Results 51 to 60 of about 45,633 (272)

Combining Electrochemical Reduction with Biosynthesis for Directed Conversion of CO2 into a Library of C3 Chemicals

Advanced Science, EarlyView.
In the H‐type electrolytic cell, carbon dioxide is reduced to acetic acid via electro‐microbial catalysis. The simply processed acetic acid is further converted through biological fermentation into high‐value‐added products, including acrylic acid, L‐lactic acid, and β‐alanine.
Kaixing Xiao, Shanquan Liang, Xujun Zhao, Zhiyao Peng, Ruoshi Luo, Jikai Zong, Ling Zhou, Yude Su, Dan Wang   +8 more
wiley   +1 more source

Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose.

PLoS Pathogens, 2015
Metabolomics coupled with heavy-atom isotope-labelled glucose has been used to probe the metabolic pathways active in cultured bloodstream form trypomastigotes of Trypanosoma brucei, a parasite responsible for human African trypanosomiasis.
Darren J Creek, Muriel Mazet, Fiona Achcar, Jana Anderson, Dong-Hyun Kim, Ruwida Kamour, Pauline Morand, Yoann Millerioux, Marc Biran, Eduard J Kerkhoven, Achuthanunni Chokkathukalam, Stefan K Weidt, Karl E V Burgess, Rainer Breitling, David G Watson, Frédéric Bringaud, Michael P Barrett   +16 more
doaj   +1 more source

Allosteric regulation of pyruvate kinase enables efficient and robust gluconeogenesis by preventing metabolic conflicts and carbon overflow

mSystems
Gluconeogenesis, the reciprocal pathway of glycolysis, is an energy-consuming process that generates glycolytic intermediates from non-carbohydrate sources. In this study, we demonstrate that robust and efficient gluconeogenesis in bacteria relies on the
Fukang She, Brent W. Anderson, Daven B. Khana, Shenwei Zhang, Wieland Steinchen, Danny K. Fung, Nathalie G. Lesser, Lauren N. Lucas, David M. Stevenson, Theresa J. Astmann, Gert Bange, Jan-Peter van Pijkeren, Daniel Amador-Noguez, Jue D. Wang   +13 more
doaj   +1 more source

The possible role of Phosphoenolpyrovate Carboxykinase (PEPCKin protein content of chickpea seeds (Cicer arietinum L [PDF]

پژوهش‌های حبوبات ایران, 2010
Phosphoenolpyruvate Carboxykinase (PEPCK) has been shown to be present in plants andanimals, playing different metabolic roles in different tissues. The basic role of this enzyme is itscontribution in the gluconeogenesis pathway.
Maria Beihaghi, Abdol Reza Bagheri, Ahmad Reza Bahrami, Faraj Alah Shahriari, Ahmad Nezami   +4 more
doaj   +1 more source

Effects of exogenous melatonin on sugar and organic acid metabolism in early-ripening peach fruits.

PLoS ONE, 2023
To evaluated the effects melatonin (MT) on the sugar and acid metabolism of early-ripening peach fruits, the concentration of 150 μmol/L MT was sprayed on the leaves of peach trees.
Kexuan Zhou, Qi Cheng, Jingtong Dai, Yuan Liu, Qin Liu, Rui Li, Jiangyue Wang, Rongping Hu, Lijin Lin   +8 more
doaj   +1 more source

Compensation Response to Hepatic Gluconeogenesis via β‐Hydroxybutyrylation of FBP1 and PCK1 in Dairy Cows

Animal Research and One Health, EarlyView.
(1) Kbhb modification of FBP1 and PCK1 is involved in regulation of the gluconeogenesis pathway. (2) Kbhb of FBP1 and PCK1 is catalyzed by p300 and removed by HDACs. (3) BHB induced an increase in the enzymatic activity of FBP1 and PCK1 through Kbhb modification at the K43 site of FBP1 and the K191 site of PCK1.
DingPing Feng, GuoYan Wang, YuanYuan Zhu, YiNing Zheng, JunHu Yao, Lei Chen, Lu Deng   +6 more
wiley   +1 more source

Activating Phosphoenolpyruvate Carboxylase and Phosphoenolpyruvate Carboxykinase in Combination for Improvement of Succinate Production [PDF]

Applied and Environmental Microbiology, 2013
ABSTRACT Phosphoenolpyruvate (PEP) carboxylation is an important step in the production of succinate by Escherichia coli . Two enzymes, PEP carboxylase (PPC) and PEP carboxykinase (PCK), are responsible for PEP carboxylation. PPC has high substrate affinity and catalytic velocity but wastes the high energy
Zaigao, Tan, Xinna, Zhu, Jing, Chen, Qingyan, Li, Xueli, Zhang   +4 more
openaire   +2 more sources

Increasing the succinate yield in Actinobacillus succinogenes by fumigation of H2 in a bioreactor

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract The microbial conversion of CO2 into value‐added chemicals offers a promising and scalable route for sustainable bioproduction, particularly under mild reaction conditions and with technically straightforward reactor configurations. Actinobacillus succinogenes, a natural succinate producer, can fix CO2 through anaplerotic carboxylation but its
Julian Tix, Gustav Zimpel, Roland Ulber, Nils Tippkötter   +3 more
wiley   +1 more source

Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice

Nature Communications, 2023
Phosphoenolpyruvate carboxykinase 1 (Pck1) is an enzyme involved in glucose production that also regulates lipogenesis and has been linked to liver steatosis.
Qian Ye, Yi Liu, Guiji Zhang, Haijun Deng, Xiaojun Wang, Lin Tuo, Chang Chen, Xuanming Pan, Kang Wu, Jiangao Fan, Qin Pan, Kai Wang, Ailong Huang, Ni Tang   +13 more
doaj   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source