Results 101 to 110 of about 20,352 (205)

Decoding the pancreatic cancer microenvironment: The multifaceted regulation of microRNAs

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
miRNAs play multiple roles in the tumour microenvironment of pancreatic cancer, including angiogenesis, interactions with cancer‐associated fibroblasts, the immune microenvironment, exosome communication, the neural microenvironment and metabolic reprogramming.
Jie Ji, Dandan Jin, Junpeng Zhao, Xudong Xie, Yujie Jiao, Xuyang He, Yuxuan Huang, Lirong Zhou, Mingbing Xiao, Xiaolei Cao   +9 more
wiley   +1 more source

Prognostic Roles of Phosphofructokinase Platelet in Clear Cell Renal Cell Carcinoma and Correlation with Immune Infiltration

International Journal of General Medicine, 2021
Bin Liu,1 Faping Li,1 Mingdi Liu,2 Zhixiang Xu,2 Baoshan Gao,1 Yishu Wang,2 Honglan Zhou1 1Department of Urology, the First Hospital of Jilin University, Changchun, 130021, Jilin, People’s Republic of China; 2Key Laboratory of Pathobiology, Ministry of ...
Liu B, Li F, Liu M, Xu Z, Gao B, Wang Y, Zhou H   +6 more
doaj  

Lactate Metabolism and Lactylation Modification: New Opportunities and Challenges in Cardiovascular Disease

MedComm, Volume 6, Issue 7, July 2025.
Lactate, beyond a metabolic byproduct, regulates immunity and inflammation, linked to cardiovascular diseases (CVD) via metabolic reprogramming. Lactylation, a lactate‐driven epigenetic mark, modulates gene expression in fibrosis, lipid disorders, and CVD progression.
Mengyang Song, Bin Liu, Haiou Wang, Wei Sun   +3 more
wiley   +1 more source

Gender-specific changes in energy metabolism and protein degradation as major pathways affected in livers of mice treated with ibuprofen. [PDF]

, 2020
Ibuprofen, an inhibitor of prostanoid biosynthesis, is a common pharmacological agent used for the management of pain, inflammation and fever. However, the chronic use of ibuprofen at high doses is associated with increased risk for cardiovascular, renal,
Gomes, Aldrin V, Mishra, Manish, Newens, Joanne L, Phinney, Brett S, Salemi, Michelle R, Tiwari, Shuchita   +5 more
core  

Metabolic Investigations of the Molecular Mechanisms Associated with Parkinson's Disease. [PDF]

, 2017
Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar cytoplasmic aggregates of α-synuclein (i.e., Lewy bodies) and the associated loss of dopaminergic cells in the substantia nigra.
Anandhan, Annadurai, Cerny, Ronald, Dodds, Eric, Franco, Rodrigo, Huang, Yuting, Lei, Shulei, Marshall, Darrell, Panagiotidis, Mihalis, Pappa, Aglaia, Powers, Robert, Worley, Bradley   +10 more
core   +2 more sources

Phase Separation Regulates Metabolism, Mitochondria, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Mitochondrion‐related liquid–liquid phase separation. (1) Phase separation mediates the self‐assembly of mitochondrial nucleoids (mt‐nucleoids). (2) Phase segregation mediates the formation of mitochondrial RNA granules (MRGs). (3) Phase separation mediates the formation of mitochondrial degradosomes.
Chuan Gao, Peng Ding, Changqing Zhang, Junjie Gao   +3 more
wiley   +1 more source

Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras [PDF]

, 2017
Yeast and cancer cells share the unusual characteristic of favoring fermentation of sugar over respiration. We now reveal an evolutionary conserved mechanism linking fermentation to activation of Ras, a major regulator of cell proliferation in yeast and ...
Bonini, B. M., Fischer, B., Peeters, K., Quezada, H., Tompa, Péter, Van Leemputte, F.   +5 more
core   +1 more source

Speed Endurance Training to Improve Performance

Scandinavian Journal of Medicine &Science in Sports, Volume 35, Issue 7, July 2025.
ABSTRACT In many sports, the physical dimension plays a crucial role in determining athletic performance. This review provides insights into the effectiveness of speed endurance training (SET), that is, exercise training performed at intensities higher than that eliciting maximum oxygen uptake (V̇O2‐max), on performance across different sports and ...
Jens Bangsbo, Julie Kissow, Morten Hostrup   +2 more
wiley   +1 more source

The Impact of the Natural Grass-Growing Model on the Development of Korla Fragrant Pear Fruit, as Well as Its Influence on Post-Harvest Sugar Metabolism and the Expression of Key Enzyme Genes Involved in Fruit Sugar Synthesis

Agriculture
In this study, the effects of natural grass cultivation and clear cultivation on the physiological characteristics of Korla fragrant pear during fruit development and storage were investigated, providing a scientific basis for high-quality fragrant pear ...
Mingyang Yu, Lanfei Wang, Yan Chen, Weifan Fan, Hao Wang, Kailu Guo, Shutian Tao, Xin Gong, Jianping Bao   +8 more
doaj   +1 more source

Activity, distribution and regulation of phosphofructokinase in salivary gland of rats with streptozotocin-induced diabetes Atividade, distribuição e regulação da fosfofrutoquinase em glândulas salivares de ratos com diabetes induzido por estreptozotocina

Brazilian Oral Research, 2006
Although the influence of diabetes on salivary glands is well studied, it still presents conflicting results. In this work, the regulation of the phosphofructokinase-1 enzyme (PFK-1) was studied utilizing the salivary glands of rats. Diabetes was induced
José Nicolau, Douglas Nesadal Souza, Fernando Neves Nogueira   +2 more
doaj   +1 more source