Results 41 to 50 of about 867,980 (166)

Orthoscuticellines A–E, β‑Carboline Alkaloids from the Bryozoan Orthoscuticella ventricosa Collected in Australia

, 2020
Antiplasmodial high-throughput screening of extracts derived from marine invertebrates collected from northern NSW, Australia, resulted in the methanol extract of the bryozoan Orthoscuticella ventricosa being identified as inhibitory toward the 3D7 ...
Sandra Duffy (1451890), Anthony R. Carroll (2071573), Guy Kleks, Vicky M. Avery (115416), Leonardo Lucantoni, Vicky M. Avery, Sandra Duffy, Anthony R. Carroll, Guy Kleks (8339613), Leonardo Lucantoni (337015)   +9 more
core   +1 more source

Cyclopropylamine‐Derived Distonic Iminium Radicals: Photoinduced Strategies in Chemo‐ and Stereo‐Selective Synthesis

Chemistry – A European Journal, EarlyView.
Cyclopropylamines have emerged as powerful photocatalytic building blocks. Upon light‐induced single‐electron oxidation, they undergo strain‐release ring opening to generate distonic iminium radicals that enable diverse transformations, including ring‐opening functionalization, formal [3 + 2] cycloadditions, radical cascades, and asymmetric bond ...
Maria Chiara Cabua, Alberto Luridiana, Francesco Secci, Emanuele Cocco   +3 more
wiley   +1 more source

Review of β-carboline Alkaloids from the Genus

Natural Product Communications, 2015
Plants belonging to the genus Aspidosperma , a member of the family Apocynaceae, provide a rich source of β-carboline alkaloids, which makes them potentially poisonous. However, some of these alkaloids possess antitumor and antimicrobial activity.
Tanya H. Layne, Joy S. Roach, Winston F. Tinto   +2 more
doaj   +1 more source

Synthesis of β‐ and γ‐Carbolinones Through a Fe(III)‐Mediated Radical 6‐Endo‐Trig Cyclization of Indole‐Based Ugi 4‐CR Adducts

European Journal of Organic Chemistry, EarlyView.
A practical strategy for synthesizing β‐ and γ‐carbolinones from indole‐based Ugi 4‐CR adducts through an intramolecular radical cyclization using Fe(III)–H species is presented. This approach enables the efficient synthesis of spiro‐carbolinones under mild reaction conditions and demonstrates the effectiveness of secondary radicals in both cyclization
María F. Olvera‐Granados, Luis A. Polindara‐García   +1 more
wiley   +1 more source

Facile Synthesis of 7‐Amino‐1,2,3,4‐tetrahydro‐β‐carboline

, 2003
7-Amino-1,2,3,4-tetrahydro-β-carboline has been prepared by a short efficient synthetic sequence based on a regioselective nitration of a fully protected 1,2,3,4-tetrahydro-β-carboline.
Papeo, Gianluca, Andrea Lombardi‐Borgia, Gianluca Papeo, Forte, Barbara, Lombardi-Borgia, Andrea, Barbara Forte   +5 more
core   +1 more source

Cytotoxic and Insecticidal Activities of Derivatives of Harmine, a Natural Insecticidal Component Isolated from Peganum harmala

Molecules, 2010
In a continuing effort to develop novel β-carbolines endowed with better insecticidal activity, a simple high-yielding method for the synthesis of harmine compounds starting from L-tryptophan has been developed and a series of 1,3-substituted β-carboline
Guohua Zhong, Meiying Hu, Qunfang Weng, Yaomou Zhang, Yong Zeng   +4 more
doaj   +1 more source

Beyond a dual role: how Purpureocillium lilacinum reprograms citrus metabolism for integrated biocontrol and growth promotion

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Plants harbor complex microbial communities that are fundamental to their health and productivity. Among them, endophytic fungi such as Purpureocillium lilacinum establish mutualistic associations, offering dual benefits as plant growth promoters and biocontrol agents.
Sana Bouzembila, Kamel Charaabi, Haytham Hamden, Salma Fadhel, Nesrine Tanfouri, Meriem Msaad Guerfali   +5 more
wiley   +1 more source

Synthesis of 6-Methoxy-2-methyl-1,2,3,4-tetrahydro-β-carboline

, 1974
A convenient, larger-scale preparation of 6-methoxy-2-methyl-l,2,3,4-tetrahydro-β-carboline, an alkaloid occurring in the pasture grass, Phalavis tuberosa L., is described.
JL Frahn, RJ Illman
core   +1 more source

Catalytic enantioselective nitrone cycloadditions enabling collective syntheses of indole alkaloids

Nature Communications
Tetrahydro-β-carboline skeletons are prominent and ubiquitous in an extraordinary range of indole alkaloid natural products and pharmaceutical compounds. Powerful synthetic approaches for stereoselective synthesis of tetrahydro-β-carboline skeletons have
Xiaochen Tian, Tengfei Xuan, Jingkun Gao, Xinyu Zhang, Tao Liu, Fengbiao Luo, Ruochen Pang, Pengcheng Shao, Yun-Fang Yang, Yang Wang   +9 more
doaj   +1 more source

β-carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer's disease-related sites.

PLoS ONE, 2011
Harmine, a β-carboline alkaloid, is a high affinity inhibitor of the dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) protein. The DYRK1A gene is located within the Down Syndrome Critical Region (DSCR) on chromosome 21.
Danielle Frost, Bessie Meechoovet, Tong Wang, Stephen Gately, Marco Giorgetti, Irina Shcherbakova, Travis Dunckley   +6 more
doaj   +1 more source