Results 61 to 70 of about 7,262 (218)
Фармакокинетика и Фармакодинамика, 2020 An experimental comparative study of the relative bioavailability of plant alkaloid harmine (native, in the form of a base) in comparison with its derivative harmine hydrochloride was carried out on chinchilla rabbit.
S. M. Adekenov +5 more
doaj +1 more source
Harmine, an inhibitor of the type III secretion system of Salmonella enterica serovar Typhimurium
Frontiers in Cellular and Infection Microbiology, 2022 New therapeutic strategies for clinical Salmonella enterica serovar Typhimurium (S. Typhimurium) infection are urgently needed due to the generation of antibiotic-resistant bacteria.
Yunjia Shi +9 more
doaj +1 more source
A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation
Food Chemistry International, EarlyView.Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee +4 more
wiley +1 more source
Prehistoric psychotropic consumption in Andean Chilean mummies [PDF]
, 2007 Hallucinogenic plants are often regarded as the main source of psychoactive drugs in antiquity to reach deep altered states of consciousness^1,2^. Many researchers believe this was particularly true during the Tiwanaku empire expansion, circa (500-1000 A.
Bernardo T. Arriaza +2 more
core +1 more source
Synthesis and serum protein binding of novel ring-substituted harmine derivatives [PDF]
, 2015 A series of new derivatives of the natural β-carboline alkaloid harmine, introducing hydrophobic substituents into positions 7 and 9 were synthetized as potential anticancer agents.
András Kotschy +6 more
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Acute lung injury (ALI) is a severe complication of sepsis, yet the role of lncRNA NORAD in its pathogenesis remains unclear. Using LPS‐stimulated BEAS‐2B and HBEC3‐KT cells as well as cecal ligation and puncture (CLP)‐induced ALI models in C57BL/6 mice, we found that NORAD expression was markedly upregulated and promoted cell injury ...
Han Liu +4 more
wiley +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur +6 more
wiley +1 more source
Effect of harmine on nicotine-induced kidney dysfunction in male mice
International Journal of Preventive Medicine, 2019 Background: The nicotine content of cigarettes plays a key role in the pathogenesis of kidney disease. Harmine is a harmal-derived alkaloid with antioxidant properties.
Mohammad Reza Salahshoor +3 more
doaj +1 more source
Harmine promotes axon regeneration through enhancing glucose metabolism. [PDF]
J Biol ChemAxon regeneration requires a substantial mitochondrial energy supply. However, injured mature neurons often fail to regenerate due to their inability to meet these elevated energy demands. Our findings indicate that harmine compensates for the energy deficit following axonal injury by enhancing the coupling between glucose metabolism and mitochondrial ...
Liu R, Zhou B.
europepmc +3 more sources
Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets [PDF]
, 2017 Glucokinase-mediated glucose signaling induces insulin secretion, proliferation, and apoptosis in pancreatic β-cells. However, the precise molecular mechanisms underlying these processes are not clearly understood.
Kyohara Mayu +8 more
core +2 more sources