Phosphofructokinase 1 Platelet Isoform Promotes β-Catenin Transactivation for Tumor Development [PDF]
Frontiers in Oncology, 2020 Metabolism plays a critical role in direct regulation of a variety of cellular activities via metabolic enzymes and metabolites. Here, we demonstrate that phosphofructokinase 1 platelet isoform (PFKP), which catalyzes a rate-limiting reaction in ...
Jong-Ho Lee +13 more
doaj +7 more sources
Structural basis for allosteric regulation of human phosphofructokinase-1 [PDF]
Nature CommunicationsPhosphofructokinase-1 (PFK1) catalyzes the rate-limiting step of glycolysis, committing glucose to conversion into cellular energy. PFK1 is highly regulated to respond to the changing energy needs of the cell.
Eric M. Lynch +6 more
doaj +10 more sources
Analysis of phosphofructokinase-1 activity as affected by pH and ATP concentration [PDF]
Scientific ReportsA key player in energy metabolism is phosphofructokinase-1 (PFK1) whose activity and behavior strongly influence glycolysis and thus have implications in many areas. In this research, PFK1 assays were performed to convert F6P and ATP into F-1,6-P and ADP
Chengcheng Wang +6 more
doaj +5 more sources
Mutual regulation between phosphofructokinase 1 platelet isoform and VEGF promotes glioblastoma tumor growth [PDF]
Cell Death and Disease, 2022 Glioblastoma (GBM) is a highly vascular malignant brain tumor that overexpresses vascular endothelial growth factor (VEGF) and phosphofructokinase 1 platelet isoform (PFKP), which catalyzes a rate-limiting reaction in glycolysis.
Je Sun Lim +10 more
doaj +8 more sources
Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis [PDF]
Nature Communications, 2017 Phosphofructokinase 1 (PFK1) plays a critical role in glycolysis. Here the authors show that PFK1 platelet isoform is upregulated in Glioblastoma and is required for tumor growth mechanistically, such upregulation is due to an increased stability induced
Jong-Ho Lee +13 more
doaj +5 more sources
TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation [PDF]
Nature Communications, 2018 TAp73 is a structural homolog of the tumor suppressor p53. Here they show that TAp73 is critical for promoting glycolysis as it stimulates the transcriptional expression of liver type of phosphofructokinase-1 (PFKL), which catalyzes the committed step in
Le Li +15 more
doaj +6 more sources
Hitting the Sweet Spot: How Glucose Metabolism Is Orchestrated in Space and Time by Phosphofructokinase-1. [PDF]
Cancers (Basel), 2023 Glycolysis is the central metabolic pathway across all kingdoms of life. Intensive research efforts have been devoted to understanding the tightly orchestrated processes of converting glucose into energy in health and disease. Our review highlights the advances in knowledge of how metabolic and gene networks are integrated through the precise ...
Campos M, Albrecht LV.
europepmc +5 more sources
MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1 [PDF]
Nature Communications, 2019 Pancreatic ductal adenocarcinoma must adapt to a nutrient-poor microenvironment. Here, the authors show that miR-135 accumulates in response to glutamine deprivation and inhibits aerobic glycolysis by targeting phosphofructokinase-1, thereby redirecting ...
Ying Yang +11 more
doaj +2 more sources
Pharmacological ResearchPhenolic acid-rich fraction from Anisopus mannii (PhAM) contains abundance of ferulic acid, gallic acid, protocatechuic acid, and syringic acid.
Peter U. Amadi +13 more
doaj +2 more sources
Romanian Journal of Laboratory MedicineWe aimed to explore the role of T helper cell 1 (Th1)/Th2 imbalance mediated by T cell glycolytic rate-limiting enzymes hexokinase 2 (HK2), phosphofructokinase-1 (PEK1) and pyruvate kinase M2 (PKM2) in oral lichen planus (OLP).
Yao Min +4 more
doaj +2 more sources