Results 81 to 90 of about 7,262 (218)
25 Years of “Loop” Radiochemistry for PET Imaging
Journal of Labelled Compounds and Radiopharmaceuticals, Volume 69, Issue 4-6, April‐May 2026.While conventional methods to 11C‐ and 18F‐labelled radiopharmaceuticals utilize a vial‐based approach, in the past quarter‐century, a modern, efficient, and cleaner “loop method” has been developed. The radiochemical diversity of reactions synthesized by the loop method are shown.
Emily Murrell, Sahil Khan, Neil Vasdev
wiley +1 more source
The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen [PDF]
, 2011 Increased brain α-synuclein (SNCA) protein expression resulting from gene duplication and triplication can cause a familial form of Parkinson's disease (PD).
Bandyopadhyay, Sanghamitra +9 more
core +1 more source
ANTIDEPRESSANT ACTION OF HARMINE HYDROCHLORIDE
Pharmacy & Pharmacology, 2015 The articles presents the results of antridepressant action of water-soluble form of harmine hydrochloride.
Zh. S. Nurmaganbetov +6 more
openaire +3 more sources
Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.ABSTRACT Major Depressive Disorder (MDD) and chronic pain are independently debilitating conditions that frequently co‐occur. This comorbidity poses a significant clinical challenge, resulting in greater symptom severity, higher disability, and worse prognosis than either condition alone.
Jordana Kazdan +2 more
wiley +1 more source
The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network [PDF]
, 2015 The experiences induced by psychedelics share a wide variety of subjective features, related to the complex changes in perception and cognition induced by this class of drugs. A remarkable increase in introspection is at the core of these altered states
Andrade, Katia C. +7 more
core +9 more sources
Molecules, 2020 The β-carboline alkaloid harmine is a potent DYRK1A inhibitor, but suffers from undesired potent inhibition of MAO-A, which strongly limits its application.
Anne Wurzlbauer +7 more
doaj +1 more source
Novel harmine derivatives for tumor targeted therapy
Oncotarget, 2015 Harmine is a beta-carboline alkaloid found in medicinal plant PeganumHarmala, which has served as a folk anticancer medicine. However, clinical applications of harmine were limited by its low pharmacological effects and noticeable neurotoxicity. In this study, we modified harmine to increase the therapeutic efficacy and to decrease the systemic ...
Siwen, Li +7 more
openaire +3 more sources
Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)
ChemMedChem, Volume 21, Issue 5, 13 March 2026.DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley +1 more source
Biologic Activity and Biotechnological Development of Natural Products [PDF]
, 2013 Rod Juscelino Kubitschek, BR-68903419 Macapa, AP, BrazilUniversidade Federal de São Paulo, Inst Ciencias Ambientais, BR-09972270 Diadema, SP, BrazilUniv Fed Fluminense, Fac Farm, Dept Tecnol Farmaceut, BR-24241002 Niteroi, RJ, BrazilUniv Antilles Guyane,
Bereau, Didier +3 more
core +2 more sources
MedComm – Future Medicine, Volume 5, Issue 1, March 2026.The DYRK family, a pivotal metabolic homeostasis regulator, mediates crosstalk between metabolic disorders and CKD via subtype‐specific mechanisms: DYRK1A drives diabetic (CKD risk), DYRK1B exacerbates metabolic renal injury, DYRK2 contributes to renal osteodystrophy, while DYRK3/4 remain unelucidated.
Yixuan Zhu +9 more
wiley +1 more source