Results 31 to 40 of about 19,721 (159)

Filament Assembly by Phosphofructokinase-1, the Gatekeeper of Glycolysis [PDF]

Biophysical Journal, 2014
The cytoskeleton is conventionally viewed as being composed of three filamentous networks; microfilaments, microtubules, and intermediate filaments. This view is challenged by the findings that metabolic enzymes can form filaments with structural functions.
Webb, Bradley, Ackerman, Larry, Barber, Diane   +2 more
openaire   +3 more sources

CBIO-15NON-METABOLIC FUNCTION OF PHOSPHOFRUCTOKINASE-1 IN GLIOBLASTOMA MAINTENANCE [PDF]

Neuro Oncol, 2015
BACKGROUND: Glioblastoma multiforme (GBM) remains one of the most lethal tumors and is associated with a median survival of only approximately 15 months, despite aggressive combination radio-chemo-therapy. Regardless of recent advances in our understanding of this deadly disease, the molecular mechanisms/genes that cause high recurrence rates and ...
Jensen K, Obara E, Gajjar M, Rasmussen R, Bartek J, Skjøth-Rasmussen J, Brennum J, Rich J, Hamerlik P.   +8 more
europepmc   +3 more sources

Some characteristics of Rabbit muscle phosphofructokinase-1 inhibition by ascorbate

Journal of Enzyme Inhibition and Medicinal Chemistry, 2008
These studies relate to a working hypothesis that glycogen storage is facilitated in resting muscle by inhibiting glycolysis via inhibition of LDH, AK, and PFK-1 by ascorbate; when muscle is active, these isozymes combine with muscle proteins and are released and protected from inhibition by ascorbate and glycolysis proceeds.
Percy, Russell, Anita, Williams, Karla, Marquez, Zunera, Tahir, Banafsheh, Hosseinian, Kelly, Lam   +5 more
openaire   +2 more sources

Computer‐assisted simulations of phosphofructokinase‐1 kinetics using simplified velocity equations [PDF]

Biochemistry and Molecular Biology Education, 2001
AbstractEquations useful for simulating the kinetic behavior of phosphofructokinase are presented. The equations, which are based on the concerted transition (symmetry) model for allosteric enzymes, account for substrate inhibition by MgATP, cooperative binding by F‐6‐P, activation by F‐2, 6‐P2, and deinhibition by AMP.
Harry Roy, Joyce Diwan, Leigh D. Segel, Irwin H. Segel   +3 more
openaire   +2 more sources

Metabolic regulation of calcium pumps in pancreatic cancer: role of phosphofructokinase-fructose-bisphosphatase-3 (PFKFB3)

Cancer & Metabolism, 2020
Background High glycolytic rate is a hallmark of cancer (Warburg effect). Glycolytic ATP is required for fuelling plasma membrane calcium ATPases (PMCAs), responsible for extrusion of cytosolic calcium, in pancreatic ductal adenocarcinoma (PDAC ...
D. A. Richardson, P. Sritangos, A. D. James, A. Sultan, J. I. E. Bruce   +4 more
doaj   +1 more source

Distribution of nesfatin-1 expression in Bactrian camels and its impact on adipocyte glucose metabolism [PDF]

Pesquisa Veterinária Brasileira
: The study aimed to investigate the distribution and expression of nesfatin-1 in Bactrian camels and its impact on adipocyte glucose metabolism. Polyclonal antibodies against a single antigenic epitope of NUCB2/nesfatin-1 protein were prepared. Nesfatin-
Siriguleng Yu, Bijun Chen, Haoyu Bai, Ziyi Li, Yaru Niu, Xingchuan He, Wen Yu, Shumin Du, Junjian Jin, Hongqiang Yao   +9 more
doaj   +1 more source

The influence of dapagliflozin on cardiac remodeling, myocardial function and metabolomics in type 1 diabetes mellitus rats

Diabetology & Metabolic Syndrome, 2023
Background Sodium-glucose cotransporter (SGLT)2 inhibitors have displayed beneficial effects on the cardiovascular system in diabetes mellitus (DM) patients.
Eder Anderson Rodrigues, Camila Moreno Rosa, Dijon Henrique Salome Campos, Felipe Cesar Damatto, Gilson Masahiro Murata, Lidiane Moreira Souza, Luana Urbano Pagan, Mariana Gatto, Jessica Yumi Brosler, Hebreia Oliveira Almeida Souza, Mario Machado Martins, Luciana Machado Bastos, Suzana Erico Tanni, Katashi Okoshi, Marina Politi Okoshi   +14 more
doaj   +1 more source

Substrate antagonism in the kinetic mechanism of E. coli phosphofructokinase‐1

FEBS Letters, 1991
In the presence of its allosteric activator GDP, the major phosphofructokinase‐1 from Escherichia coli K12 follows Michaelis—Menten kinetics. The kinetic behavior observed at steady‐state using different concentrations of the substrates ATP and fructose‐6‐phosphate and the pattern of inhibition by the substrate analogs adenylyl‐(β,γ‐methylene ...
Deville-Bonne, Dominique, Laine, Romuald, Garel, Jean-Renaud   +2 more
openaire   +2 more sources

Fructose metabolism in Chromohalobacter salexigens: interplay between the Embden–Meyerhof–Parnas and Entner–Doudoroff pathways

Microbial Cell Factories, 2019
Background The halophilic bacterium Chromohalobacter salexigens metabolizes glucose exclusively through the Entner–Doudoroff (ED) pathway, an adaptation which results in inefficient growth, with significant carbon overflow, especially at low salinity ...
José M. Pastor, Nuno Borges, Juan P. Pagán, Sara Castaño-Cerezo, Laszlo N. Csonka, Bradley W. Goodner, Kathryn A. Reynolds, Luís G. Gonçalves, Montserrat Argandoña, Joaquín J. Nieto, Carmen Vargas, Vicente Bernal, Manuel Cánovas   +12 more
doaj   +1 more source

Vanadate influence on metabolism of sugar phosphates in fungus Phycomyces blakesleeanus. [PDF]

PLoS ONE, 2014
The biological and chemical basis of vanadium action in fungi is relatively poorly understood. In the present study, we investigate the influence of vanadate (V5+) on phosphate metabolism of Phycomyces blakesleeanus.
Milan Žižić, Miroslav Živić, Vuk Maksimović, Marina Stanić, Strahinja Križak, Tijana Cvetić Antić, Joanna Zakrzewska   +6 more
doaj   +1 more source