Results 71 to 80 of about 4,239 (221)

New Synthesis of Benzo-δ-carbolines, Cryptolepines, and Their Salts: In Vitro Cytotoxic, Antiplasmodial, and Antitrypanosomal Activities of δ-Carbolines, Benzo-δ-carbolines, and Cryptolepines

, 2016
The paper describes, in its first part, a new synthesis of benzo-δ-carbolines, cryptolepines, and their salts. The strategy is based on the association between halogen-dance and hetero-ring cross-coupling.
François Frappier (274193), Christiane Gaspard (3012138), Francis Marsais (1597804), Erwan Arzel (3012144), Philippe Grellier (776508), Françoise Guéritte (2639503), Mehdi Labaeïd (3012135), Guy Quéguiner (2720968), Patrick Rocca (3012141), Alain Godard (3012147)   +9 more
core   +1 more source

Anticancer α-, γ-, and δ-carboline derivatives: structures, mechanisms of action, and SARs

European Journal of Medicinal Chemistry Reports
Carboline consists of a pyridine ring fused with an indole skeleton, and it serves as a potential drug scaffold. Depending on the relative position of the pyridine N to the indole N, carbolines can be categorized into α-, β-, γ-, and δ-subfamilies.
Jingliang Cui, Wanru Gao, Ziwei Liu, Shuang Cao, Sihui Long   +4 more
doaj   +1 more source

Mo‐Catalyzed Synthesis of N‐Polyheterocycles From Functionalized Nitroarenes and Aldehydes

Asian Journal of Organic Chemistry, Volume 15, Issue 5, May 2026.
Mo(VI)‐catalyzed one‐pot conversion of readily available functionalized nitroarenes and aldehydes yielded fused N‐polyheterocycles by sequential nitro reduction, imine formation, and cyclization. Using pinacol as a benign reductant, this sustainable tandem strategy suppresses side reactions and grants rapid access to diverse pharmacologically relevant ...
Raúl Martínez‐González, Rubén Rubio‐Presa, María R. Pedrosa, Samuel Suárez‐Pantiga, Roberto Sanz   +4 more
wiley   +1 more source

Beta-carbolines and their tetrahydro derivatives.

, 1986
The synthesis of 3-carbomethoxy-1,4-dimethyl-acarboline (50a), 3-carbomethoxy-l-ethyl-4-methyl-~carboline(50b), 3-carbomethoxy-4-methyl-l-phenyl-acarboline(50c), 3-carbomethoxy-4-methyl-1-(2-pyridyl)$-carboline(50d), 3-carbomethoxy-1-(2-furyl)-4-methyl ...
Zarrinmayeh, Hamideh
core  

Probiotic‐based strategies in vulvovaginal candidiasis management: A comprehensive review of mechanisms and future directions

Interdisciplinary Medicine, Volume 4, Issue 3, May 2026.
This review focuses on vulvovaginal candidiasis (VVC), examining its epidemiology, the pathogenesis of Candida albicans, and its relationships with vaginal microbiota. It comprehensively reviews probiotic‐based management strategies and their mechanisms of action, and concludes by discussing current limitations, challenges and future research ...
Tong Chen, Yuwei Wu, Ya Chen, Ying Li, Hui Zhao, Lei Wu, He Gao, Tong Jiang, Xiaohong Wang, Moutong Chen, Jumei Zhang, Xinqiang Xie, Tingting Liang, Qingping Wu   +13 more
wiley   +1 more source

Synthesis of 1-Substituted Carbazolyl-1,2,3,4-tetrahydro- and Carbazolyl-3,4-dihydro-β-carboline Analogs as Potential Antitumor Agents

Marine Drugs, 2011
A series of 1-substituted carbazolyl-1,2,3,4-tetrahydro- and carbazolyl-3,4-dihydro-b-carboline analogs have been synthesized and evaluated for antitumor activity against human tumor cells including KB, DLD, NCI-H661, Hepa, and HepG2/A2 cell lines. Among
Ji-Wang Chern, Sheau Farn Yeh, Lan-Chun Tu, Chia-Ching Liaw, Yao Haur Kuo, Chun-Ling Lin, Yao-To Chang, Ya-Ching Shen   +7 more
doaj   +1 more source

Tenofovir, Interferon Pathways, and Mucosal Immunity: Implications for People Living With HIV

American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.
ABSTRACT Background Antiretroviral therapy (ART) suppresses HIV replication and protects people living with HIV (PLWH) from progressing to AIDS. However, despite ART, many PLWH experience chronic immune activation, which contributes to premature aging and non‐AIDS‐related comorbidities. One reason for this chronic immune activation (CIA) is HIV and its
Florian Hladik, Sean M. Hughes, Claire N. Levy, Rachel L. Creighton, Romel Mackelprang, Germán G. Gornalusse   +5 more
wiley   +1 more source

Genotoxic potential of beta-carbolines: a review.

, 1995
The mutagenic and co-mutagenic properties of harman, norharman and of some of their pharmacologically important derivatives are reviewed. These compounds do not behave as true mutagens, but rather interact, directly or indirectly with DNA, leading to ...
De Meester, Conrad
core   +1 more source

Two food-borne heterocyclic amines: Metabolism and DNA adduct formation of amino-alpha-carbolines

, 2005
The amino-alpha-carbolines 2-amino-9H-pyrido[2,3-b]indole (A alpha C) and 2-amino-3-methyl-9H-pyrido-[2,3-b]indole (MeA alpha C) are two mutagenic and carcinogenic heterocyclic amines formed during ordinary cooking.
Frederiksen, Hanne
core   +1 more source

Harmaline Tremor: Underlying Mechanisms in a Potential Animal Model of Essential Tremor

Tremor and Other Hyperkinetic Movements, 2012
Background: Harmaline and harmine are tremorigenic β-carbolines that, on administration to experimental animals, induce an acute postural and kinetic tremor of axial and truncal musculature.
Adrian Handforth
doaj   +1 more source