Results 21 to 30 of about 700,501 (169)

Morita–Baylis–Hillman reaction of 3-formyl-9H-pyrido[3,4-b]indoles and fluorescence studies of the products

Beilstein Journal of Organic Chemistry, 2022
β-Carboline is a privileged class of the alkaloid family and is associated with a broad spectrum of biological properties. 3-Formyl-9H-pyrido[3,4-b]indole is a such potent precursor belonging to this family which can be tailored for installing diversity ...
Nisha Devi, Virender Singh
doaj   +1 more source

Regioselective Decarboxylative Transformations of Tetrahydro--carboline-1-carboxylic Acid: Reagent Controlled Selectivity toward Alkynylated or Enaminone Products

, 2023
A one-pot, regioselective decarboxylative alkynylation of tetrahydro-β-carboline-1-carboxylic acid under peroxide-free condition is reported. The reaction is highly selective for the 1-position over the 3-position of tetrahydro-β-carboline.
Subhendu Bhowmik, Md Imran Ahmed (17094096), Arka Das, Arka Das (16681594), Subhendu Bhowmik (1903357), Md Imran Ahmed, Christine Jonathan, Christine Jonathan (17094093), Rana Saha, Rana Saha (2040913)   +9 more
core   +1 more source

Increased β-Carboline 9N-Methyltransferase Activity in the Frontal Cortex in Parkinson's Disease

Neurobiology of Disease, 2000
Enzymatic β-carboline N-methyltransferase activities generate N-methylated β-carbolinium cations that are analogs of the parkinsonian-producing neurotoxin MPP+.
Debra A. Gearhart, Michael A. Collins, John M. Lee, Edward J. Neafsey   +3 more
doaj   +1 more source

A new β-carboline-type alkaloid from the flowers of Calotropis gigantea (L.) W.T.Aiton

, 2023
In our antioxidant screening of some Vietnamese plant extracts, the CHCl3-soluble fraction from Calotropis gigantea (L.) W.T.Aiton flowers showed moderate DPPH free radical scavenging activity with an IC50 value of 55.8 μg/mL.
Tho H. Le (4067821), Mai T. T. Nguyen (7255331), Nhan T. Nguyen (4067830), Tu H. Tran (10317256), Phu H. Dang (4067818), Truong N. V. Do (7255328), Hai X. Nguyen (4067812)   +6 more
core   +1 more source

Preparative Separation of Alkaloids from Picrasma quassioides (D. Don) Benn. by Conventional and pH-Zone-Refining Countercurrent Chromatography

Molecules, 2014
Two high-speed countercurrent chromatography (HSCCC) modes were compared by separation of major alkaloids from crude extract of Picrasma quassioides. The conventional HSCCC separation was performed with a two-phase solvent system composed of petroleum ...
Qinghai Zhang, Xikai Shu, Feng Jing, Xiao Wang, Changhu Lin, Aiqin Luo   +5 more
doaj   +1 more source

Orthoscuticellines A–E, β-Carboline Alkaloids from the Bryozoan Orthoscuticella ventricosa Collected in Australia

, 2020
Antiplasmodial high-throughput screening of extracts derived from marine invertebrates collected from northern NSW, Australia, resulted in the methanol extract of the bryozoan Orthoscuticella ventricosa being identified as inhibitory toward the 3D7 ...
Kleks, Guy, Lucantoni, Leonardo, Carroll, Anthony R, Avery, Vicky M, Duffy, Sandra   +4 more
core   +1 more source

Synthesis and Antimicrobial Activities of 3-Methyl-β-Carboline Derivatives

Natural Product Communications, 2015
The β-carboline alkaloids possess a diverse range of important biochemical effects and pharmacological properties. Sixteen 3-methyl-β-carboline derivatives were synthesized from indole formaldehyde and nitroethane via the Henry reaction, LAH/THF ...
Jiwen Zhang, Longbo Li, Wenjia Dan, Jian Li, Qianliang Zhang, Hongjin Bai, Junru Wang   +6 more
doaj   +1 more source

Malaria Box-Inspired Discovery of NAminoalkyl--carboline-3-carboxamides, a Novel Orally Active Class of Antimalarials

, 2022
Virtual ligand screening of a publicly available database of antimalarial hits using a pharmacophore derived from antimalarial MMV008138 identified TCMDC-140230, a tetrahydro-β-carboline amide, as worthy of exploration.
Maria B. Cassera (1577068), Sha Ding, Kevin A. Kunz, Paul R. Carlier (133079), Zaira Rizopoulos (12125949), Jopaul Mathew, Reagan S. Haney (8319402), Grant J. Butschek (11435939), Maxim Totrov (133071), Kevin A. Kunz (3589256), Joshua H. Butler, Joshua H. Butler (4573309), Paul R. Carlier, Emily E. Stacy (12125946), Emily E. Stacy, Maria B. Cassera, Emilio F. Merino, Reagan S. Haney, Sha Ding (11025173), Grant J. Butschek, Jopaul Mathew (12125943), Zaira Rizopoulos, Maxim Totrov, Emilio F. Merino (198325)   +23 more
core   +1 more source

β-Carboline dimers inhibit the tumor proliferation by the cell cycle arrest of sarcoma through intercalating to Cyclin-A2

Frontiers in Immunology, 2022
β-Carbolines are potentially strong alkaloids with a wide range of bioactivities, and their dimers exhibit stronger antitumor activity other than the monomers. However, the detailed mechanisms of the β-carboline dimers in inhibiting sarcoma (SARC) remain
Huiya Ma, Hongzhi Yu, Zhengyang Li, Zhi Cao, Youwei Du, Jiangkun Dai, Dongming Zhi, Yujie Xu, Na Li, Junru Wang   +9 more
doaj   +1 more source

Formation, Characterization, and Occurrence of β-Carboline Alkaloids Derived from α-Dicarbonyl Compounds and l-Tryptophan

, 2022
[Image: see text] β-Carbolines (βCs) are naturally occurring bioactive alkaloids, whereas α-dicarbonyl compounds are reactive substances generated in foods and in vivo.
Herraiz, Tomás, Herraiz, Marta, Marta Herraiz, Peña, Adriana, Tomás Herraiz, Haroll Mateo, Antonio Salgado, Mateo, Haroll, Salgado, Antonio, Herraiz Tomico, Tomás, Herraiz Carasa, Marta, Adriana Peña   +11 more
core   +1 more source