Results 191 to 200 of about 23,730,752 (211)
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Crystal structure of human platelet phosphofructokinase-1 locked in an activated conformation.
Biochemical Journal, 2015Phosphofructokinase-1 (Pfk) acts as the main control point of flux through glycolysis. It is involved in complex allosteric regulation and Pfk mutations have been linked to cancer development.
M. Kloos +4 more
semanticscholar +4 more sources
Kinetic Model of phosphofructokinase-1 from Escherichia coli
Journal of Bioinformatics and Computational Biology, 2008This paper presents a kinetic model of phosphofructokinase-1 from Escherichia coli. A complete catalytic cycle has been reconstructed based on available information on the oligomeric structure of the enzyme and kinetic mechanism of its monomer.
K. Peskov, I. Goryanin, O. Demin
semanticscholar +3 more sources
Nucleoredoxin regulates glucose metabolism via phosphofructokinase 1.
Biochemical and Biophysical Research Communications, 2013Phosphofructokinase (PFK) 1 is a glycolytic enzyme, and its abnormality contributes to the development of multiple human diseases, such as cancer. Here, we report that nucleoredoxin (NRX), a thioredoxin-related oxidoreductase, is a novel interacting partner of PFK1. NRX binds directly to PFK1, and endogenous NRX and PFK1 interact in vivo.
Y. Funato +4 more
semanticscholar +4 more sources
Anticancer Research, 2022
Background/Aim: Phosphofructokinase 1 platelet isoform (PFKP) catalyzes a rate-limiting reaction in glycolysis. It is highly expressed in several tumors, including breast cancer (BC).
Jong-Ho Lee
semanticscholar +1 more source
Background/Aim: Phosphofructokinase 1 platelet isoform (PFKP) catalyzes a rate-limiting reaction in glycolysis. It is highly expressed in several tumors, including breast cancer (BC).
Jong-Ho Lee
semanticscholar +1 more source
A radioassay for phosphofructokinase-1 activity in cell extracts and purified enzyme.
Journal of Biochemical and Biophysical Methods, 2002Phosphofructokinase-1 plays a key role in the regulation of carbohydrate metabolism. Its activity can be used as an indicator of the glycolytic flux in a tissue sample. The method most commonly employed to determine phosphofructokinase-1 activity is based on oxidation of NADH by the use of aldolase, triosephosphate isomerase, and alpha-glycerophosphate
M. Sola-Penna +8 more
semanticscholar +4 more sources
Experimental Mycology, 1991
Abstract Phosphofructokinase 1 was partially purified from Agaricus bisporus fruit bodies and Pythium ultimum mycelium. The enzyme from A. bisporus was similar to other fungal phosphofructokinases 1: it was inhibited by ATP, had sigmoidal kinetics toward fructose-6-phosphate, and was stimulated by fructose-2,6-bisphosphate. Phosphoenolpyruvate was
Hilde M. Joosen, André Van Laere
openaire +2 more sources
Abstract Phosphofructokinase 1 was partially purified from Agaricus bisporus fruit bodies and Pythium ultimum mycelium. The enzyme from A. bisporus was similar to other fungal phosphofructokinases 1: it was inhibited by ATP, had sigmoidal kinetics toward fructose-6-phosphate, and was stimulated by fructose-2,6-bisphosphate. Phosphoenolpyruvate was
Hilde M. Joosen, André Van Laere
openaire +2 more sources
Molecular Genetics and Metabolism, 2010
Cancer cells are characterized by increased aerobic glycolysis, which correlates with a negative prognosis. Although this correlation is well known, the mechanism of the elevated rate of glycolysis in cancer and the role of glycolytic enzymes have yet to be determined.
P. Zancan +3 more
semanticscholar +3 more sources
Cancer cells are characterized by increased aerobic glycolysis, which correlates with a negative prognosis. Although this correlation is well known, the mechanism of the elevated rate of glycolysis in cancer and the role of glycolytic enzymes have yet to be determined.
P. Zancan +3 more
semanticscholar +3 more sources
Archives of Physiology and Biochemistry, 2000
The purpose of this investigation was to study the effect of isoproterenol (IPR) treatment on the regulation of phosphofructokinase-1 of submandibular salivary glands of rats. The animals were divided into control and experimental groups. In the first set of experiments, the rats received 5 mg of IPR/kg b.w.
J. Nicolau, D. N. Souza, G. Nunez-Burgos
semanticscholar +4 more sources
The purpose of this investigation was to study the effect of isoproterenol (IPR) treatment on the regulation of phosphofructokinase-1 of submandibular salivary glands of rats. The animals were divided into control and experimental groups. In the first set of experiments, the rats received 5 mg of IPR/kg b.w.
J. Nicolau, D. N. Souza, G. Nunez-Burgos
semanticscholar +4 more sources