Results 21 to 30 of about 13,653 (252)
An intramolecular inverse electron demand Diels–Alder approach to annulated α-carbolines
Beilstein Journal of Organic Chemistry, 2012 Intramolecular inverse electron demand cycloadditions of isatin-derived 1,2,4-triazines with acetylenic dienophiles tethered by amidations or transesterifications proceed in excellent yields to produce lactam- or lactone-fused α-carbolines.
Zhiyuan Ma +6 more
doaj +2 more sources
, 2016 A Cu(I)-catalyzed asymmetric [3 + 3] cycloaddition of azomethine ylides with 2-indolylnitroethylenes is described. Challenges confronted in this reaction include chemoselectivity between [3 + 2] cycloaddition and [3 + 3] cycloaddition, reactivity and ...
Wulin Yang +5 more
semanticscholar +3 more sources
Organic Letters, 2018 An efficient, unified approach for the synthesis of β-carbolines, γ-carbolines, and other fused azaheteroaromatics has been realized under metal-free conditions, from propargylic amines and (hetero)aromatic aldehydes.
Dilipkumar Uredi +2 more
semanticscholar +2 more sources
Structural basis of regioselective double halogenation of the β-carboline tryptoline by the single-component halogenase AetF. [PDF]
Acta Crystallogr D Struct BiolA structure of the flavin‐dependent single‐component tryptophan halogenase AetF bound to the non‐native tricyclic substrate tryptoline reveals a binding pose analogous to l‐tryptophan that directs C6‐first halogenation. Product analysis identifies 6,8‐dibromotryptoline as the final product.Flavin‐dependent halogenases (FDHs) offer a biocatalytic route ...
Bork S +3 more
europepmc +2 more sources
Effect of Chemical Refining on the Reduction of β-Carboline Content in Sesame Seed Oil
Molecules, 2023 β-carbolines (harman and norharman) are potentially mutagenic and have been reported in some vegetable oils. Sesame seed oil is obtained from roasted sesame seeds. During sesame oil processing, roasting is the key procedure to aroma enhancement, in which
Lili Shi, Ziyu Cui, Wei Liu
doaj +1 more source
Foods, 2022 Heat treatment of meat can lead to the formation of carcinogenic organic compounds. The influence of dried fruits on the formation of non-polar heterocyclic aromatic amines (carbolines) and nitrogen derivatives of polycyclic aromatic hydrocarbons ...
Ewa Śnieżek +4 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2021 1,5-Disubstituted indole-2-carboxaldehyde derivatives 1a–h and glycine alkyl esters 2a–c are shown to undergo a novel cascade imination-heterocylization in the presence of the organic base DIPEA to provide 1-indolyl-3,5,8-substituted γ-carbolines 3aa–ea ...
Premansh Dudhe +6 more
doaj +1 more source
Development in the Synthesis and Biological Activities of THβ-carboline and Its Analogs: Review
Ethiopian Journal of Science and Sustainable Development, 2022 1,2,3,4-Tetrahydro-β-carbolines (THβCs) are a large group of natural and synthetic indole alkaloids that possess a common tricyclic pyrido[3,4-b] indole scaffold that are widely distributed in nature.
Ayana Melaku Yadessa, Nigatu Bejigo
doaj +1 more source
Pharmaceuticals, 2022 Herein, the synthesis and anticancer activity evaluation of a series of novel β-carbolines is reported. The reactivity of nitrosoalkenes towards indole was explored for the synthesis of novel tryptophan analogs where the carboxylic acid was replaced by a
João L. P. Ribeiro +4 more
doaj +1 more source
Synthesis of α- and β-Carbolines by a Metalation/Negishi Cross-Coupling/SNAr Reaction Sequence [PDF]
, 2021 Carbolines are considered to be privileged scaffolds in medicinal chemistry. An efficient method for the synthesis of α- and β-carbolines from fluoropyridines and 2-haloanilines is reported.
Stefan, Roesner +1 more
core +2 more sources