Results 101 to 110 of about 21,592 (215)

Nucleocytoplasmic human O-GlcNAc transferase is sufficient for O-GlcNAcylation of mitochondrial proteins [PDF]

, 2016
O-linked N-acetylglucosamine modification (O-GlcNAcylation) is a nutrient-dependent protein post-translational modification (PTM), dynamically and reversibly driven by two enzymes: O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) that catalyse the ...
Akimoto, Andrew T. Ferenbach, Banerjee, Butkinaree, Cao, Comer, Corrado, Daan M.F. van Aalten, Daniel Mariappa, Dassanayaka, Dias, Dong, Exner, Frezza, Gawlowski, Gu, Haltiwanger, Haltiwanger, Hanover, Hanover, Hart, Hart, Hofer, Housley, Hu, Hube, Iyer, Iyer, Johnsen, Kreppel, Lazarus, Lazarus, Liu, Love, Love, Lozano, Ma, Ma, Nolte, Olichon, Pathak, Pekkurnaz, Riccardo Trapannone, Ruan, Shafi, Shin, Sohn, Tan, Torres, van den Ent, Walgren, Wang, Yang, Yi, Zhao, Zhou, Zhu   +56 more
core   +3 more sources

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

Sequencing of a 9.9 kb segment on the right arm of yeast chromosome VII reveals four open reading frames, including PFK1, the gene coding for succinyl-CoA synthetase (beta-chain) and two ORFs sharing homology with ORFs of the yeast chromosome VIII [PDF]

, 1997
A 9.9 kb DNA fragment from the right arm of chromosome VII of Saccharomyces cerevisiae has been sequenced and analysed. The sequence contains four open reading frames (ORFs) longer than 100 amino acids.
Azevedo, Dulce, Barreiros, Tânia, Guerreiro, Paulo, Rodrigues-Pousada, Claudina   +3 more
core  

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

PFKM-Mediated Glycolysis: A Pathway for ASIC1 to Enhance Cell Survival in the Acidic Microenvironment of Liver Cancer

Biomolecules
The acidic tumor microenvironment plays a critical role in promoting liver cancer cell survival by enhancing glycolysis and adaptive mechanisms. Acid-sensing ion channel 1 (ASIC1) is a key regulator of pH sensing, but its role in liver cancer progression
Xiaomin Wu, Boshi Wang, Yingjian Hou, Yipeng Fang, Yuan Jiang, Yuelei Song, Youyi Liu, Cheng Jin   +7 more
doaj   +1 more source

Modeling cancer metabolism on a genome scale [PDF]

, 2015
Cancer cells have fundamentally altered cellular metabolism that is associated with their tumorigenicity and malignancy. In addition to the widely studied Warburg effect, several new key metabolic alterations in cancer have been established over the last
Barbara Chaneton, Eyal Gottlieb, Eytan Ruppin, Keren Yizhak, Kiuru M, Li L, Lobo C, Som P, Vazquez‐Martin A   +8 more
core   +1 more source

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, EarlyView.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

Prognostic Roles of Phosphofructokinase Platelet in Clear Cell Renal Cell Carcinoma and Correlation with Immune Infiltration

International Journal of General Medicine, 2021
Bin Liu,1 Faping Li,1 Mingdi Liu,2 Zhixiang Xu,2 Baoshan Gao,1 Yishu Wang,2 Honglan Zhou1 1Department of Urology, the First Hospital of Jilin University, Changchun, 130021, Jilin, People’s Republic of China; 2Key Laboratory of Pathobiology, Ministry of ...
Liu B, Li F, Liu M, Xu Z, Gao B, Wang Y, Zhou H   +6 more
doaj  

Association of predicted pathogenic mutations in mitochondrial ND genes with distant metastasis in NSCLC and colon cancer [PDF]

, 2017
Cancer cells have more mutations in their mitochondrial DNA (mtDNA) than do normal cells, and pathogenic mutations in the genes encoding mitochondrial NADH dehydrogenase (ND) subunits have been found to enhance the invasive and metastatic ability of ...
Akimoto Miho, Hayashi Jun-Ichi, Koshikawa Nobuko, Nagase Hiroki, Takenaga Keizo, 林 純一   +5 more
core   +2 more sources

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, EarlyView.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source