Substrate antagonism in the kinetic mechanism of E. coli phosphofructokinase‐1 [PDF]
FEBS Letters, 1991 In the presence of its allosteric activator GDP, the major phosphofructokinase‐1 from Escherichia coli K12 follows Michaelis—Menten kinetics. The kinetic behavior observed at steady‐state using different concentrations of the substrates ATP and fructose‐6‐phosphate and the pattern of inhibition by the substrate analogs adenylyl‐(β,γ‐methylene ...
Dominique Deville‐Bonne +2 more
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Oncology Reports, 2021 The activation of Wnt signaling has been detected in various types of human cancer and has been shown to be associated with cancer development. In the present study, it was revealed that Wnt signaling induced the expression of phosphofructokinase 1 platelet isoform (PFKP), which has been reported to catalyze a rate‑limiting reaction in glycolysis and ...
So Mi Jeon, Je Lim, Su Park, Jong-Ho Lee
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Filament Assembly by Phosphofructokinase-1, the Gatekeeper of Glycolysis [PDF]
Biophysical Journal, 2014 The cytoskeleton is conventionally viewed as being composed of three filamentous networks; microfilaments, microtubules, and intermediate filaments. This view is challenged by the findings that metabolic enzymes can form filaments with structural functions.
Bradley A. Webb +2 more
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Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations. [PDF]
Nature, 2015 Webb BA +5 more
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PKP1 promotes lung cancer by modulating energy metabolism through stabilization of PFKP [PDF]
Biomarker ResearchLung cancer is the leading cause of cancer-related deaths worldwide, with lung squamous cell carcinoma (LUSC) lacking effective targeted therapies. Recent studies have identified Plakophilin-1 (PKP1) as one of the most differentially overexpressed genes ...
Félix Ritoré-Salazar +8 more
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Pharmacological ResearchPhenolic acid-rich fraction from Anisopus mannii (PhAM) contains abundance of ferulic acid, gallic acid, protocatechuic acid, and syringic acid.
Peter U. Amadi +13 more
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Hitting the Sweet Spot: How Glucose Metabolism Is Orchestrated in Space and Time by Phosphofructokinase-1. [PDF]
Cancers (Basel), 2023 Campos M, Albrecht LV.
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Interaction of murine monoclonal subunit‐specific antibodies with phosphofructokinase‐1 from Saccharomyces cerevisiae [PDF]
FEBS Letters, 1995 Murine monoclonal subunit‐specific antibodies against heterooctameric phosphofructokinase‐1 from Saccharomyces cerevisiae exhibiting no cross‐reactivity were purified and characterized regarding complex formation with the native enzyme, immunological reactivity to the SDS‐denatured subunits originating from native and proteolytically truncated ...
Gèrhard Kopperschläger +2 more
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Reversible High Affinity Inhibition of Phosphofructokinase-1 by Acyl-CoA [PDF]
Journal of Biological Chemistry, 2011 Christopher M. Jenkins +3 more
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Functional requirements of the liver isoform of phosphofructokinase-1 in breast cancer cell migration. [PDF]
J Cell SciHansen HL, Webb BA.
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