Results 51 to 60 of about 867,980 (166)
Heterocyclic‐Based Fungicides: Emerging Strategies for Viable Plant Disease Control
Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.Heterocyclic compounds have attracted considerable attention because of their structural diversity, potent antifungal activity, and ability to interact with multiple fungal targets, offering broad‐spectrum protection against phytopathogens. Synthetic and semisynthetic/part‐natural scaffolds, particularly azole, quinoline, indole, cyclotryptamine, and ...
Sumit Tahlan +4 more
wiley +1 more source
Flavoprotein StnP2 Catalyzes the β‑Carboline Formation during the Streptonigrin Biosynthesis
, 2022 β-Carboline (βC) alkaloids constitute a large family of indole alkaloids that exhibit diverse pharmacological properties, such as antitumor, antiviral, antiparasitic, and antimicrobial activities.
Tingting Huang (496866) +6 more
core +1 more source
Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.LC–HRMS/MS profiling of the hydroethanolic root extract of A. tenuifolius identifies 58 metabolites, including luteolin, emodin, luteolin‐7‐O‐β‐D‐glucoside, subaphyllin, and N‐trans‐feruloyltyramine. Integrated biological and computational analyses reveal apoptosis induction, G0/G1 cell‐cycle arrest, and multi‐target interactions, highlighting the ...
Racha Lydia Bouchouka +7 more
wiley +1 more source
Molecular docking and ADME profiles of β-Carboline analogues as potential antibiotic agents targeting DNA gyrase [PDF]
, 2023 Antibiotic resistance remains a major threat to humans worldwide, owing to the ability of bacteria and fungi to mutate over time, as well as a dramatic decline in the antibiotic pipeline.
Hamzah, Nurasyikin +4 more
core +1 more source
Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 673-683, September 2026.One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba +7 more
wiley +1 more source
, 2023 Human ATP-binding cassette superfamily G member 2 (ABCG2) protein is a member of the ABC transporter family, which is responsible for multidrug resistance (MDR) in cancerous cells.
Tanzeel Ahmed (8304162) +3 more
core +1 more source
Synthesis and in silico screening of a library of β-carboline-containing compounds
Beilstein Journal of Organic Chemistry, 2012 The synthesis of a library of tetrahydro-β-carboline-containing compounds in milligram quantities is described. Among the unique heterocyclic frameworks are twelve tetrahydroindolizinoindoles, six tetrahydrocyclobutanindoloquinolizinones and three ...
Kay M. Brummond +4 more
doaj +1 more source
Pest Management Science, Volume 82, Issue 9, Page 8159-8170, September 2026.Alcoholic extracts from flowers, leaves, and shoots of Russian sage decreased downy mildew severity on grapevine leaf disks. Fractionation followed by metabolomic analysis revealed putative terpenoids as the main components of the active fractions. Specifically, 7‐methylrosmanol, 12‐O‐methylcarnosic acid, carnosic acid, and carnosol were identified as ...
Anna Smaldone +5 more
wiley +1 more source
The Plant Genome, Volume 19, Issue 3, September 2026.Abstract Camptothecin (CPT), a plant‐derived monoterpene indole alkaloid first identified in Camptotheca acuminata, is a drug precursor widely used for cancer chemotherapeutics. However, the full set of genes responsible for CPT biosynthesis remains unclear, hindering efforts to elucidate the complete pathway or establish biosynthetic production of CPT
Shenqi Wang +6 more
wiley +1 more source
Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors [PDF]
, 2011 Two series of fused tetrahydro-β-carboline hydantoin and tetrahydro-β-carboline thiohydantoin derivatives with a pendant 2,4-dimethoxyphenyl at position 5 were synthesized, and chiral carbons at positions 5 and 11a swing from R,R to R,S, S,R, and S,S ...
Mohammad Abdel-Halim +4 more
core +1 more source