Results 1 to 10 of about 8,115 (178)

Studies on the syntheses of β-carboline alkaloids brevicarine and brevicolline [PDF]

Beilstein Journal of Organic Chemistry
A new total synthesis of the β-carboline alkaloid brevicarine is disclosed. The synthesis was carried out starting from an aromatic triflate key intermediate, allowing the introduction of various substituents into position 4 of β-carboline by cross ...
Benedek Batizi, Patrik Pollák, András Dancsó, Péter Keglevich, Gyula Simig, Balázs Volk, Mátyás Milen   +6 more
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β-Carboline Alkaloids in Soy Sauce and Inhibition of Monoamine Oxidase (MAO) [PDF]

Molecules, 2023
Monoamine oxidase (MAO) oxidizes neurotransmitters and xenobiotic amines, including vasopressor and neurotoxic amines such as the MPTP neurotoxin. Its inhibitors are useful as antidepressants and neuroprotectants.
Tomás Herraiz
doaj   +2 more sources

Recent Advances in the Synthesis of β-Carboline Alkaloids

Molecules, 2021
β-Carboline alkaloids are a remarkable family of natural and synthetic indole-containing heterocyclic compounds and they are widely distributed in nature.
Tímea Szabó, Balázs Volk, Mátyás Milen   +2 more
doaj   +3 more sources

1-Acetyl-β-Carboline from a Jeju Gotjawal Strain Lentzea sp. JNUCC 0626 and Its Melanogenic Stimulating Activity in B16F10 Melanoma Cells [PDF]

Molecules
The genus Lentzea is a prolific source of bioactive and structurally diverse secondary metabolites. We isolated a novel strain, Lentzea sp. JNUCC 0626, from Hwasun Gotjawal on Jeju Island, Korea.
Kyung-A Hyun, Yang Xu, Kyung-Hwan Boo, Chang-Gu Hyun   +3 more
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Synthesis and Biological Activities of C1-Substituted Acylhydrazone β-Carboline Analogues as Antifungal Candidates [PDF]

Molecules
In our ongoing work to create potential antifungal agents, we synthesized and tested a group of C1-substituted acylhydrazone β-carboline analogues 9a–o and 10a–o for their effectiveness against Valsa mali, Fusarium solani, Fusarium oxysporum, and ...
Yujie Xu, Lishan Li, Jinghan Zhang, Yu Lan, Na Li, Junru Wang   +5 more
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Promising Anticancer Activity of β-Carboline Derivatives: Design, Synthesis, and Pharmacological Evaluation

Chemistry, 2022
β-carboline consists of a pyridine ring fused to an indole skeleton; it possesses numerous pharmacological activities, including anticancer. Previously, we reported a satisfactory 2D and 3D QSAR study on β-carboline derivatives. Based on QSAR studies, we
Ravindra Kumar Chourasiya, Ram Kishore Agrawal, Ankur Vaidya   +2 more
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Natural surfactants assisted an efficient synthesis of tetrahydro-β-carbolines

Results in Chemistry, 2021
An expeditious protocol for the synthesis of structurally diversified β-carboline derivatives has been reported using a readily available natural surfactant medium.
Somnath S. Gholap, Vinod R. Kadu
doaj   +1 more source

Design, synthesis of N9- acyl substituted β-carboline derivatives containing 5-phenyl-2-furan moiety as potent anticancer agents

Results in Chemistry, 2022
β-Carbolines are of great interest due to their broad spectrum of biochemical effects and pharmaceutical functions, especially antitumor activity. The N9 position at β-carboline is a modification site for important antitumor activity. Several phenylfuran
Zhi Huang, Zhi-Kun Yang, Si-Qing Chen, Jian-Wei Chen, Xiao-Ze Bao, Xin-Yi Ye, Bin Wei, Zi-Ning Cui, Ya-Sheng Li, Hong Wang   +9 more
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Alkaloids and flavonoids exert protective effects against UVB-induced damage in a 3D skin model using human keratinocytes

Results in Chemistry, 2022
This study isolated six carboline alkaloids, (3S,4R)-1-(β-carbolin-1-yl)-3,4,5-trihydroxy-1-pentanone (1), β-carboline (2), 1-hydroxymethyl-β-carboline (3), perlolyrine (4), (1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (5) and (1R,3S)
Yi-Fang Chen, Dong-Dong Zhang, Dong-Bao Hu, Xiao-Nian Li, Ji-Feng Luo, Xiao-Yan Duan, Yan-Ni Zhang, Yue-Hu Wang   +7 more
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Morita–Baylis–Hillman reaction of 3-formyl-9H-pyrido[3,4-b]indoles and fluorescence studies of the products

Beilstein Journal of Organic Chemistry, 2022
β-Carboline is a privileged class of the alkaloid family and is associated with a broad spectrum of biological properties. 3-Formyl-9H-pyrido[3,4-b]indole is a such potent precursor belonging to this family which can be tailored for installing diversity ...
Nisha Devi, Virender Singh
doaj   +1 more source