Results 31 to 40 of about 700,501 (169)

Recent evolution on synthesis strategies and anti-leishmanial activity of β-carboline derivatives – An update

Heliyon, 2020
Leishmaniasis is the most widespread pathogenic disease in several countries. Currently, no effective vaccines are available, and the control of Leishmaniasis primarily relies on decade-old chemotherapy.
Karan Kumar Banoth, Faheem, Kondapalli Venkata Gowri ChandraSekhar, Nandikolla Adinarayana, Sankaranarayanan Murugesan   +4 more
doaj   +1 more source

Effect of quercetin and oil water separation system on formation of β-carboline heterocyclic amines during frying process of braised chicken drumsticks

Current Research in Food Science, 2023
The effect of quercetin and oil water separation system on the formation of heterocyclic amines (HAs) was investigated during the frying process of braised chicken drumsticks.
Xuefei Li, Zili Yang, Jieying Deng, Conggui Chen, Baocai Xu, Peijun Li   +5 more
doaj   +1 more source

1-Formyl-β-carboline Derivatives Block Newcastle Disease Virus Proliferation through Suppressing Viral Adsorption and Entry Processes

Biomolecules, 2021
Newcastle disease virus (NDV) is one of the highly contagious pathogens causing devastating economic effects on the global poultry industry. In the present study, three 1-formyl-β-carboline derivatives (compounds 6, 7, and 9) were found to be potent ...
Chongyang Wang, Ting Wang, Jiangkun Dai, Zhiyuan An, Ruochen Hu, Liuyuan Duan, Hui Chen, Xiangwei Wang, Zhili Chu, Haijin Liu, Juan Wang, Na Li, Zengqi Yang, Junru Wang   +13 more
doaj   +1 more source

An oxidative amidation and heterocyclization approach for the synthesis of β-carbolines and dihydroeudistomin Y

Beilstein Journal of Organic Chemistry, 2014
A novel synthetic methodology has been developed for the synthesis of dihydro-β-carboline derivatives employing oxidative amidation–Bischler–Napieralski reaction conditions using tryptamine and 2,2-dibromo-1-phenylethanone as key starting materials.
Suresh Babu Meruva, Akula Raghunadh, Raghavendra Rao Kamaraju, U. K. Syam Kumar, P. K. Dubey   +4 more
doaj   +1 more source

Dual Acid Responses of Stable Luminescent Diphenylpyridylmethyl Radicals With Additional Pyridyl Groups

Chemistry – A European Journal, EarlyView.
To expand the acid‐responsive behavior of diphenylpyridylmethyl stable luminescent radicals, additional pyridyl groups were introduced. Dual acid responsiveness was observed, involving both the newly incorporated pyridyl groups and the PyBTM moieties.
Yohei Hattori, Kojiro Nakagawa, Kingo Uchida, Gwénaël Rapenne   +3 more
wiley   +1 more source

‐Butoxide‐Promoted Synthesis of Fluorescent β‐Carboline Tethered 1,3,5‐Triazines and Assessment of Their Luminescent Properties

, 2021
A transition metal-free efficient approach has been devised towards the construction of novel β-carboline C1(3)-tethered 1,3,5-triazines by using Kumujian C as a template and readily available amidines.
Singh, Virender, Saloni Mehra, Sunita Rattan, Singh, Manpreet, Jamra, Rahul, Rattan, Sunita, Virender Singh, Manpreet Singh, Rahul Jamra, Mehra, Saloni   +9 more
core   +1 more source

Transcranial Magnetic Stimulation as a Translational Biomarker in Early‐Phase Anti‐Seizure Medication Development: A Randomized, Double‐Blind, Placebo‐Controlled Study in Generalized Epilepsy

Clinical Pharmacology &Therapeutics, EarlyView.
One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba, Titia Q. Ruijs, Annika A. de Goede, Robert J. Doll, Maria Juachon, Michel J. A. M. van Putten, Geert Jan Groeneveld, Jules A. A. C. Heuberger   +7 more
wiley   +1 more source

Alcoholic extracts of Russian sage (Salvia yangii) contain bioactive terpenoids with inhibitory activity against grapevine downy mildew (Plasmopara viticola)

Pest Management Science, EarlyView.
Alcoholic extracts from flowers, leaves, and shoots of Russian sage decreased downy mildew severity on grapevine leaf disks. Fractionation followed by metabolomic analysis revealed putative terpenoids as the main components of the active fractions. Specifically, 7‐methylrosmanol, 12‐O‐methylcarnosic acid, carnosic acid, and carnosol were identified as ...
Anna Smaldone, Oscar Giovannini, Martina Magni, Michael Oberhuber, Peter Robatscher, Michele Perazzolli   +5 more
wiley   +1 more source

Orthoscuticellines A–E, β‑Carboline Alkaloids from the Bryozoan Orthoscuticella ventricosa Collected in Australia

, 2020
Antiplasmodial high-throughput screening of extracts derived from marine invertebrates collected from northern NSW, Australia, resulted in the methanol extract of the bryozoan Orthoscuticella ventricosa being identified as inhibitory toward the 3D7 ...
Sandra Duffy (1451890), Anthony R. Carroll (2071573), Guy Kleks, Vicky M. Avery (115416), Leonardo Lucantoni, Vicky M. Avery, Sandra Duffy, Anthony R. Carroll, Guy Kleks (8339613), Leonardo Lucantoni (337015)   +9 more
core   +1 more source

Discovery of a Plant Pictet–Spenglerase With R‐Stereoselectivity

Angewandte Chemie, Volume 138, Issue 20, 11 May 2026.
Strictosidine synthases (STRs) are plant Pictet–Spenglerases catalyzing the coupling of a secoiridoid with tryptamine. All previously characterized strictosidine synthases are strictly S‐selective. Here, we report the discovery of Epi‐STR, an R‐selective STR ortholog from the medicinal plant Pogonopus speciosus.
Clara Morweiser, Sarah Heinicke, Sarah E. O'Connor, Maite Colinas   +3 more
wiley   +2 more sources