Results 71 to 80 of about 867,980 (166)

Synthesis and in vitro evaluation of ¹⁸F-β-carboline alkaloids as PET ligands

, 2008
A one-step 18F-labelling strategy was used to prepare four 18F-labelled analogues of 7-methoxy-1-methyl-9H-β-carboline (harmine): 7-(2-[18F]fluoroethoxy)-1-methyl-9H-β-carboline (5), 7-(3-[18F]fluoro-propoxy)-1-methyl-9H-β-carboline (6), 7-[2-(2-[18F ...
Eriksson, Olof,, Karimi, Farhad,, Blom, Elisabeth,, Långström, Bengt,, Hall, Håkan   +4 more
core   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

First total synthesis of β-carboline alkaloid trigonostemine G and its derivatives

, 2019
The β-carboline core is the base structure of several biologically active natural and unnatural compounds. Herein, we report the first total synthesis of trigonostemine G, which is a newly isolated natural β-carboline alkaloid from the twigs of ...
Balázs Volk (2441869), Tímea Szabó (6750839), András Dancsó (6750842), Mátyás Milen (6750845)   +3 more
core   +1 more source

Design, Synthesis, Cytotoxic Activity And DNA Intercalation Of New β-Carboline Derivatives [PDF]

, 2018
The focus of this study has been to investigate the in vitro cytotoxic effects of new β-carboline derivatives on the K562 human cancer cell line. Analysis using 3D-QSAR models has revealed the importance of derivatisation at position-2 and -9 of the β ...
Mohideen, Mazlin
core   +1 more source

Chemical Constituents from the Flower of Hosta plantaginea with Cyclooxygenases Inhibition and Antioxidant Activities and Their Chemotaxonomic Significance

Molecules, 2017
Two new phenolic glucosides, hostaflavanone A (1) and anti-1-phenylpropane-1,2-diol-2-O-β-d-glucopyranoside (2), together with six known compounds, anti-1-phenylpropane-1,2-diol (3), phenethyl-O-β-d-glucopyranoside (4), phenethanol-β-d-gentiobioside (5),
Li Yang, Shu-Tai Jiang, Qin-Guang Zhou, Guo-Yue Zhong, Jun-Wei He   +4 more
doaj   +1 more source

Effects of tryptophan derivatives and β -carboline alkaloids on radiation- and peroxide-induced transformations of ethanol

, 2014
The subject of this study was investigation of interactions of tryptophan and its derivatives, including structurally related β-carboline alkaloids with oxygen- and carbon-centered radicals being formed during radiation- and peroxide-induced ...
Brinkevich, S. D., Shadyro, O. I., Sverdlov, R. L.   +2 more
core   +1 more source

Cecilin, a 1-benzyl-β-carboline from aniba santalodora

, 1980
The trunk wood of Aniba santalodora (Lauraceae) contains benzyl benzoate and a novel alkaloid, 1-p-hydroxybenzyl-6-methoxy-β-carboline ...
Sousa, Josié Rêgo de, Aguiar, Leila M.G., Maia, José Guilherme Soares, Guilherme, José, Braz-Filho, Raimundo F., Pinho, Sonildes Lamêgo Vieira, Gottlieb, Otto Richard   +6 more
core   +1 more source

Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activities of β-Carboline and Quinoline Alkaloids Derivatives from the Plants of Genus Peganum

Journal of Chemistry, 2013
It was reported that the main chemical constituents in plants of genus Peganum were a serial of β-carboline and quinoline alkaloids. These alkaloids were quantitatively assessed for selective inhibitory activities on acetylcholinesterase (AChE) and ...
Ting Zhao, Ke-min Ding, Lei Zhang, Xue-mei Cheng, Chang-hong Wang, Zheng-tao Wang   +5 more
doaj   +1 more source

β-carboline alkaloids from Stellaria dichotoma as anti-fibrotic therapeutics against chronic kidney disease

Industrial Crops and Products
β-Carboline alkaloids possess significant industrial value and considerable potential for drug development. In pursuit of potential therapeutic agents for chronic kidney disease (CKD), twenty-one β-carboline alkaloids (1–21), including seven new β ...
Bixuan Cao, Zengguang Zhang, Ye Kang, Hang Lv, Mimi Zhang, Ping Yi, Li Han, Zhongyuan Liu, Xueshi Huang   +8 more
doaj   +1 more source

In Vitro and In Silico Studies on the Anti-H1N1 Activity of Bioactive Compounds from Marine-Derived Streptomyces ardesiacus

Marine Drugs
This study explores the potential anti-H1N1 Influenza A activity of bioactive compounds extracted from Streptomyces ardesiacus, a marine-derived microorganism known for producing diverse secondary metabolites.
Yung-Husan Chen, Cheng-Yang Hsieh, Chun-Tang Chiou, Engelo John Gabriel V. Caro, Lemmuel L. Tayo, Po-Wei Tsai   +5 more
doaj   +1 more source