Results 61 to 70 of about 86,461 (284)

Disintegration of the KITENIN/ErbB4 Functional Complex by the Flavonoid Hispidulin Suppresses Colorectal Cancer Progression

Advanced Therapeutics, EarlyView.
Hispidulin disrupts the KITENIN/ErbB4 oncogenic complex and inhibits KITENIN‐mediated AP‐1 activity, cell invasion, and aerobic glycolysis. It also suppresses the production of cancer‐associated metabolites and downregulates transcriptional regulators downstream of the KITENIN complex.
Mücahit Varlı, Songjin Oh, Eunae Kim, Barış Gökalsın, Nüzhet Cenk Sesal, Kyung Keun Kim, Man Jeong Paik, Hangun Kim   +7 more
wiley   +1 more source

Phosphoenolpyruvate Carboxylase Identified as a Key Enzyme in Erythrocytic Plasmodium falciparum Carbon Metabolism

PLoS Pathogens, 2014
Phospoenolpyruvate carboxylase (PEPC) is absent from humans but encoded in the Plasmodium falciparum genome, suggesting that PEPC has a parasite-specific function. To investigate its importance in P. falciparum, we generated a pepc null mutant (D10Δpepc),
J. Storm, S. Sethia, G. Blackburn, Achuthanunni Chokkathukalam, D. Watson, R. Breitling, G. H. Coombs, S. Müller   +7 more
semanticscholar   +1 more source

Genomic and Cis‐Regulatory Basis of a Plastic C3‐C4 Photosynthesis in Eleocharis Baldwinii

Advanced Science, EarlyView.
The sedge Eleocharis baldwinii remarkably switches between C3‐like and C4‐like photosynthesis in response to environmental conditions. Combining gap‐free genome assembly with single‐cell multi‐omics, this study uncovers how subgenome dominance and cell‐specific cis‐regulation enable C4 photosynthesis.
Lu Chen, Yanfeng Jia, Zaihui Zhou, Qiying Jiang, Jianlin Liu, Jianhui Gu, Chuan Chen, Shujing Cheng, Jinfang Chu, Xin Liu, Yongjun Lin, Xiang Li   +11 more
wiley   +1 more source

Phosphorylation of phosphoenolpyruvate carboxykinase in plants. Studies in plants with C4 photosynthesis and Crassulacean acid metabolism and in germinating seeds [PDF]

, 1996
We have previously shown that phosphoenolpyruvate carboxykinase (PEPCK) is phosphorylated in vivo in the cotyledons of darkened cucumber seedlings and that phosphorylation is reversed by light [Walker and Leegood (1995) FEBS Lett. 362, 70–74].
Leegood, R.C., Walker, R.P.
core  

Structural and functional studies of phosphoenolpyruvate carboxykinase from Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2015
Tuberculosis, the second leading infectious disease killer after HIV, remains a top public health priority. The causative agent of tuberculosis, Mycobacterium tuberculosis (Mtb), which can cause both acute and clinically latent infections, reprograms ...
Iva Machová, Jan Snášel, Jiří Dostál, Jiří Brynda, Jindřich Fanfrlík, Mahavir Singh, Ján Tarábek, Ondřej Vaněk, Lucie Bednárová, Iva Pichová   +9 more
doaj   +1 more source

Mycobacterium tuberculosis Phosphoenolpyruvate Carboxykinase Is Regulated by Redox Mechanisms and Interaction with Thioredoxin*

Journal of Biological Chemistry, 2014
Background: Phosphoenolpyruvate carboxykinase (Pck) catalyzes the interconversion of phosphoenolpyruvate and oxaloacetate but typically prefers gluconeogenic formation of phosphoenolpyruvate.
I. Machová, J. Snášel, Michael Zimmermann, D. Laubitz, P. Płociński, W. Oehlmann, Mahavir Singh, J. Dostál, U. Sauer, I. Pichová   +9 more
semanticscholar   +1 more source

Model‐Guided Rational Construction of Escherichia coli Synthetic Consortia for Enhanced 2‐Methylbutyric Acid Production

Advanced Science, EarlyView.
We developed a citramalate‐derived pathway for 2‐methylbutyric acid production in E. coli mono‐culture and consortia. The optimized consortium, using 2‐keto‐3‐methylvalerate as a node, achieved 1817.03 ± 103.73 mg L−1 2‐methylbutyric acid, a 28‐fold increase from the initial strain, with a yield of 0.091 g/g glucose.
Yu Liu, Boyuan Xue, Shaojie Wang, Haijia Su   +3 more
wiley   +1 more source

Improvement of Escherichia coli production strains by modification of the phosphoenolpyruvate:sugar phosphotransferase system

Microbial Cell Factories, 2005
The application of metabolic engineering in Escherichia coli has resulted in the generation of strains with the capacity to produce metabolites of commercial interest.
Gosset Guillermo
doaj   +1 more source

Compensatory Increase of Serum Hepassocin Protects Hyperthyroidism-Induced Hepatic Dysfunction

Biomedicines, 2023
Hepatic dysfunction is commonly observed in subjects with hyperthyroidism. Hepassocin is a hepatokine playing an important role in metabolic diseases and exhibiting a hepatic protective effect.
Chih-Chen Wang, Ching-Han Lin, Hsuan-Wen Chou, Chung-Teng Wang, Yu-Cheng Liang, Hung-Tsung Wu, Horng-Yih Ou   +6 more
doaj   +1 more source

Deregulation of Feedback Inhibition of Phosphoenolpyruvate Carboxylase for Improved Lysine Production in Corynebacterium glutamicum

Applied and Environmental Microbiology, 2013
Allosteric regulation of phosphoenolpyruvate carboxylase (PEPC) controls the metabolic flux distribution of anaplerotic pathways. In this study, the feedback inhibition of Corynebacterium glutamicum PEPC was rationally deregulated, and its effect on ...
Zhen Chen, Rajesh Reddy Bommareddy, D. Frank, Sugima Rappert, A. Zeng   +4 more
semanticscholar   +1 more source