Results 171 to 180 of about 86,461 (284)

Machine Learning‐Driven Discovery of Structurally Related Natural Products as Activators of the Cardiac Calcium Pump SERCA2a

ChemMedChem, Volume 20, Issue 9, May 5, 2025.
Heart failure involves reduced SERCA2a activity, crucial for calcium regulation in heart cells. This study reports machine learning screening of 57,423 natural products, identifying several structurally related SERCA2a activators. Three compounds enhance calcium transport in cardiac cells, despite off‐target effects, offering promising hits for ...
Carlos Cruz‐Cortés, Eli Fernández‐de Gortari, Rodrigo Aguayo‐Ortiz, Jaroslava Šeflová, Adam Ard, Martin Clasby, Justus Anumonwo, L. Michel Espinoza‐Fonseca   +7 more
wiley   +1 more source

Source of Phosphoenolpyruvate for Hexose Synthesis in Liver and Muscle as Studied with Aspartate-3-C14

, 1962
Ben Bloom, Daniel W. Foster
openalex   +1 more source

Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth.

Molecules and Cells, 2015
E. Vincent, A. Sergushichev, Takla Griss, M. Gingras, B. Samborska, Thierry Ntimbane, P. Coelho, J. Blagih, T. Raissi, L. Choinière, Gäelle Bridon, Ekaterina Loginicheva, B. Flynn, Elaine C. Thomas, J. Tavaré, D. Avizonis, A. Pause, D. Elder, M. Artyomov, Russell G. Jones   +19 more
semanticscholar   +1 more source

The role of phosphoenolpyruvate carboxykinase in amino acid metabolism in muscle [PDF]

, 1978
Eric A. Newsholme, TF Williams
openalex   +1 more source

3‐Mercaptopicolinic acid, a preferential inhibitor of the cytosolic phosphoenolpyruvate carboxykinase [PDF]

, 1975
B. H. Robinson, J. Oei
openalex   +1 more source

Phosphoenolpyruvate Carboxylase in Arabidopsis Leaves Plays a Crucial Role in Carbon and Nitrogen Metabolism1

Plant Physiology, 2015
Jianghua Shi, Keke Yi, Yu Liu, Li Xie, Zhongjing Zhou, Yue Chen, Zhang-hua Hu, T. Zheng, Renhu Liu, Yunlong Chen, Jinqing Chen   +10 more
semanticscholar   +1 more source

Phosphoenolpyruvate Carboxytransphosphorylase

, 1966
Hans Lochmüller, Harland G. Wood, Judith J. Davis   +2 more
openalex   +1 more source

The effect of phosphoenolpyruvate, fructose 1,6-diphosphate and pH on allosteric pyruvate kinase in muscle tissue of the bivalve Mytilus edulis L [PDF]

, 1972
A. de Zwaan, D.A. Holwerda
openalex   +1 more source

Temperature Responses of C4 Photosynthesis: Biochemical Analysis of Rubisco, Phosphoenolpyruvate Carboxylase, and Carbonic Anhydrase in Setaria viridis1[OPEN]

Plant Physiology, 2015
Ryan A. Boyd, A. Gandin, A. Cousins
semanticscholar   +1 more source

The role of the phosphoenolpyruvate phosphotransferase system in the transport of N-acetyl-d-glucosamine by Escherichia coli [PDF]

, 1970
Richard White
openalex   +1 more source