Results 191 to 200 of about 17,744 (296)

"Cyclic nucleotides in plants: from obscure messengers to central regulators". [PDF]

Front Plant Sci
Świeżawska-Boniecka B, Szmidt-Jaworska A.   +1 more
europepmc   +1 more source

Structural‐to‐Functional Complexity Transformations Enabled by Bridged Polyheterocycles: Access to Cis‐1,3‐Diamines and Amino‐Alcohols

ChemistryEurope, Volume 4, Issue 6, June 2026.
Polycyclic intermediates enable stereocontrolled synthesis of densely functionalized cis‐1,3‐diamine and amino alcohol carbocycles and heterocycles via structural‐to‐functional complexity transformations from low‐complexity starting material. Cis‐1,3‐functionalized carbocycles and saturated heterocycles are ubiquitous motifs in natural products ...
Jiayi Zhu, Erica Benedetti, Laurent Micouin   +2 more
wiley   +1 more source

Temporally Controlled Supramolecular Catalysts with pH-Dependent Activity. [PDF]

ACS Omega
Pucciarelli G, Ranieri F, Casnati A, Di Stefano S, Volpi S, Salvio R.   +5 more
europepmc   +1 more source

Evaluating the Intercropping Systems in the Context of Agroecological Resilience in the Current Era of the Changing Climate: A Scenario of Scientific Analysis of Last Decade Data

Climate Resilience and Sustainability, Volume 5, Issue 1, June 2026.
The extreme event of climate change (CC) has become more crucial, and under the current context of CC during the last decade. The cropping system (CS) approach is more appropriate than a suitable and established package of practices for individual crops, as CS interrelates with other components and resources related to sustainable farming under the ...
Sagar Maitra, Sumit Ray, Swati Suman, K. Pushpa, B. Sai Divya, Masina Sairam, Lalichetti Sagar, Harun I. Gitari, Santosh D. T., Akbar Hossain   +9 more
wiley   +1 more source

Editorial: Cyclic nucleotide phosphodiesterases (PDEs) signaling in the endocrine system. [PDF]

Front Endocrinol (Lausanne)
Campolo F, Samidurai A.
europepmc   +1 more source

Pancreatic Islet Cell Crosstalk: Insight Into α‐/β‐Cell Compensatory Mechanisms

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
α‐cell remodeling compensates for impaired β‐cell function. Intra‐islet glucagon/GLP‐1 signaling is upregulated and becomes essential in prediabetic islets. Flexible receptor engagement reflects functional plasticity in hormonal control of insulin secretion. Created in BioRender. Plecita, L. (2026); https://BioRender.com/pgjjg3m.
Štěpánka Benáková, Blanka Holendová, Jurij Dolenšek, Monika Křivonosková, Andraž Stožer, Lydie Plecitá‐Hlavatá   +5 more
wiley   +1 more source

Integrated Pharmacophore Modeling, Molecular Docking, and Molecular Dynamics Simulations Accelerate the Discovery of Novel PDE1 Inhibitors with Potential for the Treatment of Idiopathic Pulmonary Fibrosis. [PDF]

Molecules
Cai XL, Xue ZH, He SJ, Luo WH, Liu RD, Zhou Q, Zhang C.   +6 more
europepmc   +1 more source

Cardiovascular β‐Adrenergic Receptor Distribution and Function: Influence of Species, Sex, Age, and Tissue

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Estrogen modulates β‐AR signaling in a context‐dependent manner influenced by species, sex, age, tissue, and vascular health, highlighting challenges in translating findings from experimental models to human cardiovascular physiology. ABSTRACT Cardiovascular diseases remain the leading global cause of morbidity and mortality, with notable sex‐specific ...
Basant Elsaid, Irakli Kopaliani, Birgit Zatschler, Ansam Seif, Stephan Speier, Andreas Deussen   +5 more
wiley   +1 more source

Architecture and regulatory functions of c-di-GMP signaling in classical Bordetella species. [PDF]

FEMS Microbiol Rev
Vondrova D, Mugni SL, Blumenstein J, Kasiztky C, Sisti F, Fernández J, Kamanova J.   +6 more
europepmc   +1 more source

Heart–Lung Interactions in Pulmonary Hypertension due to Heart Failure With Preserved Ejection Fraction

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
This review considers heart–lung interactions in pulmonary hypertension due to heart failure with preserved ejection fraction across scales, including organ, tissue, and cell scales. Key knowledge gaps in preclinical disease models, tools for clinical phenotyping, and underlying biological mechanisms are identified for future studies.
Pratima Prabala, Farhan Raza, Naomi C. Chesler   +2 more
wiley   +1 more source