Results 61 to 70 of about 8,115 (178)

Inhibitory Activity of Conferone on FAK Activity and Glutamine Metabolism in Human Colorectal Cancer

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Colorectal cancer (CRC) is a major global cause of death, with metastases and chemotherapy resistance contributing to poor outcomes. To identify natural compounds with anticancer potential against CRC and elucidate their action mechanisms, the cytotoxicity of 37 natural compounds was evaluated against the HCT116, leading to the identification ...
Hien Thi My Ong, Eda Ates, Jaeyong Jung, Jeong Soo Sung, Jae‐Chul Pyun, Min‐Jung Kang   +5 more
wiley   +1 more source

Synthesis of 2‐Aryl(alkyl)benzimidazole Hydroxamic Acids as HDAC Inhibitors with Anti‐Angiogenesis Properties

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
2‐Aryl(alkyl)benzimidazole hydroxamic acids (11‐16) are potent and selective HDAC6 inhibitors, with minimal activity against HDAC1/2, and also display anti‐angiogenic and anticancer activities. Compound 13 exhibited a GI50 of 3.9 μM against EPCs and inhibited the growth of HCT‐116, SK‐Hep‐1, and PC‐3 cells with GI50 values of 1.3, 4.2, and 7.5 μM ...
Yi‐Ting Liu, Cheng‐Ta Lai, Shih‐Wei Wang, Shan‐Chi Liu, Yi‐Lin Hwang, Yi‐Chen Tsai, Chi‐Yeh Lee, Yu‐Wei Lai, Juei‐Yu Yen, Po‐Chuan Wang, Hsueh‐Yun Lee   +10 more
wiley   +1 more source

Anticancer α-, γ-, and δ-carboline derivatives: structures, mechanisms of action, and SARs

European Journal of Medicinal Chemistry Reports
Carboline consists of a pyridine ring fused with an indole skeleton, and it serves as a potential drug scaffold. Depending on the relative position of the pyridine N to the indole N, carbolines can be categorized into α-, β-, γ-, and δ-subfamilies.
Jingliang Cui, Wanru Gao, Ziwei Liu, Shuang Cao, Sihui Long   +4 more
doaj   +1 more source

Synthesis and in silico screening of a library of β-carboline-containing compounds

Beilstein Journal of Organic Chemistry, 2012
The synthesis of a library of tetrahydro-β-carboline-containing compounds in milligram quantities is described. Among the unique heterocyclic frameworks are twelve tetrahydroindolizinoindoles, six tetrahydrocyclobutanindoloquinolizinones and three ...
Kay M. Brummond, John R. Goodell, Matthew G. LaPorte, Lirong Wang, Xiang-Qun Xie   +4 more
doaj   +1 more source

Impact of oral capsule of Peganum harmala on alleviating urinary symptoms in men with benign prostatic hyperplasia; a randomized clinical trial. [PDF]

, 2017
Introduction: Benign prostatic hyperplasia (BPH) is considered as a major cause of lower urinary tract symptoms (LUTS) in older men and its most common sign is nocturia. Objectives: This study aimed to determine the effect of the seeds of Peganum harmala
Heidari-Soureshjani, Saeed, Keivani Hafshejani, Zahra, Shirani-Boroujeni, Majid   +2 more
core  

Diterpenoids from Azorella compacta (Umbelliferae) active on Trypanosoma cruzi [PDF]

, 2003
The anti-Trypanosoma cruzi activity of natural products isolated from Azorella compacta was evaluated, with particular emphasis on their effect against intracellular amastigotes. Five diterpenoids from A.
Araya, Jorge E, Bórquez, Jorge, Cordero, Esteban Mauricio, González, Jorge, Loyola, Alberto, Manque, Patricio, Morales, Glauco, Mortara, Renato Arruda, Neira, Iván, Sagua, Hernán, Silva, Solange da   +10 more
core   +3 more sources

Determination of Structural Requirements of N-Substituted Tetrahydro-β-Carboline Imidazolium Salt Derivatives Using in Silico Approaches for Designing MEK-1 Inhibitors

Molecules, 2017
Novel N-substituted tetrahydro-β-carboline imidazolium salt derivatives proved to have potent antitumor activity in past research. The Topomer CoMFA and CoMSIA function in Sybyl-X 2.0 software was applied for the identification of important features of N-
Jingwei Liang, Mingyang Wang, Xinyang Li, Xin He, Chong Cao, Fanhao Meng   +5 more
doaj   +1 more source

Thiourea-Catalyzed Enantioselective Iso-Pictet-Spengler Reactions [PDF]

, 2011
A one-pot condensation of isotryptamines and aldehydes that affords enantiomerically enriched 4-substituted tetrahydro-\(\gamma\)-carbolines is reported. The reaction is induced by a chiral thiourea/benzoic acid dual catalyst system.
Jacobsen, Eric N., Klausen, Rebekka S., Lee, Yunmi   +2 more
core   +1 more source

Pharmacological and Structure-Activity Relationship Evaluation of 4-aryl-1-Diphenylacetyl(thio)semicarbazides [PDF]

, 2014
This article describes the synthesis of six 4-aryl-(thio)semicarbazides (series a and b) linked with diphenylacetyl moiety along with their pharmacological evaluation on the central nervous system in mice and computational studies, including ...
Fidecka, Sylwia, Kuśmierz, Edyta, Kędzierska, Ewa, Orzelska, Jolanta, Paneth, Agata, Paneth, Piotr, Plech, Tomasz, Wróbel, Andrzej, Wujec, Monika   +8 more
core   +2 more sources

Wherefore the Magic? The Evolutionary Role of Psilocybin in Nature

Ecology and Evolution, Volume 16, Issue 4, April 2026.
This study explores the evolutionary role of psilocybin, the psychedelic compound found in Psilocybe mushrooms. We provide the first experimental tests of defence and community‐level evidence for invertebrate responses to psilocybin‐producing fungi, revealing significant negative effects on invertebrate locomotion, development, and survival.
K. J. Matthews Nicholass, I. Flis, M. E. Hanley, M. E. Knight, S. M. Lane, G. Littlejohn, M. D. F. Thom, R. A. Billington, R. Boden, R. Cummins, B. J. Green, C. Griffin, S. Jones, D. Salmon, I. Sleep, N. Smirnoff, J. S. Ellis   +16 more
wiley   +1 more source