Results 1 to 10 of about 40,035 (261)

Fructose metabolism in Chromohalobacter salexigens: interplay between the Embden–Meyerhof–Parnas and Entner–Doudoroff pathways [PDF]

Microbial Cell Factories, 2019
Background The halophilic bacterium Chromohalobacter salexigens metabolizes glucose exclusively through the Entner–Doudoroff (ED) pathway, an adaptation which results in inefficient growth, with significant carbon overflow, especially at low salinity ...
José M. Pastor, Nuno Borges, Juan P. Pagán, Sara Castaño-Cerezo, Laszlo N. Csonka, Bradley W. Goodner, Kathryn A. Reynolds, Luís G. Gonçalves, Montserrat Argandoña, Joaquín J. Nieto, Carmen Vargas, Vicente Bernal, Manuel Cánovas   +12 more
doaj   +3 more sources

PKP1 promotes lung cancer by modulating energy metabolism through stabilization of PFKP [PDF]

Biomarker Research
Lung cancer is the leading cause of cancer-related deaths worldwide, with lung squamous cell carcinoma (LUSC) lacking effective targeted therapies. Recent studies have identified Plakophilin-1 (PKP1) as one of the most differentially overexpressed genes ...
Félix Ritoré-Salazar, Alberto M. Arenas, Ana M. Matia-González, Alessandra Zaza, Emil Aagaard Thomsen, Anne Bruun Rovsing, Jacob Giehm Mikkelsen, Nelida Ines Noguera, Pedro P. Medina   +8 more
doaj   +2 more sources

Quantitative Analysis of the Effective Functional Structure in Yeast Glycolysis [PDF]

, 2011
Yeast glycolysis is considered the prototype of dissipative biochemical oscillators. In cellular conditions, under sinusoidal source of glucose, the activity of glycolytic enzymes can display either periodic, quasiperiodic or chaotic behavior. In order
Cortes, Jesus M., De la Fuente, Ildefonso M.   +1 more
core   +39 more sources

PFKM-Mediated Glycolysis: A Pathway for ASIC1 to Enhance Cell Survival in the Acidic Microenvironment of Liver Cancer [PDF]

Biomolecules
The acidic tumor microenvironment plays a critical role in promoting liver cancer cell survival by enhancing glycolysis and adaptive mechanisms. Acid-sensing ion channel 1 (ASIC1) is a key regulator of pH sensing, but its role in liver cancer progression
Xiaomin Wu, Boshi Wang, Yingjian Hou, Yipeng Fang, Yuan Jiang, Yuelei Song, Youyi Liu, Cheng Jin   +7 more
doaj   +2 more sources

In Streptococcus thermophilus, Ammonia from Urea Hydrolysis Paradoxically Boosts Acidification and Reveals a New Regulatory Mechanism of Glycolysis

Microbiology Spectrum, 2022
Streptococcus thermophilus is widely used in the dairy industry for the manufacturing of fermented milk and cheeses and probiotic formulations. S. thermophilus evolved from closely phylogenetically related pathogenic streptococci through loss-of-function
Stefania Arioli, Giulia Della Scala, Anđela Martinović, Leonardo Scaglioni, Stefania Mazzini, Federica Volonté, Martin Bastian Pedersen, Diego Mora   +7 more
doaj   +1 more source

Research progress on the mechanism of glycolysis in ovarian cancer

Frontiers in Immunology, 2023
Glycolysis is the preferred energy metabolism pathway in cancer cells even when the oxygen content is sufficient. Through glycolysis, cancer cells convert glucose into pyruvic acid and then lactate to rapidly produce energy and promote cancer progression.
Chan Li, Fang-Yuan Liu, Ying Shen, Ying Shen, Yuan Tian, Feng-Juan Han   +5 more
doaj   +1 more source

The Phosphofructokinase Isoform AtPFK5 Is a Novel Target of Plastidic Thioredoxin-f-Dependent Redox Regulation

Antioxidants, 2021
The chloroplast primary metabolism is of central importance for plant growth and performance. Therefore, it is tightly regulated in order to adequately respond to multiple environmental conditions.
Natalia Hess, Simon Richter, Michael Liebthal, Karl-Josef Dietz, Angelika Mustroph   +4 more
doaj   +1 more source

Myostatin Mutation Promotes Glycolysis by Increasing Phosphorylation of Phosphofructokinase via Activation of PDE5A-cGMP-PKG in Cattle Heart

Frontiers in Cell and Developmental Biology, 2022
Myostatin (MSTN) is a primary negative regulator of skeletal muscle mass and causes multiple metabolic changes. However, whether MSTN mutation affects heart morphology and physiology remains unclear.
Mingjuan Gu, Mingjuan Gu, Xinyu Zhou, Xinyu Zhou, Lin Zhu, Lin Zhu, Yajie Gao, Yajie Gao, Li Gao, Chunling Bai, Chunling Bai, Lei Yang, Lei Yang, Guangpeng Li, Guangpeng Li   +14 more
doaj   +1 more source

Mitapivat for phosphofructokinase deficiency. [PDF]

Am J Hematol
Al-Samkari H.
europepmc   +3 more sources

Metabolic insights into phosphofructokinase inhibition in bloodstream-form trypanosomes

Frontiers in Cellular and Infection Microbiology, 2023
Previously, we reported the development of novel small molecules that are potent inhibitors of the glycolytic enzyme phosphofructokinase (PFK) of Trypanosoma brucei and related protists responsible for serious diseases in humans and domestic animals ...
Zandile Nare, Tessa Moses, Karl Burgess, Karl Burgess, Achim Schnaufer, Malcolm D. Walkinshaw, Paul A. M. Michels   +6 more
doaj   +1 more source