Results 61 to 70 of about 4,328 (171)
Advanced Science, Volume 13, Issue 25, 4 May 2026.Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song +4 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 5, May 2026.Moroccan medicinal plants with in silico‐approved aphrodisiac effects provide 94 phytochemicals. Docking against PDE5, AR, ERα, and aromatase gives top scores for lutein (−10.6), baicalein (−9.5), liquiritigenin (−9.2), and procyanidins (−9.7). ADMET filtering passes baicalein and liquiritigenin but excludes lutein and procyanidins. MD simulations (200
Amal Elrherabi +8 more
wiley +1 more source
Ueber Harmin und Harmalin (III.) [PDF]
Berichte der deutschen chemischen Gesellschaft, 1889 n ...
openaire +3 more sources
25 Years of “Loop” Radiochemistry for PET Imaging
Journal of Labelled Compounds and Radiopharmaceuticals, Volume 69, Issue 4-6, April‐May 2026.While conventional methods to 11C‐ and 18F‐labelled radiopharmaceuticals utilize a vial‐based approach, in the past quarter‐century, a modern, efficient, and cleaner “loop method” has been developed. The radiochemical diversity of reactions synthesized by the loop method are shown.
Emily Murrell, Sahil Khan, Neil Vasdev
wiley +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.ABSTRACT Major Depressive Disorder (MDD) and chronic pain are independently debilitating conditions that frequently co‐occur. This comorbidity poses a significant clinical challenge, resulting in greater symptom severity, higher disability, and worse prognosis than either condition alone.
Jordana Kazdan +2 more
wiley +1 more source
Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)
ChemMedChem, Volume 21, Issue 5, 13 March 2026.DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley +1 more source
The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype [PDF]
PeerJ, 2013 The end replication problem, which occurs in normal somatic cells inducing replicative senescence, is solved in most cancer cells by activating telomerase.
Lei Zhao, Michael Wink
doaj +2 more sources
MedComm – Future Medicine, Volume 5, Issue 1, March 2026.The DYRK family, a pivotal metabolic homeostasis regulator, mediates crosstalk between metabolic disorders and CKD via subtype‐specific mechanisms: DYRK1A drives diabetic (CKD risk), DYRK1B exacerbates metabolic renal injury, DYRK2 contributes to renal osteodystrophy, while DYRK3/4 remain unelucidated.
Yixuan Zhu +9 more
wiley +1 more source
ANTIDEPRESSANT ACTION OF HARMINE HYDROCHLORIDE
Pharmacy & Pharmacology, 2015 The articles presents the results of antridepressant action of water-soluble form of harmine hydrochloride.
Zh. S. Nurmaganbetov +6 more
openaire +3 more sources
BMC Infectious DiseasesBackground As antimicrobial resistance (AMR) has become a global health crisis, new strategies against AMR infection are urgently needed. Quorum sensing (QS), responsible for bacterial communication and pathogenicity, is among the targets for anti ...
Pei Chen +4 more
doaj +1 more source