Results 61 to 70 of about 4,342 (172)

Ueber Harmin und Harmalin (III.) [PDF]

open access: yesBerichte der deutschen chemischen Gesellschaft, 1889
n ...
openaire   +3 more sources

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

open access: yesPhytochemical Analysis, Volume 37, Issue 4, Page 507-535, June 2026.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek   +3 more
wiley   +1 more source

Recent Approaches for the Synthesis of Pyridine and Quinoline Cores Present in Natural Products

open access: yesAdvanced Synthesis &Catalysis, Volume 368, Issue 10, 19 May 2026.
An anthology of the most recent methods used to synthesize pyridines and quinolines found in natural products over the last decade. Pyridines, quinolines, and their derivatives represent a class of significant heterocyclic compounds that are prevalent in a multitude of natural products, including alkaloids found in plants, fungi, insects, marine ...
Carl Bowman   +2 more
wiley   +1 more source

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

open access: yesAdvanced Science, Volume 13, Issue 25, 4 May 2026.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song   +4 more
wiley   +1 more source

Multi‐Target Mechanisms of Moroccan Aphrodisiac Plants: An Integrative Computational and Phytochemical Investigation

open access: yesFood Science &Nutrition, Volume 14, Issue 5, May 2026.
Moroccan medicinal plants with in silico‐approved aphrodisiac effects provide 94 phytochemicals. Docking against PDE5, AR, ERα, and aromatase gives top scores for lutein (−10.6), baicalein (−9.5), liquiritigenin (−9.2), and procyanidins (−9.7). ADMET filtering passes baicalein and liquiritigenin but excludes lutein and procyanidins. MD simulations (200 
Amal Elrherabi   +8 more
wiley   +1 more source

25 Years of “Loop” Radiochemistry for PET Imaging

open access: yesJournal of Labelled Compounds and Radiopharmaceuticals, Volume 69, Issue 4-6, April‐May 2026.
While conventional methods to 11C‐ and 18F‐labelled radiopharmaceuticals utilize a vial‐based approach, in the past quarter‐century, a modern, efficient, and cleaner “loop method” has been developed. The radiochemical diversity of reactions synthesized by the loop method are shown.
Emily Murrell, Sahil Khan, Neil Vasdev
wiley   +1 more source

ANTIDEPRESSANT ACTION OF HARMINE HYDROCHLORIDE

open access: yesPharmacy & Pharmacology, 2015
The articles presents the results of antridepressant action of water-soluble form of harmine hydrochloride.
Zh. S. Nurmaganbetov   +6 more
openaire   +3 more sources

Psychedelic Therapies for Comorbid Major Depressive Disorder and Chronic Pain: A Review of Putative Mechanisms of Action

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
ABSTRACT Major Depressive Disorder (MDD) and chronic pain are independently debilitating conditions that frequently co‐occur. This comorbidity poses a significant clinical challenge, resulting in greater symptom severity, higher disability, and worse prognosis than either condition alone.
Jordana Kazdan   +2 more
wiley   +1 more source

Harmine acts as a quorum sensing inhibitor decreasing the virulence and antibiotic resistance of Pseudomonas aeruginosa

open access: yesBMC Infectious Diseases
Background As antimicrobial resistance (AMR) has become a global health crisis, new strategies against AMR infection are urgently needed. Quorum sensing (QS), responsible for bacterial communication and pathogenicity, is among the targets for anti ...
Pei Chen   +4 more
doaj   +1 more source

Synthetic Derivatives of Natural Alkaloid Harmine

open access: yesEurasian Chemico-Technological Journal, 2009
The indole alkaloid harmine was extracted from underground part of Peganum harmala L. With the purpose of obtaining the new biological active derivatives on base of alkaloid harmine the chemical modification was carried out.
M. M. Ismagulova   +4 more
doaj   +1 more source

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