Andrology, EarlyView.ABSTRACT Background Peyronie's disease (PD) with severe penile curvature often requires surgical correction through plaque incision and grafting (PIG). Objectives To compare surgical outcomes between polyglycolic acid polymer grafts and porcine small intestinal submucosa (SIS) grafts in patients undergoing PIG for PD.
Renan Trevisan Jost +7 more
wiley +1 more source
SIEDY Diagnostic Accuracy in Assessing Erectile Dysfunction in Young Men Living With HIV
Andrology, EarlyView.ABSTRACT Background Erectile dysfunction (ED) is a multidimensional condition commonly affecting men living with HIV. The structured interview of erectile dysfunction (SIEDY) is the only validated tool assessing organic, relational, and psychological factors contributing to ED, while dynamic penile color Doppler ultrasound (dPCDU) is a reliable method ...
Giorgio Tiecco +10 more
wiley +1 more source
Sexual Safety Signals of Common Antidiabetic Drugs: Insights From FAERS Disproportionality Analysis
Andrology, EarlyView.ABSTRACT Background Erectile dysfunction is a prevalent and distressing complication of diabetes mellitus that markedly affects quality of life in male patients. Although the role of diabetes in erectile dysfunction is well‐established, potential drug‐induced sexual dysfunction associated with commonly prescribed antidiabetic medications remains ...
Shan Lin +3 more
wiley +1 more source
Are phosphodiesterase Type 5 inhibitors potential therapies for Alzheimer's disease and related dementias? [PDF]
Brain Commun, 2022 Newby D.
europepmc +1 more source
Slit2/Robo Signaling Restores Diabetic Erectile Function via Neurovascular Remodeling
Andrology, EarlyView.ABSTRACT Background Diabetes mellitus‐induced erectile dysfunction (DMED) is a common and debilitating vascular‐neurogenic complication of diabetes. The poor responsiveness of DMED patients to phosphodiesterase type‐5 inhibitors underscores the need for therapies capable of restoring both endothelial integrity and cavernous nerve function.
Sen Fu +7 more
wiley +1 more source
Combination vardenifil and tadalifil drug induced liver injury; case report and review of the literature of liver injury associated with phosphodiesterase type 5 inhibitors. [PDF]
Can Liver J, 2023 Xu B, Braxton DR, Fong TL.
europepmc +1 more source
Andrology, EarlyView.ABSTRACT Background Erectile dysfunction (ED) secondary to cavernous nerve injury (CNI), such as that occurring after radical prostatectomy, remains a significant clinical challenge, particularly among patients who do not respond to phosphodiesterase Type 5 inhibitors (PDE5i).
Minh Nhat Vo +6 more
wiley +1 more source
Safety profile and signal detection of phosphodiesterase type 5 inhibitors for erectile dysfunction: a Food and Drug Administration Adverse Event Reporting System analysis. [PDF]
Sex Med, 2023 Shin YE +3 more
europepmc +1 more source
Adenosine—A Regulator of Human Testicular Peritubular Cells
Andrology, EarlyView.ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz +12 more
wiley +1 more source