Results 31 to 40 of about 7,762 (135)

Tadalafil: an overview and the post-mortem toxicology of a case

International Journal of Medical Toxicology and Forensic Medicine, 2023
Tadalafil is an inhibitor of the enzyme human cyclic guanosine monophosphate–specific phosphodiesterase, type 5 (PDE-5). A mild vasodilator, it is primarily used for the treatment of erectile dysfunction (ED), an increasingly common condition.
Maria Laura Schirripa, Letizia Gnetti, Edda Emanuela Guareschi   +2 more
doaj   +1 more source

Evaluation of the long-term safety and effectiveness of tadalafil once daily in Chinese men with erectile dysfunction: interim results of a multicenter, randomized, open-label trial

Asian Journal of Andrology, 2018
Once-daily tadalafil administration has been well established; however, studies about tadalafil once-daily treatment in the Chinese population are lacking.
Hui Jiang, Lian-Ming Zhao, Hao-Cheng Lin, Su Yan, Ji-Hong Liu, Zhao-Hui Zhu, Jin-Dan Luo, Yu-Tian Dai, Fu-Biao Li, Ying Lou, Zhi-Chao Zhang   +10 more
doaj   +1 more source

Tadalafil, a Long-Acting Inhibitor of PDE5, Improves Pulmonary Hemodynamics and Survival Rate of Monocrotaline-Induced Pulmonary Artery Hypertension in Rats

Journal of Pharmacological Sciences, 2009
The aim of this study was to assess the effect of tadalafil (0.5, 2.5, and 10 mg/kg per day) on the progression of pulmonary arterial hypertension (PAH) in early treatment and on the survival rate in late treatment on the monocrotaline (MCT)-induced PAH ...
Fusae Sawamura, Masami Kato, Kazuhisa Fujita, Takahiro Nakazawa, Anthony Beardsworth   +4 more
doaj   +1 more source

Tadalafil for Treatment of Fetal Growth Restriction: A Review of Experimental and Clinical Studies

Biomedicines
Fetal growth restriction (FGR) is a major concern in perinatal care. Various medications have been proposed as potential treatments for this serious condition. Nonetheless, there is still no definitive treatment. We studied tadalafil, a phosphodiesterase-
Shintaro Maki, Sho Takakura, Makoto Tsuji, Shoichi Magawa, Yuya Tamaishi, Masafumi Nii, Michiko Kaneda, Kenta Yoshida, Kuniaki Toriyabe, Eiji Kondo, Tomoaki Ikeda   +10 more
doaj   +1 more source

Histomorphological Effects of Tadalafil on the Liver of Adult Wistar Rat

Journal of Applied Sciences and Environmental Management
Tadalafil is used to treat erectile dysfunction and improve exercise capacity in people with pulmonary arterial hypertension. It promotes blood circulation to the penis during sexual stimulation, thus facilitating the occurrence of an erection.
P. O. Onyilo, B. O. Samuel
doaj   +1 more source

Impact of tadalafil on cardiovascular and organ dysfunction induced by experimental sepsis [PDF]

Acute and Critical Care
Background Sepsis is a life-threatening condition that affects the cardiovascular and renal systems. Severe hypotension during sepsis compromises tissue perfusion, which can lead to multiple organ dysfunction and death.
Marcelo Almeida Nakashima, Gabrielle Delfrate, Lucas Braga Albino, Gustavo Ferreira Alves, Junior Garcia Oliveira, Daniel Fernandes   +5 more
doaj   +1 more source

The protective effects of tadalafil on renal damage following ischemia reperfusion injury in rats

Kaohsiung Journal of Medical Sciences, 2015
Ischemia-reperfusion injury can cause renal damage, and phosphodiesterase inhibitors are reported to regulate antioxidant activity. We investigated the prevention of renal damage using tadalafil after renal ischemia reperfusion (I/R) injury in rats.
Bulent Erol, Tugrul Turker, Adem Tok, Sibel Bektas, Gorkem Mungan, Seyma Ozkanli, Bugra Karakas, Husnu Tokgoz, Bulent Akduman, Aydin Mungan   +9 more
doaj   +1 more source

Effect of tadalafil on erectile function in patients after robotic-assisted radical prostatectomy with unilateral or bilateral nerve sparing

Urological Science, 2019
Objective: Erectile dysfunction (ED) is a major complication of radical prostatectomy. Despite advances in surgical techniques, the postoperative continence and potency rates are still not satisfactory.
I-Yen Lee, Min-Che Tung, Chao-Yu Hsu, Jue-Hawn Yin, Yu-Kang Chang, Wei-Chun Weng, Li-Hua Huang, Zhon-Min Huang, Cheng-Kuang Yang, Yen-Chuan Ou   +9 more
doaj   +1 more source

Effect of Tadalafil on Prevention of Urethral Stricture after Direct Vision Internal Urethrotomy: A Prospective Cohort Study

Journal of Clinical and Diagnostic Research
Introduction: Urethral stricture recurrence following Direct Vision Internal Urethrotomy (DVIU) remains a significant challenge. Phosphodiesterase type-5 inhibitors (PDE5-Is), such as tadalafil, have been proposed to reduce fibrosis and stricture ...
Shyam Sundar Sarkar, Soumya Mondal, Debansu Sarkar   +2 more
doaj   +1 more source

Enhanced Bioavailability of Tadalafil after Intranasal Administration in Beagle Dogs

Pharmaceutics, 2018
Tadalafil is an oral selective phosphodiesterase type-5 inhibitor with demonstrated efficacy and safety that is used to treat erectile dysfunction. The purpose of this study is to compare the pharmacokinetic properties of tadalafil after conventional ...
Jeong-Soo Kim, Min-Soo Kim, In-hwan Baek
doaj   +1 more source