Results 81 to 90 of about 700,501 (169)

In Vitro and In Silico Studies on the Anti-H1N1 Activity of Bioactive Compounds from Marine-Derived Streptomyces ardesiacus

Marine Drugs
This study explores the potential anti-H1N1 Influenza A activity of bioactive compounds extracted from Streptomyces ardesiacus, a marine-derived microorganism known for producing diverse secondary metabolites.
Yung-Husan Chen, Cheng-Yang Hsieh, Chun-Tang Chiou, Engelo John Gabriel V. Caro, Lemmuel L. Tayo, Po-Wei Tsai   +5 more
doaj   +1 more source

Cecilin, a 1-benzyl-β-carboline from aniba santalodora

, 1980
The trunk wood of Aniba santalodora (Lauraceae) contains benzyl benzoate and a novel alkaloid, 1-p-hydroxybenzyl-6-methoxy-β-carboline ...
Sousa, Josié Rêgo de, Aguiar, Leila M.G., Maia, José Guilherme Soares, Guilherme, José, Braz-Filho, Raimundo F., Pinho, Sonildes Lamêgo Vieira, Gottlieb, Otto Richard   +6 more
core   +1 more source

Two novel β-carboline compounds from the Maillard reaction between xylose and tryptophan

, 1999
Two nonvolatile β-carboline alkaloids were isolated from the Maillard reaction between xylose and tryptophan by solvent extraction and flash silica gel column chromatography.
Ho, CT, Jin, Y, Li, J, Wang, M
core   +1 more source

Synthesis, ADME, and In Silico Molecular Docking Study of Novel N-Substituted β-Carboline Analogs as a Potential Anticancer Agent

Chemistry Proceedings
The present study designed and computationally optimized a series of novel β-carboline derivatives to investigate the interaction between designed ligands and selected proteins.
Sunil Gaikwad
doaj   +1 more source

A Facile Synthesis of 3-Substituted 9H-Pyrido[3,4-b]indol-1(2H)-one Derivatives from 3-Substituted β-Carbolines

Molecules, 2010
A mild and efficient two-step synthesis of 3-substituted β-carbolinone derivatives from 3-substituted β-carboline in good yields is described. A possible reaction mechanism for the formation of the skeleton of β-carbolin-1-one is proposed. The structures
Tao Lu, Jian Wang, Qingfa Zhou, Weifang Tang, Yue Wang, Guowu Lin   +5 more
doaj   +1 more source

Design, Synthesis, Cytotoxic Activity And DNA Intercalation Of New β-Carboline Derivatives [PDF]

, 2018
The focus of this study has been to investigate the in vitro cytotoxic effects of new β-carboline derivatives on the K562 human cancer cell line. Analysis using 3D-QSAR models has revealed the importance of derivatisation at position-2 and -9 of the β ...
Mohideen, Mazlin
core  

Synthesis and biological evaluation of novel N9-heterobivalent β-carbolines as angiogenesis inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
A series of novel N9-heterobivalent β-carbolines has been synthesized. All the novel compounds were tested for their anticancer activity against six tumour cell lines in vitro.
Liang Guo, Qin Ma, Wei Chen, Wenxi Fan, Jie Zhang, Bin Dai   +5 more
doaj   +1 more source

Synthesis and Bioactivity of β-Carboline Derivatives

Natural Product Communications, 2010
The β-carboline alkaloids possess a wide diversity of important biochemical effects and pharmacological properties. A series of β-carboline derivatives were synthesized from L-tryptophan through the Pictet-Spengler reaction and oxidation of K 2 Cr 2 O 7 ...
Shengkun Li, Bing Yang, Qianliang Zhang, Jiwen Zhang, Junru Wang, Wenjun Wu   +5 more
doaj   +1 more source

Two new β-carboline alkaloids from the roots of Gypsophila oldhamiana

, 2015
Phytochemical investigation of the roots of Gypsophila oldhamiana afforded two new β-carboline alkaloids, oldhamiaines A and B (1 and 2), along with a known analogue (3). Their structures were elucidated by using spectroscopic and chemical methods.
Lingyi Kong (536841), Jianguang Luo (536840), Huawei Lv (536839), Gang Wang (36685), Yangmei Zhang (451324)   +4 more
core   +1 more source

Pd(II)-catalyzed C–H annulation and lactonization of indole-2-carboxamides with hydroxyalkynoates using air as an oxidant

Tetrahedron Chem
A novel palladium(II) catalyzed C–H annulation strategy has been developed for the synthesis of a diverse range of furo[3′,4':5,6]pyrido[3,4-b]indole-1,5(3H)-dione scaffolds. This is the first report on the construction of polycyclic carboline frameworks
Kiran Aswale, Rajashaker Bantu, B. Sridhar, B.V. Subba Reddy   +3 more
doaj   +1 more source