Results 121 to 130 of about 45,633 (272)

A Modular Chemoenzymatic Cascade Simplifies Divergent Synthesis of Natural and Unnatural Benzylisoquinoline Alkaloids

open access: yesAdvanced Science, Volume 13, Issue 1, 5 January 2026.
A simplified chemoenzymatic platform is designed to integrate an enzyme cascade with subsequent chemical steps, enabling the divergent production of diverse benzylisoquinoline alkaloids (BIAs). Demonstrating remarkable versatility and enantioselectivity, four distinct classes of BIAs are efficiently generated, in which the natural medicine papaverine ...
Huiling Liu   +8 more
wiley   +1 more source

Differentiated T Lymphocytes and Cancer Cell Mitochondrial Metabolism to Enhance Radioimmunotherapy by a Biomimetic Nanozyme System

open access: yesAdvanced Science, Volume 13, Issue 3, 14 January 2026.
T cell membrane‐coated MgCO3/Fe‐CD nanozyme loaded with TEPP‐46 (TFMP) enhances breast cancer radioimmunotherapy by reprogramming mitochondrial metabolism in T cells and tumors. It targets PD‐L1, converts H2O2 into ROS, neutralizes acidity, and releases Mg2⁺/TEPP‐46 to boost T cell activation.
Hanyu Zhang   +7 more
wiley   +1 more source

Metabolism‐Regulating Nanomedicines for Cancer Therapy

open access: yesAdvanced NanoBiomed Research, Volume 6, Issue 1, January 2026.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

Machine Learning Integration Framework Constructs a Lactylation‐Associated Gene Signature to Improve Prognosis in Bladder Cancer

open access: yesCancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Bladder cancer remains a significant challenge in oncology owing to its high recurrence rates and limited treatment options, particularly in cases of resistance to standard therapies. Aims Our study aimed to pinpoint a lactylation‐associated gene signature capable of predicting prognosis and providing important theoretical support ...
Jingsong Wang   +8 more
wiley   +1 more source

Biological Conversion of Formate to Organic Compounds: Toward a Sustainable Formate Bioeconomy

open access: yesCarbon Energy, Volume 8, Issue 1, January 2026.
Formate bioconversion plays a crucial role in achieving renewable resource utilization and sustainable development. To tap its full potential, it is important to identify the most appropriate microbial hosts for incorporating formate into building blocks, design the most promising metabolic pathways for transmitting formate into central carbon ...
Jinyi Qian   +3 more
wiley   +1 more source

Small‐Molecule Sarco/Endoplasmic Reticulum Ca2+‐ATPase Activators Reverse Methylglyoxal‐Induced Inhibition through Nonantioxidant Mechanisms

open access: yesChemMedChem, Volume 21, Issue 1, January 2026.
Endoplasmic reticulum (ER) Ca2+ dysregulation drives β‐cell dysfunction under diabetic stressors like methylglyoxal, which inhibits the sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA) pump through oxidative modifications. We show that synthetic SERCA activators restore pump activity after methylglyoxal‐induced damage.
Carlos Cruz‐Cortés   +4 more
wiley   +1 more source

Evolutionary Changes in Crassulacean Acid Metabolism (CAM) and Related Traits During the Diversification of Aichryson (Crassulaceae) on the Macaronesian Islands

open access: yesEcology and Evolution, Volume 16, Issue 1, January 2026.
We explore evolutionary changes in Crassulacean acid metabolism (CAM) and associated traits during the diversification of Aichryson (Crassulaceae) across the Macaronesian Islands. By combining field data, physiological measurements and phylogenetic analysis, we identify shifts in photosynthetic strategy linked to habitat transitions.
Jessica A. Berasategui   +5 more
wiley   +1 more source

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