Results 71 to 80 of about 1,643,257 (174)

Synthesis and Evaluation of New β-Carboline-3-(4-benzylidene)-<em>4H</em>-oxazol-5-one Derivatives as Antitumor Agents

Molecules, 2012
In the present work, we report the synthesis and<em> in vitro</em> anticancer and antimicrobial activity evaluation of a new series of 1-substituted-β-carboline derivatives<strong> </strong>bearing a 4-benzylidene-<em>4H-<
Maria Helena Sarragiotto, Emerson Meyer, Marta C. T. Duarte, Mauricio Ferreira da Rosa, João Ernesto de Carvalho, Ana Lúcia T. G. Ruiz, Mary Ann Foglio, Franciele Cristina Savariz   +7 more
doaj   +1 more source

Diastereoselective approach to rationally design tetrahydro-β-carboline–isatin conjugates as potential SERMs against breast cancer

RSC Advances, 2019
A series of tetrahydro-β-carboline–isatin conjugates, with varying substituents as well as stereochemistry at C-1 and C-5 position of tetrahydro-β-carboline (THβC) and isatin ring, were prepared and assayed for anti-proliferative efficacy on Estrogen ...
Bharvi Sharma, Amandeep Singh, Liang Gu, S. Saha, Ashona Singh-Pillay, Nosipho Cele, Parvesh Singh, Mandeep Kaur, Vipan Kumar   +8 more
semanticscholar   +1 more source

Synthesis, ADME, and In Silico Molecular Docking Study of Novel N-Substituted β-Carboline Analogs as a Potential Anticancer Agent

Chemistry Proceedings
The present study designed and computationally optimized a series of novel β-carboline derivatives to investigate the interaction between designed ligands and selected proteins.
Sunil Gaikwad
doaj   +1 more source

A Facile Synthesis of 3-Substituted 9H-Pyrido[3,4-b]indol-1(2H)-one Derivatives from 3-Substituted β-Carbolines

Molecules, 2010
A mild and efficient two-step synthesis of 3-substituted β-carbolinone derivatives from 3-substituted β-carboline in good yields is described. A possible reaction mechanism for the formation of the skeleton of β-carbolin-1-one is proposed. The structures
Tao Lu, Jian Wang, Qingfa Zhou, Weifang Tang, Yue Wang, Guowu Lin   +5 more
doaj   +1 more source

Synthesis and biological evaluation of novel N9-heterobivalent β-carbolines as angiogenesis inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
A series of novel N9-heterobivalent β-carbolines has been synthesized. All the novel compounds were tested for their anticancer activity against six tumour cell lines in vitro.
Liang Guo, Qin Ma, Wei Chen, Wenxi Fan, Jie Zhang, Bin Dai   +5 more
doaj   +1 more source

Synthesis and Bioactivity of β-Carboline Derivatives

Natural Product Communications, 2010
The β-carboline alkaloids possess a wide diversity of important biochemical effects and pharmacological properties. A series of β-carboline derivatives were synthesized from L-tryptophan through the Pictet-Spengler reaction and oxidation of K 2 Cr 2 O 7 ...
Shengkun Li, Bing Yang, Qianliang Zhang, Jiwen Zhang, Junru Wang, Wenjun Wu   +5 more
doaj   +1 more source

Pd(II)-catalyzed C–H annulation and lactonization of indole-2-carboxamides with hydroxyalkynoates using air as an oxidant

Tetrahedron Chem
A novel palladium(II) catalyzed C–H annulation strategy has been developed for the synthesis of a diverse range of furo[3′,4':5,6]pyrido[3,4-b]indole-1,5(3H)-dione scaffolds. This is the first report on the construction of polycyclic carboline frameworks
Kiran Aswale, Rajashaker Bantu, B. Sridhar, B.V. Subba Reddy   +3 more
doaj   +1 more source

7-Bromo-1-ethyl-β-carboline, an Alkaloid from the New Zealand Marine Bryozoan

Natural Product Communications, 2013
A new alkaloid, 7-bromo-1-ethyl-β-carboline ( 1 ) has been isolated from the New Zealand marine bryozoan Pterocella vesiculosa (Lamarck, 1816). Structural elucidation was achieved through NMR spectroscopic and mass spectrometric analysis.
Michèle R. Prinsep, Mérine Dumté
doaj   +1 more source

Dual-pathway detoxification by Dendrobium nobile Lindl. Polysaccharide: concurrent suppression of bound heterocyclic amine release and heterocyclic amine-elicited cytotoxicity during gastrointestinal digestion

Food Chemistry: X
This study investigated Dendrobium nobile Lindl. polysaccharides (DNP) for their effects on bound heterocyclic amine (HAs) release in beef patties, myofibrillar protein (MP) and sarcoplasmic protein (SP) models.
Yi Le, Chenxia Zhang, Jinrun Xiao, Huirong Lei, Wei Quan, Hongkang Zhu, Siwei Xiong, Jun Sheng, Peiyuan Sun, Huanhuan Xu, Chaoyi Xue   +10 more
doaj   +1 more source

Identification, Formation, and Occurrence of Perlolyrine: A β-Carboline Alkaloid with a Furan Moiety in Foods. [PDF]

J Agric Food Chem, 2023
Herraiz T, Peña A, Salgado A.
europepmc   +1 more source