Results 61 to 70 of about 700,501 (169)

Determination of Structural Requirements of N-Substituted Tetrahydro-β-Carboline Imidazolium Salt Derivatives Using in Silico Approaches for Designing MEK-1 Inhibitors

Molecules, 2017
Novel N-substituted tetrahydro-β-carboline imidazolium salt derivatives proved to have potent antitumor activity in past research. The Topomer CoMFA and CoMSIA function in Sybyl-X 2.0 software was applied for the identification of important features of N-
Jingwei Liang, Mingyang Wang, Xinyang Li, Xin He, Chong Cao, Fanhao Meng   +5 more
doaj   +1 more source

Total Synthesis of rac‐Keramamine C Enabled by Intrinsic H‐Bond‐Induced Conformational Fixation of Amides

European Journal of Organic Chemistry, Volume 29, Issue 18, 14 May 2026.
The total synthesis of the manzamine alkaloid keramamine C (2) in its racemic form was achieved in 5 steps, with ring‐closing metathesis as the key step. The metathesis is strongly improved by an intramolecular H‐bond‐induced conformational fixation of the amide bond, inducing close proximity of the terminal double bonds in the precursor molecule.
Jana Ganzmann, Ryan Thurston, Pascal Riester, Nina Hegmann, Markus R. Heinrich   +4 more
wiley   +1 more source

4-Trifloxy-9-SEM-β-Carboline:  Preparation and Synthetic Utility

, 2016
4-Trifloxy-9-SEM-β-Carboline:  Preparation and Synthetic ...
Carl A. Busacca (1434076), Annette M. Salvagno (3047721), Matt A. Tschantz (3014616), Magnus C. Eriksson (1944784), Anthony S. Prokopowicz (3014613), Yong Dong (683776)   +5 more
core   +1 more source

Deep eutectic solvent mediated synthesis of β-carbolines and related natural products via Pictet–Spengler reaction and aerobic oxidation

Tetrahedron Green Chem
An eco-friendly, one-pot synthesis of β-carboline derivatives using deep eutectic solvent is reported. This protocol utilizes commercially available aldehydes and tryptamine, involving Pictet–Spengler cyclization followed by aerobic oxidation.
Bhuvana Narasimman
doaj   +1 more source

Naturally-occurring tetrahydro-β-carboline alkaloids derived from tryptophan are oxidized to bioactive β-carboline alkaloids by heme peroxidases

, 2014
β-Carbolines are indole alkaloids that occur in plants, foods, and endogenously in mammals and humans, and which exhibit potent biological, psychopharmacological and toxicological activities.
Galisteo, Juan, Herraiz Tomico, Tomás
core   +1 more source

Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors [PDF]

, 2011
Two series of fused tetrahydro-β-carboline hydantoin and tetrahydro-β-carboline thiohydantoin derivatives with a pendant 2,4-dimethoxyphenyl at position 5 were synthesized, and chiral carbons at positions 5 and 11a swing from R,R to R,S, S,R, and S,S ...
Mohammad Abdel-Halim, Mohamed S. M. Ali, Jochen Lehmann, Ashraf H. Abadi, Gary A. Piazza   +4 more
core   +1 more source

Mo‐Catalyzed Synthesis of N‐Polyheterocycles From Functionalized Nitroarenes and Aldehydes

Asian Journal of Organic Chemistry, Volume 15, Issue 5, May 2026.
Mo(VI)‐catalyzed one‐pot conversion of readily available functionalized nitroarenes and aldehydes yielded fused N‐polyheterocycles by sequential nitro reduction, imine formation, and cyclization. Using pinacol as a benign reductant, this sustainable tandem strategy suppresses side reactions and grants rapid access to diverse pharmacologically relevant ...
Raúl Martínez‐González, Rubén Rubio‐Presa, María R. Pedrosa, Samuel Suárez‐Pantiga, Roberto Sanz   +4 more
wiley   +1 more source

Investigations of Natural Products from Bryozoa Inhabiting Aotearoa New Zealand

, 2012
Two species of bryozoa, Pterocella vesiculosa and Plumatella repens, were investigated in an endeavour to isolate and characterise novel secondary metabolites.
Andersen, Aaron John Christian
core  

Probiotic‐based strategies in vulvovaginal candidiasis management: A comprehensive review of mechanisms and future directions

Interdisciplinary Medicine, Volume 4, Issue 3, May 2026.
This review focuses on vulvovaginal candidiasis (VVC), examining its epidemiology, the pathogenesis of Candida albicans, and its relationships with vaginal microbiota. It comprehensively reviews probiotic‐based management strategies and their mechanisms of action, and concludes by discussing current limitations, challenges and future research ...
Tong Chen, Yuwei Wu, Ya Chen, Ying Li, Hui Zhao, Lei Wu, He Gao, Tong Jiang, Xiaohong Wang, Moutong Chen, Jumei Zhang, Xinqiang Xie, Tingting Liang, Qingping Wu   +13 more
wiley   +1 more source

Tenofovir, Interferon Pathways, and Mucosal Immunity: Implications for People Living With HIV

American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.
ABSTRACT Background Antiretroviral therapy (ART) suppresses HIV replication and protects people living with HIV (PLWH) from progressing to AIDS. However, despite ART, many PLWH experience chronic immune activation, which contributes to premature aging and non‐AIDS‐related comorbidities. One reason for this chronic immune activation (CIA) is HIV and its
Florian Hladik, Sean M. Hughes, Claire N. Levy, Rachel L. Creighton, Romel Mackelprang, Germán G. Gornalusse   +5 more
wiley   +1 more source