Results 41 to 50 of about 20,352 (205)

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Investigation of mRNA Levels of PFK-1, LDH-A, p53, and HIF-1α Genes Involved in Metabolic Reprogramming in Non-small Cell Lung Carcinoma

Journal of Kerman University of Medical Sciences, 2023
Background: It is expected that the expression of key enzymes of the glycolysis pathway, specially PFK-1, increases tumor cells and so enhances the function of this pathway.
Fatemeh Shakeri, Mehdi Ebrahimi, Shohre Zare Karizi   +2 more
doaj   +1 more source

Natural products targeting glycolytic signaling pathways-an updated review on anti-cancer therapy

Frontiers in Pharmacology, 2022
Glycolysis is a complex metabolic process that occurs to convert glucose into pyruvate to produce energy for living cells. Normal cells oxidized pyruvate into adenosine triphosphate and carbon dioxide in the presence of oxygen in mitochondria while ...
Yuting Cui, Chuang Li, Feng Sang, Weiling Cao, Zhuo Qin, Peng Zhang   +5 more
doaj   +1 more source

Transcriptome profiling of A549 non-small cell lung cancer cells in response to Trichinella spiralis muscle larvae excretory/secretory products

Frontiers in Veterinary Science, 2023
Trichinella spiralis (T. spiralis) muscle-larva excretory/secretory products (ML-ESPs) is a complex array of proteins with antitumor activity. We previously demonstrated that ML-ESPs inhibit the proliferation of A549 non-small cell lung cancer (NSCLC ...
Haoxuan Wang, Yingying Zhu, Meichen Li, Jingdan Pan, Dan Li, Wen-Ping Guo, Guangcheng Xie, Luanying Du   +7 more
doaj   +1 more source

Metabolic alterations during the growth of tumour spheroids [PDF]

, 2005
Solid tumours undergo considerable alterations in their metabolism of nutrients in order to generate sufficient energy and biomass for sustained growth and proliferation.
A Yalcin, AJ Primeau, Alexander Fletcher, AS Marsin, C Cosentino, Catherine Kelly, CC Wykoff, CM Jenkins, CV Dang, CV Dang, D Hanahan, D Holten, DA Okar, David Gavaghan, E Bustamante, F Hirschhaeuser, F Li, GL Semenza, GL Semenza, H Li, H Yun, Hannah Smith, HG Hers, HR Christofk, HR Christofk, HR Mellor, HR Mellor, I Mor, J Chesney, J Friedrich, JD Dombrauckas, JE Wilson, JG Pastorino, JG Pastorino, JJ Casciari, JQ Chen, JS Moon, K Ashizawa, K Bensaad, Katarzyna Bloch, KB Nolop, KL Talks, LA Kunz-Schughart, LG Baggetto, LG Boros, M Israel, M Kimata, M Linden, M Tamada, MD Hall, MG Vander Heiden, MH Rider, O Feron, O Minchenko, O Warburg, P Jiang, P Swietach, P Vaupel, Philip Maini, PL Pedersen, PS Ward, PW Vaupel, R Moreno-Sanchez, RC Stanton, RF Kletzien, Richard Callaghan, RJ DeBerardinis, RT Tong, S Gottschalk, S Mazurek, S Modok, S Rodriguez-Enriquez, S Tudzarova, S Weinhouse, T Contractor, T Hitosugi, T Wood, Victoria Hamel Parsons, VR Fantin, W Hu, WM Frederiks   +80 more
core   +3 more sources

Metformin lowers Glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation [PDF]

, 2020
The chronic effects of metformin on liver gluconeogenesis involve repression of the G6pc gene, which is regulated by the carbohydrate-response element-binding protein through raised cellular intermediates of glucose metabolism.
Adam-Primus, Natasha S., Agius, Loranne, Al-Oanzi, Ziad H., Alshawi, Ahmed, Arden, Catherine, Cascante i Serratosa, Marta, Chachra, Shruti S., Ford, Brian E., Foretz, Marc, Marin Martinez, Moonira, Tabassum, Viollet, Benoit   +11 more
core   +2 more sources

The Role of Reprogrammed Glucose Metabolism in Cancer

Metabolites, 2023
Cancer cells reprogram their metabolism to meet biosynthetic needs and to adapt to various microenvironments. Accelerated glycolysis offers proliferative benefits for malignant cells by generating glycolytic products that move into branched pathways to ...
Meran Keshawa Ediriweera, Sharmila Jayasena   +1 more
doaj   +1 more source

Mice with low levels of Shc proteins display reduced glycolytic and increased gluconeogenic activities in liver. [PDF]

, 2016
Shc proteins play a role in energy metabolism through interaction with the insulin receptor. The aim of this study was to determine whether Shc proteins influence liver glycolysis and gluconeogenesis under both fed and fasted states. Decreased glycolytic
Cortopassi, Gino A, Hagopian, Kevork, Kim, Kyoungmi, López-Dominguez, José Alberto, Ramsey, Jon J, Tomilov, Alexey A   +5 more
core   +3 more sources

Increased Adenine Nucleotide Degradation in Skeletal Muscle Atrophy [PDF]

, 2019
Adenine nucleotides (AdNs: ATP, ADP, AMP) are essential biological compounds that facilitate many necessary cellular processes by providing chemical energy, mediating intracellular signaling, and regulating protein metabolism and solubilization.
Brault, Jeffrey J., Hafen, Paul S., Miller, Spencer G.   +2 more
core   +1 more source

Control of fructose 2,6-bisphosphate levels in rat macrophages by glucose and phorbol ester [PDF]

, 1989
The presence of fructose 2,6-bisphosphate (Fru 2,6-P2) in elicited peritoneal macrophages of rat was examined. These cells possess an active phosphofructokinase-2 which is diminished by citrate and only slightly inhibited by glycerol 3-phosphate ...
Bustos, R., Sobrino, F.
core   +1 more source