Results 31 to 40 of about 4,239 (221)

Mild and efficient ammonium chloride catalyzed Greener synthesis of tetrahydro-β-carboline

Current Research in Green and Sustainable Chemistry, 2022
This protocol involves the NH4Cl catalyzed Pictet−Spengler reactions of tryptamine and arylaldehydes in anhydrous MeOH solvent to gives corresponding tetrahydro-β-carbolines (THβC) with 90% yield. This methodology offers mild, efficient and green reagent
Milind V. Gaikwad, Sunil V. Gaikwad, Rahul D. Kamble   +2 more
doaj   +1 more source

The Simultaneous Formation of Acrylamide, β-carbolines, and Advanced Glycation End Products in a Chemical Model System: Effect of Multiple Precursor Amino Acids

Frontiers in Nutrition, 2022
This study investigated the effect of multiple precursor amino acids on the simultaneous formation of acrylamide, β-carbolines (i. e., harmane and norharmane), and advanced glycation end products (AGEs) [i.e., Nε-(carboxymethyl)lysine and Nε ...
Cuyu Chen, Ye Jiao, Maomao Zeng, Zhiyong He, Qingwu Shen, Jie Chen, Jie Chen, Wei Quan, Wei Quan   +8 more
doaj   +1 more source

Intramolecular C_sp²–C_sp² Friedel–Crafts Arylation: Substrate- and Condition-Controlled Divergent Synthesis of Fused-β-carbolines

, 2016
A triple cooperative catalysis-mediated multicomponent reaction between 1-formyl-N-substituted-β-carbolines, a terminal alkyne, and a secondary amine allows access to unprecedented polycyclic β-carbolines via sequential A3-coupling and an intramolecular ...
Sanjay Batra (1613422), Veena D. Yadav (3355610), Shashikant U. Dighe (1613434), Rohit Mahar (1896931), Sanjeev K. Shukla (1896934)   +4 more
core   +2 more sources

Metal-Catalyzed Cyclotrimerization Reactions of Cyanamides: Synthesis of 2‑Aryl-α-carbolines

, 2020
The synthesis of annulated 2-aryl-α-carboline heterocycles is described using transition metal catalysis. A linear strategy is described that uses Rh­(I) catalysis to form the α-carboline scaffold by [2+2+2] cyclotrimerization.
Kyle M. Medas (8681829), Friendship B. Edioma (8681835), Vincent Ndahayo (8681841), Robert W. Lesch (8681832), Seann P. Mulcahy (1490983), Sean P. Wrenn (8681838)   +5 more
core   +1 more source

Marine Indole Alkaloids

Marine Drugs, 2015
Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development.
Natalie Netz, Till Opatz
doaj   +1 more source

Synthesis of α- and β-Carbolines by a Metalation/Negishi Cross-Coupling/SNAr Reaction Sequence

, 2021
Carbolines are considered to be privileged scaffolds in medicinal chemistry. An efficient method for the synthesis of α- and β-carbolines from fluoropyridines and 2-haloanilines is reported.
Stefan, Roesner, Shainthavaan, Sathiyalingam   +1 more
core   +1 more source

Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction

Nature Communications, 2019
Tetrahydro-γ-carbolines are the basic structural unit in many natural products and pharmaceuticals. Here, the authors report a synergistic Cu/Ir system to assemble chiral tetrahydro-γ-carbolines via a stereodivergent allylation followed by a ...
Shi-Ming Xu, Liang Wei, Chong Shen, Lu Xiao, Hai-Yan Tao, Chun-Jiang Wang   +5 more
doaj   +1 more source

Biodiversity of β-Carboline Profile of Banisteriopsis caapi and Ayahuasca, a Plant and a Brew with Neuropharmacological Potential

Plants, 2020
Ayahuasca is a psychoactive infusion with a large pharmacological application normally prepared with Banisteriopsis caapi, which contains the monoamine oxidase inhibitors β-carbolines, and Psichotria virids, which contains the serotonin receptor agonist ...
Beatriz Werneck Lopes Santos, Regina Célia de Oliveira, Julia Sonsin-Oliveira, Christopher William Fagg, José Beethoven Figueiredo Barbosa, Eloisa Dutra Caldas   +5 more
doaj   +1 more source

Facile synthesis of indolizino[8,7-b]indole and pyrido[1,2-a:3,4-b’]diindole derivatives based on domino reactions of 1-aroyl-3,4-dihydro-β-carbolines

, 2022
A convenient approach to the synthesis of 1-aroyl-3,4-dihydro-β-carbolines via Pictet–Spengler reaction has been developed. A variety of reagents, such as unsaturated aldehydes, ketones, maleic anhydride in the construction of functionally diverse ...
Victor B. Rybakov (1490095), Alexey V. Varlamov (2433964), Leonid G. Voskressensky (2270389), Tatiana N. Borisova (14140730), Anna D. Zinoveva (14140727), Alexander A. Titov (14140733), Valentina V. Ilyushenkova (13216080), Elena A. Sorokina (14140736)   +7 more
core   +1 more source

Mild and Efficient Winterfeldt Oxidation of 1,2,3,4-Tetrahydro-γ-carbolines for the Synthesis of Dihydropyrrolo[3,2-b]-quinolones and Pyrrolo[3,2-b]quinolones

Molecules, 2012
The Winterfeldt oxidation (NaOH, DMF, air, rt) of substituted 1,2,3,4-tetrahydro-γ-carbolines has been developed, which provides a convenient and efficient method for the synthesis of the corresponding dihydropyrrolo[3,2-b]quinolones in moderate to ...
Rong Sheng, Jiangwei Zhu, Yongzhou Hu
doaj   +1 more source