Results 21 to 30 of about 4,239 (221)
Beilstein Journal of Organic Chemistry, 2021 1,5-Disubstituted indole-2-carboxaldehyde derivatives 1a–h and glycine alkyl esters 2a–c are shown to undergo a novel cascade imination-heterocylization in the presence of the organic base DIPEA to provide 1-indolyl-3,5,8-substituted γ-carbolines 3aa–ea ...
Premansh Dudhe +6 more
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Development in the Synthesis and Biological Activities of THβ-carboline and Its Analogs: Review
Ethiopian Journal of Science and Sustainable Development, 2022 1,2,3,4-Tetrahydro-β-carbolines (THβCs) are a large group of natural and synthetic indole alkaloids that possess a common tricyclic pyrido[3,4-b] indole scaffold that are widely distributed in nature.
Ayana Melaku Yadessa, Nigatu Bejigo
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Acta Crystallographica Section C Crystal Structure Communications, 2011 The structure of β-carboline, also called norharman (systematic name: 9H-pyrido[3,4-b]indole), C(11)H(8)N(2), has been determined at 110 K. Norharman is prevalent in the environment and the human body and is of wide biological interest. The structure exhibits intermolecular N-H···N hydrogen bonding, which results in a one-dimensional herringbone motif.
Robert J, Thatcher +1 more
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Tricyclic Imidazolidin-4-ones by Witkop Oxidation of Tetrahydro-β-carbolines
, 2020 1-Substituted and 1,1-disubstituted tetrahydro-β-carbolines undergo sodium periodate oxidative ring expansion in the presence of formaldehyde and other aldehydes to form 5,6-dihydro-7H-1,4-methanobenzo[e][1,4]diazonine-2,7(3H)-diones in 30–81% yield.
Douglas E. Stack (2429443) +6 more
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Bioactivity of selected materials for coffee substitute. [PDF]
PLoS ONE, 2018 Epidemiological studies have suggested that coffee consumption is negatively correlated with the incidence of Parkinson's disease. Coffee contains relatively high levels of β-carbolines, which have been ascribed neuroactive effects in humans however the ...
Renata Zawirska-Wojtasiak +4 more
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2-(2,5-Dimethoxyphenyl)pyrrole-3-carbonitrile
Molbank, 2023 The Cadogan reaction of 2-aryl-3-nitropyridines leads to δ-carbolines. The title compound is a side product in this reaction, generated via a ring opening of a nitrene and cyclization. A crystal structure analysis gives an enormous unit cell.
Yannic Grimm +2 more
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Journal of Spectroscopy, 1997 The reactions of carboline under various oxidative conditions are reported. The soft aerobic radiolysis, hydroxylation and rearrangement transformations are studied using isotopic labelling and GC–MS techniques.
Christophe Dardonville +3 more
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, 2023 Enantioconvergent iso-Pictet-Spengler reactions of chiral racemic ß-formyl esters and a ß-keto ester are reported, providing complex tetrahydro-γ-carbolines containing two contiguous stereocenters.
Jeffrey S. Johnson (1312380) +5 more
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Cytotoxic Bis-3,4-dihydro-β-carbolines and Bis-β-carbolines [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2002 Ten bis-beta-carboline 1, 2 and bis-3,4-dihydro-beta-carboline 3, 4 derivatives, linked between carbons 1 and 1' by a polymethylene spacer, were synthesized from bistryptamine amides 9, 10. Some of them display a micromolar IC50 towards L-1210 cells.
Wei-Qun, Jiang +6 more
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, 2022 Chapter One opens with an overview of the role of pyridines in the pharmaceutical industry. This is followed by an in-depth survey of literature methods that have been reported for pyridine synthesis, including the Bohlmann-Rahtz reaction.
Tyler Nichols (4466107)
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