Results 81 to 90 of about 5,752 (199)
Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur +6 more
wiley +1 more source
Harmine suppresses the degradation of p53 and increases the accumulation of p53 in the nucleus.
, 2012 (A) Nuclear accumulation of p53 protein and MDM2 expression in HUVECs after harmine treatment for 48 hours. (B) Harmine prevented the degradation of p53 in HUVECs in the presence of CHX. (C) Harmine increased the nuclear levels of p53. Cells were treated
Zhengfang Yi (107425) +11 more
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Preclinical models for evaluating psychedelics in the treatment of major depressive disorder
British Journal of Pharmacology, Volume 183, Issue 14, Page 3970-3991, July 2026.Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander +5 more
wiley +1 more source
Harmine inhibits angiogenesis ex vivo and in vivo.
, 2012 (A) Representative images (left panel) and the optical density (right panel) of microvessels sprouting from rat thoracic aorta rings in the absence or presence of harmine. The microvessel density of the untreated group was considered as 100%.
Zhengfang Yi (107425) +11 more
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, 2020 Recently, our group identified that harmine is able to induce β-cell proliferation both in vitro and in vivo, mediated via the DYRK1A-NFAT pathway. Since, harmine suffers from a lack of selectivity, both against other kinases and CNS off-targets, we ...
Viktor Zlatanic (8468457) +12 more
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Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.Thiosemicarbazones generally show higher MAO‐B inhibitory potential than their corresponding semicarbazones, and particularly T6 is the most potent, which contains R = H and X = S in its Tail Unit, with an IC50 value of 6.45 µM with SI of 3.6. ABSTRACT Twenty semicarbazone and thiosemicarbazone derivatives (T1–T20) were synthesized and evaluated for ...
Sandeep Bindra +11 more
wiley +1 more source
Phytochemical Analysis, Volume 37, Issue 4, Page 507-535, June 2026.ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek +3 more
wiley +1 more source
Über Harmin und Harmalin [PDF]
Berichte der deutschen chemischen Gesellschaft, 1914 n ...
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Novel Trisubstituted Harmine Derivatives with Original in Vitro Anticancer Activity
, 2016 To overcome the intrinsic resistance of cancer cells to apoptotic stimuli, we designed and synthesized approximately 50 novel β-carbolines structurally related to harmine. Harmine is known for its anticancer properties and is a DYRK1A inhibitor.
Raphaël Frédérick (2060428) +9 more
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ANTIBACTERIAL ACTIVITY OF HARMINE, HgCl2 AND THEIR COMPLEX
, 2006 Harmine and its mercury (II)-complex were isolated from seeds of Peganum harmala by an already reported method (Munir et al. 1995) and studied for their antibacterial activity against ten different species of gram positive and gram negative bacteria. For
ZAIDI, M IDREES, GUL, ALVINA
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