Results 91 to 100 of about 41,991 (249)

Phosphoenolpyruvate carboxykinase. I. Its role in gluconeogenesis

, 1972
The de novo synthesis of glucose in mam-malian liver involves a number of enzymatic reactions, some specific to this process and others acting in reverse of their role in gly-colysis (Fig. 1).
Richard W. Hanson, Alan J. Garber
core   +1 more source

Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets. [PDF]

PLoS ONE, 2014
In this study, gestational sows were fed control or betaine-supplemented diets (3 g/kg) throughout the pregnancy, and the newborn piglets were used to elucidate whether maternal dietary betaine affected offspring hepatic gluconeogenic genes through ...
Demin Cai, Yimin Jia, Haogang Song, Shiyan Sui, Jingyu Lu, Zheng Jiang, Ruqian Zhao   +6 more
doaj   +1 more source

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
wiley   +1 more source

The Ω-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function

Biochemistry, 2012
Phosphoenolpyruvate carboxykinase (PEPCK) is an essential metabolic enzyme operating in the gluconeogenesis and glyceroneogenesis pathways. Recent studies have demonstrated that the enzyme contains a mobile active site lid domain that transitions between
T. Johnson, T. Holyoak
semanticscholar   +1 more source

Computational and Pharmacological Evaluation of Carveol for Antidiabetic Potential

Frontiers in Pharmacology, 2020
BackgroundCarveol is a natural drug product present in the essential oils of orange peel, dill, and caraway seeds. The seed oil of Carum Carvi has been reported to be antioxidant, anti-inflammatory, anti-hyperlipidemic, antidiabetic, and hepatoprotective.
Muhammad Shabir Ahmed, Arif-ullah Khan, Lina Tariq Al Kury, Fawad Ali Shah   +3 more
doaj   +1 more source

Glutamine Metabolism in Health and Diseases

MedComm, Volume 7, Issue 10, October 2026.
Glutamine metabolism acts as a metabolic hub connecting cellular stress adaptation, immune regulation, and disease development. Through regulating energy production, biosynthesis, redox balance, and nitrogen metabolism, glutamine supports cellular homeostasis under physiological and pathological conditions.
Yi Ding, Fan Tong, Jing Zeng, Chun‐Ping Cui   +3 more
wiley   +1 more source

-Glutamine supplementation promotes an improved energetic balance in Walker-256 tumor–bearing rats

Tumor Biology, 2017
We evaluated the effects of supplementation with oral l -glutamine in Walker-256 tumor–bearing rats. A total of 32 male Wistar rats aged 54 days were randomly divided into four groups: rats without Walker-256 tumor, that is, control rats (C group ...
Heber Amilcar Martins, Roberto Barbosa Bazotte, Geraldo Emilio Vicentini, Mariana Machado Lima, Flavia Alessandra Guarnier, Catchia Hermes-Uliana, Flavia Cristina Vieira Frez, Gleison Daion Piovezana Bossolani, Luciane Fracaro, Larissa dos Santos Fávaro, Mariana Inocêncio Manzano, Jacqueline Nelisis Zanoni   +11 more
doaj   +1 more source

Transcriptomic changes associated with PCK1 overexpression in hepatocellular carcinoma cells detected by RNA-seq

Genes and Diseases, 2020
Phosphoenolpyruvate carboxykinase 1 (PCK1), a step limiting enzyme of gluconeogenesis, is downregulated in hepatocellular carcinoma (HCC). Overexpression of PCK1 has been shown to suppress hepatoma cell growth, but the underlying mechanism remains ...
Jin Xiang, Yuhong Zhang, Lin Tuo, Rui Liu, Dongmei Gou, Li Liang, Chang Chen, Jie Xia, Ni Tang, Kai Wang   +9 more
doaj   +1 more source

The appropriate dietary methionine content reduces deamination and gluconeogenesis in Chinese perch (Siniperca chuatsi)

Journal of the World Aquaculture Society, Volume 57, Issue 5, October 2026.
Abstract This study evaluated the effects of different dietary methionine (Met) levels on the feeding, growth, and protein metabolism of Chinese perch, Siniperca chuatsi. Six diets containing graded levels of Met (0.88%, 1.11%, 1.68%, 2.02%, 2.27%, and 2.72%) were fed to fish (initial weight: 13.74 ± 0.12 g) for 8 weeks.
Xinyao Ji, Jiacheng Hu, Baoye Hao, Jinguo Chen, Binhua Niu, Yufei Zhang, Xu‐Fang Liang, Liwei Liu   +7 more
wiley   +1 more source

Phosphoenolpyruvate Carboxykinase and Glucose-6-phosphatase Are Required for Steroidogenesis in Testicular Leydig Cells*

Journal of Biological Chemistry, 2012
Background: PEPCK is expressed in Leydig cells of testes, but its role has not been studied. Results: Knockdown and inhibition of PEPCK and Glc-6-Pase inhibited steroidogenesis via activation of AMPK.
S. Ahn, Gil-Tae Gang, Surendar Tadi, Balachandar Nedumaran, Y. D. Kim, Ji Hoon Park, G. Kweon, Seung-Hoi Koo, Keesook Lee, R. Ahn, Y. Yim, Chul-Ho Lee, Robert A. Harris, Hueng-Sik Choi   +13 more
semanticscholar   +1 more source