Pharmaceuticals, 2022 Herein, the synthesis and anticancer activity evaluation of a series of novel β-carbolines is reported. The reactivity of nitrosoalkenes towards indole was explored for the synthesis of novel tryptophan analogs where the carboxylic acid was replaced by a
João L. P. Ribeiro +4 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2020 A robust transition-metal-free strategy is presented to access novel β-carboline-tethered benzothiophenone derivatives from 1(3)-formyl-β-carbolines using elemental sulfur activated by Et3N/DMSO.
Dharmender Singh +2 more
doaj +1 more source
Increased β-Carboline 9N-Methyltransferase Activity in the Frontal Cortex in Parkinson's Disease
Neurobiology of Disease, 2000 Enzymatic β-carboline N-methyltransferase activities generate N-methylated β-carbolinium cations that are analogs of the parkinsonian-producing neurotoxin MPP+.
Debra A. Gearhart +3 more
doaj +1 more source
Synthesis and cytotoxic activity of pyridazino[1 ',6 ': 1,2] pyrido[3,4-b]indol-5-inium derivatives as anti-cancer agents [PDF]
, 2002 Several new pyridazino[1′,6′:1,2]pyrido[3,4-b]indol-5-inium derivatives were synthesised from β-carboline derivatives and their cytotoxic activity and effect on the cell cycle were evaluated against L1210 cancer ...
Alajarín Ferrández, Ramón +10 more
core +2 more sources
Synthesis and Herbicidal Activity Evaluation of Novel β-Carboline Derivatives
Molecules, 2012 Based on the original structure of harmine, several novel 1,2,3,4-tetrahydro-β-carboline, β-carboline and 1-substituted-β-carboline derivatives bearing a substituted carbohydrazide group at C-3 were designed and synthesized to investigate the structure ...
Meiying Hu +4 more
doaj +1 more source
Preparation of 1-Substituted Tetrahydro-beta-carbolines by Lithiation-Substitution [PDF]
, 2015 A method to prepare 1-substituted N-Boctetrahydro-β-carbolines was developed by lithiation followed by electrophilic substitution. The deprotonation to give the organolithium was optimized by in situ IR spectroscopy and showed that the Boc group ...
Cochrane, E.J. +2 more
core +1 more source
UVA photoactivation of harmol enhances its antifungal activity against the phytopathogens Penicillium digitatum and Botrytis cinerea [PDF]
, 2017 Phytopathogenic fungi responsible for post-harvest diseases on fruit and vegetables cause important economic losses. We have previously reported that harmol (1-methyl-9H-pyrido[3,4-b]indol-7-ol) is active against the causal agents of green and gray molds
Cabrerizo, Franco Martín +5 more
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Molecules, 2014 Two high-speed countercurrent chromatography (HSCCC) modes were compared by separation of major alkaloids from crude extract of Picrasma quassioides. The conventional HSCCC separation was performed with a two-phase solvent system composed of petroleum ...
Qinghai Zhang +5 more
doaj +1 more source
Inhibition of alpha oscillations through serotonin-2A receptor activation underlies the visual effects of ayahuasca in humans [PDF]
, 2016 Ayahuasca is an Amazonian psychotropic plant tea typically obtained from two plants, Banisteriopsis caapi and Psychotria viridis. It contains the psychedelic 5-HT2A and sigma-1 agonist N,N-dimethyltryptamine (DMT) plus ß-carboline alkaloids with ...
Alonso, Joan Francesc +12 more
core +3 more sources
Synthesis and serum protein binding of novel ring-substituted harmine derivatives [PDF]
, 2015 A series of new derivatives of the natural β-carboline alkaloid harmine, introducing hydrophobic substituents into positions 7 and 9 were synthetized as potential anticancer agents.
András Kotschy +6 more
core +1 more source