Results 51 to 60 of about 13,653 (252)

Bioassay-Guided Interpretation of Antimicrobial Compounds in Kumu, a TCM Preparation From Picrasma quassioides’ Stem via UHPLC-Orbitrap-Ion Trap Mass Spectrometry Combined With Fragmentation and Retention Time Calculation

Frontiers in Pharmacology, 2021
The stem of Picrasma quassioides (PQ) was recorded as a prominent traditional Chinese medicine, Kumu, which was effective for microbial infection, inflammation, fever, and dysentery, etc.
Haibo Hu, Haibo Hu, Changling Hu, Jinnian Peng, Alokesh Kumar Ghosh, Ajmal Khan, Dan Sun, Dan Sun, Walter Luyten   +8 more
doaj   +1 more source

Diversity-oriented synthesis derived indole based spiro and fused small molecules kills artemisinin-resistant Plasmodium falciparum

Malaria Journal, 2021
Background Despite numerous efforts to eradicate the disease, malaria continues to remain one of the most dangerous infectious diseases plaguing the world. In the absence of any effective vaccines and with emerging drug resistance in the parasite against
Akshaykumar Nayak, Himani Saxena, Chandramohan Bathula, Tarkeshwar Kumar, Souvik Bhattacharjee, Subhabrata Sen, Ashish Gupta   +6 more
doaj   +1 more source

Tandem Rh(II) and Chiral Squaramide Relay Catalysis: Enantioselective Synthesis of Dihydro-β-carbolines via Insertion to C-H Bond and Aza-Michael Reaction.

Organic Letters, 2019
An efficient tandem rhodium(II)/squaramide relay catalysis of readily accessible indole derivatives and N-sulfonyl-1,2,3-triazoles has been developed for the enantioselective synthesis of dihydro-β-carbolines in good yield and enantioselectivity.
Shanmugam Rajasekar, P. Anbarasan
semanticscholar   +1 more source

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

Angewandte Chemie International Edition, EarlyView.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee, Sumin Son, Jeong Yeon Yoo, Ji Hyae Lee, Meehyun Chun, Seung Bum Park   +5 more
wiley   +1 more source

Synthesis and biological activity of N-substituted-tetrahydro-γ-carbolines containing peptide residues

Beilstein Journal of Organic Chemistry, 2014
The synthesis of novel peptide conjugates of N-substituted-tetrahydro-γ-carbolines has been performed using the sequence of the Ugi multicomponent reaction and Cu(I)-catalyzed click chemistry.
Nadezhda V. Sokolova, Valentine G. Nenajdenko, Vladimir B. Sokolov, Daria V. Vinogradova, Elena F. Shevtsova, Ludmila G. Dubova, Sergey O. Bachurin   +6 more
doaj   +1 more source

Design, Synthesis, and Biological Evaluation of Novel N-Acylhydrazone Bond Linked Heterobivalent β-Carbolines as Potential Anticancer Agents

Molecules, 2019
Utilizing a pharmacophore hybridization approach, we have designed and synthesized a novel series of 28 new heterobivalent β-carbolines. The in vitro cytotoxic potential of each compound was evaluated against the five cancer cell lines (LLC, BGC-823,
Xiaofei Chen, Liang Guo, Qin Ma, Wei Chen, Wenxi Fan, Jie Zhang   +5 more
doaj   +1 more source

Consecutive Four-Component Coupling-Addition Aza-Anellation Pictet–Spengler Synthesis of Tetrahydro-β-Carbolines: An Optimized Michael Addition and Computational Study on the Aza-Anellation Step

Organics, 2023
Starting from acid chlorides, alkynes, tryptamines, and acryloyl chloride, 21 densely substituted tetrahydro-β-carbolines were prepared in a four-component, one-pot reaction.
Kai Ries, Françoise A. Aouane, Thomas J. J. Müller   +2 more
doaj   +1 more source

Cyclopropylamine‐Derived Distonic Iminium Radicals: Photoinduced Strategies in Chemo‐ and Stereo‐Selective Synthesis

Chemistry – A European Journal, EarlyView.
Cyclopropylamines have emerged as powerful photocatalytic building blocks. Upon light‐induced single‐electron oxidation, they undergo strain‐release ring opening to generate distonic iminium radicals that enable diverse transformations, including ring‐opening functionalization, formal [3 + 2] cycloadditions, radical cascades, and asymmetric bond ...
Maria Chiara Cabua, Alberto Luridiana, Francesco Secci, Emanuele Cocco   +3 more
wiley   +1 more source

Carbenium catalysis toward β-carbolines [PDF]

, 2023
This preview highlights the findings of Liu, Jia, Loh, and co-workers, reported recently in Cell Reports Physical Science on the synthesis of β-carbolines in good to excellent yields, catalyzed by the [Ph3C]+[B(C6F5)4]− ion pair.
Richards, Emma, Melen, Rebecca L.
core   +1 more source

Synthesis of β‐ and γ‐Carbolinones Through a Fe(III)‐Mediated Radical 6‐Endo‐Trig Cyclization of Indole‐Based Ugi 4‐CR Adducts

European Journal of Organic Chemistry, EarlyView.
A practical strategy for synthesizing β‐ and γ‐carbolinones from indole‐based Ugi 4‐CR adducts through an intramolecular radical cyclization using Fe(III)–H species is presented. This approach enables the efficient synthesis of spiro‐carbolinones under mild reaction conditions and demonstrates the effectiveness of secondary radicals in both cyclization
María F. Olvera‐Granados, Luis A. Polindara‐García   +1 more
wiley   +1 more source