Results 21 to 30 of about 21,239 (239)

Transitioning From Oral to Intravenous Treprostinil in Pulmonary Arterial Hypertension: A Case Report. [PDF]

Clin Case Rep
ABSTRACT The optimal approach to transitioning from oral treprostinil to intravenous treprostinil in pulmonary arterial hypertension (PAH) has been poorly characterized in published literature. We present a case involving a 21‐year‐old male with PAH experiencing worsening symptoms despite treatment with high doses of oral treprostinil (36.75 mg three ...
Cummings AM, Konkol SB, Mihalek AD, Roth ME.   +3 more
europepmc   +2 more sources

Effects of tadalafil on sexual behavior of male rats induced by chronic unpredictable mild stress

Sexual Medicine, 2023
Background Few studies have investigated psychogenic sexual dysfunction including psychogenic erectile dysfunction (pED); the effect of tadalafil on sexual behavior of male rats induced by chronic unpredictable mild stress (CUMS) remains unclear. Aim The
Heng Wang, Xueping Liu, Ziheng Zhang, Ziyang Han, Yongsheng Jiang, Yu-Ting Qiao, Tao Liu, Jianhuai Chen, Yun Chen   +8 more
semanticscholar   +1 more source

The PASTIS trial: Testing tadalafil for possible use in vascular cognitive impairment

Alzheimer's & Dementia, 2022
There are few randomized clinical trials in vascular cognitive impairment (VCI). This trial tested the hypothesis that the PDE5 inhibitor tadalafil, a widely used vasodilator, increases cerebral blood flow (CBF) in older people with symptomatic small ...
M. Pauls, L. Binnie, P. Benjamin, S. Betteridge, B. Clarke, Mohani-Preet K Dhillon, R. Ghatala, Fearghal A. H. Hainsworth, F. Howe, U. Khan, C. Kruuse, J. Madigan, B. Moynihan, B. Patel, Anthony C. Pereira, E. Rostrup, A. Shtaya, Catherine A. Spilling, S. Trippier, Rebecca Williams, R. Young, T. Barrick, J. Isaacs, A. Hainsworth   +23 more
semanticscholar   +1 more source

Daily low-dose tadalafil may reduce the penile curvature progression rate in patients with acute Peyronie’s disease: a retrospective comparative analysis

International journal of impotence research, 2022
The aim of this study was to evaluate the clinical outcomes of patients in acute phase of Peyronie’s disease (PD) treated with daily low-dose of Tadalafil.
L. Spirito, C. Manfredi, R. la Rocca, L. Napolitano, Antonio di Girolamo, M. Capece, F. Trama, C. Sciorio, I. Sokolakis, M. Creta, D. Arcaniolo   +10 more
semanticscholar   +1 more source

The Wound Healing Effect of Nanoclay, Collagen, and Tadalafil in Diabetic Rats: An In Vivo Study

Advances in Materials Science and Engineering, 2022
The diabetic wound is the most challenging one to manage, which is associated with microvascular and macrovascular dysfunction, and novel strategies such as using hydrogels demonstrate their promising prospect in treatment and management approaches of ...
Allahyar Noori Ordeghan, D. Khayatan, Mohammad Reza Saki, Mostafa Alam, Kamyar Abbasi, H. Shirvani, M. Yazdanian, R. Soufdoost, Haidar Taimouri Raad, A. Karami, H. Tebyaniyan   +10 more
semanticscholar   +1 more source

Effects of furosemide and tadalafil in both conventional and nanoforms against adenine-induced chronic renal failure in rats

European Journal of Medical Research, 2022
Background Chronic renal failure (CRF) is a progressive loss of renal function that lead to reduced sodium filtration and inappropriate suppression of tubular reabsorption that ultimately leads to volume expansion.
M. Hamdy, M. Abdel-Rahman, D. Badary, Mahmoud S. Sabra   +3 more
semanticscholar   +1 more source

Tadalafil Enhances Immune Signatures in Response to Neoadjuvant Nivolumab in Resectable Head and Neck Squamous Cell Carcinoma

Clinical Cancer Research, 2021
Purpose: We hypothesize that the addition of the phosphodiesterase-5 inhibitor tadalafil to the PD-1 inhibitor nivolumab, is safe and will augment immune-mediated antitumor responses in previously untreated squamous cell carcinoma of the head and neck ...
A. Luginbuhl, J. Johnson, L. Harshyne, A. Linnenbach, S. Shukla, A. Alnemri, G. Kumar, D. Cognetti, J. Curry, N. Kotlov, Zoya Antysheva, Sandrine Degryse, K. Mannion, M. Gibson, J. Netterville, Brandee T. Brown, R. Axelrod, R. Zinner, M. Tuluc, S. Gargano, B. Leiby, A. Shimada, M. Mahoney, U. Martinez-Outschoorn, U. Rodeck, Young J Kim, A. South, A. Argiris   +27 more
semanticscholar   +1 more source

Maternal Blood Concentration of Tadalafil and Uterine Blood Flow in Pregnancy

Medicina, 2019
Background and Objectives: Tadalafil for treatment of fetal growth restriction (FGR) or preeclampsia is given once a day orally. The drug kinetics of tadalafil were investigated to determine the ideal dosage to promote uterine blood flow.
Hiroaki Tanaka, Shintaro Maki, Shoichi Magawa, Masafumi Nii, Kayo Tanaka, Kenji Ikemura, Kuniaki Toriyabe, Tomoaki Ikeda   +7 more
doaj   +1 more source

Tadalafil modulates aromatase activity and androgen receptor expression in a human osteoblastic cell in vitro model [PDF]

, 2016
Purpose Phosphodiesterase type-5 inhibitor (PDE5i) tadalafil administration in men with erectile dysfunction is associated with increased testosterone/estradiol ratio, leading to hypothesize a potential increased effect of androgen action on target ...
Aversa, Antonio, Bimonte, V. M., Fittipaldi, Simona, Francomano, Davide, Greco, E. A., Lenzi, Andrea, Migliaccio, S., Papa, V., Wannenes, F.   +8 more
core   +1 more source

Prospective comparison of tadalafil 5 mg alone, silodosin 8 mg alone, and the combination of both in treatment of lower urinary tract symptoms related to benign prostatic hyperplasia

World journal of urology, 2022
Men with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH), will have deterioration in the quality of life. Likewise, BPH can be complicated by damage to bladder function, bladder stones formation, hematuria, and ...
M. AbdelRazek, A. Abolyosr, Omar Mhammed, A. Fathi, Mohammed M. Talaat, A. Hassan   +5 more
semanticscholar   +1 more source