Results 21 to 30 of about 10,553 (193)

Comparative Effects of Tadalafil Cream Versus Oral Tadalafil on Males with Erectile Disfunction Regarding Relationship Dynamics: A Secondary Analysis of Dyadic Adjustment Outcomes in a Randomized Crossover Trial

Life
Background/Objectives: Relationship quality is closely tied to sexual health. This study compared the effects of tadalafil cream and oral tadalafil on Dyadic Adjustment Scale (DAS) subscales and assessed the influence of age on treatment outcomes ...
Dragoș-Mihail Trifu, Daniel-Corneliu Leucuța, Martina-Luciana Pintea-Trifu, Florin Elec, Nicolae Crișan, Dan Eniu, Ioan Coman   +6 more
doaj   +2 more sources

A phase 3 randomized placebo-controlled trial of tadalafil for Duchenne muscular dystrophy. [PDF]

, 2017
peer reviewedOBJECTIVE: To conduct a randomized trial to test the primary hypothesis that once-daily tadalafil, administered orally for 48 weeks, lessens the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD).
Wolfgang Mueller-Felber, Tadalafil DMD Study Group, Susan Iannaccone, Pereon, Yann, Russell Butterfield, Dubrovsky, A.L., Finkel, Richard, Schallner, Jens, Cox, D., Haluk Topaloglu, Susan Sparks, Finkel, R., Butterfield, Russell, Dubrovsky, Alberto AL, Cox, David A., Victor RG, null null, Vandenborne, Krista, Saleel Chandratre, Ben Renfroe, Belousova, Elena, Selby, Kathryn, Mcdonald, Craig M, Dooley, Joseph, Claudio Bruno, Robert Elashoff, Chae, Jong-Hee, Pat Furlong, Jean Mah, Anne Connolly, Susan Apkon, McDonald, C.M., Sparks, Susan, Michelle Eagle, de Munain, Adolfo Lopez, Kirschner, JanBerd, McDonald, Craig M., Cox David, Hattori, Ayako, Eagle M, Giacomo Comi, Wilichoswki, Ekkehard, Victor, R.G., Wang-Tso Lee, Janas, Joanne, Sendra, Isabel Illa, Elashoff, Robert, Dubrovsky, Alberto, Hoda Abdel-Hamid, McDonald, Craig, Sanka, Ratna Bhavaraju, Miceli, Carrie MC, Enrico Bertini, Eagle, M., Dubrovsky AL, Jong-Hee Chae, Katherine Mathews, JanBerd Kirschner, Katsuhisa Ogata, Finkel, Richard S., Miceli, MC, Matthew Wicklund, Sweeney HL, Finkel, Richard RS, John Landry, Yuh-Jyh Jong, Bertini, Enrico, McDonald CM, Sweeney, H. Lee, Sweeney, Lee HL, Landry J, Kuntz, Nancy, Group, Tadalafil DMD Study, Harper, Amy, Kathryn Selby, Campbell, Craig, Pascual, Samuel, Connolly, Anne, Elashoff R, Hirofumi Komaki, Edward Smith, William Burnette, Tadalafil DMD Study Grp, Bruno, Claudio, Mueller-Felber, Wolfgang, Topaloglu H, Victor, Ronald G, Vandenborne K, Miceli, M. Carrie, Erik Niks, Sweeney, H.L., Eugenio Mercuri, Burnette, William, Lee, Wang-Tso, David Cox, Victor, Ron, Cox, David, Isabel Illa Sendra, Jong, Yuh-Jyh, H. Lee Sweeney, Furlong P, McMillan, Hugh, Dubrovsky, Alberto L, Jose Carlo, Juan Jose Vilchez, Carlo, Jose, Vilchez, Juan Jose, Jens Schallner, Krista Vandenborne, Goemans N, Renfroe, Ben, Mah, Jean, Victor, Ronald G., Joanne Janas, Craig McDonald, Hugh McMillan, Joseph Dooley, Richard Finkel, Finkel R, Sweeney, H Lee, Nicolas Deconinck, Ronald G. Victor, Byrne B, De Groot, Imelda, Herguner, Ozlem, Goemans, Nathalie, Wong, Brenda, Iannaccone, Susan, Dubrovsky, Alberto L., Comi, Giacomo, Ozlem Herguner, Imelda De Groot, Adolfo Lopez de Munain, Schara, Ulrike, Eagle, Michelle, Mathews, Katherine, Edward Leung, Elena Pegoraro, Frank, L Matthew, Leung, Edward, Tadalafil DMD Study Group,, Landry, John, Cox D, Ogata, Katsuhisa, Wicklund, Matthew, Pegoraro, Elena, Miceli, M Carrie, Laurent Servais, Barry Byrne, Byrne, B., Topaloglu, H., John Brandsema, Samuel Pascual, Yann Pereon, Niks, Erik, Brandsema, John, Ulrike Schara, Landry, J., Servais, Laurent, Byrne, Barry, Elashoff, Robert M., Barohn, Richard, Tadalafil DMD, [Study group], Craig M. McDonald, Elashoff, R., Akinori Nakamura, Mercuri, Eugenio, Amy Harper, Ratna Bhavaraju Sanka, L Matthew Frank, Julien Durigneux, Nancy Kuntz, Abdel-Hamid, Hoda, Nakamura, Akinori, Ayako Hattori, Nathalie Goemans, Deconinck, Nicolas, Ron Victor, Alberto L. Dubrovsky, Goemans, N., Ekkehard Wilichoswki, Miceli MC, Miceli, M.C., Richard Barohn, Apkon, Susan, Alberto Dubrovsky, Elena Belousova, Durigneux, Julien, Topaloglu, Haluk, Smith, Edward, Vandenborne, K., Furlong, Pat, Craig Campbell, Furlong, P., Chandratre, Saleel, M. Carrie Miceli, Komaki, Hirofumi, Brenda Wong, Finanger, Erika, Erika Finanger   +199 more
core   +6 more sources

Tadalafil monotherapy and as add-on to background bosentan in patients with pulmonary arterial hypertension.

, 2011
Background: Tadalafil 40 mg orally once daily, was shown to be well-tolerated and efficacious for pulmonary arterial hypertension in a 16-week, double-blind, placebo (PBO)-controlled trial.
Simonneau G, Oudiz RJ, Brundage BH, Response to Tadalafil Study Group, Beardsworth A, Ghofrani HA, Barst RJ, Sundin DP, Pulmonary Arterial Hypertension, GALIE', NAZZARENO   +9 more
core   +2 more sources

Does the Daily Dose of Tadalafil for the Treatment of Erectile Dysfunction Increase Penile Sensation?

, 2023
Objective:To investigate the effect of tadalafil, used for treating erectile dysfunction (ED) at a daily dose of 5 mg for 12 weeks, on penile sensation.Materials and Methods:Our study included 30 male patients who applied to our andrology outpatient ...
Murat Savaş, Selim Taş, Ali Eren, Ekrem İslamoğlu   +3 more
core   +1 more source

Integration of Transcriptomics and Metabolomics Reveals the Antitumor Mechanism Underlying Tadalafil in Colorectal Cancer

Frontiers in Pharmacology, 2022
The potential role of tadalafil, a PDE5 inhibitor, in anticancer activity and prolonged survival has been proposed. However, the systematic effects of tadalafil in colorectal cancer were not fully understood.
Pan Zhao, Yao Shen, Mengyang Li, Hanjun Dan, Zhiming Zhao, Jian Zhang   +5 more
doaj   +1 more source

Tadalafil Promotes the Recovery of Peripheral Neuropathy in Type II Diabetic Mice. [PDF]

PLoS ONE, 2016
We previously demonstrated that treatment of diabetic peripheral neuropathy with the short (4 hours) half-life phosphodiesterase 5 (PDE5) inhibitor, sildenafil, improved functional outcome in diabetic db/db mice.
Lei Wang, Michael Chopp, Alexandra Szalad, XueRong Lu, LongFei Jia, Mei Lu, Rui Lan Zhang, Zheng Gang Zhang   +7 more
doaj   +1 more source

Meta-Analysis of the Long-Term Efficacy and Tolerance of Tadalafil Daily Compared With Tadalafil On-Demand in Treating Men With Erectile Dysfunction

Sexual Medicine, 2019
Background: Erectile dysfunction (ED) is highly prevalent in aging men. Tadalafil daily and on-demand are widely used for the treatment of ED. Aim: We performed a meta-analysis to evaluate the efficacy and safety of tadalafil daily compared with ...
Zhongbao Zhou, MM, Hongyan Chen, MM, Jitao Wu, MD, Jipeng Wang, MM, Xuebao Zhang, MM, Jiajia Ma, MM, Yuanshan Cui, MD   +6 more
doaj   +1 more source

Endothelial Dysfunction in Patients With Erectile Dysfunction: A Double-Blind, Randomized-Control Trial Using Tadalafil

Sexual Medicine, 2019
Objective: To assess whether tadalafil improves endothelial dysfunction(EnD) in a placebo-controlled randomized-control trial. Methods: Erectile dysfunction and EnD were assessed by the International Index of Erectile Function (IIEF-5) and flow-mediated ...
Smita Pattanaik, DM, Pawan Kaundal, MS, Ravimohan S. Mavuduru, MCh, Shrawan K. Singh, MCh, Arup K. Mandal, MCh   +4 more
doaj   +1 more source

Bioequivalence and food effect of a fixed‐dose combination of macitentan and tadalafil: Adaptive design in the COVID‐19 pandemic

Pharmacology Research & Perspectives, 2021
The COVID‐19 pandemic has forced clinical studies to accommodate imposed limitations. In this study, the bioequivalence part could not be conducted as planned.
Dénes Csonka, Vladislav Fishman, Jaya Natarajan, Hans Stieltjes, Danielle Armas, Victor Dishy, Juan Jose Perez Ruixo   +6 more
doaj   +1 more source

EFFECTS OF TADALAFIL AND/OR SILYMARIN ON GONADAL FUNCTION IN ADULTS MALE ALBINO RATS [PDF]

Basrah Journal of Veterinary Research, 2018
         Taldalafil is a long acting phosphodiesterase-5 inhibitor  widely used in the treatment of erectile dysfunction.
doaj   +1 more source