Results 41 to 50 of about 13,653 (252)

Intramolecular C_sp²–C_sp² Friedel–Crafts Arylation: Substrate- and Condition-Controlled Divergent Synthesis of Fused-β-carbolines

, 2016
A triple cooperative catalysis-mediated multicomponent reaction between 1-formyl-N-substituted-β-carbolines, a terminal alkyne, and a secondary amine allows access to unprecedented polycyclic β-carbolines via sequential A3-coupling and an intramolecular ...
Sanjay Batra (1613422), Veena D. Yadav (3355610), Shashikant U. Dighe (1613434), Rohit Mahar (1896931), Sanjeev K. Shukla (1896934)   +4 more
core   +2 more sources

Marine Indole Alkaloids

Marine Drugs, 2015
Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development.
Natalie Netz, Till Opatz
doaj   +1 more source

Cytotoxic Bis-3,4-dihydro-β-carbolines and Bis-β-carbolines [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2002
Ten bis-beta-carboline 1, 2 and bis-3,4-dihydro-beta-carboline 3, 4 derivatives, linked between carbons 1 and 1' by a polymethylene spacer, were synthesized from bistryptamine amides 9, 10. Some of them display a micromolar IC50 towards L-1210 cells.
Wei-Qun, Jiang, Catherine, Charlet-Fagnère, Janos, Sapi, Jean-Yves, Laronze, Pierre, Renard, Bruno, Pfeiffer, Stéphane, Léonce   +6 more
openaire   +2 more sources

Generation of the Camptothecin Scaffold by a Flavin‐Catalyzed Photooxidative Skeletal Reorganization

Angewandte Chemie, Volume 138, Issue 36, 1 September 2026.
The biosynthetic pathway of the anticancer drug precursor camptothecin involves an enigmatic skeletal reorganization from a 6/5/6 tetrahydro‐β‐carboline to a 6/6/5 pyrroloquinoline ring system. Here, we show that this transformation can be achieved by photooxidation with flavin cofactors, such as flavin mononucleotide (FMN) as catalysts.
Shenyu Liu, Zeliang Zhang, Benedikt Seligmann, Van Hung Bui, Tuan‐Anh Minh Nguyen, Thu‐Thuy T. Dang, Jakob Franke   +6 more
wiley   +2 more sources

Mild and Efficient Winterfeldt Oxidation of 1,2,3,4-Tetrahydro-γ-carbolines for the Synthesis of Dihydropyrrolo[3,2-b]-quinolones and Pyrrolo[3,2-b]quinolones

Molecules, 2012
The Winterfeldt oxidation (NaOH, DMF, air, rt) of substituted 1,2,3,4-tetrahydro-γ-carbolines has been developed, which provides a convenient and efficient method for the synthesis of the corresponding dihydropyrrolo[3,2-b]quinolones in moderate to ...
Rong Sheng, Jiangwei Zhu, Yongzhou Hu
doaj   +1 more source

Biodiversity of β-Carboline Profile of Banisteriopsis caapi and Ayahuasca, a Plant and a Brew with Neuropharmacological Potential

Plants, 2020
Ayahuasca is a psychoactive infusion with a large pharmacological application normally prepared with Banisteriopsis caapi, which contains the monoamine oxidase inhibitors β-carbolines, and Psichotria virids, which contains the serotonin receptor agonist ...
Beatriz Werneck Lopes Santos, Regina Célia de Oliveira, Julia Sonsin-Oliveira, Christopher William Fagg, José Beethoven Figueiredo Barbosa, Eloisa Dutra Caldas   +5 more
doaj   +1 more source

4-Azafluorenone and α-Carboline Fluorophores with Green and Violet/Blue Emission

Molecules, 2019
The emission properties of three 4-azafluorenone and five new α-carboline fluorophores in both solution and thin solid films were investigated. Fluorescence of the azafluorenone is clearly enhanced in thin solid films due to the presence of phenyl ...
Marek Cigáň, Peter Danko, Henrich Brath, Matúš Čakurda, Roman Fišera, Jana Donovalová, Juraj Filo, Martin Weis, Ján Jakabovič, Miroslav Novota, Anton Gáplovský   +10 more
doaj   +1 more source

Facile synthesis of indolizino[8,7-b]indole and pyrido[1,2-a:3,4-b’]diindole derivatives based on domino reactions of 1-aroyl-3,4-dihydro-β-carbolines

, 2022
A convenient approach to the synthesis of 1-aroyl-3,4-dihydro-β-carbolines via Pictet–Spengler reaction has been developed. A variety of reagents, such as unsaturated aldehydes, ketones, maleic anhydride in the construction of functionally diverse ...
Victor B. Rybakov (1490095), Alexey V. Varlamov (2433964), Leonid G. Voskressensky (2270389), Tatiana N. Borisova (14140730), Anna D. Zinoveva (14140727), Alexander A. Titov (14140733), Valentina V. Ilyushenkova (13216080), Elena A. Sorokina (14140736)   +7 more
core   +1 more source

Rumors of Psychedelics, Psychotropics and Related Derivatives in Vachellia and Senegalia in Contrast with Verified Records in Australian Acacia

Plants, 2022
There are almost 1000 species of Acacia sensu stricto in Australia, while the 44 species and 4 subspecies in southern Africa were taxonomically revised in the year 2011 to Senegalia and Vachellia.
Nicholas J. Sadgrove
doaj   +1 more source

Comparative Effects of α-, β-, and γ-Carbolines on Platelet Aggregation and Lipid Membranes

Journal of Toxicology, 2011
Cigarette smoking and alcohol consumption possibly affect platelet functions. To verify the hypothesis that some α-, β-, and γ-carboline components in cigarette smoke and alcoholic beverages may change platelet aggregability, their effects on human ...
Hironori Tsuchiya
doaj   +1 more source