancer and neurodegeneration, i.e., its overexpression drives Down syndrome, neurodegenerative disease etc., and underexpression causes intellectual disability, seizures, etc.
Paul S, Dubey S, Tiwari P.
europepmc   +2 more sources

Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine

Frontiers in Pharmacology, 2023
Recently, the Amazonian plant medicine “ayahuasca”—containing the psychedelic compound N,N-dimethyltryptamine (DMT) and numerous β-carboline alkaloids, such as harmine—has been suggested to exhibit beneficial effects in patients with affective and other ...
Dario A. Dornbierer, Dario A. Dornbierer, Dario A. Dornbierer, Laurenz Marten, Laurenz Marten, Jovin Mueller, Helena D. Aicher, Helena D. Aicher, Helena D. Aicher, Michael J. Mueller, Michael J. Mueller, Michael J. Mueller, Martina Boxler, Michael Kometer, Davor Kosanic, Robin von Rotz, Maxim Puchkov, Thomas Kraemer, Hans-Peter Landolt, Hans-Peter Landolt, Erich Seifritz, Erich Seifritz, Milan Scheidegger, Milan Scheidegger   +23 more
doaj   +1 more source

Anti-Diabetic and Anti-Adipogenic Effect of Harmine in High-Fat-Diet-Induced Diabetes in Mice

Life, 2023
One of the most important health issues facing the world today is obesity. It is an important independent risk factor for developing type 2 diabetes. Harmine offers various pharmacological effects, such as anti-inflammatory and anti-tumor effects.
Menna H. E. Morsy, Zohour I. Nabil, Samah T. Darwish, Rasha A. Al-Eisa, Amir E. Mehana   +4 more
doaj   +1 more source

LXXIX.—Harmine and harmaline. Part III [PDF]

J. Chem. Soc., Trans., 1919
n ...
Perkin, William Henry, Robinson, Robert
openaire   +1 more source

Effects of Harmine on endothelial cell apoptosis

, 2012
, G2/M arrest and proliferation. (A) The proportion of apoptotic cells was increased by harmine. Harmine induced cleavage of PARP and suppressed the expression of survivin and Bcl-2.
Zhengfang Yi (107425), Fujun Dai (107395), Tao Zhang (43681), Dali Li (107420), Xiufeng Pang (107423), Yajuan Song (107404), Li Lai (107417), Li Huang (107408), Yihua Chen (107400), Yanmin Dong (107414), Dong Zhai (107411), Mingyao Liu (38997)   +11 more
core   +1 more source

Ueber Harmin und Harmalin [PDF]

Berichte der deutschen chemischen Gesellschaft, 1905
n ...
Fischer, O., Buck, C.-H.-R.
openaire   +2 more sources

Dynamic Changes of Endogenic or Exogenic β-Carboline Alkaloid Harmine in Different Mammals and Human in vivo at Developmental and Physiological States

Frontiers in Aging Neuroscience, 2022
ObjectiveSeveral β-carboline alkaloids (βCBs), such as harmine, harmaline, harmane, and nor-harmane, are effective for Alzheimer’s disease mouse models. They can be found in some plants, common foodstuffs, and blank plasma of various mammals.
Ning Cao, Shuping Li, Aimin Xu, Manlin Li, Xiaoguang Zou, Zunji Ke, Gang Deng, Xuemei Cheng, Changhong Wang   +8 more
doaj   +1 more source