Results 41 to 50 of about 3,969 (129)

Synthesis of β‐ and γ‐Carbolinones Through a Fe(III)‐Mediated Radical 6‐Endo‐Trig Cyclization of Indole‐Based Ugi 4‐CR Adducts

European Journal of Organic Chemistry, Volume 29, Issue 38, 13 October 2026.
A practical strategy for synthesizing β‐ and γ‐carbolinones from indole‐based Ugi 4‐CR adducts through an intramolecular radical cyclization using Fe(III)–H species is presented. This approach enables the efficient synthesis of spiro‐carbolinones under mild reaction conditions and demonstrates the effectiveness of secondary radicals in both cyclization
María F. Olvera‐Granados, Luis A. Polindara‐García   +1 more
wiley   +1 more source

Colombiains A–C, Three New Alkaloids From the Soft Coral‐Derived Fungus Cladosporium colombiae CSGL 10M10

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Three new alkaloids, colombiains A–C (1–3), together with eight known ones (4–11) were isolated from the soft coral‐derived fungus Cladosporium colombiae CSGL 10M10. Compounds 6 and 11 exhibited significant cardioprotective activity against OGD/R‐induced injury in H9c2 cardiomyocytes at 10 µM.
Jing Xie, Bing‐Bing Liu, Yang‐Ying Zheng, Jun‐Feng Huan, Xiao‐Yu Tian, Xiu‐Ping Lin, Hui‐Mei Xie, Yuan‐Yuan Cheng, Cui‐Xian Zhang   +8 more
wiley   +1 more source

Synthesis and in silico screening of a library of β-carboline-containing compounds

Beilstein Journal of Organic Chemistry, 2012
The synthesis of a library of tetrahydro-β-carboline-containing compounds in milligram quantities is described. Among the unique heterocyclic frameworks are twelve tetrahydroindolizinoindoles, six tetrahydrocyclobutanindoloquinolizinones and three ...
Kay M. Brummond, John R. Goodell, Matthew G. LaPorte, Lirong Wang, Xiang-Qun Xie   +4 more
doaj   +1 more source

Synthesis and antibiotic activity of some β-Carboline alkaloids [PDF]

Acta Amazonica, 1988
Nine β-carboline alkaloids were synthetized and screened for antibiotic activity. Six of the compounds testes showed inhibitory activity against one or more of the microorganisms assayed.
Astréa M. Giesbrecht, José R. de Sousa, Leila M. G. Aguiar   +2 more
doaj   +1 more source

Acute ayahuasca administration attenuates binge‐like eating and anxiety‐related behaviors in mice subjected to intermittent fasting

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract Human binge eating disorder is characterized by recurrent episodes of excessive food consumption accompanied by loss of control and is strongly associated with alterations in reward processing and emotional regulation. Ayahuasca, a psychoactive botanical preparation traditionally used in Amazonian medicine, has been shown to modulate ...
Cristian Ferreira Corona, Felipe Alves Alencar Lima, Jessica Sabrina Canedo da Silva Sumensse, Kevin Donansan Carvalho, Pedro Henrique Grignet, Heloisa Deola Confortim, Maria Claudia Gross, Fabiana Aidar Firmino, Fernanda Ferreira Evangelista, Francisney Pinto Nascimento, Jean Franciesco Vettorazzi   +10 more
wiley   +1 more source

Anticancer α-, γ-, and δ-carboline derivatives: structures, mechanisms of action, and SARs

European Journal of Medicinal Chemistry Reports
Carboline consists of a pyridine ring fused with an indole skeleton, and it serves as a potential drug scaffold. Depending on the relative position of the pyridine N to the indole N, carbolines can be categorized into α-, β-, γ-, and δ-subfamilies.
Jingliang Cui, Wanru Gao, Ziwei Liu, Shuang Cao, Sihui Long   +4 more
doaj   +1 more source

Determination of Structural Requirements of N-Substituted Tetrahydro-β-Carboline Imidazolium Salt Derivatives Using in Silico Approaches for Designing MEK-1 Inhibitors

Molecules, 2017
Novel N-substituted tetrahydro-β-carboline imidazolium salt derivatives proved to have potent antitumor activity in past research. The Topomer CoMFA and CoMSIA function in Sybyl-X 2.0 software was applied for the identification of important features of N-
Jingwei Liang, Mingyang Wang, Xinyang Li, Xin He, Chong Cao, Fanhao Meng   +5 more
doaj   +1 more source

Deep eutectic solvent mediated synthesis of β-carbolines and related natural products via Pictet–Spengler reaction and aerobic oxidation

Tetrahedron Green Chem
An eco-friendly, one-pot synthesis of β-carboline derivatives using deep eutectic solvent is reported. This protocol utilizes commercially available aldehydes and tryptamine, involving Pictet–Spengler cyclization followed by aerobic oxidation.
Bhuvana Narasimman
doaj   +1 more source

Heterocyclic‐Based Fungicides: Emerging Strategies for Viable Plant Disease Control

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Heterocyclic compounds have attracted considerable attention because of their structural diversity, potent antifungal activity, and ability to interact with multiple fungal targets, offering broad‐spectrum protection against phytopathogens. Synthetic and semisynthetic/part‐natural scaffolds, particularly azole, quinoline, indole, cyclotryptamine, and ...
Sumit Tahlan, Meenakshi Kaira, Sucheta Singh, Hrithik Dey, Kailash C. Pandey   +4 more
wiley   +1 more source

Phytochemical Analysis Using LC–MS/MS and Anticancer Activity of Asphodelus tenuifolius Roots: Cell Cycle Arrest, Apoptosis, and In Silico Insights

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
LC–HRMS/MS profiling of the hydroethanolic root extract of A. tenuifolius identifies 58 metabolites, including luteolin, emodin, luteolin‐7‐O‐β‐D‐glucoside, subaphyllin, and N‐trans‐feruloyltyramine. Integrated biological and computational analyses reveal apoptosis induction, G0/G1 cell‐cycle arrest, and multi‐target interactions, highlighting the ...
Racha Lydia Bouchouka, Farida Larit, Zahia Kabouche, Marlène Debiossat, Laurent Riou, Catherine Ghezzi, Francisco León, Ahmed Kabouche   +7 more
wiley   +1 more source