Results 41 to 50 of about 7,262 (218)
The Role of Harmine in Up-regulating p53 Gene Expression and Inducing Apoptosis in MCF-7 Cell Line
Middle East Journal of Cancer, 2020 Background: As a major tumor suppressor gene, P53 plays a principal role in the apoptosis of cancer cells. Harmine is a harmal-derived alkaloid with antioxidant and anticancer properties.
Shiva Roshankhah +3 more
doaj +1 more source
A natural small molecule harmine inhibits angiogenesis and suppresses tumour growth through activation of p53 in endothelial cells. [PDF]
PLoS ONE, 2012 Activation of p53 effectively inhibits tumor angiogenesis that is necessary for tumor growth and metastasis. Reactivation of the p53 by small molecules has emerged as a promising new strategy for cancer therapy.
Fujun Dai +11 more
doaj +1 more source
Research in Pharmaceutical Sciences, 2022 Background and purpose: Cisplatin is a chemotherapeutic drug used to treat cancer, however, causes kidney toxicity. Harmine is a plant-derived alkaloid with a wide range of therapeutic applications.
Ali Ghanbari +5 more
doaj +1 more source
BMC Complementary and Alternative Medicine, 2017 Background Compound Muniziqi granule (MNZQ) is a multi-component herbal preparation and a popular traditional Uighur medicine used in China for treating endocrine disorder-induced acne, chloasma, dysmenorrhea, menopausal syndrome, and melanoma.
Nan Zou +5 more
doaj +1 more source
Molecules, 2020 Recently, we have shown that harmine induces β-cell proliferation both in vitro and in vivo, mediated via the DYRK1A-NFAT pathway. We explore structure–activity relationships of the 7-position of harmine for both DYRK1A kinase inhibition and β-cell ...
Kunal Kumar +8 more
doaj +1 more source
Chemical screening identifies the β-Carboline alkaloid harmine to be synergistically lethal with doxorubicin. [PDF]
, 2017 Despite being an invaluable chemotherapeutic agent for several types of cancer, the clinical utility of doxorubicin is hampered by its age-related and dose-dependent cardiotoxicity.
Ashour, M.E. +4 more
core +1 more source
Harmine and Piperlongumine Revert TRIB2-Mediated Drug Resistance [PDF]
Cancers, 2020 Therapy resistance is responsible for most relapses in patients with cancer and is the major challenge to improving the clinical outcome. The pseudokinase Tribbles homologue 2 (TRIB2) has been characterized as an important driver of resistance to several anti-cancer drugs, including the dual ATP-competitive PI3K and mTOR inhibitor dactolisib (BEZ235 ...
Susana Machado +11 more
openaire +4 more sources
Harmine enhances the activity of the HIV-1 latency-reversing agents ingenol A and SAHA
Biology Open, 2020 Infection with human immunodeficiency virus 1 (HIV-1) remains incurable because long-lived, latently-infected cells persist during prolonged antiretroviral therapy.
Jared P. Taylor +4 more
doaj +1 more source
Inhibition of alpha oscillations through serotonin-2A receptor activation underlies the visual effects of ayahuasca in humans [PDF]
, 2016 Ayahuasca is an Amazonian psychotropic plant tea typically obtained from two plants, Banisteriopsis caapi and Psychotria viridis. It contains the psychedelic 5-HT2A and sigma-1 agonist N,N-dimethyltryptamine (DMT) plus ß-carboline alkaloids with ...
Alonso, Joan Francesc +12 more
core +3 more sources
Different photolysis kinetics at the surface of frozen freshwater vs. frozen salt solutions [PDF]
, 2010 Reactions at air-ice interfaces can proceed at very different rates than those in aqueous solution, due to the unique disordered region at the ice surface known as the quasi-liquid layer (QLL) . The physical and chemical nature of the surfacial region of
D. J. Donaldson +2 more
core +2 more sources