Results 1 to 10 of about 28,503 (264)
Frontiers in Plant Science, 2013 Plants possess two types of phosphofructokinase proteins for phosphorylation of fructose-6-phosphate, the ATP-dependent phosphofructokinase (PFK) and the pyrophosphate-(PPi) dependent pyrophosphate-fructose-6-phosphate-phosphotransferase (PFP).
Angelika Mustroph, Bernhard Grimm
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Nature Communications, 2019 Pancreatic ductal adenocarcinoma must adapt to a nutrient-poor microenvironment. Here, the authors show that miR-135 accumulates in response to glutamine deprivation and inhibits aerobic glycolysis by targeting phosphofructokinase-1, thereby redirecting ...
Eric A Hanse, Thai Q Tran, Haiqing Li
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Nature Communications, 2017 Cancer cell survival under metabolic stress is a critical step for metastasis. Here, the authors show that under glucose deprivation, Snail, a key regulator of the metastatic process, promotes survival by diverting glucose to the pentose phosphate ...
Nam Hee Kim +2 more
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Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis
Nature Communications, 2017 Phosphofructokinase 1 (PFK1) plays a critical role in glycolysis. Here the authors show that PFK1 platelet isoform is upregulated in Glioblastoma and is required for tumor growth mechanistically, such upregulation is due to an increased stability induced
Jong-ho Lee, Rui Liu, Jing Li
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Nature Communications, 2018 TAp73 is a structural homolog of the tumor suppressor p53. Here they show that TAp73 is critical for promoting glycolysis as it stimulates the transcriptional expression of liver type of phosphofructokinase-1 (PFKL), which catalyzes the committed step in
Dong Wang, Peng Jiang, Wenjing Du
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Journal of Biological Chemistry, 1967 Abstract Purified rabbit muscle phosphofructokinase required K+ ion for maximal activity and was inactive at pH 7 unless the Mg++ concentration exceeded the total adenosine triphosphate concentration. Enzymatic activity was proportional to sulfhydryl reduction, and was reversibly lost by sulfhydryl oxidation with oxidized glutathione.
Verner Paetkau, Henry A. Lardy
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Activation by phosphate of yeast phosphofructokinase. [PDF]
Journal of Biological Chemistry, 1977 The activity of yeast phosphofructokinase assayed in vitro at physiological concentrations of known substrates and effectors is 100-fold lower than the glycolytic flux observed in vivo. Phosphate synergistically with AMP activates the enzyme to a level within the range of the physiological needs.
Marcelino Bañuelos +2 more
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PFKM-Mediated Glycolysis: A Pathway for ASIC1 to Enhance Cell Survival in the Acidic Microenvironment of Liver Cancer [PDF]
BiomoleculesThe acidic tumor microenvironment plays a critical role in promoting liver cancer cell survival by enhancing glycolysis and adaptive mechanisms. Acid-sensing ion channel 1 (ASIC1) is a key regulator of pH sensing, but its role in liver cancer progression
Xiaomin Wu +7 more
doaj +2 more sources
Light‐emitting diode irradiation targets aerobic glycolysis in cancer‐associated fibroblasts to inhibit metabolic coupling with colon cancer cells [PDF]
Ann Gastroenterol SurgBlue LED irradiation targeted metabolic coupling between CAFs and colon cancer cells. Abstract Background The concepts examined in tumor metabolism research have been moving away from cancer cells themselves and the tumor microenvironment has become a focus of investigation.
Nishi M +8 more
europepmc +2 more sources
Anais Da Academia Brasileira De Ciencias, 2004 In this work, we report evidences that the association of phosphofructokinase and F-actin can be affected by insulin stimulation in rabbit skeletal muscle homogenates and that this association can be a mechanism of phos-phofructokinase regulation ...
Gutemberg Gomes Alves, Mauro Sola-penna
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