Results 1 to 10 of about 21,592 (215)

Structural basis for allosteric regulation of human phosphofructokinase-1 [PDF]

Nature Communications
Phosphofructokinase-1 (PFK1) catalyzes the rate-limiting step of glycolysis, committing glucose to conversion into cellular energy. PFK1 is highly regulated to respond to the changing energy needs of the cell.
Eric M. Lynch, Heather Hansen, Lauren Salay, Madison Cooper, Stepan Timr, Justin M. Kollman, Bradley A. Webb   +6 more
doaj   +10 more sources

Mutual regulation between phosphofructokinase 1 platelet isoform and VEGF promotes glioblastoma tumor growth [PDF]

Cell Death and Disease, 2022
Glioblastoma (GBM) is a highly vascular malignant brain tumor that overexpresses vascular endothelial growth factor (VEGF) and phosphofructokinase 1 platelet isoform (PFKP), which catalyzes a rate-limiting reaction in glycolysis.
Je Sun Lim, YuJie Shi, Su Hwan Park, So Mi Jeon, Chuanbao Zhang, Yun-Yong Park, Rui Liu, Jing Li, Wan-Seob Cho, Linyong Du, Jong-Ho Lee   +10 more
doaj   +7 more sources

Phosphofructokinase 1 Platelet Isoform Promotes β-Catenin Transactivation for Tumor Development [PDF]

Frontiers in Oncology, 2020
Metabolism plays a critical role in direct regulation of a variety of cellular activities via metabolic enzymes and metabolites. Here, we demonstrate that phosphofructokinase 1 platelet isoform (PFKP), which catalyzes a rate-limiting reaction in ...
Jong-Ho Lee, Fei Shao, Jinjie Ling, Sean Lu, Rui Liu, Linyong Du, Jin Woong Chung, Sang Seok Koh, Sun-Hee Leem, Jichun Shao, Dongming Xing, Dongming Xing, Zhiqiang An, Zhimin Lu   +13 more
doaj   +6 more sources

TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation [PDF]

Nature Communications, 2018
TAp73 is a structural homolog of the tumor suppressor p53. Here they show that TAp73 is critical for promoting glycolysis as it stimulates the transcriptional expression of liver type of phosphofructokinase-1 (PFKL), which catalyzes the committed step in
Le Li, Lijia Li, Wei Li, Taiqi Chen, Bin Zou, Lina Zhao, Huili Wang, Xueying Wang, Lina Xu, Xiaohui Liu, Dong Wang, Bo Li, Tak W. Mak, Wenjing Du, Xiaolu Yang, Peng Jiang   +15 more
doaj   +6 more sources

Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis [PDF]

Nature Communications, 2017
Phosphofructokinase 1 (PFK1) plays a critical role in glycolysis. Here the authors show that PFK1 platelet isoform is upregulated in Glioblastoma and is required for tumor growth mechanistically, such upregulation is due to an increased stability induced
Jong-Ho Lee, Rui Liu, Jing Li, Chuanbao Zhang, Yugang Wang, Qingsong Cai, Xu Qian, Yan Xia, Yanhua Zheng, Yuji Piao, Qianming Chen, John F. de Groot, Tao Jiang, Zhimin Lu   +13 more
doaj   +5 more sources

EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation. [PDF]

Mol Cell, 2018
EGFR activates phosphatidylinositide 3-kinase (PI3K), but the mechanism underlying this activation is not completely understood. We demonstrated here that EGFR activation resulted in lysine acetyltransferase 5 (KAT5)-mediated K395 acetylation of the platelet isoform of phosphofructokinase 1 (PFKP) and subsequent translocation of PFKP to the plasma ...
Lee JH, Liu R, Li J, Wang Y, Tan L, Li XJ, Qian X, Zhang C, Xia Y, Xu D, Guo W, Ding Z, Du L, Zheng Y, Chen Q, Lorenzi PL, Mills GB, Jiang T, Lu Z.   +18 more
europepmc   +5 more sources

The glycolytic enzyme phosphofructokinase-1 assembles into filaments. [PDF]

J Cell Biol, 2017
Despite abundant knowledge of the regulation and biochemistry of glycolytic enzymes, we have limited understanding on how they are spatially organized in the cell.
Webb BA, Dosey AM, Wittmann T, Kollman JM, Barber DL.   +4 more
europepmc   +6 more sources

Phosphofructokinase-1 and fructose bisphosphatase-1 in canine liver and kidney. [PDF]

J Vet Med Sci, 2019
In healthy individuals, plasma glucose levels are maintained within a normal range. During fasting, endogenous glucose is released either through glycogenolysis or gluconeogenesis. Gluconeogenesis involves the formation of glucose-6-phosphate from a variety of precursors followed by its subsequent hydrolysis to glucose.
Kanai S, Shimada T, Narita T, Okabayashi K.   +3 more
europepmc   +5 more sources

Protein phosphatase 4 dephosphorylates phosphofructokinase-1 to regulate its enzymatic activity. [PDF]

BMB Rep, 2023
Most cancer cells utilize glucose at a high rate to produce energy and precursors for the biosynthesis of macromolecules such as lipids, proteins, and nucleic acids. This phenomenon is called the Warburg effect or aerobic glycolysis— this distinct characteristic is an attractive target for developing anticancer drugs.
Park J, Lee DH.
europepmc   +4 more sources

MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1 [PDF]

Nature Communications, 2019
Pancreatic ductal adenocarcinoma must adapt to a nutrient-poor microenvironment. Here, the authors show that miR-135 accumulates in response to glutamine deprivation and inhibits aerobic glycolysis by targeting phosphofructokinase-1, thereby redirecting ...
Ying Yang, Mari B. Ishak Gabra, Eric A. Hanse, Xazmin H. Lowman, Thai Q. Tran, Haiqing Li, Neta Milman, Juan Liu, Michael A. Reid, Jason W. Locasale, Ziv Gil, Mei Kong   +11 more
doaj   +4 more sources