Results 31 to 40 of about 7,262 (218)
Frontiers in Immunology, 2021 Peri-prosthetic osteolysis (PPO) and following aseptic loosening are regarded as the prime reasons for implant failure after joint replacement. Increasing evidence indicated that wear-debris-irritated inflammatory response and macrophage polarization ...
Liangliang Wang +13 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Sepsis is a dysregulated systemic inflammatory response that often leads to cardiac dysfunction, which is termed sepsis-induced cardiomyopathy (SIC). Harmine, a natural β-carboline alkaloid compound, has been shown to exert pharmacological effects on ...
Weibin Ruan +11 more
doaj +1 more source
Intra- and extra-cellular DNA damage by harmine and 9-methyl-harmine
Journal of Photochemistry and Photobiology B: Biology, 2014 It is known that β-carbolines are able to produce photosensitized damage in cell-free DNA, but there is little information on their effects on cellular DNA. Therefore, we have analyzed the DNA damage produced by harmine and 9-methyl-harmine under UVA irradiation in V79 cells, together with the associated generation of micronuclei and photocytotoxicity.
Vignoni, Mariana +3 more
openaire +5 more sources
Regulation of Cardiomyocyte Proliferation by microRNAs and Small Molecules [PDF]
, 2018 Understanding the molecular mechanisms regulating cardiac cell proliferation during the embryonic, fetal and adult life holds a paramount importance in view of developing innovative strategies aimed at inducing myocardial regeneration after cardiac ...
Torrini, Consuelo
core +1 more source
Frontiers in Pharmacology, 2017 Harmaline and harmine occur naturally in plants and are distributed endogenously in human and animal tissues. The two β-carboline alkaloids possess potential for treating Alzheimer's disease, Parkinson's disease, depression and other central nervous ...
Shuping Li +10 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Diabetes mellitus (DM) is considered a risk factor for cognitive dysfunction. Harmine not only effectively improves the symptoms of DM but also provides neuroprotective effects in central nervous system diseases. However, whether harmine has an effect on
Peifang Liu +7 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Rationale: The psychedelic effects of the traditional Amazonian botanical decoction known as ayahuasca are often attributed to agonism at brain serotonin 5-HT2A receptors by N,N-dimethyltryptamine (DMT).
Klemens Egger +25 more
doaj +1 more source
Harmine and 7,8-dihydroxyflavone synergistically suitable for amyotrophic lateral sclerosis management: An in silico study [PDF]
Research Results in Pharmacology, 2022 Introduction: Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease characterized by progressive degeneration of both upper and lower motor neurons, resulting in paralysis and eventually leads to death from respiratory failure typically ...
Toluwase Fatoki +10 more
doaj +3 more sources
Chemical and photochemical properties of chloroharmine derivatives in aqueous solutions [PDF]
, 2016 Thermal and photochemical stability (ΦR), room temperature UV-vis absorption and fluorescence spectra, fluorescence quantum yields (ΦF) and lifetimes (τF), quantum yields of hydrogen peroxide (ΦH2O2) and singlet oxygen (ΦΔ) production, and triplet ...
Cabrerizo, Franco Martín +7 more
core +1 more source
UVA photoactivation of harmol enhances its antifungal activity against the phytopathogens Penicillium digitatum and Botrytis cinerea [PDF]
, 2017 Phytopathogenic fungi responsible for post-harvest diseases on fruit and vegetables cause important economic losses. We have previously reported that harmol (1-methyl-9H-pyrido[3,4-b]indol-7-ol) is active against the causal agents of green and gray molds
Cabrerizo, Franco Martín +5 more
core +1 more source