Results 51 to 60 of about 7,262 (218)

Anti-Diabetic and Anti-Adipogenic Effect of Harmine in High-Fat-Diet-Induced Diabetes in Mice

Life, 2023
One of the most important health issues facing the world today is obesity. It is an important independent risk factor for developing type 2 diabetes. Harmine offers various pharmacological effects, such as anti-inflammatory and anti-tumor effects.
Menna H. E. Morsy, Zohour I. Nabil, Samah T. Darwish, Rasha A. Al-Eisa, Amir E. Mehana   +4 more
doaj   +1 more source

Recreational use, analysis and toxicity of tryptamines [PDF]

, 2015
The definition New psychoactive substances (NPS) refers to emerging drugs whose chemical structures are similar to other psychoactive compounds but not identical, representing a "legal" alternative to internationally controlled drugs.
Mannocchi, Giulio, Pantano, Flaminia, Romolo, Francesco Saverio, Tittarelli, Roberta   +3 more
core   +1 more source

Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine

Frontiers in Pharmacology, 2023
Recently, the Amazonian plant medicine “ayahuasca”—containing the psychedelic compound N,N-dimethyltryptamine (DMT) and numerous β-carboline alkaloids, such as harmine—has been suggested to exhibit beneficial effects in patients with affective and other ...
Dario A. Dornbierer, Dario A. Dornbierer, Dario A. Dornbierer, Laurenz Marten, Laurenz Marten, Jovin Mueller, Helena D. Aicher, Helena D. Aicher, Helena D. Aicher, Michael J. Mueller, Michael J. Mueller, Michael J. Mueller, Martina Boxler, Michael Kometer, Davor Kosanic, Robin von Rotz, Maxim Puchkov, Thomas Kraemer, Hans-Peter Landolt, Hans-Peter Landolt, Erich Seifritz, Erich Seifritz, Milan Scheidegger, Milan Scheidegger   +23 more
doaj   +1 more source

Quantification of glycosaminoglycans using harmine extract from Peganum harmala L. in mucopolysaccharidoses researches

Biomedical and Biotechnology Research Journal
Background: Harmine is used in the quantification of glycosaminoglycans (GAGs) for the research on mucopolysaccharidoses (MPSs). Although this product is commercially available, researchers may consider preparing it under laboratory conditions when it is
Houda El Fissi, Fadoua Bouzid, Ikram Achqra, Mohammed Said Sebbar, Fouad Msanda, Mohamed Amine Serghini, Najat Alif   +6 more
doaj   +1 more source

Dynamic Changes of Endogenic or Exogenic β-Carboline Alkaloid Harmine in Different Mammals and Human in vivo at Developmental and Physiological States

Frontiers in Aging Neuroscience, 2022
ObjectiveSeveral β-carboline alkaloids (βCBs), such as harmine, harmaline, harmane, and nor-harmane, are effective for Alzheimer’s disease mouse models. They can be found in some plants, common foodstuffs, and blank plasma of various mammals.
Ning Cao, Shuping Li, Aimin Xu, Manlin Li, Xiaoguang Zou, Zunji Ke, Gang Deng, Xuemei Cheng, Changhong Wang   +8 more
doaj   +1 more source

Harmine promotes periodontal ligament cell‐induced tissue regeneration [PDF]

Oral Diseases, 2017
AbstractObjectiveto investigate whether harmine has a promotive effect on human periodontal ligament cells (hPDLCs)‐induced tissue regeneration.Materials and MethodsVarious concentrations of harmine on hPDLCs proliferation were tested. Osteogenic and cementogenic characteristics were examined in hPDLC/rhBMP‐2 and hPDLC/harmine by alizarin red S ...
Lim, Hyun-Chang, Cha, B-Y, Song, S U, Yun, J-H   +3 more
openaire   +3 more sources

Antiplasmodial activity of harmirins – novel harmine – coumarin hybrids

Macedonian Pharmaceutical Bulletin, 2022
Harmirins are hybrid compounds comprising both harmine and coumarin pharmacophores linked by 1, 2, 3-triazole. We have evaluated in vitro antiplasmodial activity against the erythrocytic stage of P. falciparum of five series of harmirins. Compound 12b showed the highest activity against the tested P.
Pavić, Kristina, Rajić, Zrinka, Pessanha de Carvalho, Lais, Held, Jana   +3 more
openaire   +2 more sources

Innovative spectrofluorometric method for determination of harmaline and harmine in different matrices

Scientific Reports, 2023
Harmaline and harmine are naturally occurring closely related β-carboline alkaloids found in Peganum and Banisteriopsis plants. They have historical significance in traditional practices due to their potential psychoactive and therapeutic properties ...
Ahmed H. Abdelazim, Majed A. Algarni, Atiah H. Almalki   +2 more
doaj   +1 more source

Identification of plant-derived alkaloids with therapeutic potential for myotonic dystrophy type I [PDF]

, 2016
Myotonic dystrophy type I (DM1) is a disabling neuromuscular disease with no causal treatment available. This disease is caused by expanded CTG trinucleotide repeats in the 3 UTR of the dystrophia myotonica protein kinase gene. On the RNA level, expanded
Erne, B., Faleschini, M. T., Hamburger, M., Herrendorff, R., Kern, F., Kinter, J., Potterat, O., Sinnreich, M., Stiefvater, A., Wiktorowicz, T.   +9 more
core   +1 more source

Cardiovascular and Respiratory Effects of Harmine

Experimental Biology and Medicine, 1970
SummaryIntravenously administered harmine in cats, rats, and humans induced bradycardia and hypotension; cats exhibited apnea and ventricular arrhythmias. In the cat, bradycardia was eliminated by vagotomy and apnea by atropinization. The effects of acetylcholine and epinephrine were potentiated by harmine; possibly this was due to the inhibition of ...
T A, Slotkin, V, DiStefano
openaire   +2 more sources