Results 11 to 20 of about 1,643,257 (174)

Synthesis and Biological Activities of C1-Substituted Acylhydrazone β-Carboline Analogues as Antifungal Candidates [PDF]

Molecules
In our ongoing work to create potential antifungal agents, we synthesized and tested a group of C1-substituted acylhydrazone β-carboline analogues 9a–o and 10a–o for their effectiveness against Valsa mali, Fusarium solani, Fusarium oxysporum, and ...
Yujie Xu, Lishan Li, Jinghan Zhang, Yu Lan, Na Li, Junru Wang   +5 more
doaj   +2 more sources

Promising Anticancer Activity of β-Carboline Derivatives: Design, Synthesis, and Pharmacological Evaluation

Chemistry, 2022
β-carboline consists of a pyridine ring fused to an indole skeleton; it possesses numerous pharmacological activities, including anticancer. Previously, we reported a satisfactory 2D and 3D QSAR study on β-carboline derivatives. Based on QSAR studies, we
Ravindra Kumar Chourasiya, Ram Kishore Agrawal, Ankur Vaidya   +2 more
doaj   +1 more source

Effects of β-carboline alkaloids from Peganum harmala on the FAK/PI3K/AKT/Mtor pathway in human gastric cancer cell line

Pakistan Journal of Pharmaceutical Sciences, 2021
This study investigates the effects of β-carboline alkaloids from Peganum harmala on FAK/PI3K/AKT/mTOR pathway in gastric cancer cell line SGC-7901 and tumor-bearing mice. Western blot, immunohistochemistry and RT-PCR were performed to detect protein and
SGC-, tumor-bearing mice Yuxiang Fan, Fanye Zeng, Lili Ma, Hongliang Zhang   +4 more
doaj   +1 more source

Antiviral activities of plant-derived indole and β-carboline alkaloids against human and avian influenza viruses

Scientific Reports, 2023
The persistent evolution of drug-resistant influenza strains represents a global concern. The innovation of new treatment approaches through drug screening strategies and investigating the antiviral potential of bioactive natural-based chemicals may ...
Akram Hegazy, Sara H Mahmoud, Y. Elshaier, N. M. A. Shama, N. Nasr, M. A. Ali, A. El-Shazly, Islam Mostafa, A. Mostafa   +8 more
semanticscholar   +1 more source

Natural surfactants assisted an efficient synthesis of tetrahydro-β-carbolines

Results in Chemistry, 2021
An expeditious protocol for the synthesis of structurally diversified β-carboline derivatives has been reported using a readily available natural surfactant medium.
Somnath S. Gholap, Vinod R. Kadu
doaj   +1 more source

Review of β‐carboline and its derivatives as selective MAO‐A inhibitors

Archiv der Pharmazie, 2023
As flavin adenine dinucleotide (FAD)‐dependent enzymes, monoamine oxidases (MAOs) catalyze the oxidative deamination of various endogenous and exogenous amines.
Feba Benny, Sunil Kumar, Jayalakshmi Jayan, M. Abdelgawad, M. Ghoneim, Ashok Kumar, Amritha Manoharan, R. Susan, S. Sudevan, Bijo Mathew   +9 more
semanticscholar   +1 more source

Design, synthesis of N9- acyl substituted β-carboline derivatives containing 5-phenyl-2-furan moiety as potent anticancer agents

Results in Chemistry, 2022
β-Carbolines are of great interest due to their broad spectrum of biochemical effects and pharmaceutical functions, especially antitumor activity. The N9 position at β-carboline is a modification site for important antitumor activity. Several phenylfuran
Zhi Huang, Zhi-Kun Yang, Si-Qing Chen, Jian-Wei Chen, Xiao-Ze Bao, Xin-Yi Ye, Bin Wei, Zi-Ning Cui, Ya-Sheng Li, Hong Wang   +9 more
doaj   +1 more source

Alkaloids and flavonoids exert protective effects against UVB-induced damage in a 3D skin model using human keratinocytes

Results in Chemistry, 2022
This study isolated six carboline alkaloids, (3S,4R)-1-(β-carbolin-1-yl)-3,4,5-trihydroxy-1-pentanone (1), β-carboline (2), 1-hydroxymethyl-β-carboline (3), perlolyrine (4), (1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (5) and (1R,3S)
Yi-Fang Chen, Dong-Dong Zhang, Dong-Bao Hu, Xiao-Nian Li, Ji-Feng Luo, Xiao-Yan Duan, Yan-Ni Zhang, Yue-Hu Wang   +7 more
doaj   +1 more source

Formation, Characterization, and Occurrence of β-Carboline Alkaloids Derived from α-Dicarbonyl Compounds and l-Tryptophan

Journal of Agricultural and Food Chemistry, 2022
β-Carbolines (βCs) are naturally occurring bioactive alkaloids, whereas α-dicarbonyl compounds are reactive substances generated in foods and in vivo. In this work, l-tryptophan reacted with α-dicarbonyl compounds affording new β-carbolines.
T. Herraiz, Adriana Peña, Haroll Mateo, M. Herraiz, A. Salgado   +4 more
semanticscholar   +1 more source

β-Carboline as a Privileged Scaffold for Multitarget Strategies in Alzheimer's Disease Therapy.

Journal of Medicinal Chemistry, 2021
The natural β-carboline alkaloids display similarities with neurotransmitters that can be favorably exploited to design bioactive and bioavailable drugs for Alzheimer's disease (AD) therapy.
Aurélien Beato, A. Gori, B. Boucherle, Marine Peuchmaur, R. Haudecoeur   +4 more
semanticscholar   +1 more source