Results 11 to 20 of about 19,634 (91)

Evolving a New Efficient Mode of Fructose Utilization for Improved Bioproduction in Corynebacterium glutamicum

Frontiers in Bioengineering and Biotechnology, 2021
Fructose utilization in Corynebacterium glutamicum starts with its uptake and concomitant phosphorylation via the phosphotransferase system (PTS) to yield intracellular fructose 1-phosphate, which enters glycolysis upon ATP-dependent phosphorylation to ...
Irene Krahn, Daniel Bonder, Lucía Torregrosa-Barragán, Dominik Stoppel, Jens P. Krause, Natalie Rosenfeldt, Tobias M. Meiswinkel, Gerd M. Seibold, Gerd M. Seibold, Volker F. Wendisch, Steffen N. Lindner, Steffen N. Lindner   +11 more
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Neonatal Vitamin C and Cysteine Deficiencies Program Adult Hepatic Glutathione and Specific Activities of Glucokinase, Phosphofructokinase, and Acetyl-CoA Carboxylase in Guinea Pigs’ Livers

Antioxidants, 2021
Premature neonates are submitted to an early-life oxidative stress from parenteral nutrition, which is vitamin C (VC) deficient and induces low endogenous levels of glutathione.
Vitor Teixeira, Ibrahim Mohamed, Jean-Claude Lavoie   +2 more
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Investigation of mRNA Levels of PFK-1, LDH-A, p53, and HIF-1α Genes Involved in Metabolic Reprogramming in Non-small Cell Lung Carcinoma

Journal of Kerman University of Medical Sciences, 2023
Background: It is expected that the expression of key enzymes of the glycolysis pathway, specially PFK-1, increases tumor cells and so enhances the function of this pathway.
Fatemeh Shakeri, Mehdi Ebrahimi, Shohre Zare Karizi   +2 more
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Transcriptome profiling of A549 non-small cell lung cancer cells in response to Trichinella spiralis muscle larvae excretory/secretory products

Frontiers in Veterinary Science, 2023
Trichinella spiralis (T. spiralis) muscle-larva excretory/secretory products (ML-ESPs) is a complex array of proteins with antitumor activity. We previously demonstrated that ML-ESPs inhibit the proliferation of A549 non-small cell lung cancer (NSCLC ...
Haoxuan Wang, Yingying Zhu, Meichen Li, Jingdan Pan, Dan Li, Wen-Ping Guo, Guangcheng Xie, Luanying Du   +7 more
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Natural products targeting glycolytic signaling pathways-an updated review on anti-cancer therapy

Frontiers in Pharmacology, 2022
Glycolysis is a complex metabolic process that occurs to convert glucose into pyruvate to produce energy for living cells. Normal cells oxidized pyruvate into adenosine triphosphate and carbon dioxide in the presence of oxygen in mitochondria while ...
Yuting Cui, Chuang Li, Feng Sang, Weiling Cao, Zhuo Qin, Peng Zhang   +5 more
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Long noncoding RNA BBOX1-AS1 increased radiotherapy sensitivity in colorectal cancer by stabilizing and activating PFK1

Translational Oncology, 2023
Purpose: Our study explored the effect of long noncoding RNA BBOX1-AS1 on colorectal cancer (CRC) radiosensitivity in vivo and in vitro. Methods: Differentially expressed lncRNAs in CRC were screened using a bioinformatics database and an online ...
Qi Wang, Xiao-Fei Li, Ying-Hui Zhou, Xiang-Hong Qin, Li-Hui Wang, Meng-Qing Xiao, Ke Cao, John K. Ma, Cheng-Hui Huang   +8 more
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The Role of Reprogrammed Glucose Metabolism in Cancer

Metabolites, 2023
Cancer cells reprogram their metabolism to meet biosynthetic needs and to adapt to various microenvironments. Accelerated glycolysis offers proliferative benefits for malignant cells by generating glycolytic products that move into branched pathways to ...
Meran Keshawa Ediriweera, Sharmila Jayasena   +1 more
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Glycolysis Rate-Limiting Enzymes: Novel Potential Regulators of Rheumatoid Arthritis Pathogenesis

Frontiers in Immunology, 2021
Rheumatoid arthritis (RA) is a classic autoimmune disease characterized by uncontrolled synovial proliferation, pannus formation, cartilage injury, and bone destruction.
Jianlin Zuo, Jinshuo Tang, Meng Lu, Zhongsheng Zhou, Yang Li, Hao Tian, Enbo Liu, Baoying Gao, Te Liu, Pu Shao, Pu Shao   +10 more
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Genome-Wide Identification and Expression Analysis Elucidates the Potential Role of PFK Gene Family in Drought Stress Tolerance and Sugar Metabolism in Cotton

Frontiers in Genetics, 2022
Drought has been identified as a major threat for global crop production worldwide. Phosphofructokinase (PFK) is vital for sugar metabolism. During phosphorylation, plants have two enzymes: ATP-dependent phosphofructokinase (PFK) and pyrophosphate ...
Teame Gereziher Mehari, Yanchao Xu, Muhammad Jawad Umer, Fang Hui, Xiaoyan Cai, Zhongli Zhou, Yuqing Hou, Kai Wang, Baohua Wang, Fang Liu, Fang Liu   +10 more
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Identification of three gene families coordinating the conversion between fructose-6-phosphate and fructose-1,6-bisphosphate in wheat

Biologia Plantarum, 2021
Saccharides are a direct energy source for most organisms and the primary components in grains of common wheat (Triticum aestivum L., 2n = 6x = 42, AABBDD).
C.M. YU, Y.C. KE, K.P. ZHANG, M. YAN, H.R. JIN, Y.H. CHEN, J. ZHANG   +6 more
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