Results 61 to 70 of about 21,592 (215)

The influence of dapagliflozin on cardiac remodeling, myocardial function and metabolomics in type 1 diabetes mellitus rats

Diabetology & Metabolic Syndrome, 2023
Background Sodium-glucose cotransporter (SGLT)2 inhibitors have displayed beneficial effects on the cardiovascular system in diabetes mellitus (DM) patients.
Eder Anderson Rodrigues, Camila Moreno Rosa, Dijon Henrique Salome Campos, Felipe Cesar Damatto, Gilson Masahiro Murata, Lidiane Moreira Souza, Luana Urbano Pagan, Mariana Gatto, Jessica Yumi Brosler, Hebreia Oliveira Almeida Souza, Mario Machado Martins, Luciana Machado Bastos, Suzana Erico Tanni, Katashi Okoshi, Marina Politi Okoshi   +14 more
doaj   +1 more source

Biological aspects of mTOR in leukemia [PDF]

, 2018
The mammalian target of rapamycin (mTOR) is a central processor of intra-and extracellular signals, regulating many fundamental cellular processes such as metabolism, growth, proliferation, and survival.
Bianchi, Mp, Gianfelici, V, Mirabilii, S, Piedimonte, M, Ricciardi, Mr, Tafuri, A.   +5 more
core   +1 more source

Unique PFK regulatory property from some mosquito vectors of disease, and from Drosophila melanogaster [PDF]

, 2016
Effect of F2, 6BP on Aedes aegypti PFK activity. PFK activity was measured at pH = 7.4, 1 mM F6P, 5 mM ATP at several F2, 6BP concentrations (0.01–50 μM). Values are the means ± SEM of three independent experiments.
Glória Regina Cardoso Braz, Hugo Tremonte De Carvalho, Jean Ribeiro Moreira, Mauro Sola-Penna, Mário Alberto C. Silva-Neto, Nelilma Correia Romeiro, Rodrigo Dutra Nunes   +6 more
core   +3 more sources

Metabolic adaptations in skeletal muscle after 84 days of bed rest with and without concurrent flywheel resistance exercise [PDF]

, 2017
As metabolic changes in human skeletal muscle after long-term (simulated) spaceflight are not well understood, this study examined the effects of long-term microgravity, with and without concurrent resistance exercise, on skeletal muscle oxidative and ...
Cadefau, Joan A., Cussó, Roser, Fernandez-Gonzalo, Rodrigo, Guerrero, Mario, Irimia, José M., Rodriguez-Miquelez, Paula, Tesch, Per A.   +6 more
core   +1 more source

Organ-specific responses during brain death:increased aerobic metabolism in the liver and anaerobic metabolism with decreased perfusion in the kidneys [PDF]

, 2018
Hepatic and renal energy status prior to transplantation correlates with graft survival. However, effects of brain death (BD) on organ-specific energy status are largely unknown.
Burgerhof, J G M, Bøtker, H E, Ciapaite, J, Hoeksma, D, Jespersen, B, Jespersen, N R, Laustsen, C, Leuvenink, H G D, Nørregaard, R, Ottens, P J, Pedersen, M, Rebolledo, R A, Van Erp, A C, Wolters, J C   +13 more
core   +2 more sources

Vanadate influence on metabolism of sugar phosphates in fungus Phycomyces blakesleeanus. [PDF]

PLoS ONE, 2014
The biological and chemical basis of vanadium action in fungi is relatively poorly understood. In the present study, we investigate the influence of vanadate (V5+) on phosphate metabolism of Phycomyces blakesleeanus.
Milan Žižić, Miroslav Živić, Vuk Maksimović, Marina Stanić, Strahinja Križak, Tijana Cvetić Antić, Joanna Zakrzewska   +6 more
doaj   +1 more source

Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas

BMC Cancer, 2011
Background HIF-1 deficiency has marked effects on tumour glycolysis and growth. We therefore investigated the consequences of HIF-1 deficiency in mice, using the well established Hepa-1 wild-type (WT) and HIF-1β-deficient (c4) model.
Airley Rachel E, Williams Kaye J, Ly Lucy, Yin Xiaoke, Mayr Manuel, McSheehy Paul M, Chung Yuen-Li, Troy Helen, Golinska Monika, Harris Adrian L, Latigo John, Perumal Meg, Aboagye Eric O, Perrett David, Stubbs Marion, Griffiths John R   +15 more
doaj   +1 more source

Blockage of glycolysis by targeting PFKFB3 suppresses the development of infantile hemangioma

Journal of Translational Medicine, 2023
Background Infantile hemangioma (IH) is the most common tumor among infants, but the exact pathogenesis of IH is largely unknown. Our previous study revealed that glucose metabolism may play an important role in the pathogenesis of IH and that the ...
Kaiying Yang, Tong Qiu, Jiangyuan Zhou, Xue Gong, Xuepeng Zhang, Yuru Lan, Zixin Zhang, Yi Ji   +7 more
doaj   +1 more source

A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment

Advanced Healthcare Materials, EarlyView.
A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim, Tianxin Cao, Zhengpeng Wan, Jaesang Kim, Zhuxuan Li, Legairre A. Radden II, Rakesh Santhanam, Eunkyung Clare Ko, Tatsuya Osaki, Sarah Spitz, Hyunmin Moon, Maria Proestaki, Seokbeom Roh, Gyudo Lee, Jessie S. Jeon, Curtis R. Warren, Roger D. Kamm   +16 more
wiley   +1 more source

Unveiling Global Diversity of Patescibacteriota and Functional Interactions with Host Microbes

Advanced Science, EarlyView.
Patescibacteriota represents a diverse group of ultra‐small epibiotic bacteria, which is largely overlooked. By integrating ribosomal protein S3‐based community profiling with MAG‐based metabolic potential analyses, this study provides new insights into their distribution, diversity, and potential interactions with other bacteria across diverse ...
Yanhan Ji, Xu Liu, Shuai Zhao, Sihan Zhou, Yufan Yang, Ping Zhang, Yu Shi, Wei Qin, Guibing Zhu, Yongguan Zhu, Yanzheng Gao, Jiandong Jiang, Baozhan Wang   +12 more
wiley   +1 more source