Results 91 to 100 of about 13,653 (252)
Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur +6 more
wiley +1 more source
A comprehensive overview of β-carbolines and its derivatives as anticancer agents.
European journal of medicinal chemistry, 2021 B. Luo, Xinqiang Song
semanticscholar +1 more source
Marine Drugs, 2011 A series of 1-substituted carbazolyl-1,2,3,4-tetrahydro- and carbazolyl-3,4-dihydro-b-carboline analogs have been synthesized and evaluated for antitumor activity against human tumor cells including KB, DLD, NCI-H661, Hepa, and HepG2/A2 cell lines. Among
Ji-Wang Chern +7 more
doaj +1 more source
New reactions of 2-methyleneaziridines [PDF]
Chapter One reviews the synthesis, properties and reactions of 2-methyleneaziridines, the subject of this thesis. Chapter Two describes the use of these heterocycles in the development of a new four-component synthesis of biologically important α ...
Mumford, Peter Marten
core
Harmaline Tremor: Underlying Mechanisms in a Potential Animal Model of Essential Tremor
Tremor and Other Hyperkinetic Movements, 2012 Background: Harmaline and harmine are tremorigenic β-carbolines that, on administration to experimental animals, induce an acute postural and kinetic tremor of axial and truncal musculature.
Adrian Handforth
doaj +1 more source
Antiviral activity of natural and synthetic β-carbolines against dengue virus.
Antiviral Research, 2016 Dengue virus (DENV) is the most prevalent mosquito borne viral pathogen worldwide. In this work we first evaluated the antiviral activity of natural and synthetic β-carbolines against DENV-2 multiplication in cell cultures. We determined that the natural
V. Quintana +5 more
semanticscholar +1 more source
An unprecedented Sc(OTf)3-catalyzed C2-selective cyanation/defluorination cascade of perfluoroalkylated 3-indolylmethanols with TMSCN is described, which provides a novel and practical strategy for the synthesis of structurally diverse 3-(2-cyano ...
Weidong Rao (1598017) +6 more
core +1 more source
A review of synthetic bioactive tetrahydro-β-carbolines: A medicinal chemistry perspective.
European journal of medicinal chemistry, 2021 Jiayun Wang +8 more
semanticscholar +1 more source
Genotoxic potential of beta-carbolines: a review.
, 1995 The mutagenic and co-mutagenic properties of harman, norharman and of some of their pharmacologically important derivatives are reviewed. These compounds do not behave as true mutagens, but rather interact, directly or indirectly with DNA, leading to ...
De Meester, Conrad
core +1 more source
Two food-borne heterocyclic amines: Metabolism and DNA adduct formation of amino-alpha-carbolines
, 2005 The amino-alpha-carbolines 2-amino-9H-pyrido[2,3-b]indole (A alpha C) and 2-amino-3-methyl-9H-pyrido-[2,3-b]indole (MeA alpha C) are two mutagenic and carcinogenic heterocyclic amines formed during ordinary cooking.
Frederiksen, Hanne
core +1 more source