Results 51 to 60 of about 4,239 (221)

Dual Acid Responses of Stable Luminescent Diphenylpyridylmethyl Radicals With Additional Pyridyl Groups

Chemistry – A European Journal, EarlyView.
To expand the acid‐responsive behavior of diphenylpyridylmethyl stable luminescent radicals, additional pyridyl groups were introduced. Dual acid responsiveness was observed, involving both the newly incorporated pyridyl groups and the PyBTM moieties.
Yohei Hattori, Kojiro Nakagawa, Kingo Uchida, Gwénaël Rapenne   +3 more
wiley   +1 more source

Synthesis and biological activity of N-substituted-tetrahydro-γ-carbolines containing peptide residues

Beilstein Journal of Organic Chemistry, 2014
The synthesis of novel peptide conjugates of N-substituted-tetrahydro-γ-carbolines has been performed using the sequence of the Ugi multicomponent reaction and Cu(I)-catalyzed click chemistry.
Nadezhda V. Sokolova, Valentine G. Nenajdenko, Vladimir B. Sokolov, Daria V. Vinogradova, Elena F. Shevtsova, Ludmila G. Dubova, Sergey O. Bachurin   +6 more
doaj   +1 more source

Transcranial Magnetic Stimulation as a Translational Biomarker in Early‐Phase Anti‐Seizure Medication Development: A Randomized, Double‐Blind, Placebo‐Controlled Study in Generalized Epilepsy

Clinical Pharmacology &Therapeutics, EarlyView.
One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba, Titia Q. Ruijs, Annika A. de Goede, Robert J. Doll, Maria Juachon, Michel J. A. M. van Putten, Geert Jan Groeneveld, Jules A. A. C. Heuberger   +7 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Novel N-Acylhydrazone Bond Linked Heterobivalent β-Carbolines as Potential Anticancer Agents

Molecules, 2019
Utilizing a pharmacophore hybridization approach, we have designed and synthesized a novel series of 28 new heterobivalent β-carbolines. The in vitro cytotoxic potential of each compound was evaluated against the five cancer cell lines (LLC, BGC-823,
Xiaofei Chen, Liang Guo, Qin Ma, Wei Chen, Wenxi Fan, Jie Zhang   +5 more
doaj   +1 more source

Alcoholic extracts of Russian sage (Salvia yangii) contain bioactive terpenoids with inhibitory activity against grapevine downy mildew (Plasmopara viticola)

Pest Management Science, EarlyView.
Alcoholic extracts from flowers, leaves, and shoots of Russian sage decreased downy mildew severity on grapevine leaf disks. Fractionation followed by metabolomic analysis revealed putative terpenoids as the main components of the active fractions. Specifically, 7‐methylrosmanol, 12‐O‐methylcarnosic acid, carnosic acid, and carnosol were identified as ...
Anna Smaldone, Oscar Giovannini, Martina Magni, Michael Oberhuber, Peter Robatscher, Michele Perazzolli   +5 more
wiley   +1 more source

Synthesis and Investigation of Tetrahydro-β-carboline Derivatives as Inhibitors of Plant Pathogenic Fungi

Molecules, 2021
A series of tetrahydro-ß-carbolines substituted with an alkyl or acyl side chain was synthesized and screened for its antifungal activity against plant pathogenic fungi (Bipolaris oryzae, Curvularia lunata, Fusarium semitectum, and Fusarium fujikuroi ...
Koonchira Buaban, Weerachai Phutdhawong, Thongchai Taechowisan, Waya S. Phutdhawong   +3 more
doaj   +1 more source

Structural basis of regioselective double halogenation of the β‐carboline tryptoline by the single‐component halogenase AetF

Acta Crystallographica Section D, EarlyView.
A structure of the flavin‐dependent single‐component tryptophan halogenase AetF bound to the non‐native tricyclic substrate tryptoline reveals a binding pose analogous to l‐tryptophan that directs C6‐first halogenation. Product analysis identifies 6,8‐dibromotryptoline as the final product.Flavin‐dependent halogenases (FDHs) offer a biocatalytic route ...
Simon Bork, Hendrik J. Horstmeier, Bjarne Scharkowski, Hartmut H. Niemann   +3 more
wiley   +1 more source

Discovery of a Plant Pictet–Spenglerase With R‐Stereoselectivity

Angewandte Chemie, Volume 138, Issue 20, 11 May 2026.
Strictosidine synthases (STRs) are plant Pictet–Spenglerases catalyzing the coupling of a secoiridoid with tryptamine. All previously characterized strictosidine synthases are strictly S‐selective. Here, we report the discovery of Epi‐STR, an R‐selective STR ortholog from the medicinal plant Pogonopus speciosus.
Clara Morweiser, Sarah Heinicke, Sarah E. O'Connor, Maite Colinas   +3 more
wiley   +2 more sources

Morita–Baylis–Hillman reaction of 3-formyl-9H-pyrido[3,4-b]indoles and fluorescence studies of the products

Beilstein Journal of Organic Chemistry, 2022
β-Carboline is a privileged class of the alkaloid family and is associated with a broad spectrum of biological properties. 3-Formyl-9H-pyrido[3,4-b]indole is a such potent precursor belonging to this family which can be tailored for installing diversity ...
Nisha Devi, Virender Singh
doaj   +1 more source

Registered Clinical Trials of Ayahuasca and DMT: A Scoping Review

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 94-108, July 2026.
Interest in ayahuasca and its main component, N,N‐Dimethyltryptamine (DMT), has currently moved from historical and experimental use into modern clinical development. Yet, current evidence is fragmented, and systematic mapping of trial methods and design choices remains limited.
Tijana Stojanović, Kent W. Nilsson, Robert Fredriksson, Helgi B. Schiöth, Thiago C. Moulin   +4 more
wiley   +1 more source