Results 61 to 70 of about 5,752 (199)
Novel trisubstituted harmine derivatives with original in vitro anticancer activity. [PDF]
, 2012 To overcome the intrinsic resistance of cancer cells to apoptotic stimuli, we designed and synthesized approximately 50 novel β-carbolines structurally related to harmine. Harmine is known for its anticancer properties and is a DYRK1A inhibitor.
Vancraeynest, Christelle +17 more
core +1 more source
Cancer Cell International, 2018 Background Neuroblastoma (NB) is an early childhood malignancy that arises from the developing sympathetic nervous system. Harmine is a tricyclic β-carboline alkaloid isolated from the harmal plant that exhibits both cytostatic and cytotoxic effects ...
Katie L. Uhl +3 more
doaj +1 more source
A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation
Food Chemistry International, Volume 2, Issue 3, Page 334-351, September 2026.Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee +4 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: Reversion-inducing cysteine-rich protein with kazal motifs (RECK) is a novel tumor suppressor gene that is critical for regulating tumor cell invasion and metastasis. The expression of RECK is dramatically down-regulated in human cancers.
Jia Shen +7 more
doaj +1 more source
iMetaOmics, Volume 3, Issue 3, September 2026.Advances in sequencing and mass spectrometry have propelled life sciences into the multi‐omics era. Metabolomics and microbiomics are widely applied across various research fields, yet massive data analysis faces challenges like limited tool functionality and high technical barriers.
Jianhua Zhao +16 more
wiley +1 more source
Harmine Acts as an Indirect Inhibitor of Intracellular Protein Aggregation
, 2020 Protein aggregation and oxidative stress are two pathological hallmarks of a number of protein misfolding diseases, including Huntington’s disease (HD).
Swati Jain (569859) +3 more
core +1 more source
The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.ABSTRACT Acute lung injury (ALI) is a severe complication of sepsis, yet the role of lncRNA NORAD in its pathogenesis remains unclear. Using LPS‐stimulated BEAS‐2B and HBEC3‐KT cells as well as cecal ligation and puncture (CLP)‐induced ALI models in C57BL/6 mice, we found that NORAD expression was markedly upregulated and promoted cell injury ...
Han Liu +4 more
wiley +1 more source
Japanese Journal of Pharmacology, 1987 Brain harmine was simply and sensitively determined by high performance liquid chromatography (HPLC), and the relationship between brain harmine concentrations and the jumping behavior induced by harmine and apomorphine was investigated. The concentration of harmine and the peak height in HPLC showed a good correlation, and the detection limit was 0.05
MOROI, Kayoko, KUGA, Tetsuro
openaire +2 more sources
Molecules, 2021 All-solid-state potentiometric sensors have attracted great attention over other types of potentiometric sensors due to their outstanding properties such as enhanced portability, simplicity of handling, affordability and flexibility.
Abde El-Galil E. Amr +4 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 15, 14 August 2026.Pioglitazone is an antidiabetic drug acting as a peroxisome proliferator‐activated receptor γ (PPARγ) agonist and later repositioned as a monoamine oxidase B (MAO‐B) inhibitor. Despite promising preclinical premises, it showed a lack of efficacy in clinical trials as a treatment for neurodegenerative diseases.
Filippo Basagni +12 more
wiley +1 more source