Results 71 to 80 of about 4,342 (172)

Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley   +1 more source

The DYRK Family: A Key Regulator of Metabolic Homeostasis and Its Therapeutic Potential in Kidney Diseases

MedComm – Future Medicine, Volume 5, Issue 1, March 2026.
The DYRK family, a pivotal metabolic homeostasis regulator, mediates crosstalk between metabolic disorders and CKD via subtype‐specific mechanisms: DYRK1A drives diabetic (CKD risk), DYRK1B exacerbates metabolic renal injury, DYRK2 contributes to renal osteodystrophy, while DYRK3/4 remain unelucidated.
Yixuan Zhu, Pengfei Qiao, Yukun Gan, Xiushuo Fu, Xiayue Huang, Sirui Sun, Yafei Gou, Wenjie Xia, Feng Ma, Limin Liu   +9 more
wiley   +1 more source

Insights on the comparative affinity of ribonucleic acids with plant-based beta carboline alkaloid, harmine: Spectroscopic, calorimetric and computational evaluation

Heliyon
Small molecules as ligands target multifunctional ribonucleic acids (RNA) for therapeutic engagement. This study explores how the anticancer DNA intercalator harmine interacts various motifs of RNAs, including the single-stranded A-form poly (rA), the ...
Paromita Sarkar, Priyanka Gopi, Prateek Pandya, Samaresh Paria, Maidul Hossain, Manzer H. Siddiqui, Saud Alamri, Kakali Bhadra   +7 more
doaj   +1 more source

The Possible Regenerative Capability of Harmine on Diabetic Pancreas Experimentally Induced by Streptozotocin in Adult Male Rats [PDF]

The Egyptian Journal of Histology
Introduction: A significant global public health issue is diabetes. By repairing, maintaining, or increasing the original tissue function, regenerative medicine aims to lessen the patients' suffering.
alshimaa eldahshan, mona mohamed, rania mohamady   +2 more
doaj   +1 more source

Über Harmin und Harmalin [PDF]

Berichte der deutschen chemischen Gesellschaft, 1914
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openaire   +1 more source

Harmine-mediated Reduction of Bone Cancer Pain in Rats Correlates With Suppressed DYRK1A/NF-κB Signaling Axis

Journal of Integrative Neuroscience
Background: Bone cancer pain (BCP) is a prevalent chronic pain condition and a common clinical symptom in patients with advanced cancer. It significantly affects the mobility and quality of life of patients; however, current treatments
Shuyao Zhang, Shang Zheng, Jia Jin, Yuhua Li, Liping Chen, Junjie Lin, Ming Yao, Longsheng Xu   +7 more
doaj   +1 more source

Neuroprotective and anxiolytic effects of Matricaria chamomilla ethanolic extract against harmine-induced anxiety and oxidative stress in rats exposed to forced swimming stress [PDF]

Archives of Biological Sciences
The global rise in anxiety and depression disorders has drawn attention to compounds like harmine, a Peganum harmala alkaloid, which induces a pronounced anxiety response.
Hamida Youcef Islam, Chouba Ibtissem, Habbachi Wafa   +2 more
doaj   +1 more source

Efficient in vitro elicitation of β-carboline alkaloids in transformed root cultures of Peganum harmala

Bulletin of Faculty of Pharmacy Cairo University, 2011
An efficient in vitro production of biomass hairy root cultures and elicitation of β-carboline alkaloids of Peganum harmala was established from P. harmala seedlings. Hairy root culture was arised by inoculation of the excised seedling with Agrobacterium
Rawia Zayed
doaj   +1 more source

Calorimetric, Thermogravimetric, and Theoretical Study of Norharmane, Harmane, and Harmine: Insights into the Energetics of β-Carbolines

Thermo
The thermochemical properties of Norharmane, Harmane, and Harmine were investigated using DSC, combustion calorimetry, thermogravimetry, and G3B3 computational methods.
Ana Ivette Delgado-Moreno, Raúl Ricardo Quiñonez-López, María de Jesús Palacios-Sánchez, Oscar Guillermo Zúñiga-González, Francisco Javier Moscoso-Sánchez, Eulogio Orozco-Guareño, Jesús Baudelio Campos-García   +6 more
doaj   +1 more source

Assessment of the Anti-Cancer Properties of Harmine and Low-Frequency Electromagnetic Field (50 Hz) on Ovarian Cancer Cells (A2780) [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk
Introduction: Harmine is an alkaloid from the carboline family, belonging to the harmal plant, which has extensive applications in traditional medicine, with numerous studies highlighting its anti-cancer effects. Since biological processes are influenced
Malihe Keykhapour, Javad Baharara, Hamed Hatami, Maryam Lotfi, Sajad Farrokhyar   +4 more
doaj