Results 91 to 100 of about 5,636 (198)

Insights on the comparative affinity of ribonucleic acids with plant-based beta carboline alkaloid, harmine: Spectroscopic, calorimetric and computational evaluation

Heliyon
Small molecules as ligands target multifunctional ribonucleic acids (RNA) for therapeutic engagement. This study explores how the anticancer DNA intercalator harmine interacts various motifs of RNAs, including the single-stranded A-form poly (rA), the ...
Paromita Sarkar, Priyanka Gopi, Prateek Pandya, Samaresh Paria, Maidul Hossain, Manzer H. Siddiqui, Saud Alamri, Kakali Bhadra   +7 more
doaj   +1 more source

Chronic administration of harmine elicits antidepressant-like effects and increases BDNF levels in rat hippocampus

, 2010
A growing body of evidence has pointed to the beta-carboline harmine as a potential therapeutic target for the treatment of major depression. The present study was aimed to evaluate behavioural and molecular effects of the chronic treatment with harmine ...
KAPCZINSKI, Flavio, CRIPPA, Jose A., Gabriel R. Fries, FRIES, Gabriel R., HALLAK, Jaime E., QUEVEDO, Joao, Flávio Kapczinski, KIRSCH, Tamires R., José A. Crippa, ZUARDI, Antonio W., REUS, Gislaine Z., STRINGARI, Roberto B., Jaime E. Hallak, Antônio W. Zuardi, João Quevedo, FORTUNATO, Jucelia J., Roberto B. Stringari, Gislaine Z. Réus, Jucélia J. Fortunato, Tamires R. Kirsch   +19 more
core   +1 more source

Harmine-mediated Reduction of Bone Cancer Pain in Rats Correlates With Suppressed DYRK1A/NF-κB Signaling Axis

Journal of Integrative Neuroscience
Background: Bone cancer pain (BCP) is a prevalent chronic pain condition and a common clinical symptom in patients with advanced cancer. It significantly affects the mobility and quality of life of patients; however, current treatments
Shuyao Zhang, Shang Zheng, Jia Jin, Yuhua Li, Liping Chen, Junjie Lin, Ming Yao, Longsheng Xu   +7 more
doaj   +1 more source

The Possible Regenerative Capability of Harmine on Diabetic Pancreas Experimentally Induced by Streptozotocin in Adult Male Rats [PDF]

The Egyptian Journal of Histology
Introduction: A significant global public health issue is diabetes. By repairing, maintaining, or increasing the original tissue function, regenerative medicine aims to lessen the patients' suffering.
alshimaa eldahshan, mona mohamed, rania mohamady   +2 more
doaj   +1 more source

Synthesis of harmine derivatives with potential antimalarial activity

, 2018
U ovom radu provedena je sinteza novih biološki aktivnih 1,4-disupstituiranih 1,2,3-triazolnih derivata harmina i cimetne kiseline. Kako bi se pripravili različito supstituirani propargilirani derivati prvotno se provelo prevođenje metoksi skupine ...
Beriša, Arben
core   +1 more source

Novel trisubstituted harmine derivatives with original in vitro anticancer activity. [PDF]

, 2012
To overcome the intrinsic resistance of cancer cells to apoptotic stimuli, we designed and synthesized approximately 50 novel β-carbolines structurally related to harmine. Harmine is known for its anticancer properties and is a DYRK1A inhibitor.
Vancraeynest, Christelle, Wouters, Johan, Backlund, Anders, Backlund, A, Reniers, Jérémy, Masereel, Bernard, Meinguet, Céline, Backlund, Anders,, Bruyère, Céline, Pochet, L, Kiss, Robert, Reniers, J., Meinguet, C, Wouters, Johan; id_orcid, Pochet, Lionel, Pochet, Lionel; id_orcid, Frederick, Raphael, Vancraeynest, C   +17 more
core   +1 more source

Harmine inhibits angiogenesis ex vivo and in vivo.

, 2012
(A) Representative images (left panel) and the optical density (right panel) of microvessels sprouting from rat thoracic aorta rings in the absence or presence of harmine. The microvessel density of the untreated group was considered as 100%.
Zhengfang Yi (107425), Fujun Dai (107395), Tao Zhang (43681), Dali Li (107420), Xiufeng Pang (107423), Yajuan Song (107404), Li Lai (107417), Li Huang (107408), Yihua Chen (107400), Yanmin Dong (107414), Dong Zhai (107411), Mingyao Liu (38997)   +11 more
core   +1 more source

The parameters of the binding of harmine to MDM2.

, 2012
The parameters of the binding of harmine to MDM2.
Zhengfang Yi (107425), Fujun Dai (107395), Tao Zhang (43681), Dali Li (107420), Xiufeng Pang (107423), Yajuan Song (107404), Li Lai (107417), Li Huang (107408), Yihua Chen (107400), Yanmin Dong (107414), Dong Zhai (107411), Mingyao Liu (38997)   +11 more
core   +1 more source

Novel harmine derivatives for tumor targeted therapy

Oncotarget, 2015
Harmine is a beta-carboline alkaloid found in medicinal plant PeganumHarmala, which has served as a folk anticancer medicine. However, clinical applications of harmine were limited by its low pharmacological effects and noticeable neurotoxicity. In this study, we modified harmine to increase the therapeutic efficacy and to decrease the systemic ...
Siwen, Li, Aqin, Wang, Fan, Gu, Zhaohui, Wang, Caiping, Tian, Zhiyu, Qian, Liping, Tang, Yueqing, Gu   +7 more
openaire   +3 more sources

Neuroprotective and anxiolytic effects of Matricaria chamomilla ethanolic extract against harmine-induced anxiety and oxidative stress in rats exposed to forced swimming stress [PDF]

Archives of Biological Sciences
The global rise in anxiety and depression disorders has drawn attention to compounds like harmine, a Peganum harmala alkaloid, which induces a pronounced anxiety response.
Hamida Youcef Islam, Chouba Ibtissem, Habbachi Wafa   +2 more
doaj   +1 more source