Results 81 to 90 of about 867,980 (166)

Quality Assessment of Kumu Injection, a Traditional Chinese Medicine Preparation, Using HPLC Combined with Chemometric Methods and Qualitative and Quantitative Analysis of Multiple Alkaloids by Single Marker

Molecules, 2018
Kumu injection (KMI) is a common-used traditional Chinese medicine (TCM) preparation made from Picrasma quassioides (D. Don) Benn. rich in alkaloids.
Ning Wang, Zhi-Yong Li, Xiao-Li Zheng, Qiao Li, Xin Yang, Hui Xu   +5 more
doaj   +1 more source

Synthesis and Evaluation of New β-Carboline-3-(4-benzylidene)-<em>4H</em>-oxazol-5-one Derivatives as Antitumor Agents

Molecules, 2012
In the present work, we report the synthesis and<em> in vitro</em> anticancer and antimicrobial activity evaluation of a new series of 1-substituted-β-carboline derivatives<strong> </strong>bearing a 4-benzylidene-<em>4H-<
Maria Helena Sarragiotto, Emerson Meyer, Marta C. T. Duarte, Mauricio Ferreira da Rosa, João Ernesto de Carvalho, Ana Lúcia T. G. Ruiz, Mary Ann Foglio, Franciele Cristina Savariz   +7 more
doaj   +1 more source

Synthesis and Characterization of the Food-Derived Carcinogens 2-(Hydroxylamino)-α-carboline and 2-(Hydroxylamino)-3-methyl-α-carboline

, 2016
Synthesis and Characterization of the Food-Derived Carcinogens 2-(Hydroxylamino)-α-carboline and 2-(Hydroxylamino)-3-methyl-α ...
Shahrokh Kazerani (3008535), Michael Novak (1691365)   +1 more
core   +1 more source

Two novel β-carboline compounds from the Maillard reaction between xylose and tryptophan

, 1999
Two nonvolatile β-carboline alkaloids were isolated from the Maillard reaction between xylose and tryptophan by solvent extraction and flash silica gel column chromatography.
Ho, CT, Jin, Y, Li, J, Wang, M
core   +1 more source

Benzodiazepine agonists protect a histidine residue from modification by diethyl pyrocarbonate whereas propyl β-carboline does not [PDF]

, 1987
The pH sensitivity of benzodiazepine binding suggests that a histidine residue may be present in, or close to the benzodiazepine binding site. This was confirmed by the selective modification of histidine residues using diethyl pyrocarbonate which was ...
Rossier, J., J. Rossier, B. Lambolez, Lambolez, B.   +3 more
core   +1 more source

Variabines A and B: new β-carboline alkaloids from the marine sponge Luffariella variabilis [PDF]

, 2013
Two new β-carboline alkaloids, variabines A (1) and B (2), were isolated from the Indonesian marine sponge Luffariella variabilis. Their structures were elucidated from spectral data, and 1 was found to be a sulfonated derivative of 2.
Rotinsulu, Henki, 165408, Mangindaan, Remy E. P., 165407, 165406, 165405, Kato, Hikaru, 165249, 165248, Losung, Fitje, Tsukamoto, Sachiko, Sakai, Eriko, 165254, 165263, de Voogd, Nicole J., Yokosawa, Hideyoshi   +15 more
core   +1 more source

Synthesis, ADME, and In Silico Molecular Docking Study of Novel N-Substituted β-Carboline Analogs as a Potential Anticancer Agent

Chemistry Proceedings
The present study designed and computationally optimized a series of novel β-carboline derivatives to investigate the interaction between designed ligands and selected proteins.
Sunil Gaikwad
doaj   +1 more source

Synthesis and biological evaluation of novel N9-heterobivalent β-carbolines as angiogenesis inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
A series of novel N9-heterobivalent β-carbolines has been synthesized. All the novel compounds were tested for their anticancer activity against six tumour cell lines in vitro.
Liang Guo, Qin Ma, Wei Chen, Wenxi Fan, Jie Zhang, Bin Dai   +5 more
doaj   +1 more source

Two new β-carboline alkaloids from the roots of Gypsophila oldhamiana

, 2015
Phytochemical investigation of the roots of Gypsophila oldhamiana afforded two new β-carboline alkaloids, oldhamiaines A and B (1 and 2), along with a known analogue (3). Their structures were elucidated by using spectroscopic and chemical methods.
Lingyi Kong (536841), Jianguang Luo (536840), Huawei Lv (536839), Gang Wang (36685), Yangmei Zhang (451324)   +4 more
core   +1 more source

Pd(II)-catalyzed C–H annulation and lactonization of indole-2-carboxamides with hydroxyalkynoates using air as an oxidant

Tetrahedron Chem
A novel palladium(II) catalyzed C–H annulation strategy has been developed for the synthesis of a diverse range of furo[3′,4':5,6]pyrido[3,4-b]indole-1,5(3H)-dione scaffolds. This is the first report on the construction of polycyclic carboline frameworks
Kiran Aswale, Rajashaker Bantu, B. Sridhar, B.V. Subba Reddy   +3 more
doaj   +1 more source