Results 61 to 70 of about 17,985,271 (268)

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

PENGARUH PEMBERIAN PHOSPHODIESTERASE TYPE 5 INHIBITORS PADA TIKUS SPRAGUE DAWLEY JANTAN YANG DILAKUKAN TINDAKAN TORSI-DETORSI TESTIS [PDF]

, 2015
Background: Testicular torsion is an emergency that needs to be treated less than 6 hours (golden period) to prevent further tissue damage permanently.
Prasetyo, Agung Aji, Arifin, M. Thohar, Cahya, Bagus Indra   +2 more
core   +1 more source

Peyronie′s disease and erectile dysfunction: Current understanding and future direction

Indian Journal of Urology, 2006
Peyronie′s disease is a physically and psychologically devastating disorder affecting close to 10% of adult men. It is currently believed to be a form of wound healing disorder where there is excessive scar formation in response to a triggering process ...
Laurence A Levine
doaj   +1 more source

A review of analytical methods for the determination of four new phosphodiesterase type 5 inhibitors in biological samples and pharmaceutical preparations

Brazilian Journal of Pharmaceutical Sciences, 2013
The introduction of oral phosphodiesterase type 5 inhibitor therapy in 1998 revolutionized the treatment of erectile dysfunction. Erectile dysfunction is the most common sexual problem in men.
Cristiane Franco Codevilla, Tamara dos Santos Castilhos, Ana Maria Bergold   +2 more
doaj  

The use of antimuscarinics, phosphodiesterase type V inhibitors and phytotherapy for lower urinary tract symptoms in men

Asian Journal of Urology, 2017
Besides the mainstay of α-blockers and 5α-reductase inhibitors, other forms of medical therapy complete the armamentarium in the treatment of lower urinary tract symptoms (LUTS) in men.
Kok Kit Ng, Foo Cheong Ng
doaj   +1 more source

Targeted therapy with phosphodiesterase 5 inhibitors in patients with pulmonary hypertension due to heart failure and elevated pulmonary vascular resistance: a systematic review

Pulmonary Circulation, 2020
Pulmonary Hypertension due to left heart disease is the most common type of Pulmonary Hypertension. Morbidity and mortality significantly increase once Pulmonary Hypertension is present.
Galo M. Sanchez Palacios, Cindy Schmidt, Tammy Wichman   +2 more
doaj   +1 more source

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

Women taking the “blue pill” (sildenafil citrate): such a big deal?

Drug Design, Development and Therapy, 2014
Giuseppe Lo Monte, Angela Graziano, Isabella Piva, Roberto Marci Department of Morphology, Surgery, and Experimental Medicine, University of Ferrara, Ferrara, Italy Abstract: For years, phosphodiesterase type 5 inhibitors have been used for the ...
Lo Monte G, Graziano A, Piva I, Marci R
doaj  

Tadalafil once daily and intralesional verapamil injection: A new therapeutic direction in Peyronie′s disease

Urology Annals, 2015
Introduction: The aim of this study was to evaluate the combination of intralesional verapamil injection (IVI) therapy with and tadalafil in men affected by Peyronie′s disease (PD).
Lucio Dell′Atti
doaj   +1 more source

Phosphodiesterase 5 Inhibitors from Derris scandens

, 2018
Phosphodiesterase 5 inhibitors have been used as a first-line medicine for the treatment of erectile dysfunction. In the search for new phosphodiesterase 5 inhibitors from natural sources, we found that the 95% ethanol extract of Derris scandens stem ...
Yuthana Siriwattanasathien, Nitra Nuengchamnong, Nantaka Khorana, Pornnarin Taepavarapruk, Prompan Pitpakdeeanan, Kornkanok Ingkaninan, Apichart Suksamrarn, Nattiya Chaichamnong, Prapapan Temkitthawon   +8 more
core   +1 more source