Results 51 to 60 of about 6,872 (221)
Molecules, 2021 A series of tetrahydro-ß-carbolines substituted with an alkyl or acyl side chain was synthesized and screened for its antifungal activity against plant pathogenic fungi (Bipolaris oryzae, Curvularia lunata, Fusarium semitectum, and Fusarium fujikuroi ...
Koonchira Buaban +3 more
doaj +1 more source
Normal spatial learning and improved spatial working memory in mice (mus musculus) lacking dopamine d4 receptors [PDF]
, 2001 Dopamine terminals in the hippocampus and prefrontal cortex modulate cognitive processes such as spatial learning and working memory. Because dopamine D4 receptors are expressed in these brain areas we have analyzed mutant mice lacking this receptor ...
Avale, Maria Elena +3 more
core +1 more source
European Journal of Organic Chemistry, EarlyView.The total synthesis of the manzamine alkaloid keramamine C (2) in its racemic form was achieved in 5 steps, with ring‐closing metathesis as the key step. The metathesis is strongly improved by an intramolecular H‐bond‐induced conformational fixation of the amide bond, inducing close proximity of the terminal double bonds in the precursor molecule.
Jana Ganzmann +4 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2022 β-Carboline is a privileged class of the alkaloid family and is associated with a broad spectrum of biological properties. 3-Formyl-9H-pyrido[3,4-b]indole is a such potent precursor belonging to this family which can be tailored for installing diversity ...
Nisha Devi, Virender Singh
doaj +1 more source
A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs [PDF]
, 2016 Chikungunya virus (CHIKV) is a globally spreading alphavirus against which there is no commercially available vaccine or therapy. Here we use a genome-wide siRNA screen to identify 156 proviral and 41 antiviral host factors affecting CHIKV replication ...
Berre, Stefano +16 more
core +5 more sources
Medicinal Research Reviews, EarlyView.ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur +6 more
wiley +1 more source
Natural surfactants assisted an efficient synthesis of tetrahydro-β-carbolines
Results in Chemistry, 2021 An expeditious protocol for the synthesis of structurally diversified β-carboline derivatives has been reported using a readily available natural surfactant medium.
Somnath S. Gholap, Vinod R. Kadu
doaj +1 more source
Elevated blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor [PDF]
, 2008 Essential tremor (ET) is a widespread late-life neurological disease. Genetic and environmental factors likely play an etiological role. Harmane (1-methyl-9H-pyrido[3,4-b]indole) is a potent tremor-producing neurotoxin.
Factor-Litvak, Pam +6 more
core +2 more sources
Pest Management Science, EarlyView.Alcoholic extracts from flowers, leaves, and shoots of Russian sage decreased downy mildew severity on grapevine leaf disks. Fractionation followed by metabolomic analysis revealed putative terpenoids as the main components of the active fractions. Specifically, 7‐methylrosmanol, 12‐O‐methylcarnosic acid, carnosic acid, and carnosol were identified as ...
Anna Smaldone +5 more
wiley +1 more source
Frontiers in Neuroscience, 2022 Conventional tobacco cigarettes appear to have greater abuse liability than non-combusted products such as electronic cigarettes (ECs) and nicotine replacement therapy (NRT).
Andrew C. Harris +8 more
doaj +1 more source