Results 21 to 30 of about 3,969 (129)

Synthesis of Large‐ and Medium‐Sized Heterobiaryl Atropisomeric Rings and Atropopeptides by Catalytic Intramolecular SNAr

Angewandte Chemie, Volume 138, Issue 45, 2 November 2026.
Catalytic, intramolecular N‐heterocycle arylation by nucleophilic aromatic substitution (SNAr) is now available for synthesis of highly strained macrocycles and medium‐sized heterobiaryl atropisomeric rings, including atropopeptides. Key to the approach is the ability to generate a strong base catalytically, taking advantage of base‐embedding ...
Alireza Abbasi Kejani, Paritosh Dey, Nicholas H. Stillman, Daniel M. Andrade, Michal Šimek, Martin Dračínský, Daniel Bím, Paulo H. S. Paioti   +7 more
wiley   +2 more sources

Efficient in vitro elicitation of β-carboline alkaloids in transformed root cultures of Peganum harmala

Bulletin of Faculty of Pharmacy Cairo University, 2011
An efficient in vitro production of biomass hairy root cultures and elicitation of β-carboline alkaloids of Peganum harmala was established from P. harmala seedlings. Hairy root culture was arised by inoculation of the excised seedling with Agrobacterium
Rawia Zayed
doaj   +1 more source

Recent evolution on synthesis strategies and anti-leishmanial activity of β-carboline derivatives – An update

Heliyon, 2020
Leishmaniasis is the most widespread pathogenic disease in several countries. Currently, no effective vaccines are available, and the control of Leishmaniasis primarily relies on decade-old chemotherapy.
Karan Kumar Banoth, Faheem, Kondapalli Venkata Gowri ChandraSekhar, Nandikolla Adinarayana, Sankaranarayanan Murugesan   +4 more
doaj   +1 more source

Effect of quercetin and oil water separation system on formation of β-carboline heterocyclic amines during frying process of braised chicken drumsticks

Current Research in Food Science, 2023
The effect of quercetin and oil water separation system on the formation of heterocyclic amines (HAs) was investigated during the frying process of braised chicken drumsticks.
Xuefei Li, Zili Yang, Jieying Deng, Conggui Chen, Baocai Xu, Peijun Li   +5 more
doaj   +1 more source

1-Formyl-β-carboline Derivatives Block Newcastle Disease Virus Proliferation through Suppressing Viral Adsorption and Entry Processes

Biomolecules, 2021
Newcastle disease virus (NDV) is one of the highly contagious pathogens causing devastating economic effects on the global poultry industry. In the present study, three 1-formyl-β-carboline derivatives (compounds 6, 7, and 9) were found to be potent ...
Chongyang Wang, Ting Wang, Jiangkun Dai, Zhiyuan An, Ruochen Hu, Liuyuan Duan, Hui Chen, Xiangwei Wang, Zhili Chu, Haijin Liu, Juan Wang, Na Li, Zengqi Yang, Junru Wang   +13 more
doaj   +1 more source

Phytochemical Investigation and In Vitro Assessment of Antioxidant, Anti‐Inflammatory and Immunomodulatory Properties of Melia azedarach Linn. Extract in Chicken Lymphocyte Model

Flavour and Fragrance Journal, EarlyView.
Phytochemistry and biopotential of Melia azedarach Linn. ABSTRACT Melia azedarach Linn. (chinaberry), a medicinal plant native to tropical Asia, is a rich source of diverse bioactive compounds with reported pharmacological activities and promising therapeutic potential.
Priya Chand, Sonu Ambwani, Ravendra Kumar, Stefania Garzoli   +3 more
wiley   +1 more source

An oxidative amidation and heterocyclization approach for the synthesis of β-carbolines and dihydroeudistomin Y

Beilstein Journal of Organic Chemistry, 2014
A novel synthetic methodology has been developed for the synthesis of dihydro-β-carboline derivatives employing oxidative amidation–Bischler–Napieralski reaction conditions using tryptamine and 2,2-dibromo-1-phenylethanone as key starting materials.
Suresh Babu Meruva, Akula Raghunadh, Raghavendra Rao Kamaraju, U. K. Syam Kumar, P. K. Dubey   +4 more
doaj   +1 more source

Interactions between lactobacillus and yeast: A recent update

Food Biomacromolecules, EarlyView.
Abstract Lactobacillus and yeast are microorganisms widely distributed in nature. Their interactions significantly impact fermentation processes, human health, and medical care. However, there is a lack of a systematic summary of the characteristics of these interactions, and the mechanisms underlying these interactions remain unclear.
Yang Chen, Mengyuan Liu, Mengchen Li, Zhiyun Yue, Yang Mu, Chao Wang, Lusha Xia, Junjun Gao, Mingye Peng, Ran Wang, Mengzhou Zhou   +10 more
wiley   +1 more source

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

Angewandte Chemie, Volume 138, Issue 40, 28 September 2026.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee, Sumin Son, Jeong Yeon Yoo, Ji Hyae Lee, Meehyun Chun, Seung Bum Park   +5 more
wiley   +2 more sources

Anticholinesterase activity of β-carboline-1,3,5-triazine hybrids

Brazilian Journal of Pharmaceutical Sciences, 2022
The β-carboline-1,3,5-triazine hydrochlorides 8-13 were evaluated in vitro against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The analysed compounds were selective to BuChE, with IC50 values in the range from 1.0-18.8 µM being ...
Paula Baréa, Valéria Aquilino Barbosa, Diego Alberto dos Santos Yamazaki, Carla Maria Beraldi Gomes, Claudio R. Novello, Willian Ferreira da Costa, Gisele de Freitas Gauze, Maria Helena Sarragiotto   +7 more
doaj   +1 more source