Results 31 to 40 of about 5,636 (198)

Anti-tumor potential of Harmine and its derivatives: recent trends and advancements [PDF]

Discover Oncology
Harmine is a β-carboline alkaloid derived from Peganum harmala, showing a solid antitumor potential in different types of human cancer cells. Unfortunately, the clinical application of this natural alkaloid has been impeded till now by severe toxic side ...
Hemant Joshi, Sakshi Bhushan, Tanisha Dimri, Deepak Sharma, Katrin Sak, Abhishek Chauhan, Ritu Chauhan, Shafiul Haque, Faraz Ahmad, Manoj Kumar, Hardeep Singh Tuli, Damandeep Kaur   +11 more
doaj   +2 more sources

1-hydroxymethyl Harmine-TGFβSF Inhibitor: Inovasi Terapi Diabetes Melitus Terbaru Melalui Inisiasi Proses Regenerasi Sel β Pankreas pada Penderita DM Tipe 1 dan 2

Scripta Score Scientific Medical Journal, 2021
Background: Type 1 and 2 diabetes mellitus (DM) is a chronic metabolic disease most commonly affects millions of people worldwide. Despite the differences in pathogenesis, both share one thing in common - that is the drastic depletion in the number of ...
Ghea Mangkuliguna, Glenardi, Rexel Kuatama   +2 more
doaj   +1 more source

Effect and Mechanism of Harmine on Echinococcosis Based on Network Pharmacology

Natural Product Communications, 2023
Objective The aim of this research was to explore the effects on echinococcosis of harmine, an active ingredient of Peganum harmala . Methods The gene targets were screened out by use of an online database.
Bei Chen, Jun Zhao, Liang Teng, Yimaierjiang Buhuliqianmu, Zhaohui Xu, Yuehong Gong, Huijing Gao   +6 more
doaj   +1 more source

Loading Harmine On Nanographene Changes The Inhibitory Effects of Free Harmine Against MCF7 and Fibroblast Cells [PDF]

Medicinal Chemistry Research, 2021
Abstract Today cancer is one of the main causes of death all over the world. Chemotherapy, which is one of the main therapies in the treatment of cancer, causes several side effects by damaging healthy cells. Therefore, carbon nanomaterial systems have been developed to optimize therapeutics procedures with the least negative consequences ...
Newsha Mortazavi, Mahboobeh Heidari, Zohreh Rabiei, Sattar Tahmasebi Enferadi, Maryam Monazzah   +4 more
openaire   +3 more sources

Harmine Inhibits Multiple TLR-Induced Inflammatory Expression through Modulation of NF-κB p65, JNK, and STAT1

Life, 2022
Harmine is a beta-carboline alkaloid present in various plants, including in the seeds of Peganum harmala L. This study aimed to investigate the anti-inflammatory activity and mechanism of harmine using macrophages stimulated with various toll-like ...
So-Jung Jin, Youngju Song, Hong Shik Park, Kye Won Park, SeungGwan Lee, Hee Kang   +5 more
doaj   +1 more source

Harmine Alleviates Titanium Particle-Induced Inflammatory Bone Destruction by Immunomodulatory Effect on the Macrophage Polarization and Subsequent Osteogenic Differentiation

Frontiers in Immunology, 2021
Peri-prosthetic osteolysis (PPO) and following aseptic loosening are regarded as the prime reasons for implant failure after joint replacement. Increasing evidence indicated that wear-debris-irritated inflammatory response and macrophage polarization ...
Liangliang Wang, Qing Wang, Wei Wang, Gaoran Ge, Nanwei Xu, Dong Zheng, Shijie Jiang, Gongyin Zhao, Yaozeng Xu, Yuji Wang, Yuji Wang, Yuji Wang, Ruixia Zhu, Dechun Geng   +13 more
doaj   +1 more source

Integrative Insights Into DYRK1A From Molecular Function to Therapeutic Advancement. [PDF]

Chem Biol Drug Des
At the center the 3D structure of DYRK1A has been displayed. The dual‐function of DYRK1A involved in cancer and neurodegeneration, i.e., its overexpression drives Down syndrome, neurodegenerative disease etc., and underexpression causes intellectual disability, seizures, etc.
Paul S, Dubey S, Tiwari P.
europepmc   +2 more sources

Harmine Alleviated Sepsis-Induced Cardiac Dysfunction by Modulating Macrophage Polarization via the STAT/MAPK/NF-κB Pathway

Frontiers in Cell and Developmental Biology, 2022
Sepsis is a dysregulated systemic inflammatory response that often leads to cardiac dysfunction, which is termed sepsis-induced cardiomyopathy (SIC). Harmine, a natural β-carboline alkaloid compound, has been shown to exert pharmacological effects on ...
Weibin Ruan, Xinyun Ji, Yating Qin, Xinxin Zhang, Xiaoning Wan, Chuanmeng Zhu, Chao Lv, Chongqing Hu, Juan Zhou, Li Lu, Li Lu, Xiaomei Guo   +11 more
doaj   +1 more source

Exposure Characteristics of the Analogous β-Carboline Alkaloids Harmaline and Harmine Based on the Efflux Transporter of Multidrug Resistance Protein 2

Frontiers in Pharmacology, 2017
Harmaline and harmine occur naturally in plants and are distributed endogenously in human and animal tissues. The two β-carboline alkaloids possess potential for treating Alzheimer's disease, Parkinson's disease, depression and other central nervous ...
Shuping Li, Yunpeng Zhang, Gang Deng, Yuwen Wang, Shenglan Qi, Xuemei Cheng, Xuemei Cheng, Yueming Ma, Yan Xie, Changhong Wang, Changhong Wang   +10 more
doaj   +1 more source

Harmine Ameliorates Cognitive Impairment by Inhibiting NLRP3 Inflammasome Activation and Enhancing the BDNF/TrkB Signaling Pathway in STZ-Induced Diabetic Rats

Frontiers in Pharmacology, 2020
Diabetes mellitus (DM) is considered a risk factor for cognitive dysfunction. Harmine not only effectively improves the symptoms of DM but also provides neuroprotective effects in central nervous system diseases. However, whether harmine has an effect on
Peifang Liu, Hui Li, Yueqiu Wang, Xiaolin Su, Yang Li, Meiling Yan, Lan Ma, Hui Che   +7 more
doaj   +1 more source