Results 31 to 40 of about 8,115 (178)
Biomolecules, 2021 Newcastle disease virus (NDV) is one of the highly contagious pathogens causing devastating economic effects on the global poultry industry. In the present study, three 1-formyl-β-carboline derivatives (compounds 6, 7, and 9) were found to be potent ...
Chongyang Wang +13 more
doaj +1 more source
Nicotinamide N-methyltransferase catalyses the N-methylation of the endogenous ß-carboline norharman: evidence for a novel detoxification pathway [PDF]
, 2016 Nicotinamide N-methyltransferase (NNMT) is responsible for the N-methylation of nicotinamide to 1-methylnicotinamide. Our recent studies have demonstrated that NNMT regulates cellular processes fundamental to the correct functioning and survival of the ...
Barlow, David J +10 more
core +2 more sources
Molecular composition of particulate matter emissions from dung and brushwood burning household cookstoves in Haryana, India [PDF]
, 2018 Emissions of airborne particles from biomass burning are a significant source of black carbon (BC) and brown carbon (BrC) in rural areas of developing countries where biomass is the predominant energy source for cooking and heating.
Arora, NK +12 more
core +2 more sources
Synthesis, in vitro antiproliferative and anti-mycobacterium tuberculosis activities of novel β-carboline derivatives [PDF]
, 2020 A series of β-carboline derivatives with amino or guanidinium were synthesized and evaluated in vitro against anti-Mycobacterium tuberculosis and for antiproliferative activities against nine human cancer cell lines.
Carvalho, J.E. +6 more
core +4 more sources
Beilstein Journal of Organic Chemistry, 2014 A novel synthetic methodology has been developed for the synthesis of dihydro-β-carboline derivatives employing oxidative amidation–Bischler–Napieralski reaction conditions using tryptamine and 2,2-dibromo-1-phenylethanone as key starting materials.
Suresh Babu Meruva +4 more
doaj +1 more source
Anticholinesterase activity of β-carboline-1,3,5-triazine hybrids
Brazilian Journal of Pharmaceutical Sciences, 2022 The β-carboline-1,3,5-triazine hydrochlorides 8-13 were evaluated in vitro against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The analysed compounds were selective to BuChE, with IC50 values in the range from 1.0-18.8 µM being ...
Paula Baréa +7 more
doaj +1 more source
Bone marrow transplantation alters the tremor phenotype in the murine model of globoid-cell leukodystrophy [PDF]
, 2012 Tremor is a prominent phenotype of the twitcher mouse, an authentic genetic model of Globoid-Cell Leukodystrophy (GLD, Krabbe’s disease). In the current study, the tremor was quantified using a force-plate actometer designed to accommodate low-weight ...
Dearborn, Joshua T +5 more
core +4 more sources
Discovery of a Plant Pictet–Spenglerase With R‐Stereoselectivity
Angewandte Chemie International Edition, EarlyView.Strictosidine synthases (STRs) are plant Pictet–Spenglerases catalyzing the coupling of a secoiridoid with tryptamine. All previously characterized strictosidine synthases are strictly S‐selective. Here, we report the discovery of Epi‐STR, an R‐selective STR ortholog from the medicinal plant Pogonopus speciosus.
Clara Morweiser +3 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 15, 6 April 2026.Targeted covalent inhibitors (TCI) containing cyclic imine warheads react with tyrosine and tryptophan residues via the Mannich reaction. These cyclic imine warheads show comparable reaction kinetics to cysteine‐reactive electrophiles commonly used in TCIs.
Sijie Wang +6 more
wiley +2 more sources
Chemistry – A European Journal, EarlyView.A straightforward one‐step protocol enables the synthesis of bio‐based and biologically active isochromans through the Oxa‐Pictet cyclization involving diverse aldehydes, including vanillin in combination with lignin‐derivable homovanillyl alcohol, a prominent aromatic platform chemical obtainable via diol‐assisted fractionation of lignocellulose ...
Anjali Kottayi +6 more
wiley +1 more source