Results 81 to 90 of about 6,872 (221)

The cyanobacterial alkaloid nostocarboline: an inhibitor of acetylcholinesterase and trypsin [PDF]

, 2018
Preselected cyanobacterial strains (available from culture collections and our own isolates), belonging primarily to the heterocystous cluster, were screened for inhibitors against butyrylcholinesterase.
Baumann, Heike, Becher, Paul, Gademann, Karl, Jüttner, Friedrich   +3 more
core  

Psychedelic Therapies for Comorbid Major Depressive Disorder and Chronic Pain: A Review of Putative Mechanisms of Action

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
ABSTRACT Major Depressive Disorder (MDD) and chronic pain are independently debilitating conditions that frequently co‐occur. This comorbidity poses a significant clinical challenge, resulting in greater symptom severity, higher disability, and worse prognosis than either condition alone.
Jordana Kazdan, Karim S. Ladha, M. Ishrat Husain   +2 more
wiley   +1 more source

Anticancer α-, γ-, and δ-carboline derivatives: structures, mechanisms of action, and SARs

European Journal of Medicinal Chemistry Reports
Carboline consists of a pyridine ring fused with an indole skeleton, and it serves as a potential drug scaffold. Depending on the relative position of the pyridine N to the indole N, carbolines can be categorized into α-, β-, γ-, and δ-subfamilies.
Jingliang Cui, Wanru Gao, Ziwei Liu, Shuang Cao, Sihui Long   +4 more
doaj   +1 more source

Interkingdom Interactions in the Gut: Ecological Mechanisms, Homeostasis, and Therapeutic Modulation

Gut Medicine, Volume 2, Issue 1, Page 23-39, March 2026.
ABSTRACT The gut microbiota constitutes a highly complex and dynamic ecosystem that profoundly influences host physiology, metabolism, and immunity. This review provides an integrative overview of the mechanisms through which gut microorganisms—particularly bacteria and fungi—interact with host cells and with each other to maintain intestinal ...
Rui‐Qi Wei, Xin‐Wei Sun, Hao‐Jie Huang, Yu‐Zhi Zhao, Shuang‐Jiang Liu, Chang Liu   +5 more
wiley   +1 more source

Sexual enhancement products for sale online : raising awareness of the psychoactive effects of Yohimbine, Maca, Horny Goat Weed and Ginkgo Biloba [PDF]

, 2014
Copyright © 2014 Ornella Corazza et al.This is an open access article distributed under theCreativeCommonsAttribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Eleonora Chillemi, Fabrizio Schifano, Giovanni Martinotti, Massimo Di Giannantonio, Ornella Corazza, Rita Santacroce, Selim Cellek   +6 more
core   +4 more sources

Orthoquinone, Cyclic, and Acyclic α‐Diketone Natural Products: From Food Applications to Pharmacotherapy

Phytochemicals in Food and Medicine, Volume 1, Issue 1, March 2026.
The orthoquinone metabolites from plants have antimicrobial, antioxidant, antiviral, cytotoxic, and anti‐inflammatory effects. ABSTRACT The structural diversity of natural products is vast and fascinating, and they have been recognized as an enormously diverse source of new lead compounds.
Hidayat Hussain, Daijie Wang, Satyajit D. Sarker, Lutfun Nahar, Nilufar Z. Mamadalieva, Jianbo Xiao   +5 more
wiley   +1 more source

Synthesis of 1-Substituted Carbazolyl-1,2,3,4-tetrahydro- and Carbazolyl-3,4-dihydro-β-carboline Analogs as Potential Antitumor Agents

Marine Drugs, 2011
A series of 1-substituted carbazolyl-1,2,3,4-tetrahydro- and carbazolyl-3,4-dihydro-b-carboline analogs have been synthesized and evaluated for antitumor activity against human tumor cells including KB, DLD, NCI-H661, Hepa, and HepG2/A2 cell lines. Among
Ji-Wang Chern, Sheau Farn Yeh, Lan-Chun Tu, Chia-Ching Liaw, Yao Haur Kuo, Chun-Ling Lin, Yao-To Chang, Ya-Ching Shen   +7 more
doaj   +1 more source

Vaginal‐Derived Potential Probiotics and Their Postbiotics Alleviate Aerobic Vaginitis via Suppressing TLR4/MyD88/NF‐κB Signalling Pathway and Potentially Enhancing Vaginal Barrier

Microbial Biotechnology, Volume 19, Issue 3, March 2026.
Consolidated diagram of the mechanism by which L. crispatus YBR‐01, L. plantarum YBR‐01, and their postbiotics improve AV progression. ABSTRACT Antibiotic therapy is currently challenged by drug resistance and high recurrence in aerobic vaginitis (AV), making it urgent to seek novel strategies. In this study, we selected two potential probiotic strains
Meiyun Tian, Xinyi Zhang, Xuan Xu, Xia He, Xiaoyun Wu, Jing Wei, Buzhen Tan, Tingtao Chen   +7 more
wiley   +1 more source

Meta‐analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape

Epilepsia, Volume 67, Issue 3, Page 1421-1432, March 2026.
Abstract Objective Despite decades of development in anti‐seizure medications, ~30% of individuals remain refractory to all treatments, and none of the existing therapies are disease modifying. Identifying targets outside the current preclinical paradigm is critically important.
Giovanna L. Durante, Anna L. Tyler, Rod C. Scott, Amanda E. Hernan, J. Matthew Mahoney   +4 more
wiley   +1 more source

Asymmetric synthesis of 2-substituted oxetan-3-ones via metalated SAMP/RAMP hydrazones [PDF]

, 2013
2-Substituted oxetan-3-ones can be prepared in good yields and enantioselectivities (up to 84% ee) by the metalation of the SAMP/RAMP hydrazones of oxetan-3-one, followed by reaction with a range of electrophiles that include alkyl, allyl, and benzyl ...
Beasley, Benjamin, Clarkson, Guy J., Geden, Joanna V., Shipman, Michael   +3 more
core   +1 more source