PFKM-Mediated Glycolysis: A Pathway for ASIC1 to Enhance Cell Survival in the Acidic Microenvironment of Liver Cancer [PDF]
BiomoleculesThe acidic tumor microenvironment plays a critical role in promoting liver cancer cell survival by enhancing glycolysis and adaptive mechanisms. Acid-sensing ion channel 1 (ASIC1) is a key regulator of pH sensing, but its role in liver cancer progression
Xiaomin Wu +7 more
doaj +2 more sources
Reconstruction of Insulin Signal Flow from Phosphoproteome and Metabolome Data [PDF]
Cell Reports, 2014 Cellular homeostasis is regulated by signals through multiple molecular networks that include protein phosphorylation and metabolites. However, where and when the signal flows through a network and regulates homeostasis has not been explored.
Katsuyuki Yugi +17 more
doaj +4 more sources
The refinement of the yeast phosphofructokinase-1 atomic model [PDF]
Acta Crystallographica Section A Foundations of Crystallography, 2005 K. Banaszak +3 more
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Non-metabolic functions of phosphofructokinase-1 orchestrate tumor cellular invasion and genome maintenance under bevacizumab therapy. [PDF]
Neuro Oncol, 2023 Lim YC +16 more
europepmc +3 more sources
Filament assembly by the liver phosphofructokinase‐1, the “gatekeeper” of glycolysis
The FASEB Journal, 2020 Despite abundant knowledge of the regulation and biochemistry of glycolytic enzymes, we have limited understanding on how they are spatially organized in the cell. Emerging evidence indicates that metabolic enzymes from diverse pathways can assemble into filaments.
Bradley A. Webb +4 more
openalex +4 more sources
Filament Assembly by Phosphofructokinase-1, the Gatekeeper of Glycolysis [PDF]
Biophysical Journal, 2014 The cytoskeleton is conventionally viewed as being composed of three filamentous networks; microfilaments, microtubules, and intermediate filaments. This view is challenged by the findings that metabolic enzymes can form filaments with structural functions.
Bradley A. Webb +2 more
openalex +5 more sources
Light‐emitting diode irradiation targets aerobic glycolysis in cancer‐associated fibroblasts to inhibit metabolic coupling with colon cancer cells [PDF]
Ann Gastroenterol SurgBlue LED irradiation targeted metabolic coupling between CAFs and colon cancer cells. Abstract Background The concepts examined in tumor metabolism research have been moving away from cancer cells themselves and the tumor microenvironment has become a focus of investigation.
Nishi M +8 more
europepmc +2 more sources
The a-Subunit of the V-type H+-ATPase Interacts with Phosphofructokinase-1 in Humans [PDF]
Journal of Biological Chemistry, 2003 V-type or H+-ATPases are a family of ATP-dependent proton pumps that move protons across the plasma membrane at specialized sites such as kidney epithelial cells and osteoclasts as well as acidifying intracellular compartments. The 100-kDa polytopic a-subunit of this group of ATPases is suggested to play an important role in coupling the two functions ...
Ya Su +3 more
openalex +5 more sources
How Phosphofructokinase-1 Promotes PI3K and YAP/TAZ in Cancer: Therapeutic Perspectives. [PDF]
Cancers (Basel), 2022 PI3K/AKT is one of the most frequently altered signaling pathways in human cancers, supporting the activation of many proteins sustaining cell metabolism, proliferation, and aggressiveness. Another important pathway frequently altered in cancer cells is the one regulating the YAP/TAZ transcriptional coactivators, which promote the expression of genes ...
Simula L, Alifano M, Icard P.
europepmc +3 more sources
The structure of yeast phosphofructokinase 1 [PDF]
Acta Crystallographica Section A Foundations of Crystallography, 2005 W. Rypniewski +3 more
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