Results 71 to 80 of about 5,636 (198)

Harmine inhibits HUVEC migration and tube formation.

, 2012
(A) Representative images and quantitative data of a wound healing migration assay in the presence or absence of 20 µM harmine for 8 hours. (B) Results of transwell migration assays of HUVECs treated or untreated by harmine for 8 hours.
Zhengfang Yi (107425), Fujun Dai (107395), Tao Zhang (43681), Dali Li (107420), Xiufeng Pang (107423), Yajuan Song (107404), Li Lai (107417), Li Huang (107408), Yihua Chen (107400), Yanmin Dong (107414), Dong Zhai (107411), Mingyao Liu (38997)   +11 more
core   +1 more source

Ueber Harmin und Harmalin (III.) [PDF]

Berichte der deutschen chemischen Gesellschaft, 1889
n ...
openaire   +3 more sources

Design, Synthesis, and Biological Evaluation of Chiral Urea and Thiourea Derivatives as Multitarget‐Directed Anti‐Alzheimer Agents

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A series of novel chiral urea and thiourea compounds were designed as multitarget‐directed ligands for Alzheimer's disease and evaluated against hAChE, hBChE, and hMAO‐B, with exploratory assessment of HSD10. These chiral compounds were synthesized and fully characterized, and their enantiopurity was confirmed via HPLC.
Sule Erol Gunal, Senel Teke Tuncel, İlke Demir, İpek Baysal, Gökçen Telli, Safiye Sag Erdem, Gulberk Ucar, Michaela Hanzlova, Kamil Musilek, İlknur Dogan, Nesrin Gokhan Kelekci   +10 more
wiley   +1 more source

Pharmacokinetic and Pharmacodynamic Interaction of the Ayahuasca Constituents Harmine and Dimethyltryptamine (DMT) in the Rat Brain

, 2023
Rationale The psychedelic effects of the traditional Amazonian botanical decoction known as ayahuasca are attributed to the effects of N,N-dimethyltryptamine (DMT) at brain serotonin 5-HT2A receptors. To make oral DMT bioavailable, ayahuasca additionally
Mikael Palner, Paul Cumming, Sandra Pötzsch, Klemens Egger, Milan Scheidegger, Matthias M. Herth, Boris B. Quednow, Vladimir Shalgunov, Frederik Gudmundsen, Christina Baun, Naja Støckel Jessen, Dario Dornbierer, Chantal Martin-Soelch   +12 more
core   +1 more source

How to Separate Kinase Inhibition from Undesired Monoamine Oxidase A Inhibition—The Development of the DYRK1A Inhibitor AnnH75 from the Alkaloid Harmine

Molecules, 2020
The β-carboline alkaloid harmine is a potent DYRK1A inhibitor, but suffers from undesired potent inhibition of MAO-A, which strongly limits its application.
Anne Wurzlbauer, Katharina Rüben, Ece Gürdal, Apirat Chaikuad, Stefan Knapp, Wolfgang Sippl, Walter Becker, Franz Bracher   +7 more
doaj   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Harmine induces the expression of p53-target genes.

, 2012
(A) Protein expression levels of p21, cyclin B1, CDC2, cyclin A, CDK2, cyclin D1 and cyclin E in HUVECs treated by harmine for 48 hours. (B) Expression levels of endogenous angiogenesis inhibitors TSP-1 and Bai1 in HUVECs. Protein expression level of TSP-
Zhengfang Yi (107425), Fujun Dai (107395), Tao Zhang (43681), Dali Li (107420), Xiufeng Pang (107423), Yajuan Song (107404), Li Lai (107417), Li Huang (107408), Yihua Chen (107400), Yanmin Dong (107414), Dong Zhai (107411), Mingyao Liu (38997)   +11 more
core   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, Volume 183, Issue 14, Page 3970-3991, July 2026.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Harmine activates p53 by inducing phosphorylation of p53 and binding to MDM2.

, 2012
(A) Chemical structure, molecular formula and 212.25 molecular weight of harmine. (B) MDM2-p53 interaction assay of harmine-treated HUVECs. After harmine treatment for 48 hours, the endogenous p53-MDM2 interaction was detected by a co-immunoprecipitation
Zhengfang Yi (107425), Fujun Dai (107395), Tao Zhang (43681), Dali Li (107420), Xiufeng Pang (107423), Yajuan Song (107404), Li Lai (107417), Li Huang (107408), Yihua Chen (107400), Yanmin Dong (107414), Dong Zhai (107411), Mingyao Liu (38997)   +11 more
core   +1 more source

Monoamine Oxidase and Cholinesterase Inhibition Profiles of Semicarbazone and Thiosemicarbazone Derivatives

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
Thiosemicarbazones generally show higher MAO‐B inhibitory potential than their corresponding semicarbazones, and particularly T6 is the most potent, which contains R = H and X = S in its Tail Unit, with an IC50 value of 6.45 µM with SI of 3.6. ABSTRACT Twenty semicarbazone and thiosemicarbazone derivatives (T1–T20) were synthesized and evaluated for ...
Sandeep Bindra, Won Kyeong Jeong, Muzammil Kabier, Sunil Kumar, Sachithra Thazhathuveedu Sudevan, Harish Chandra vishwakarma, Della Grace Thomas Parambi, Naseer Maliyakkal, Sandeep Kumar, Leena K. Pappachen, Hoon Kim, Bijo Mathew   +11 more
wiley   +1 more source