Results 41 to 50 of about 21,592 (215)
Journal of Kerman University of Medical Sciences, 2023 Background: It is expected that the expression of key enzymes of the glycolysis pathway, specially PFK-1, increases tumor cells and so enhances the function of this pathway.
Fatemeh Shakeri +2 more
doaj +1 more source
Frontiers in Veterinary Science, 2023 Trichinella spiralis (T. spiralis) muscle-larva excretory/secretory products (ML-ESPs) is a complex array of proteins with antitumor activity. We previously demonstrated that ML-ESPs inhibit the proliferation of A549 non-small cell lung cancer (NSCLC ...
Haoxuan Wang +7 more
doaj +1 more source
Natural products targeting glycolytic signaling pathways-an updated review on anti-cancer therapy
Frontiers in Pharmacology, 2022 Glycolysis is a complex metabolic process that occurs to convert glucose into pyruvate to produce energy for living cells. Normal cells oxidized pyruvate into adenosine triphosphate and carbon dioxide in the presence of oxygen in mitochondria while ...
Yuting Cui +5 more
doaj +1 more source
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Translational Oncology, 2023 Purpose: Our study explored the effect of long noncoding RNA BBOX1-AS1 on colorectal cancer (CRC) radiosensitivity in vivo and in vitro. Methods: Differentially expressed lncRNAs in CRC were screened using a bioinformatics database and an online ...
Qi Wang +8 more
doaj +1 more source
Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts. [PDF]
, 2019 Pancreatic cancer is a complex disease, in need of new therapeutic approaches. In this study, we explored the effect and mechanism of action of epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, alone and in combination with current ...
Hackman, Robert M +3 more
core +1 more source
The Role of Reprogrammed Glucose Metabolism in Cancer
Metabolites, 2023 Cancer cells reprogram their metabolism to meet biosynthetic needs and to adapt to various microenvironments. Accelerated glycolysis offers proliferative benefits for malignant cells by generating glycolytic products that move into branched pathways to ...
Meran Keshawa Ediriweera +1 more
doaj +1 more source
Modulation of glycolisis and the pentose phosphate pathway influences porcine oocyte in vitro maturation [PDF]
, 2013 Glycolytic and pentose phosphate pathway (PPP) activities were modulated in porcine cumulus-oocyte complexes (COCs) during in vitro maturation (IVM) by the addition of inhibitors or stimulators of key enzymes of the pathways to elucidate their relative ...
Alvarez, Gabriel Martín +4 more
core +2 more sources
Glycolysis Rate-Limiting Enzymes: Novel Potential Regulators of Rheumatoid Arthritis Pathogenesis
Frontiers in Immunology, 2021 Rheumatoid arthritis (RA) is a classic autoimmune disease characterized by uncontrolled synovial proliferation, pannus formation, cartilage injury, and bone destruction.
Jianlin Zuo +10 more
doaj +1 more source
Increased Adenine Nucleotide Degradation in Skeletal Muscle Atrophy [PDF]
, 2019 Adenine nucleotides (AdNs: ATP, ADP, AMP) are essential biological compounds that facilitate many necessary cellular processes by providing chemical energy, mediating intracellular signaling, and regulating protein metabolism and solubilization.
Brault, Jeffrey J. +2 more
core +1 more source