Results 71 to 80 of about 13,653 (252)
Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 673-683, September 2026.One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba +7 more
wiley +1 more source
Angewandte Chemie, 2018 Stereoselective methods for the synthesis of tetrahydro‐ß‐carbolines are of significant interest due to the broad spectrum of biological activity of the target molecules.
Desiree Pressnitz +9 more
semanticscholar +1 more source
Pest Management Science, Volume 82, Issue 9, Page 8159-8170, September 2026.Alcoholic extracts from flowers, leaves, and shoots of Russian sage decreased downy mildew severity on grapevine leaf disks. Fractionation followed by metabolomic analysis revealed putative terpenoids as the main components of the active fractions. Specifically, 7‐methylrosmanol, 12‐O‐methylcarnosic acid, carnosic acid, and carnosol were identified as ...
Anna Smaldone +5 more
wiley +1 more source
The Plant Genome, Volume 19, Issue 3, September 2026.Abstract Camptothecin (CPT), a plant‐derived monoterpene indole alkaloid first identified in Camptotheca acuminata, is a drug precursor widely used for cancer chemotherapeutics. However, the full set of genes responsible for CPT biosynthesis remains unclear, hindering efforts to elucidate the complete pathway or establish biosynthetic production of CPT
Shenqi Wang +6 more
wiley +1 more source
European Journal of Inorganic Chemistry, Volume 29, Issue 24, 21 August 2026.A versatile library of backbone‐functionalized N‐heterocyclic carbene (NHC) ligands was developed and efficiently converted into Cu(I) and Ru(II) NHC complexes, demonstrating that ligand functionalization strongly modulates anticancer activity, with Cu(I)–NHC species showing potent and selective antiproliferative effects against ovarian and breast ...
Alessia Schiavo +4 more
wiley +1 more source
Chemistry – A European Journal, Volume 32, Issue 31, 18 August 2026.To expand the acid‐responsive behavior of diphenylpyridylmethyl stable luminescent radicals, additional pyridyl groups were introduced. Dual acid responsiveness was observed, involving both the newly incorporated pyridyl groups and the PyBTM moieties.
Yohei Hattori +3 more
wiley +1 more source
Molecules, 2018 Ru-catalyzed tandem amine oxidative dehydrogenation/formal aza-Diels–Alder reaction for enantio- and diastereoselective synthesis of indoloquinolizidine-2-ones from tetrahydro-β-carbolines and α,β-unsaturated ketones is described ...
Xiang Wu +3 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2020 A robust transition-metal-free strategy is presented to access novel β-carboline-tethered benzothiophenone derivatives from 1(3)-formyl-β-carbolines using elemental sulfur activated by Et3N/DMSO.
Dharmender Singh +2 more
doaj +1 more source
Журнал органічної та фармацевтичної хімії, 2020 Aim. To synthesize 4-cyanoindolo[2,3-c]pyrilium salts and examine their reactivity towards N-nucleophiles. Results and discussion. The acylation reaction of 2-(indolyl-3)-2-aroylacetonitriles under acid catalysis conditions was studied. 4-Cyanoindolo[2,3-
N. M. Bogdan +2 more
doaj +1 more source
Chemistry – A European Journal, Volume 32, Issue 30, 13 August 2026.A straightforward one‐step protocol enables the synthesis of bio‐based and biologically active isochromans through the Oxa‐Pictet cyclization involving diverse aldehydes, including vanillin in combination with lignin‐derivable homovanillyl alcohol, a prominent aromatic platform chemical obtainable via diol‐assisted fractionation of lignocellulose ...
Anjali Kottayi +6 more
wiley +1 more source