Results 31 to 40 of about 867,980 (166)

β-Carboline dimers inhibit the tumor proliferation by the cell cycle arrest of sarcoma through intercalating to Cyclin-A2

Frontiers in Immunology, 2022
β-Carbolines are potentially strong alkaloids with a wide range of bioactivities, and their dimers exhibit stronger antitumor activity other than the monomers. However, the detailed mechanisms of the β-carboline dimers in inhibiting sarcoma (SARC) remain
Huiya Ma, Hongzhi Yu, Zhengyang Li, Zhi Cao, Youwei Du, Jiangkun Dai, Dongming Zhi, Yujie Xu, Na Li, Junru Wang   +9 more
doaj   +1 more source

Malaria Box-Inspired Discovery of NAminoalkyl--carboline-3-carboxamides, a Novel Orally Active Class of Antimalarials

, 2022
Virtual ligand screening of a publicly available database of antimalarial hits using a pharmacophore derived from antimalarial MMV008138 identified TCMDC-140230, a tetrahydro-β-carboline amide, as worthy of exploration.
Maria B. Cassera (1577068), Sha Ding, Kevin A. Kunz, Paul R. Carlier (133079), Zaira Rizopoulos (12125949), Jopaul Mathew, Reagan S. Haney (8319402), Grant J. Butschek (11435939), Maxim Totrov (133071), Kevin A. Kunz (3589256), Joshua H. Butler, Joshua H. Butler (4573309), Paul R. Carlier, Emily E. Stacy (12125946), Emily E. Stacy, Maria B. Cassera, Emilio F. Merino, Reagan S. Haney, Sha Ding (11025173), Grant J. Butschek, Jopaul Mathew (12125943), Zaira Rizopoulos, Maxim Totrov, Emilio F. Merino (198325)   +23 more
core   +1 more source

Recent evolution on synthesis strategies and anti-leishmanial activity of β-carboline derivatives – An update

Heliyon, 2020
Leishmaniasis is the most widespread pathogenic disease in several countries. Currently, no effective vaccines are available, and the control of Leishmaniasis primarily relies on decade-old chemotherapy.
Karan Kumar Banoth, Faheem, Kondapalli Venkata Gowri ChandraSekhar, Nandikolla Adinarayana, Sankaranarayanan Murugesan   +4 more
doaj   +1 more source

Generation of the Camptothecin Scaffold by a Flavin‐Catalyzed Photooxidative Skeletal Reorganization

Angewandte Chemie, Volume 138, Issue 36, 1 September 2026.
The biosynthetic pathway of the anticancer drug precursor camptothecin involves an enigmatic skeletal reorganization from a 6/5/6 tetrahydro‐β‐carboline to a 6/6/5 pyrroloquinoline ring system. Here, we show that this transformation can be achieved by photooxidation with flavin cofactors, such as flavin mononucleotide (FMN) as catalysts.
Shenyu Liu, Zeliang Zhang, Benedikt Seligmann, Van Hung Bui, Tuan‐Anh Minh Nguyen, Thu‐Thuy T. Dang, Jakob Franke   +6 more
wiley   +2 more sources

Effect of quercetin and oil water separation system on formation of β-carboline heterocyclic amines during frying process of braised chicken drumsticks

Current Research in Food Science, 2023
The effect of quercetin and oil water separation system on the formation of heterocyclic amines (HAs) was investigated during the frying process of braised chicken drumsticks.
Xuefei Li, Zili Yang, Jieying Deng, Conggui Chen, Baocai Xu, Peijun Li   +5 more
doaj   +1 more source

1-Formyl-β-carboline Derivatives Block Newcastle Disease Virus Proliferation through Suppressing Viral Adsorption and Entry Processes

Biomolecules, 2021
Newcastle disease virus (NDV) is one of the highly contagious pathogens causing devastating economic effects on the global poultry industry. In the present study, three 1-formyl-β-carboline derivatives (compounds 6, 7, and 9) were found to be potent ...
Chongyang Wang, Ting Wang, Jiangkun Dai, Zhiyuan An, Ruochen Hu, Liuyuan Duan, Hui Chen, Xiangwei Wang, Zhili Chu, Haijin Liu, Juan Wang, Na Li, Zengqi Yang, Junru Wang   +13 more
doaj   +1 more source

Investigations of Natural Products from Bryozoa Inhabiting Aotearoa New Zealand [PDF]

, 2012
Two species of bryozoa, Pterocella vesiculosa and Plumatella repens, were investigated in an endeavour to isolate and characterise novel secondary metabolites.
Andersen, Aaron John Christian
core  

‐Butoxide‐Promoted Synthesis of Fluorescent β‐Carboline Tethered 1,3,5‐Triazines and Assessment of Their Luminescent Properties

, 2021
A transition metal-free efficient approach has been devised towards the construction of novel β-carboline C1(3)-tethered 1,3,5-triazines by using Kumujian C as a template and readily available amidines.
Singh, Virender, Saloni Mehra, Sunita Rattan, Singh, Manpreet, Jamra, Rahul, Rattan, Sunita, Virender Singh, Manpreet Singh, Rahul Jamra, Mehra, Saloni   +9 more
core   +1 more source

An oxidative amidation and heterocyclization approach for the synthesis of β-carbolines and dihydroeudistomin Y

Beilstein Journal of Organic Chemistry, 2014
A novel synthetic methodology has been developed for the synthesis of dihydro-β-carboline derivatives employing oxidative amidation–Bischler–Napieralski reaction conditions using tryptamine and 2,2-dibromo-1-phenylethanone as key starting materials.
Suresh Babu Meruva, Akula Raghunadh, Raghavendra Rao Kamaraju, U. K. Syam Kumar, P. K. Dubey   +4 more
doaj   +1 more source

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

Angewandte Chemie International Edition, EarlyView.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee, Sumin Son, Jeong Yeon Yoo, Ji Hyae Lee, Meehyun Chun, Seung Bum Park   +5 more
wiley   +1 more source