Results 11 to 20 of about 700,501 (169)

Anticholinesterase activity of β-carboline-1,3,5-triazine hybrids

Brazilian Journal of Pharmaceutical Sciences, 2022
The β-carboline-1,3,5-triazine hydrochlorides 8-13 were evaluated in vitro against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The analysed compounds were selective to BuChE, with IC50 values in the range from 1.0-18.8 µM being ...
Paula Baréa, Valéria Aquilino Barbosa, Diego Alberto dos Santos Yamazaki, Carla Maria Beraldi Gomes, Claudio R. Novello, Willian Ferreira da Costa, Gisele de Freitas Gauze, Maria Helena Sarragiotto   +7 more
doaj   +3 more sources

Inhibiting β-Catenin by β-Carboline-Type MDM2 Inhibitor for Pancreatic Cancer Therapy

Frontiers in Pharmacology, 2018
The β-catenin and MDM2 oncoproteins are overexpressed and constitutively activated in human pancreatic cancer and contribute to its initiation, progression, and metastasis.
Jiang-Jiang Qin, Wei Wang, Wei Wang, Xin Li, Hemantkumar Deokar, John K. Buolamwini, Ruiwen Zhang, Ruiwen Zhang   +7 more
doaj   +2 more sources

Efficient in vitro elicitation of β-carboline alkaloids in transformed root cultures of Peganum harmala

Bulletin of Faculty of Pharmacy Cairo University, 2011
An efficient in vitro production of biomass hairy root cultures and elicitation of β-carboline alkaloids of Peganum harmala was established from P. harmala seedlings. Hairy root culture was arised by inoculation of the excised seedling with Agrobacterium
Rawia Zayed
doaj   +2 more sources

Synthesis and antibiotic activity of some β-Carboline alkaloids [PDF]

Acta Amazonica, 1988
Nine β-carboline alkaloids were synthetized and screened for antibiotic activity. Six of the compounds testes showed inhibitory activity against one or more of the microorganisms assayed.
Astréa M. Giesbrecht, José R. de Sousa, Leila M. G. Aguiar   +2 more
doaj   +2 more sources

Identification, Formation, and Occurrence of Perlolyrine: A β-Carboline Alkaloid with a Furan Moiety in Foods. [PDF]

J Agric Food Chem, 2023
β-Carbolines are naturally occurring bioactive alkaloids found in foods and in vivo. This research reports the identification, characterization, mechanism of formation, and occurrence of perlolyrine (1-(5-(hydroxymethyl)furan-2-yl)-9H-pyrido[3,4-b]indole)
Herraiz T, Peña A, Salgado A.
europepmc   +2 more sources

Alkaloids and flavonoids exert protective effects against UVB-induced damage in a 3D skin model using human keratinocytes

Results in Chemistry, 2022
This study isolated six carboline alkaloids, (3S,4R)-1-(β-carbolin-1-yl)-3,4,5-trihydroxy-1-pentanone (1), β-carboline (2), 1-hydroxymethyl-β-carboline (3), perlolyrine (4), (1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (5) and (1R,3S)
Yi-Fang Chen, Dong-Dong Zhang, Dong-Bao Hu, Xiao-Nian Li, Ji-Feng Luo, Xiao-Yan Duan, Yan-Ni Zhang, Yue-Hu Wang   +7 more
doaj   +1 more source

Synthesis, in vitro antiproliferative and anti-mycobacterium tuberculosis activities of novel β-carboline derivatives [PDF]

, 2020
A series of β-carboline derivatives with amino or guanidinium were synthesized and evaluated in vitro against anti-Mycobacterium tuberculosis and for antiproliferative activities against nine human cancer cell lines.
Foglio, M.A., Ruiz, A.L.T.G., Croda, J., Carvalho, J.E., Moreira, F.M.F., Formagio, A.S.N., Sarragiotto, M.H.   +6 more
core   +3 more sources

3-(1,2,3-Triazol-4-yl)-β-Carbolines and 3-(1H-Tetrazol-5-yl)-β-Carbolines: Synthesis and Evaluation as Anticancer Agents

Pharmaceuticals, 2022
Herein, the synthesis and anticancer activity evaluation of a series of novel β-carbolines is reported. The reactivity of nitrosoalkenes towards indole was explored for the synthesis of novel tryptophan analogs where the carboxylic acid was replaced by a
João L. P. Ribeiro, Joana B. Loureiro, Susana M. M. Lopes, Lucília Saraiva, Teresa M. V. D. Pinho e Melo   +4 more
doaj   +1 more source

Regioselective Decarboxylative Transformations of Tetrahydro-β-carboline-1-carboxylic Acid: Reagent Controlled Selectivity toward Alkynylated or Enaminone Products

, 2023
A one-pot, regioselective decarboxylative alkynylation of tetrahydro-β-carboline-1-carboxylic acid under peroxide-free condition is reported. The reaction is highly selective for the 1-position over the 3-position of tetrahydro-β-carboline.
Md Imran Ahmed (17094096), Arka Das (16681594), Subhendu Bhowmik (1903357), Christine Jonathan (17094093), Rana Saha (2040913)   +4 more
core   +1 more source

Et3N/DMSO-supported one-pot synthesis of highly fluorescent β-carboline-linked benzothiophenones via sulfur insertion and estimation of the photophysical properties

Beilstein Journal of Organic Chemistry, 2020
A robust transition-metal-free strategy is presented to access novel β-carboline-tethered benzothiophenone derivatives from 1(3)-formyl-β-carbolines using elemental sulfur activated by Et3N/DMSO.
Dharmender Singh, Vipin Kumar, Virender Singh   +2 more
doaj   +1 more source