Results 131 to 140 of about 23,730,752 (211)

Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development. [PDF]

open access: yes, 2019
Pancreatic ductal adenocarcinoma (PDAC) remains a deadly disease with no efficacious treatment options. PDAC incidence is projected to increase, which may be caused at least partially by the obesity epidemic.
Eibl, Guido, Rozengurt, Enrique
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Exploring the impact of elevated muscle temperature on the rate and extent of postmortem pH decline in porcine skeletal muscle [PDF]

open access: yes, 2018
When an animal is harvested for meat, the resulting carcass is processed to provide safe and wholesome meat products for the consumer. One of these processing steps for pigs known as scalding involves heating the carcass in hot water (60ºC) in order to ...
Montgomery, Madison
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Detection of Mycobacterium lepromatosis in patients with leprosy in India

open access: yesInfection and Drug Resistance, 2018
Madhvi Ahuja,1,* Mallika Lavania,1,* Itu Singh,1 Ravindra P Turankar,1 Seema Chhabra,2 Tarun Narang,3 Sunil Dogra,3 Utpal Sengupta1 1Department of Molecular Biology, Stanley Browne Laboratory, TLM Community Hospital, Delhi, India; 2Department of ...
Ahuja M   +7 more
doaj  

The PCK2-glycolysis axis assists three-dimensional-stiffness maintaining stem cell osteogenesis

open access: yesBioactive Materials, 2022
Understanding mechanisms underlying the heterogeneity of multipotent stem cells offers invaluable insights into biogenesis and tissue development. Extracellular matrix (ECM) stiffness has been acknowledged as a crucial factor regulating stem cell fate ...
Zheng Li   +6 more
doaj  

Methyl- and acetyltransferases are stable epigenetic markers postmortem [PDF]

open access: yes, 2018
Postmortem brain tissue has been reported to be suitable to delineate regional pattern of possible disturbances underlying epigenetic functionality. However, from many parameters that have been detected in postmortem brain regions it is noteworthy that ...
Al-Saraj, Safa   +13 more
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Phosphorylation of PFKL regulates metabolic reprogramming in macrophages following pattern recognition receptor activation

open access: yesNature Communications
Innate immune responses are linked to key metabolic pathways, yet the proximal signaling events that connect these systems remain poorly understood. Here we show that phosphofructokinase 1, liver type (PFKL), a rate-limiting enzyme of glycolysis, is ...
Meiyue Wang   +17 more
doaj   +1 more source

Changes in expression of genes related to glucose metabolism in liver and skeletal muscle of rats exposed to acute hypoxia

open access: yesHeliyon, 2020
The aim of this study was to determine changes in gene expression associated with glucose metabolism in the liver and soleus muscles of rats exposed to hypoxia to improve work capacity under high altitude conditions.
Yurie Hara, Nakamichi Watanabe
doaj  

p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP

open access: yesCell Reports, 2023
Summary: Aerobic glycolysis is critical for cancer progression and can be exploited in cancer therapy. Here, we report that the human carboxymethylenebutenolidase homolog (carboxymethylenebutenolidase-like [CMBL]) acts as a tumor suppressor by ...
Yingdan Huang   +10 more
doaj  

Acute control of fatty acid synthesis by cyclic AMP in the chick liver cell: possible site of inhibition of citrate formation.

open access: yesJournal of Lipid Research, 1979
Glucagon and N,(6)O(2)-dibutyryl cyclic adenosine 3‘,5‘-cyclic monophosphate (Bt(2)cAMP) inhibit fatty acid synthesis from acetate by more than 90% and prevent citrate formation in chick hepatocytes metabolizing glucose.
S D Clarke, P A Watkins, M D Lane
doaj  

Regulated acid-base transport in the collecting duct [PDF]

open access: yes, 2018
The renal collecting system serves the fine-tuning of renal acid-base secretion. Acid-secretory type-A intercalated cells secrete protons via a luminally expressed V-type H+-ATPase and generate new bicarbonate released by basolateral chloride/bicarbonate
Bourgeois, Soline   +3 more
core  

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