Results 41 to 50 of about 1,643,257 (174)

Cytotoxic and Insecticidal Activities of Derivatives of Harmine, a Natural Insecticidal Component Isolated from Peganum harmala

Molecules, 2010
In a continuing effort to develop novel β-carbolines endowed with better insecticidal activity, a simple high-yielding method for the synthesis of harmine compounds starting from L-tryptophan has been developed and a series of 1,3-substituted β-carboline
Guohua Zhong, Meiying Hu, Qunfang Weng, Yaomou Zhang, Yong Zeng   +4 more
doaj   +1 more source

Transcranial Magnetic Stimulation as a Translational Biomarker in Early‐Phase Anti‐Seizure Medication Development: A Randomized, Double‐Blind, Placebo‐Controlled Study in Generalized Epilepsy

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 673-683, September 2026.
One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba, Titia Q. Ruijs, Annika A. de Goede, Robert J. Doll, Maria Juachon, Michel J. A. M. van Putten, Geert Jan Groeneveld, Jules A. A. C. Heuberger   +7 more
wiley   +1 more source

Catalytic enantioselective nitrone cycloadditions enabling collective syntheses of indole alkaloids

Nature Communications
Tetrahydro-β-carboline skeletons are prominent and ubiquitous in an extraordinary range of indole alkaloid natural products and pharmaceutical compounds. Powerful synthetic approaches for stereoselective synthesis of tetrahydro-β-carboline skeletons have
Xiaochen Tian, Tengfei Xuan, Jingkun Gao, Xinyu Zhang, Tao Liu, Fengbiao Luo, Ruochen Pang, Pengcheng Shao, Yun-Fang Yang, Yang Wang   +9 more
doaj   +1 more source

Systematic prioritization of candidate genes in camptothecin biosynthesis using multi‐omics and deep learning

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Camptothecin (CPT), a plant‐derived monoterpene indole alkaloid first identified in Camptotheca acuminata, is a drug precursor widely used for cancer chemotherapeutics. However, the full set of genes responsible for CPT biosynthesis remains unclear, hindering efforts to elucidate the complete pathway or establish biosynthetic production of CPT
Shenqi Wang, Xing Wu, Maria Moreno, Joonseok Oh, Stephen L. Dellaporta, Jason M. Crawford, Farren J. Isaacs   +6 more
wiley   +1 more source

β-carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer's disease-related sites.

PLoS ONE, 2011
Harmine, a β-carboline alkaloid, is a high affinity inhibitor of the dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) protein. The DYRK1A gene is located within the Down Syndrome Critical Region (DSCR) on chromosome 21.
Danielle Frost, Bessie Meechoovet, Tong Wang, Stephen Gately, Marco Giorgetti, Irina Shcherbakova, Travis Dunckley   +6 more
doaj   +1 more source

Pre-clinical investigations of β-carboline alkaloids as antidepressant agents: A systematic review.

Fitoterapia, 2019
Depressive disorders remain a current public health problem whose prevalence has increased in the past decades. In the constant search for new therapeutic alternatives, β-carboline alkaloids have been identified as good candidates for new antidepressant ...
Christiane Adrielly Alves Ferraz, Raimundo Gonçalves de Oliveira Júnior, Laurent Picot, J. D. S. da Silva Almeida, X. P. Nunes   +4 more
semanticscholar   +1 more source

The JAK1/2 Inhibitor Baricitinib Ameliorates Neuroinflammation and Symptoms in an Animal Model of Essential Tremor

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
In a harmaline‐induced essential tremor mouse model, baricitinib attenuated tremor severity and affective‐like abnormalities, suppressed cerebellar TNF‐α, IL‐6, NF‐κB, and Lingo‐1 expression, and showed supportive Purkinje‐cell morphological preservation.
Mehran Ilaghi, Fatemeh Shahsavari, Monavareh Soti, Sina Elyasifar, Leila Bagherzadeh, Zeynab Pirmoradi, Mohammad Shabani   +6 more
wiley   +1 more source

β-carboline chemical signals induce reveromycin production through a LuxR family regulator in Streptomyces sp. SN-593

Scientific Reports, 2020
Actinomycetes bacteria produce diverse bioactive molecules that are useful as drug seeds. To improve their yield, researchers often optimize the fermentation medium.
Suresh Panthee, Naoko Kito, Teruo Hayashi, Takeshi Shimizu, J. Ishikawa, H. Hamamoto, H. Osada, Shunji Takahashi   +7 more
semanticscholar   +1 more source

Registered Clinical Trials of Ayahuasca and DMT: A Scoping Review

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 94-108, July 2026.
Interest in ayahuasca and its main component, N,N‐Dimethyltryptamine (DMT), has currently moved from historical and experimental use into modern clinical development. Yet, current evidence is fragmented, and systematic mapping of trial methods and design choices remains limited.
Tijana Stojanović, Kent W. Nilsson, Robert Fredriksson, Helgi B. Schiöth, Thiago C. Moulin   +4 more
wiley   +1 more source

Food Safety and Nutritional Aspects of Plant‐Based Dairy and Meat Alternatives: A Review

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Plant‐based dairy and meat alternatives (PBDA and PBMA) offer sustainability benefits but also introduce chemical and microbiological hazards to the diet. Key concerns include emerging mycotoxins, heavy metals, process contaminants, and heat‐resistant spore‐forming bacteria.
Elina Sohlberg, Petra Pasonen, Hanna‐Leena Alakomi, Johanna Suomi   +3 more
wiley   +1 more source