Results 151 to 160 of about 21,592 (215)

PFKM phosphorylates histone H3 and promotes mitotic progression by sensing the levels of citrate

open access: yesNature Communications
Emerging evidence indicates that metabolic signals—including nutrient availability, biosynthetic intermediates, and energy balance—are linked to cell cycle progression.
Pianpian Lin   +11 more
doaj   +1 more source

Pharmacological Modulation of Mutant TP53 with Oncotargets Against Esophageal Cancer and Therapy Resistance

open access: yesBiomedicines
The prevalence and deaths from esophageal cancer (EC) have recently increased. Although therapeutic strategies depend on the EC stage and recurrence, such as surgical intervention, chemotherapy, radiation therapy, chemoradiation therapy, targeted therapy,
Pei-I Lin   +3 more
doaj   +1 more source

PFKL Inhibition by DT-13: A Novel Approach to Combat Hepatocellular Carcinoma

open access: yesInternational Journal of Hepatology
Aerobic glycolysis modulates proliferation, apoptosis, immune evasion, and targeted drug resistance in hepatocellular carcinoma (HCC) patients. Therefore, inhibiting aerobic glycolysis could represent a novel chemotherapeutic strategy for HCC.
Qiang Yu   +4 more
doaj   +1 more source

The mechanism of PFK-1 in the occurrence and development of bladder cancer by regulating ZEB1 lactylation

open access: yesBMC Urology
Background Bladder cancer (BC) is one of the most common malignancies of the genitourinary system. Phosphofructokinase 1 (PFK-1) is one of member of PFK, which plays an important role in reprogramming cancer metabolism, such as lactylation modification ...
Rong Wang   +5 more
doaj   +1 more source

Phosphorylation of Bad at Thr-201 by JNK1 Promotes Glycolysis through Activation of Phosphofructokinase-1

open access: hybrid, 2008
Hongbin Deng   +5 more
openalex   +1 more source

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